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Protein

Protein transport protein Sec16B

Gene

Sec16b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.By similarity

GO - Biological processi

  1. COPII vesicle coating Source: InterPro
  2. endoplasmic reticulum organization Source: MGI
  3. peroxisome fission Source: MGI
  4. peroxisome organization Source: MGI
  5. positive regulation of gene expression Source: MGI
  6. positive regulation of protein exit from endoplasmic reticulum Source: MGI
  7. protein localization to endoplasmic reticulum Source: MGI
  8. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec16B
Alternative name(s):
Leucine zipper transcription regulator 2
Regucalcin gene promoter region-related protein p117
Short name:
RGPR-p117
SEC16 homolog B
Gene namesi
Name:Sec16b
Synonyms:Kiaa1928, Lztr2, Rgpr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2148802. Sec16b.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. Golgi membrane Source: UniProtKB-SubCell
  3. intracellular membrane-bounded organelle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10511051Protein transport protein Sec16BPRO_0000341975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Phosphoserine1 Publication
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei863 – 8631Phosphoserine1 Publication
Modified residuei866 – 8661Phosphoserine1 Publication
Modified residuei874 – 8741Phosphoserine1 Publication
Modified residuei875 – 8751Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91XT4.
PaxDbiQ91XT4.
PRIDEiQ91XT4.

PTM databases

PhosphoSiteiQ91XT4.

Expressioni

Tissue specificityi

Liver.1 Publication

Gene expression databases

BgeeiQ91XT4.
GenevestigatoriQ91XT4.

Interactioni

Subunit structurei

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91XT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 2264Poly-Ser
Compositional biasi900 – 98081Ser-richAdd
BLAST
Compositional biasi1009 – 10124Poly-Pro

Sequence similaritiesi

Belongs to the SEC16 family.Curated

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00530000063746.
HOGENOMiHOG000049067.
HOVERGENiHBG108463.
InParanoidiQ91XT4.
OMAiATCCGDK.
OrthoDBiEOG7MH0XQ.
TreeFamiTF316276.

Family and domain databases

InterProiIPR024880. Sec16.
IPR024340. Sec16_CCD.
[Graphical view]
PANTHERiPTHR13402. PTHR13402. 1 hit.
PfamiPF12932. Sec16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XT4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPWVPQTQG RTTGPSRDTN RGLQSGHYRP RLHSQYSGDK YHQWQDAHKN
60 70 80 90 100
SKSQQDLRDD HQQSHSVSRS GEWSQPVSGA DYLKGSYPSH LYSRSGYGDP
110 120 130 140 150
YQRYHTPTPR DEYAYGNYYY HGHPQLLPEE RVARQGSPYI WHEDHGDQRY
160 170 180 190 200
FGEHHREKHN GTFGANSDTQ FQFTSKNPYR DSPASVSGQE QPGEFFPESE
210 220 230 240 250
AQKQKPLLTS KSSLLQQHES GLSSSSYELS QYMTAAPEEY EPMVSAAWRP
260 270 280 290 300
IQADDTSATV PKAPMRFYVP HVSVSFGPGG QLVCVPPNSP ADGQTALVEV
310 320 330 340 350
HSMEVLLNDF EDQEEMRAFP GPLIREDIHK VDIMTFCQQK ATQCLKSETP
360 370 380 390 400
GSRDSALLWQ LLVLLCRQNG SMVGSDIAEL LMQDCKKLEK YKRQPPVANL
410 420 430 440 450
INLTDEDWPV LSSGTRDLLT GEIPPNVDTP AQIVEKFTKL LYYGRKKEAL
460 470 480 490 500
EWAMKNHLWG HALFLASKMD PRTYNWVMSG FTSTLALNDP LQTLFQLMSG
510 520 530 540 550
RIPQAATVCG DKQWGDWRPH LAVILSNQAG DTELYQRAIV SMGDTLAGKG
560 570 580 590 600
LVEASHFCYL MAHVPFGHYT VKTDHLALVG SSHSQEFMKF ATIEAIQRTE
610 620 630 640 650
IFEYCQMLGR PKSFIPSFQV YKLLYASRLA DYGLASQALH YCEAIGAAVL
660 670 680 690 700
SQEGSSHPVL LAELIKLAEK LKLSDPLVLE RRRGDRDLEP DWLVQLRRKH
710 720 730 740 750
KDLEQNRTGA PRDPDSTPSD IYGAGGTTDT PYPDLSGHQN YSEDSEYSST
760 770 780 790 800
LWSTAEQTSL TNPLAQQSFP LQRDTYSGHM GTPVPLYSVP ATHLAVTSGA
810 820 830 840 850
SGSSVAVTGT PGGRVGEDML RTHPAFGENT MTQEPLEDPD GLEVISSLQT
860 870 880 890 900
PAAPRVPSFS EDSAASAKED EEGSSDGADK PSHPDASQKG KLGDGKNTKS
910 920 930 940 950
SGFGWFSWFR SKPASSVSTS GDEDSSDSSD SEESPRASSP HHASPGLSPT
960 970 980 990 1000
PPLTSPSLPG ASTFSRGTGG SILQGSSNSS GIAEGMGIGG FSGTQGVSSE
1010 1020 1030 1040 1050
FYSQPGALPP PPTLQGAVPL YNPSQVPQLP TASSLNRPNR LAQRRYPTQP

C
Length:1,051
Mass (Da):115,513
Last modified:July 27, 2011 - v3
Checksum:iCA802D45E2E39748
GO

Sequence cautioni

The sequence BAD32580.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71Q → H in AAH59194. (PubMed:15489334)Curated
Sequence conflicti32 – 321L → P in BAB61034. (PubMed:11605020)Curated
Sequence conflicti32 – 321L → P in AAH59194. (PubMed:15489334)Curated
Sequence conflicti168 – 1681D → G in BAB61034. (PubMed:11605020)Curated
Sequence conflicti199 – 1991S → R in BAB61034. (PubMed:11605020)Curated
Sequence conflicti286 – 2861P → S in BAB61034. (PubMed:11605020)Curated
Sequence conflicti322 – 3221P → A in BAB61034. (PubMed:11605020)Curated
Sequence conflicti329 – 3291H → P in BAB61034. (PubMed:11605020)Curated
Sequence conflicti711 – 7111P → L in BAB61034. (PubMed:11605020)Curated
Sequence conflicti711 – 7111P → L in AAH59194. (PubMed:15489334)Curated
Sequence conflicti939 – 9391S → P in BAB61034. (PubMed:11605020)Curated
Sequence conflicti939 – 9391S → P in AAH59194. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063356 mRNA. Translation: BAB61034.1.
AK173302 mRNA. Translation: BAD32580.1. Different initiation.
AC161108 Genomic DNA. No translation available.
BC059194 mRNA. Translation: AAH59194.1.
CCDSiCCDS15400.1.
RefSeqiNP_001153458.1. NM_001159986.1.
NP_203505.3. NM_033354.3.
UniGeneiMm.87114.

Genome annotation databases

EnsembliENSMUST00000027881; ENSMUSP00000027881; ENSMUSG00000026589.
ENSMUST00000086130; ENSMUSP00000083300; ENSMUSG00000026589.
ENSMUST00000111700; ENSMUSP00000107329; ENSMUSG00000026589.
GeneIDi89867.
KEGGimmu:89867.
UCSCiuc007ddl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063356 mRNA. Translation: BAB61034.1.
AK173302 mRNA. Translation: BAD32580.1. Different initiation.
AC161108 Genomic DNA. No translation available.
BC059194 mRNA. Translation: AAH59194.1.
CCDSiCCDS15400.1.
RefSeqiNP_001153458.1. NM_001159986.1.
NP_203505.3. NM_033354.3.
UniGeneiMm.87114.

3D structure databases

ProteinModelPortaliQ91XT4.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ91XT4.

Proteomic databases

MaxQBiQ91XT4.
PaxDbiQ91XT4.
PRIDEiQ91XT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027881; ENSMUSP00000027881; ENSMUSG00000026589.
ENSMUST00000086130; ENSMUSP00000083300; ENSMUSG00000026589.
ENSMUST00000111700; ENSMUSP00000107329; ENSMUSG00000026589.
GeneIDi89867.
KEGGimmu:89867.
UCSCiuc007ddl.2. mouse.

Organism-specific databases

CTDi89866.
MGIiMGI:2148802. Sec16b.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00530000063746.
HOGENOMiHOG000049067.
HOVERGENiHBG108463.
InParanoidiQ91XT4.
OMAiATCCGDK.
OrthoDBiEOG7MH0XQ.
TreeFamiTF316276.

Miscellaneous databases

NextBioi351362.
PROiQ91XT4.
SOURCEiSearch...

Gene expression databases

BgeeiQ91XT4.
GenevestigatoriQ91XT4.

Family and domain databases

InterProiIPR024880. Sec16.
IPR024340. Sec16_CCD.
[Graphical view]
PANTHERiPTHR13402. PTHR13402. 1 hit.
PfamiPF12932. Sec16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver."
    Misawa H., Yamaguchi M.
    Int. J. Mol. Med. 8:513-520(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreatic islet.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "Gene expression for a novel protein RGPR-p117 in various species: the stimulation by intracellular signaling factors."
    Misawa H., Yamaguchi M.
    J. Cell. Biochem. 87:188-193(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-182; SER-863; SER-866; SER-874 AND SER-875, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSC16B_MOUSE
AccessioniPrimary (citable) accession number: Q91XT4
Secondary accession number(s): E9QL61, Q69Z64, Q6PCR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.