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Protein
Submitted name:

CREB-binding protein

Gene

Crebbp

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. histone acetyltransferase activity Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  5. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. germ-line stem cell maintenance Source: Ensembl
  2. N-terminal peptidyl-lysine acetylation Source: Ensembl
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_274139. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_274348. Notch-HLH transcription pathway.
REACT_274349. formation of the beta-catenin:TCF transactivating complex.
REACT_275282. TRAF3-dependent IRF activation pathway.
REACT_275619. Factors involved in megakaryocyte development and platelet production.
REACT_285313. PPARA activates gene expression.
REACT_300088. Orphan transporters.
REACT_301576. TRAF6 mediated IRF7 activation.
REACT_304415. Transcriptional activation of mitochondrial biogenesis.
REACT_316815. Regulation of gene expression by Hypoxia-inducible Factor.
REACT_316889. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_327685. Attenuation phase.
REACT_329374. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_336113. HATs acetylate histones.
REACT_341409. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_341940. Activation of gene expression by SREBF (SREBP).
REACT_344709. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_352162. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Submitted name:
CREB-binding proteinImported
Gene namesi
Name:CrebbpImported
Synonyms:CBPImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2401. Crebbp.

Subcellular locationi

GO - Cellular componenti

  1. condensed chromosome outer kinetochore Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. histone acetyltransferase complex Source: Ensembl
  4. nuclear body Source: Ensembl
  5. nuclear chromatin Source: Ensembl
  6. transcription factor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ91XT1. baseline and differential.
GenevestigatoriQ91XT1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007079.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG074064.
PhylomeDBiQ91XT1.

Sequencei

Sequence statusi: Complete.

Q91XT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENLLDGPP NPKRAKLSSP GFSANDSTDF GSLFDLENDL PDELIPNGEL
60 70 80 90 100
SLLNSGNLVP DAASKHKQLS ELLRGGSGSS ITPGIGNVSA SSPVQQGLGG
110 120 130 140 150
QAQGQPNSTS MASLGAMGKS PLNPGDSSTP SLPKQAASTS GPTPPASQAL
160 170 180 190 200
NPQAQKQVGL VTSSPATSQT GPGICMNANF NQTHPGLLNS NSGHSLMNQA
210 220 230 240 250
QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE TLTQVSPQMA
260 270 280 290 300
GHAGLNTAQA GGMTKMGMTG NTSPFGQPFS QTGGQPMGAT GVNPQLASKQ
310 320 330 340 350
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPAQGIA TGPTADPEKR

K
Length:351
Mass (Da):35,189
Last modified:December 1, 2001 - v1
Checksum:iFFDCDCAA2506ED7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB066219 mRNA. Translation: BAB62424.1.
UniGeneiRn.12815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB066219 mRNA. Translation: BAB62424.1.
UniGeneiRn.12815.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2401. Crebbp.

Phylogenomic databases

HOVERGENiHBG074064.
PhylomeDBiQ91XT1.

Enzyme and pathway databases

ReactomeiREACT_274139. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_274348. Notch-HLH transcription pathway.
REACT_274349. formation of the beta-catenin:TCF transactivating complex.
REACT_275282. TRAF3-dependent IRF activation pathway.
REACT_275619. Factors involved in megakaryocyte development and platelet production.
REACT_285313. PPARA activates gene expression.
REACT_300088. Orphan transporters.
REACT_301576. TRAF6 mediated IRF7 activation.
REACT_304415. Transcriptional activation of mitochondrial biogenesis.
REACT_316815. Regulation of gene expression by Hypoxia-inducible Factor.
REACT_316889. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_327685. Attenuation phase.
REACT_329374. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
REACT_336113. HATs acetylate histones.
REACT_341409. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_341940. Activation of gene expression by SREBF (SREBP).
REACT_344709. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
REACT_352162. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Gene expression databases

ExpressionAtlasiQ91XT1. baseline and differential.
GenevestigatoriQ91XT1.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2."
    Mochizuki K., Suruga K., Sakaguchi N., Takase S., Goda T.
    Gene 291:271-277(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Small intestineImported.

Entry informationi

Entry nameiQ91XT1_RAT
AccessioniPrimary (citable) accession number: Q91XT1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.