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Q91XT0

- Q91XT0_RAT

UniProt

Q91XT0 - Q91XT0_RAT

Protein
Submitted name:

E1A-binding protein

Gene

Ep300

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. activating transcription factor binding Source: RGD
    2. antigen binding Source: RGD
    3. bHLH transcription factor binding Source: RGD
    4. chromatin binding Source: RGD
    5. chromatin DNA binding Source: RGD
    6. core promoter binding Source: RGD
    7. core promoter proximal region DNA binding Source: RGD
    8. glucocorticoid receptor binding Source: RGD
    9. histone acetyltransferase activity Source: RGD
    10. lysine N-acetyltransferase activity, acting on acetyl phosphate as donor Source: RGD
    11. mitogen-activated protein kinase binding Source: RGD
    12. NF-kappaB binding Source: RGD
    13. p53 binding Source: RGD
    14. peroxisome proliferator activated receptor binding Source: RGD
    15. protein binding Source: RGD
    16. protein complex binding Source: RGD
    17. protein kinase binding Source: RGD
    18. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: RGD
    19. SMAD binding Source: RGD
    20. transcription coactivator activity Source: Ensembl
    21. transcription factor binding Source: RGD

    GO - Biological processi

    1. cellular response to antibiotic Source: RGD
    2. cellular response to cAMP Source: RGD
    3. cellular response to dexamethasone stimulus Source: RGD
    4. cellular response to drug Source: RGD
    5. cellular response to glucose stimulus Source: RGD
    6. cellular response to hydrogen peroxide Source: RGD
    7. cellular response to mineralocorticoid stimulus Source: RGD
    8. cellular response to nerve growth factor stimulus Source: RGD
    9. cellular response to organic cyclic compound Source: RGD
    10. cellular response to retinoic acid Source: RGD
    11. cellular response to trichostatin A Source: RGD
    12. digestive tract development Source: RGD
    13. heart development Source: Ensembl
    14. histone H2B acetylation Source: Ensembl
    15. histone H3 acetylation Source: RGD
    16. histone H4 acetylation Source: Ensembl
    17. internal peptidyl-lysine acetylation Source: RGD
    18. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    19. liver development Source: RGD
    20. lung development Source: Ensembl
    21. negative regulation of cell death Source: RGD
    22. negative regulation of cellular metabolic process Source: RGD
    23. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    24. negative regulation of miRNA metabolic process Source: RGD
    25. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. N-terminal peptidyl-lysine acetylation Source: Ensembl
    27. organ morphogenesis Source: Ensembl
    28. positive regulation by host of viral transcription Source: Ensembl
    29. positive regulation of axon extension Source: RGD
    30. positive regulation of cell death Source: RGD
    31. positive regulation of cell growth Source: RGD
    32. positive regulation of cell size Source: RGD
    33. positive regulation of cellular metabolic process Source: RGD
    34. positive regulation of collagen biosynthetic process Source: RGD
    35. positive regulation of DNA binding Source: RGD
    36. positive regulation of gene expression Source: RGD
    37. positive regulation of glycoprotein biosynthetic process Source: RGD
    38. positive regulation of muscle atrophy Source: RGD
    39. positive regulation of protein acetylation Source: RGD
    40. positive regulation of protein binding Source: Ensembl
    41. positive regulation of protein import into nucleus, translocation Source: RGD
    42. positive regulation of protein phosphorylation Source: RGD
    43. positive regulation of protein secretion Source: RGD
    44. positive regulation of proteolysis Source: RGD
    45. positive regulation of sarcomere organization Source: RGD
    46. positive regulation of sequence-specific DNA binding transcription factor activity Source: RGD
    47. positive regulation of transcription from RNA polymerase II promoter Source: RGD
    48. positive regulation of translation Source: RGD
    49. protein-DNA complex assembly Source: RGD
    50. protein kinase B signaling Source: RGD
    51. regulation of androgen receptor signaling pathway Source: Ensembl
    52. regulation of angiotensin metabolic process Source: RGD
    53. response to calcium ion Source: RGD
    54. response to cobalt ion Source: RGD
    55. response to dexamethasone Source: RGD
    56. response to drug Source: RGD
    57. response to estrogen Source: RGD
    58. response to ethanol Source: RGD
    59. response to fatty acid Source: RGD
    60. response to glucose Source: RGD
    61. response to hydrogen peroxide Source: RGD
    62. response to hypoxia Source: RGD
    63. response to organic cyclic compound Source: RGD
    64. response to retinoic acid Source: RGD
    65. response to tumor necrosis factor Source: RGD
    66. skeletal muscle tissue development Source: Ensembl
    67. somitogenesis Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_196250. TRAF6 mediated IRF7 activation.
    REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_196408. PPARA activates gene expression.
    REACT_196852. REV-ERBA represses gene expression.
    REACT_196856. RORA activates circadian gene expression.
    REACT_198375. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.
    REACT_206546. Attenuation phase.
    REACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    E1A-binding proteinImported
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:Ep300Imported
    Synonyms:p300Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi620036. Ep300.

    Subcellular locationi

    GO - Cellular componenti

    1. chromatin Source: RGD
    2. cytoplasm Source: RGD
    3. histone acetyltransferase complex Source: Ensembl
    4. nucleus Source: RGD
    5. protein-DNA complex Source: RGD
    6. transcription factor complex Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XT0.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00730000110623.
    HOGENOMiHOG000111353.
    HOVERGENiHBG074064.
    InParanoidiQ91XT0.
    OMAiEHRASSM.
    TreeFamiTF101097.

    Sequencei

    Sequence statusi: Complete.

    Q91XT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS    50
    TELGLTNGGD ISQLQTSLGI VQDAASKHKQ LSELLRSGSS PNLNMGVGGP 100
    GQVMASQAQQ NSPGLSLINS MVKSPMAQTG LTSPNMGMGS SGPNQGPTQS 150
    TAGMMNSPVN QPAMGMNTGM NAGMNPGMLA AGNGQGIMPN QVMNGSIGAG 200
    RGRPNMQYPN AGMGNAGSLL TEPLQQGSPQ MGGQPGLRGP QSHKMGMMSN 250
    PTPYGSPYTQ NSGQQIGASG LGLQIQTKTV LPNNLSPFAM DKKAVTGGGM 300
    PNMGQQPTPS VQQPGLVNPV APGMGSGAHT ADPEKRKLIQ QQLVLLLHAH 350
    KCQ 353
    Length:353
    Mass (Da):36,049
    Last modified:December 1, 2001 - v1
    Checksum:iF12C37E246848407
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06052095 Genomic DNA. No translation available.
    AB066220 mRNA. Translation: BAB62425.1.
    UniGeneiRn.12447.
    Rn.232499.

    Genome annotation databases

    EnsembliENSRNOT00000000206; ENSRNOP00000000206; ENSRNOG00000000190.
    UCSCiRGD:620036. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06052095 Genomic DNA. No translation available.
    AB066220 mRNA. Translation: BAB62425.1 .
    UniGenei Rn.12447.
    Rn.232499.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000206 ; ENSRNOP00000000206 ; ENSRNOG00000000190 .
    UCSCi RGD:620036. rat.

    Organism-specific databases

    RGDi 620036. Ep300.

    Phylogenomic databases

    GeneTreei ENSGT00730000110623.
    HOGENOMi HOG000111353.
    HOVERGENi HBG074064.
    InParanoidi Q91XT0.
    OMAi EHRASSM.
    TreeFami TF101097.

    Enzyme and pathway databases

    Reactomei REACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_196250. TRAF6 mediated IRF7 activation.
    REACT_196405. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    REACT_196408. PPARA activates gene expression.
    REACT_196852. REV-ERBA represses gene expression.
    REACT_196856. RORA activates circadian gene expression.
    REACT_198375. LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.
    REACT_198659. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_198750. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_198752. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_199199. Regulation of gene expression by Hypoxia-inducible Factor.
    REACT_206546. Attenuation phase.
    REACT_226234. formation of the beta-catenin:TCF transactivating complex.

    Miscellaneous databases

    NextBioi 35576275.

    Gene expression databases

    Genevestigatori Q91XT0.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2."
      Mochizuki K., Suruga K., Sakaguchi N., Takase S., Goda T.
      Gene 291:271-277(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Small intestineImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ91XT0_RAT
    AccessioniPrimary (citable) accession number: Q91XT0
    Secondary accession number(s): F1LPY5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3