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Q91XT1

- Q91XT1_RAT

UniProt

Q91XT1 - Q91XT1_RAT

Protein
Submitted name:

CREB-binding protein

Gene

Crebbp

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. core promoter proximal region sequence-specific DNA binding Source: Ensembl
    3. histone acetyltransferase activity Source: Ensembl
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    5. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    6. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. germ-line stem cell maintenance Source: Ensembl
    2. N-terminal peptidyl-lysine acetylation Source: Ensembl
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_196250. TRAF6 mediated IRF7 activation.
    REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_196408. PPARA activates gene expression.
    REACT_196852. REV-ERBA represses gene expression.
    REACT_196856. RORA activates circadian gene expression.
    REACT_198375. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_198384. HATs acetylate histones.
    REACT_198613. Activation of gene expression by SREBF (SREBP).
    REACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.
    REACT_206546. Attenuation phase.
    REACT_216049. Transcriptional activation of mitochondrial biogenesis.
    REACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CREB-binding proteinImported
    Gene namesi
    Name:CrebbpImported
    Synonyms:CBPImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2401. Crebbp.

    Subcellular locationi

    GO - Cellular componenti

    1. condensed chromosome outer kinetochore Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. histone acetyltransferase complex Source: Ensembl
    4. nuclear body Source: Ensembl
    5. nuclear chromatin Source: Ensembl
    6. transcription factor complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XT1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007079.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG074064.
    InParanoidiQ91XT1.
    PhylomeDBiQ91XT1.

    Sequencei

    Sequence statusi: Complete.

    Q91XT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENLLDGPP NPKRAKLSSP GFSANDSTDF GSLFDLENDL PDELIPNGEL    50
    SLLNSGNLVP DAASKHKQLS ELLRGGSGSS ITPGIGNVSA SSPVQQGLGG 100
    QAQGQPNSTS MASLGAMGKS PLNPGDSSTP SLPKQAASTS GPTPPASQAL 150
    NPQAQKQVGL VTSSPATSQT GPGICMNANF NQTHPGLLNS NSGHSLMNQA 200
    QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE TLTQVSPQMA 250
    GHAGLNTAQA GGMTKMGMTG NTSPFGQPFS QTGGQPMGAT GVNPQLASKQ 300
    SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPAQGIA TGPTADPEKR 350
    K 351
    Length:351
    Mass (Da):35,189
    Last modified:December 1, 2001 - v1
    Checksum:iFFDCDCAA2506ED7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB066219 mRNA. Translation: BAB62424.1.
    UniGeneiRn.12815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB066219 mRNA. Translation: BAB62424.1 .
    UniGenei Rn.12815.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2401. Crebbp.

    Phylogenomic databases

    HOVERGENi HBG074064.
    InParanoidi Q91XT1.
    PhylomeDBi Q91XT1.

    Enzyme and pathway databases

    Reactomei REACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_196250. TRAF6 mediated IRF7 activation.
    REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_196408. PPARA activates gene expression.
    REACT_196852. REV-ERBA represses gene expression.
    REACT_196856. RORA activates circadian gene expression.
    REACT_198375. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_198384. HATs acetylate histones.
    REACT_198613. Activation of gene expression by SREBF (SREBP).
    REACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198793. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.
    REACT_206546. Attenuation phase.
    REACT_216049. Transcriptional activation of mitochondrial biogenesis.
    REACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Gene expression databases

    Genevestigatori Q91XT1.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2."
      Mochizuki K., Suruga K., Sakaguchi N., Takase S., Goda T.
      Gene 291:271-277(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Small intestineImported.

    Entry informationi

    Entry nameiQ91XT1_RAT
    AccessioniPrimary (citable) accession number: Q91XT1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)