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Q91XT4 (SC16B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein Sec16B
Alternative name(s):
Leucine zipper transcription regulator 2
Regucalcin gene promoter region-related protein p117
Short name=RGPR-p117
SEC16 homolog B
Gene names
Name:Sec16b
Synonyms:Kiaa1928, Lztr2, Rgpr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1051 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization By similarity.

Subunit structure

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Golgi apparatus membrane; Peripheral membrane protein By similarity.

Tissue specificity

Liver. Ref.5

Sequence similarities

Belongs to the SEC16 family.

Sequence caution

The sequence BAD32580.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10511051Protein transport protein Sec16B
PRO_0000341975

Regions

Compositional bias223 – 2264Poly-Ser
Compositional bias900 – 98081Ser-rich
Compositional bias1009 – 10124Poly-Pro

Amino acid modifications

Modified residue701Phosphoserine Ref.6
Modified residue1821Phosphoserine Ref.6
Modified residue8631Phosphoserine Ref.6
Modified residue8661Phosphoserine Ref.6
Modified residue8741Phosphoserine Ref.6
Modified residue8751Phosphoserine Ref.6

Experimental info

Sequence conflict71Q → H in AAH59194. Ref.4
Sequence conflict321L → P in BAB61034. Ref.1
Sequence conflict321L → P in AAH59194. Ref.4
Sequence conflict1681D → G in BAB61034. Ref.1
Sequence conflict1991S → R in BAB61034. Ref.1
Sequence conflict2861P → S in BAB61034. Ref.1
Sequence conflict3221P → A in BAB61034. Ref.1
Sequence conflict3291H → P in BAB61034. Ref.1
Sequence conflict7111P → L in BAB61034. Ref.1
Sequence conflict7111P → L in AAH59194. Ref.4
Sequence conflict9391S → P in BAB61034. Ref.1
Sequence conflict9391S → P in AAH59194. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q91XT4 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: CA802D45E2E39748

FASTA1,051115,513
        10         20         30         40         50         60 
MEPWVPQTQG RTTGPSRDTN RGLQSGHYRP RLHSQYSGDK YHQWQDAHKN SKSQQDLRDD 

        70         80         90        100        110        120 
HQQSHSVSRS GEWSQPVSGA DYLKGSYPSH LYSRSGYGDP YQRYHTPTPR DEYAYGNYYY 

       130        140        150        160        170        180 
HGHPQLLPEE RVARQGSPYI WHEDHGDQRY FGEHHREKHN GTFGANSDTQ FQFTSKNPYR 

       190        200        210        220        230        240 
DSPASVSGQE QPGEFFPESE AQKQKPLLTS KSSLLQQHES GLSSSSYELS QYMTAAPEEY 

       250        260        270        280        290        300 
EPMVSAAWRP IQADDTSATV PKAPMRFYVP HVSVSFGPGG QLVCVPPNSP ADGQTALVEV 

       310        320        330        340        350        360 
HSMEVLLNDF EDQEEMRAFP GPLIREDIHK VDIMTFCQQK ATQCLKSETP GSRDSALLWQ 

       370        380        390        400        410        420 
LLVLLCRQNG SMVGSDIAEL LMQDCKKLEK YKRQPPVANL INLTDEDWPV LSSGTRDLLT 

       430        440        450        460        470        480 
GEIPPNVDTP AQIVEKFTKL LYYGRKKEAL EWAMKNHLWG HALFLASKMD PRTYNWVMSG 

       490        500        510        520        530        540 
FTSTLALNDP LQTLFQLMSG RIPQAATVCG DKQWGDWRPH LAVILSNQAG DTELYQRAIV 

       550        560        570        580        590        600 
SMGDTLAGKG LVEASHFCYL MAHVPFGHYT VKTDHLALVG SSHSQEFMKF ATIEAIQRTE 

       610        620        630        640        650        660 
IFEYCQMLGR PKSFIPSFQV YKLLYASRLA DYGLASQALH YCEAIGAAVL SQEGSSHPVL 

       670        680        690        700        710        720 
LAELIKLAEK LKLSDPLVLE RRRGDRDLEP DWLVQLRRKH KDLEQNRTGA PRDPDSTPSD 

       730        740        750        760        770        780 
IYGAGGTTDT PYPDLSGHQN YSEDSEYSST LWSTAEQTSL TNPLAQQSFP LQRDTYSGHM 

       790        800        810        820        830        840 
GTPVPLYSVP ATHLAVTSGA SGSSVAVTGT PGGRVGEDML RTHPAFGENT MTQEPLEDPD 

       850        860        870        880        890        900 
GLEVISSLQT PAAPRVPSFS EDSAASAKED EEGSSDGADK PSHPDASQKG KLGDGKNTKS 

       910        920        930        940        950        960 
SGFGWFSWFR SKPASSVSTS GDEDSSDSSD SEESPRASSP HHASPGLSPT PPLTSPSLPG 

       970        980        990       1000       1010       1020 
ASTFSRGTGG SILQGSSNSS GIAEGMGIGG FSGTQGVSSE FYSQPGALPP PPTLQGAVPL 

      1030       1040       1050 
YNPSQVPQLP TASSLNRPNR LAQRRYPTQP C 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver."
Misawa H., Yamaguchi M.
Int. J. Mol. Med. 8:513-520(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreatic islet.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
[5]"Gene expression for a novel protein RGPR-p117 in various species: the stimulation by intracellular signaling factors."
Misawa H., Yamaguchi M.
J. Cell. Biochem. 87:188-193(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-182; SER-863; SER-866; SER-874 AND SER-875, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB063356 mRNA. Translation: BAB61034.1.
AK173302 mRNA. Translation: BAD32580.1. Different initiation.
AC161108 Genomic DNA. No translation available.
BC059194 mRNA. Translation: AAH59194.1.
CCDSCCDS15400.1.
RefSeqNP_001153458.1. NM_001159986.1.
NP_203505.3. NM_033354.3.
UniGeneMm.87114.

3D structure databases

ProteinModelPortalQ91XT4.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91XT4.

Proteomic databases

MaxQBQ91XT4.
PaxDbQ91XT4.
PRIDEQ91XT4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027881; ENSMUSP00000027881; ENSMUSG00000026589.
ENSMUST00000086130; ENSMUSP00000083300; ENSMUSG00000026589.
ENSMUST00000111700; ENSMUSP00000107329; ENSMUSG00000026589.
GeneID89867.
KEGGmmu:89867.
UCSCuc007ddl.2. mouse.

Organism-specific databases

CTD89866.
MGIMGI:2148802. Sec16b.
RougeSearch...

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00530000063746.
HOGENOMHOG000049067.
HOVERGENHBG108463.
InParanoidQ91XT4.
OMAATCCGDK.
OrthoDBEOG7MH0XQ.
TreeFamTF316276.

Gene expression databases

BgeeQ91XT4.
GenevestigatorQ91XT4.

Family and domain databases

InterProIPR024880. Sec16.
IPR024340. Sec16_CCD.
[Graphical view]
PANTHERPTHR13402. PTHR13402. 1 hit.
PfamPF12932. Sec16. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio351362.
PROQ91XT4.
SOURCESearch...

Entry information

Entry nameSC16B_MOUSE
AccessionPrimary (citable) accession number: Q91XT4
Secondary accession number(s): E9QL61, Q69Z64, Q6PCR8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot