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Q91XT4

- SC16B_MOUSE

UniProt

Q91XT4 - SC16B_MOUSE

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Protein
Protein transport protein Sec16B
Gene
Sec16b, Kiaa1928, Lztr2, Rgpr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization By similarity.

GO - Biological processi

  1. COPII vesicle coating Source: InterPro
  2. endoplasmic reticulum organization Source: Ensembl
  3. peroxisome fission Source: Ensembl
  4. positive regulation of gene expression Source: Ensembl
  5. positive regulation of protein exit from endoplasmic reticulum Source: Ensembl
  6. protein localization to endoplasmic reticulum Source: Ensembl
  7. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec16B
Alternative name(s):
Leucine zipper transcription regulator 2
Regucalcin gene promoter region-related protein p117
Short name:
RGPR-p117
SEC16 homolog B
Gene namesi
Name:Sec16b
Synonyms:Kiaa1928, Lztr2, Rgpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2148802. Sec16b.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10511051Protein transport protein Sec16B
PRO_0000341975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Phosphoserine1 Publication
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei863 – 8631Phosphoserine1 Publication
Modified residuei866 – 8661Phosphoserine1 Publication
Modified residuei874 – 8741Phosphoserine1 Publication
Modified residuei875 – 8751Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91XT4.
PaxDbiQ91XT4.
PRIDEiQ91XT4.

PTM databases

PhosphoSiteiQ91XT4.

Expressioni

Tissue specificityi

Liver.1 Publication

Gene expression databases

BgeeiQ91XT4.
GenevestigatoriQ91XT4.

Interactioni

Subunit structurei

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ91XT4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 2264Poly-Ser
Compositional biasi900 – 98081Ser-rich
Add
BLAST
Compositional biasi1009 – 10124Poly-Pro

Sequence similaritiesi

Belongs to the SEC16 family.

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00530000063746.
HOGENOMiHOG000049067.
HOVERGENiHBG108463.
InParanoidiQ91XT4.
OMAiATCCGDK.
OrthoDBiEOG7MH0XQ.
TreeFamiTF316276.

Family and domain databases

InterProiIPR024880. Sec16.
IPR024340. Sec16_CCD.
[Graphical view]
PANTHERiPTHR13402. PTHR13402. 1 hit.
PfamiPF12932. Sec16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XT4-1 [UniParc]FASTAAdd to Basket

« Hide

MEPWVPQTQG RTTGPSRDTN RGLQSGHYRP RLHSQYSGDK YHQWQDAHKN     50
SKSQQDLRDD HQQSHSVSRS GEWSQPVSGA DYLKGSYPSH LYSRSGYGDP 100
YQRYHTPTPR DEYAYGNYYY HGHPQLLPEE RVARQGSPYI WHEDHGDQRY 150
FGEHHREKHN GTFGANSDTQ FQFTSKNPYR DSPASVSGQE QPGEFFPESE 200
AQKQKPLLTS KSSLLQQHES GLSSSSYELS QYMTAAPEEY EPMVSAAWRP 250
IQADDTSATV PKAPMRFYVP HVSVSFGPGG QLVCVPPNSP ADGQTALVEV 300
HSMEVLLNDF EDQEEMRAFP GPLIREDIHK VDIMTFCQQK ATQCLKSETP 350
GSRDSALLWQ LLVLLCRQNG SMVGSDIAEL LMQDCKKLEK YKRQPPVANL 400
INLTDEDWPV LSSGTRDLLT GEIPPNVDTP AQIVEKFTKL LYYGRKKEAL 450
EWAMKNHLWG HALFLASKMD PRTYNWVMSG FTSTLALNDP LQTLFQLMSG 500
RIPQAATVCG DKQWGDWRPH LAVILSNQAG DTELYQRAIV SMGDTLAGKG 550
LVEASHFCYL MAHVPFGHYT VKTDHLALVG SSHSQEFMKF ATIEAIQRTE 600
IFEYCQMLGR PKSFIPSFQV YKLLYASRLA DYGLASQALH YCEAIGAAVL 650
SQEGSSHPVL LAELIKLAEK LKLSDPLVLE RRRGDRDLEP DWLVQLRRKH 700
KDLEQNRTGA PRDPDSTPSD IYGAGGTTDT PYPDLSGHQN YSEDSEYSST 750
LWSTAEQTSL TNPLAQQSFP LQRDTYSGHM GTPVPLYSVP ATHLAVTSGA 800
SGSSVAVTGT PGGRVGEDML RTHPAFGENT MTQEPLEDPD GLEVISSLQT 850
PAAPRVPSFS EDSAASAKED EEGSSDGADK PSHPDASQKG KLGDGKNTKS 900
SGFGWFSWFR SKPASSVSTS GDEDSSDSSD SEESPRASSP HHASPGLSPT 950
PPLTSPSLPG ASTFSRGTGG SILQGSSNSS GIAEGMGIGG FSGTQGVSSE 1000
FYSQPGALPP PPTLQGAVPL YNPSQVPQLP TASSLNRPNR LAQRRYPTQP 1050
C 1051
Length:1,051
Mass (Da):115,513
Last modified:July 27, 2011 - v3
Checksum:iCA802D45E2E39748
GO

Sequence cautioni

The sequence BAD32580.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71Q → H in AAH59194. 1 Publication
Sequence conflicti32 – 321L → P in BAB61034. 1 Publication
Sequence conflicti32 – 321L → P in AAH59194. 1 Publication
Sequence conflicti168 – 1681D → G in BAB61034. 1 Publication
Sequence conflicti199 – 1991S → R in BAB61034. 1 Publication
Sequence conflicti286 – 2861P → S in BAB61034. 1 Publication
Sequence conflicti322 – 3221P → A in BAB61034. 1 Publication
Sequence conflicti329 – 3291H → P in BAB61034. 1 Publication
Sequence conflicti711 – 7111P → L in BAB61034. 1 Publication
Sequence conflicti711 – 7111P → L in AAH59194. 1 Publication
Sequence conflicti939 – 9391S → P in BAB61034. 1 Publication
Sequence conflicti939 – 9391S → P in AAH59194. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB063356 mRNA. Translation: BAB61034.1.
AK173302 mRNA. Translation: BAD32580.1. Different initiation.
AC161108 Genomic DNA. No translation available.
BC059194 mRNA. Translation: AAH59194.1.
CCDSiCCDS15400.1.
RefSeqiNP_001153458.1. NM_001159986.1.
NP_203505.3. NM_033354.3.
UniGeneiMm.87114.

Genome annotation databases

EnsembliENSMUST00000027881; ENSMUSP00000027881; ENSMUSG00000026589.
ENSMUST00000086130; ENSMUSP00000083300; ENSMUSG00000026589.
ENSMUST00000111700; ENSMUSP00000107329; ENSMUSG00000026589.
GeneIDi89867.
KEGGimmu:89867.
UCSCiuc007ddl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB063356 mRNA. Translation: BAB61034.1 .
AK173302 mRNA. Translation: BAD32580.1 . Different initiation.
AC161108 Genomic DNA. No translation available.
BC059194 mRNA. Translation: AAH59194.1 .
CCDSi CCDS15400.1.
RefSeqi NP_001153458.1. NM_001159986.1.
NP_203505.3. NM_033354.3.
UniGenei Mm.87114.

3D structure databases

ProteinModelPortali Q91XT4.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91XT4.

Proteomic databases

MaxQBi Q91XT4.
PaxDbi Q91XT4.
PRIDEi Q91XT4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027881 ; ENSMUSP00000027881 ; ENSMUSG00000026589 .
ENSMUST00000086130 ; ENSMUSP00000083300 ; ENSMUSG00000026589 .
ENSMUST00000111700 ; ENSMUSP00000107329 ; ENSMUSG00000026589 .
GeneIDi 89867.
KEGGi mmu:89867.
UCSCi uc007ddl.2. mouse.

Organism-specific databases

CTDi 89866.
MGIi MGI:2148802. Sec16b.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00530000063746.
HOGENOMi HOG000049067.
HOVERGENi HBG108463.
InParanoidi Q91XT4.
OMAi ATCCGDK.
OrthoDBi EOG7MH0XQ.
TreeFami TF316276.

Miscellaneous databases

NextBioi 351362.
PROi Q91XT4.
SOURCEi Search...

Gene expression databases

Bgeei Q91XT4.
Genevestigatori Q91XT4.

Family and domain databases

InterProi IPR024880. Sec16.
IPR024340. Sec16_CCD.
[Graphical view ]
PANTHERi PTHR13402. PTHR13402. 1 hit.
Pfami PF12932. Sec16. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver."
    Misawa H., Yamaguchi M.
    Int. J. Mol. Med. 8:513-520(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreatic islet.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "Gene expression for a novel protein RGPR-p117 in various species: the stimulation by intracellular signaling factors."
    Misawa H., Yamaguchi M.
    J. Cell. Biochem. 87:188-193(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-182; SER-863; SER-866; SER-874 AND SER-875, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSC16B_MOUSE
AccessioniPrimary (citable) accession number: Q91XT4
Secondary accession number(s): E9QL61, Q69Z64, Q6PCR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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