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Protein

Myotubularin-related protein 4

Gene

Mtmr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei407Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei453SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1109 – 1169FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1660516 Synthesis of PIPs at the early endosome membrane
R-MMU-1660517 Synthesis of PIPs at the late endosome membrane
R-MMU-2173788 Downregulation of TGF-beta receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 4 (EC:3.1.3.48)
Gene namesi
Name:Mtmr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2180699 Mtmr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003048101 – 1190Myotubularin-related protein 4Add BLAST1190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei610PhosphoserineCombined sources1
Modified residuei629PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91XS1
PRIDEiQ91XS1

PTM databases

iPTMnetiQ91XS1
PhosphoSitePlusiQ91XS1

Expressioni

Gene expression databases

BgeeiENSMUSG00000018401
CleanExiMM_MTMR4
ExpressionAtlasiQ91XS1 baseline and differential
GenevisibleiQ91XS1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099468

Structurei

3D structure databases

ProteinModelPortaliQ91XS1
SMRiQ91XS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 570Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST418

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni320 – 323Substrate bindingBy similarity4
Regioni345 – 346Substrate bindingBy similarity2
Regioni407 – 413Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1020 – 1052Sequence analysisAdd BLAST33

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1109 – 1169FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410INM5 Eukaryota
ENOG410XPYG LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000004861
HOVERGENiHBG052526
InParanoidiQ91XS1
KOiK18082
OMAiSNGHCTG
OrthoDBiEOG091G0TBM
PhylomeDBiQ91XS1
TreeFamiTF315197

Family and domain databases

CDDicd13342 PH-GRAM_MTMR4, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR030590 MTMR4
IPR035997 MTMR4_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF64 PTHR10807:SF64, 1 hit
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91XS1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRATD
60 70 80 90 100
ALIAISNYRL HIKFKDSVIN VPLRMIDSVE SRDMFQLHIA CKDSKVVRCH
110 120 130 140 150
FSTFKQCQEW LSRLSRATAR PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ
160 170 180 190 200
PGEHIRCRQE AELARMGFDL QNVWRVSHIN SNYKLCPSYP QKLLVPVWIT
210 220 230 240 250
DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW WGWRNADDEY
260 270 280 290 300
LVTSIAKACA LDPGTRASGG SLSTGTNDAS EACDTDFDSS LTACSGVEST
310 320 330 340 350
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVLF MGMANIHAIR
360 370 380 390 400
NSFQYLRAVC SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG
410 420 430 440 450
RPVLVHCSDG WDRTPQIVAL AKILLDPYYR TLEGFQVLVE SDWLDFGHKF
460 470 480 490 500
GDRCGHQENA EDQNEQCPVF LQWLDSVHQL LKQFPCLFEF NEAFLVKLVQ
510 520 530 540 550
HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN FHNFLYTPGS
560 570 580 590 600
DVVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR
610 620 630 640 650
SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHSQEV RGSLEPWHSS
660 670 680 690 700
PEGAETVIDS GVGSPQLTVG EMGLPPPLPS SQKEYLSNKP FKGHKSCSLS
710 720 730 740 750
YKLLNTSVSW EMKSNTSDIK VLEETEALAP DPSAQEEQGR TSDGLGKPPE
760 770 780 790 800
QFLEKEAVSS LCSVSSKCGG ACDFPEPPQD PLTGTPQQPH LDSMQISPSR
810 820 830 840 850
CTPDHSQGSL CNPPSVASQT PEPNTDLLSQ DPPGSTASIS HQEQPSSVPD
860 870 880 890 900
LIYKKEDAGK RGSKNGQLLE NPRFGKMPLE LARKPISQSQ ISEFSFLGSN
910 920 930 940 950
WDSFQGMMTS FPSGETTPRR LLAYGCCSKR PSNKHIRAAG PCLGGQWAQR
960 970 980 990 1000
EGMKSPVCSS HSNGHCTGPG GKNNRMWFSS HPKQVSSTKP SLLSCPSPVP
1010 1020 1030 1040 1050
PLYLDDDGLP FPTDVIQHRL RQIEAGYRQE VEQLRRQVRE LQMRLDIRHC
1060 1070 1080 1090 1100
CAPPAEPPMD YEDDFTCLKE SDGSDTEDFG SDHSEDCLSE ASWEPVDKKE
1110 1120 1130 1140 1150
TEVTRWVPDH MASHCFNCDC EFWLAKRRHH CRNCGNVFCA GCCHLKLPIP
1160 1170 1180 1190
DQQLYDPVLV CNSCYEHIQV SRARELMSQH LKKPIATASS
Length:1,190
Mass (Da):132,885
Last modified:December 1, 2001 - v1
Checksum:i37E6741227E9DBFF
GO
Isoform 2 (identifier: Q91XS1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-553: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,133
Mass (Da):126,264
Checksum:iCE0E99F35F68107E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028126497 – 553Missing in isoform 2. CuratedAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262986 mRNA Translation: AAK58180.1
AK146641 mRNA Translation: BAE27324.1
AL596086 Genomic DNA No translation available.
CCDSiCCDS25214.1 [Q91XS1-1]
RefSeqiNP_573478.1, NM_133215.1 [Q91XS1-1]
XP_006532447.1, XM_006532384.3 [Q91XS1-1]
XP_006532448.1, XM_006532385.3 [Q91XS1-1]
XP_011247082.1, XM_011248780.2 [Q91XS1-1]
UniGeneiMm.399376

Genome annotation databases

EnsembliENSMUST00000092802; ENSMUSP00000090478; ENSMUSG00000018401 [Q91XS1-2]
ENSMUST00000103179; ENSMUSP00000099468; ENSMUSG00000018401 [Q91XS1-1]
ENSMUST00000119628; ENSMUSP00000112902; ENSMUSG00000018401 [Q91XS1-1]
GeneIDi170749
KEGGimmu:170749
UCSCiuc007ktz.1 mouse [Q91XS1-1]
uc007kua.1 mouse [Q91XS1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMTMR4_MOUSE
AccessioniPrimary (citable) accession number: Q91XS1
Secondary accession number(s): Q5ND06, Q5ND08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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