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Protein

Serine/threonine-protein kinase 17B

Gene

Stk17b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621ATPPROSITE-ProRule annotation
Active sitei158 – 1581Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 479ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • positive regulation of fibroblast apoptotic process Source: UniProtKB
  • programmed cell death Source: RGD
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 17B (EC:2.7.11.1)
Alternative name(s):
DAP kinase-related apoptosis-inducing protein kinase 2
Gene namesi
Name:Stk17b
Synonyms:Drak2
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620457. Stk17b.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi62 – 621K → A: Inhibits kinase activity. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Serine/threonine-protein kinase 17BPRO_0000086708Add
BLAST

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91XS8.
PRIDEiQ91XS8.

PTM databases

iPTMnetiQ91XS8.
PhosphoSiteiQ91XS8.

Expressioni

Tissue specificityi

Highly expressed in thymus, spleen, and testis, lower levels present in the brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000012502.
GenevisibleiQ91XS8. RN.

Interactioni

Subunit structurei

Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Chp1P610236EBI-77460,EBI-917838
RhovQ9Z1Y02EBI-77460,EBI-77480

Protein-protein interaction databases

IntActiQ91XS8. 2 interactions.
STRINGi10116.ENSRNOP00000016857.

Structurei

3D structure databases

ProteinModelPortaliQ91XS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 293261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG106718.
InParanoidiQ91XS8.
KOiK08804.
OMAiCPHVINL.
OrthoDBiEOG091G0J2O.
PhylomeDBiQ91XS8.
TreeFamiTF314166.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRRFDCRS ISGLLTTTPQ TPMKTENFNN FYTLTPKELG RGKFAVVRQC
60 70 80 90 100
ISKSTGQEYA AKFLKKRRRG QDCRAEILHE IAVLELARSC PHVINLHEVY
110 120 130 140 150
ETATEIILVL EYAAGGEIFN LCLPELAEMV SENDVIRLIK QILEGVHYLH
160 170 180 190 200
QNNIVHLDLK PQNILLSSIY PLGDIKIVDF GMSRKIGNAS ELREIMGTPE
210 220 230 240 250
YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN QETYLNISQV
260 270 280 290 300
NVDYSEEMFS SVSQLATDFI QSLLVKNPEK RPTAESCLSH SWLQQWDFGS
310 320 330 340 350
LFHPEETSES SQTQDLSLRS SEDKTPKSCN GSCGDREDKE NIPEDDSLLS
360 370
KRFRFDDSLP SPHELVPDLF C
Length:371
Mass (Da):42,133
Last modified:December 1, 2001 - v1
Checksum:i7BD4E83D98896F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070349 mRNA. Translation: BAB63368.1.
PIRiJC7733.
RefSeqiNP_596883.1. NM_133392.1.
XP_006244970.1. XM_006244908.2.
UniGeneiRn.1300.
Rn.163064.

Genome annotation databases

EnsembliENSRNOT00000016856; ENSRNOP00000016857; ENSRNOG00000012502.
GeneIDi170904.
KEGGirno:170904.
UCSCiRGD:620457. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070349 mRNA. Translation: BAB63368.1.
PIRiJC7733.
RefSeqiNP_596883.1. NM_133392.1.
XP_006244970.1. XM_006244908.2.
UniGeneiRn.1300.
Rn.163064.

3D structure databases

ProteinModelPortaliQ91XS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91XS8. 2 interactions.
STRINGi10116.ENSRNOP00000016857.

PTM databases

iPTMnetiQ91XS8.
PhosphoSiteiQ91XS8.

Proteomic databases

PaxDbiQ91XS8.
PRIDEiQ91XS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016856; ENSRNOP00000016857; ENSRNOG00000012502.
GeneIDi170904.
KEGGirno:170904.
UCSCiRGD:620457. rat.

Organism-specific databases

CTDi9262.
RGDi620457. Stk17b.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
GeneTreeiENSGT00760000118877.
HOGENOMiHOG000233016.
HOVERGENiHBG106718.
InParanoidiQ91XS8.
KOiK08804.
OMAiCPHVINL.
OrthoDBiEOG091G0J2O.
PhylomeDBiQ91XS8.
TreeFamiTF314166.

Miscellaneous databases

PROiQ91XS8.

Gene expression databases

BgeeiENSRNOG00000012502.
GenevisibleiQ91XS8. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiST17B_RAT
AccessioniPrimary (citable) accession number: Q91XS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.