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Q91XT4

- SC16B_MOUSE

UniProt

Q91XT4 - SC16B_MOUSE

Protein

Protein transport protein Sec16B

Gene

Sec16b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization.By similarity

    GO - Biological processi

    1. COPII vesicle coating Source: InterPro
    2. endoplasmic reticulum organization Source: Ensembl
    3. peroxisome fission Source: Ensembl
    4. positive regulation of gene expression Source: Ensembl
    5. positive regulation of protein exit from endoplasmic reticulum Source: Ensembl
    6. protein localization to endoplasmic reticulum Source: Ensembl
    7. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein Sec16B
    Alternative name(s):
    Leucine zipper transcription regulator 2
    Regucalcin gene promoter region-related protein p117
    Short name:
    RGPR-p117
    SEC16 homolog B
    Gene namesi
    Name:Sec16b
    Synonyms:Kiaa1928, Lztr2, Rgpr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2148802. Sec16b.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10511051Protein transport protein Sec16BPRO_0000341975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701Phosphoserine1 Publication
    Modified residuei182 – 1821Phosphoserine1 Publication
    Modified residuei863 – 8631Phosphoserine1 Publication
    Modified residuei866 – 8661Phosphoserine1 Publication
    Modified residuei874 – 8741Phosphoserine1 Publication
    Modified residuei875 – 8751Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ91XT4.
    PaxDbiQ91XT4.
    PRIDEiQ91XT4.

    PTM databases

    PhosphoSiteiQ91XT4.

    Expressioni

    Tissue specificityi

    Liver.1 Publication

    Gene expression databases

    BgeeiQ91XT4.
    GenevestigatoriQ91XT4.

    Interactioni

    Subunit structurei

    SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi223 – 2264Poly-Ser
    Compositional biasi900 – 98081Ser-richAdd
    BLAST
    Compositional biasi1009 – 10124Poly-Pro

    Sequence similaritiesi

    Belongs to the SEC16 family.Curated

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00530000063746.
    HOGENOMiHOG000049067.
    HOVERGENiHBG108463.
    InParanoidiQ91XT4.
    OMAiATCCGDK.
    OrthoDBiEOG7MH0XQ.
    TreeFamiTF316276.

    Family and domain databases

    InterProiIPR024880. Sec16.
    IPR024340. Sec16_CCD.
    [Graphical view]
    PANTHERiPTHR13402. PTHR13402. 1 hit.
    PfamiPF12932. Sec16. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPWVPQTQG RTTGPSRDTN RGLQSGHYRP RLHSQYSGDK YHQWQDAHKN     50
    SKSQQDLRDD HQQSHSVSRS GEWSQPVSGA DYLKGSYPSH LYSRSGYGDP 100
    YQRYHTPTPR DEYAYGNYYY HGHPQLLPEE RVARQGSPYI WHEDHGDQRY 150
    FGEHHREKHN GTFGANSDTQ FQFTSKNPYR DSPASVSGQE QPGEFFPESE 200
    AQKQKPLLTS KSSLLQQHES GLSSSSYELS QYMTAAPEEY EPMVSAAWRP 250
    IQADDTSATV PKAPMRFYVP HVSVSFGPGG QLVCVPPNSP ADGQTALVEV 300
    HSMEVLLNDF EDQEEMRAFP GPLIREDIHK VDIMTFCQQK ATQCLKSETP 350
    GSRDSALLWQ LLVLLCRQNG SMVGSDIAEL LMQDCKKLEK YKRQPPVANL 400
    INLTDEDWPV LSSGTRDLLT GEIPPNVDTP AQIVEKFTKL LYYGRKKEAL 450
    EWAMKNHLWG HALFLASKMD PRTYNWVMSG FTSTLALNDP LQTLFQLMSG 500
    RIPQAATVCG DKQWGDWRPH LAVILSNQAG DTELYQRAIV SMGDTLAGKG 550
    LVEASHFCYL MAHVPFGHYT VKTDHLALVG SSHSQEFMKF ATIEAIQRTE 600
    IFEYCQMLGR PKSFIPSFQV YKLLYASRLA DYGLASQALH YCEAIGAAVL 650
    SQEGSSHPVL LAELIKLAEK LKLSDPLVLE RRRGDRDLEP DWLVQLRRKH 700
    KDLEQNRTGA PRDPDSTPSD IYGAGGTTDT PYPDLSGHQN YSEDSEYSST 750
    LWSTAEQTSL TNPLAQQSFP LQRDTYSGHM GTPVPLYSVP ATHLAVTSGA 800
    SGSSVAVTGT PGGRVGEDML RTHPAFGENT MTQEPLEDPD GLEVISSLQT 850
    PAAPRVPSFS EDSAASAKED EEGSSDGADK PSHPDASQKG KLGDGKNTKS 900
    SGFGWFSWFR SKPASSVSTS GDEDSSDSSD SEESPRASSP HHASPGLSPT 950
    PPLTSPSLPG ASTFSRGTGG SILQGSSNSS GIAEGMGIGG FSGTQGVSSE 1000
    FYSQPGALPP PPTLQGAVPL YNPSQVPQLP TASSLNRPNR LAQRRYPTQP 1050
    C 1051
    Length:1,051
    Mass (Da):115,513
    Last modified:July 27, 2011 - v3
    Checksum:iCA802D45E2E39748
    GO

    Sequence cautioni

    The sequence BAD32580.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71Q → H in AAH59194. (PubMed:15489334)Curated
    Sequence conflicti32 – 321L → P in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti32 – 321L → P in AAH59194. (PubMed:15489334)Curated
    Sequence conflicti168 – 1681D → G in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti199 – 1991S → R in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti286 – 2861P → S in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti322 – 3221P → A in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti329 – 3291H → P in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti711 – 7111P → L in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti711 – 7111P → L in AAH59194. (PubMed:15489334)Curated
    Sequence conflicti939 – 9391S → P in BAB61034. (PubMed:11605020)Curated
    Sequence conflicti939 – 9391S → P in AAH59194. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063356 mRNA. Translation: BAB61034.1.
    AK173302 mRNA. Translation: BAD32580.1. Different initiation.
    AC161108 Genomic DNA. No translation available.
    BC059194 mRNA. Translation: AAH59194.1.
    CCDSiCCDS15400.1.
    RefSeqiNP_001153458.1. NM_001159986.1.
    NP_203505.3. NM_033354.3.
    UniGeneiMm.87114.

    Genome annotation databases

    EnsembliENSMUST00000027881; ENSMUSP00000027881; ENSMUSG00000026589.
    ENSMUST00000086130; ENSMUSP00000083300; ENSMUSG00000026589.
    ENSMUST00000111700; ENSMUSP00000107329; ENSMUSG00000026589.
    GeneIDi89867.
    KEGGimmu:89867.
    UCSCiuc007ddl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063356 mRNA. Translation: BAB61034.1 .
    AK173302 mRNA. Translation: BAD32580.1 . Different initiation.
    AC161108 Genomic DNA. No translation available.
    BC059194 mRNA. Translation: AAH59194.1 .
    CCDSi CCDS15400.1.
    RefSeqi NP_001153458.1. NM_001159986.1.
    NP_203505.3. NM_033354.3.
    UniGenei Mm.87114.

    3D structure databases

    ProteinModelPortali Q91XT4.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91XT4.

    Proteomic databases

    MaxQBi Q91XT4.
    PaxDbi Q91XT4.
    PRIDEi Q91XT4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027881 ; ENSMUSP00000027881 ; ENSMUSG00000026589 .
    ENSMUST00000086130 ; ENSMUSP00000083300 ; ENSMUSG00000026589 .
    ENSMUST00000111700 ; ENSMUSP00000107329 ; ENSMUSG00000026589 .
    GeneIDi 89867.
    KEGGi mmu:89867.
    UCSCi uc007ddl.2. mouse.

    Organism-specific databases

    CTDi 89866.
    MGIi MGI:2148802. Sec16b.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00530000063746.
    HOGENOMi HOG000049067.
    HOVERGENi HBG108463.
    InParanoidi Q91XT4.
    OMAi ATCCGDK.
    OrthoDBi EOG7MH0XQ.
    TreeFami TF316276.

    Miscellaneous databases

    NextBioi 351362.
    PROi Q91XT4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91XT4.
    Genevestigatori Q91XT4.

    Family and domain databases

    InterProi IPR024880. Sec16.
    IPR024340. Sec16_CCD.
    [Graphical view ]
    PANTHERi PTHR13402. PTHR13402. 1 hit.
    Pfami PF12932. Sec16. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver."
      Misawa H., Yamaguchi M.
      Int. J. Mol. Med. 8:513-520(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreatic islet.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    5. "Gene expression for a novel protein RGPR-p117 in various species: the stimulation by intracellular signaling factors."
      Misawa H., Yamaguchi M.
      J. Cell. Biochem. 87:188-193(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-182; SER-863; SER-866; SER-874 AND SER-875, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSC16B_MOUSE
    AccessioniPrimary (citable) accession number: Q91XT4
    Secondary accession number(s): E9QL61, Q69Z64, Q6PCR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 71 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3