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Q91XS1

- MTMR4_MOUSE

UniProt

Q91XS1 - MTMR4_MOUSE

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Protein

Myotubularin-related protein 4

Gene

Mtmr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei407 – 4071Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei453 – 4531SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1109 – 116961FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to denervation involved in regulation of muscle adaptation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198972. Synthesis of PIPs at the late endosome membrane.
REACT_198975. Synthesis of PIPs at the early endosome membrane.
REACT_215733. Downregulation of TGF-beta receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 4 (EC:3.1.3.48)
Gene namesi
Name:Mtmr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2180699. Mtmr4.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity
Note: Localized to perinuclear region.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular space Source: Ensembl
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11901190Myotubularin-related protein 4PRO_0000304810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei610 – 6101Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91XS1.
PaxDbiQ91XS1.
PRIDEiQ91XS1.

PTM databases

PhosphoSiteiQ91XS1.

Expressioni

Gene expression databases

BgeeiQ91XS1.
CleanExiMM_MTMR4.
ExpressionAtlasiQ91XS1. baseline and differential.
GenevestigatoriQ91XS1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112902.

Structurei

3D structure databases

ProteinModelPortaliQ91XS1.
SMRiQ91XS1. Positions 48-571, 1106-1168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 570418Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni320 – 3234Substrate bindingBy similarity
Regioni345 – 3462Substrate bindingBy similarity
Regioni407 – 4137Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1020 – 105233Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1109 – 116961FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
InParanoidiQ91XS1.
KOiK18082.
OMAiGHCTGPG.
OrthoDBiEOG7PVWNJ.
PhylomeDBiQ91XS1.
TreeFamiTF315197.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91XS1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRATD
60 70 80 90 100
ALIAISNYRL HIKFKDSVIN VPLRMIDSVE SRDMFQLHIA CKDSKVVRCH
110 120 130 140 150
FSTFKQCQEW LSRLSRATAR PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ
160 170 180 190 200
PGEHIRCRQE AELARMGFDL QNVWRVSHIN SNYKLCPSYP QKLLVPVWIT
210 220 230 240 250
DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW WGWRNADDEY
260 270 280 290 300
LVTSIAKACA LDPGTRASGG SLSTGTNDAS EACDTDFDSS LTACSGVEST
310 320 330 340 350
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVLF MGMANIHAIR
360 370 380 390 400
NSFQYLRAVC SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG
410 420 430 440 450
RPVLVHCSDG WDRTPQIVAL AKILLDPYYR TLEGFQVLVE SDWLDFGHKF
460 470 480 490 500
GDRCGHQENA EDQNEQCPVF LQWLDSVHQL LKQFPCLFEF NEAFLVKLVQ
510 520 530 540 550
HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN FHNFLYTPGS
560 570 580 590 600
DVVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR
610 620 630 640 650
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHSQEV RGSLEPWHSS
660 670 680 690 700
PEGAETVIDS GVGSPQLTVG EMGLPPPLPS SQKEYLSNKP FKGHKSCSLS
710 720 730 740 750
YKLLNTSVSW EMKSNTSDIK VLEETEALAP DPSAQEEQGR TSDGLGKPPE
760 770 780 790 800
QFLEKEAVSS LCSVSSKCGG ACDFPEPPQD PLTGTPQQPH LDSMQISPSR
810 820 830 840 850
CTPDHSQGSL CNPPSVASQT PEPNTDLLSQ DPPGSTASIS HQEQPSSVPD
860 870 880 890 900
LIYKKEDAGK RGSKNGQLLE NPRFGKMPLE LARKPISQSQ ISEFSFLGSN
910 920 930 940 950
WDSFQGMMTS FPSGETTPRR LLAYGCCSKR PSNKHIRAAG PCLGGQWAQR
960 970 980 990 1000
EGMKSPVCSS HSNGHCTGPG GKNNRMWFSS HPKQVSSTKP SLLSCPSPVP
1010 1020 1030 1040 1050
PLYLDDDGLP FPTDVIQHRL RQIEAGYRQE VEQLRRQVRE LQMRLDIRHC
1060 1070 1080 1090 1100
CAPPAEPPMD YEDDFTCLKE SDGSDTEDFG SDHSEDCLSE ASWEPVDKKE
1110 1120 1130 1140 1150
TEVTRWVPDH MASHCFNCDC EFWLAKRRHH CRNCGNVFCA GCCHLKLPIP
1160 1170 1180 1190
DQQLYDPVLV CNSCYEHIQV SRARELMSQH LKKPIATASS
Length:1,190
Mass (Da):132,885
Last modified:December 1, 2001 - v1
Checksum:i37E6741227E9DBFF
GO
Isoform 2 (identifier: Q91XS1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-553: Missing.

Note: Gene prediction based on EST data.

Show »
Length:1,133
Mass (Da):126,264
Checksum:iCE0E99F35F68107E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei497 – 55357Missing in isoform 2. CuratedVSP_028126Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262986 mRNA. Translation: AAK58180.1.
AK146641 mRNA. Translation: BAE27324.1.
AL596086 Genomic DNA. Translation: CAI35136.2.
AL596086 Genomic DNA. Translation: CAI35138.1.
CCDSiCCDS25214.1. [Q91XS1-1]
RefSeqiNP_573478.1. NM_133215.1. [Q91XS1-1]
XP_006532447.1. XM_006532384.1. [Q91XS1-1]
XP_006532448.1. XM_006532385.1. [Q91XS1-1]
XP_006536498.1. XM_006536435.1. [Q91XS1-1]
XP_006536499.1. XM_006536436.1. [Q91XS1-1]
UniGeneiMm.399376.

Genome annotation databases

EnsembliENSMUST00000092802; ENSMUSP00000090478; ENSMUSG00000018401. [Q91XS1-2]
ENSMUST00000103179; ENSMUSP00000099468; ENSMUSG00000018401. [Q91XS1-1]
ENSMUST00000119628; ENSMUSP00000112902; ENSMUSG00000018401. [Q91XS1-1]
GeneIDi170749.
KEGGimmu:170749.
UCSCiuc007ktz.1. mouse. [Q91XS1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262986 mRNA. Translation: AAK58180.1 .
AK146641 mRNA. Translation: BAE27324.1 .
AL596086 Genomic DNA. Translation: CAI35136.2 .
AL596086 Genomic DNA. Translation: CAI35138.1 .
CCDSi CCDS25214.1. [Q91XS1-1 ]
RefSeqi NP_573478.1. NM_133215.1. [Q91XS1-1 ]
XP_006532447.1. XM_006532384.1. [Q91XS1-1 ]
XP_006532448.1. XM_006532385.1. [Q91XS1-1 ]
XP_006536498.1. XM_006536435.1. [Q91XS1-1 ]
XP_006536499.1. XM_006536436.1. [Q91XS1-1 ]
UniGenei Mm.399376.

3D structure databases

ProteinModelPortali Q91XS1.
SMRi Q91XS1. Positions 48-571, 1106-1168.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000112902.

PTM databases

PhosphoSitei Q91XS1.

Proteomic databases

MaxQBi Q91XS1.
PaxDbi Q91XS1.
PRIDEi Q91XS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092802 ; ENSMUSP00000090478 ; ENSMUSG00000018401 . [Q91XS1-2 ]
ENSMUST00000103179 ; ENSMUSP00000099468 ; ENSMUSG00000018401 . [Q91XS1-1 ]
ENSMUST00000119628 ; ENSMUSP00000112902 ; ENSMUSG00000018401 . [Q91XS1-1 ]
GeneIDi 170749.
KEGGi mmu:170749.
UCSCi uc007ktz.1. mouse. [Q91XS1-1 ]

Organism-specific databases

CTDi 9110.
MGIi MGI:2180699. Mtmr4.

Phylogenomic databases

eggNOGi NOG322789.
GeneTreei ENSGT00760000118832.
HOGENOMi HOG000004861.
HOVERGENi HBG052526.
InParanoidi Q91XS1.
KOi K18082.
OMAi GHCTGPG.
OrthoDBi EOG7PVWNJ.
PhylomeDBi Q91XS1.
TreeFami TF315197.

Enzyme and pathway databases

Reactomei REACT_198972. Synthesis of PIPs at the late endosome membrane.
REACT_198975. Synthesis of PIPs at the early endosome membrane.
REACT_215733. Downregulation of TGF-beta receptor signaling.

Miscellaneous databases

NextBioi 370322.
PROi Q91XS1.
SOURCEi Search...

Gene expression databases

Bgeei Q91XS1.
CleanExi MM_MTMR4.
ExpressionAtlasi Q91XS1. baseline and differential.
Genevestigatori Q91XS1.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a FYVE zinc finger containing phosphatase expressed in mouse bone marrow derived dendritic cells."
    Gorski K.S., Shin T., Otuji M., Suyi T., Pardoll D., Tsuchiya H.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Bone marrow.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Amnion.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMTMR4_MOUSE
AccessioniPrimary (citable) accession number: Q91XS1
Secondary accession number(s): Q5ND06, Q5ND08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3