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Q91XS1

- MTMR4_MOUSE

UniProt

Q91XS1 - MTMR4_MOUSE

Protein

Myotubularin-related protein 4

Gene

Mtmr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei407 – 4071Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei453 – 4531SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1109 – 116961FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to denervation involved in regulation of muscle adaptation Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198972. Synthesis of PIPs at the late endosome membrane.
    REACT_198975. Synthesis of PIPs at the early endosome membrane.
    REACT_215733. Downregulation of TGF-beta receptor signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 4 (EC:3.1.3.48)
    Gene namesi
    Name:Mtmr4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2180699. Mtmr4.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity
    Note: Localized to perinuclear region.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11901190Myotubularin-related protein 4PRO_0000304810Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei610 – 6101Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ91XS1.
    PRIDEiQ91XS1.

    PTM databases

    PhosphoSiteiQ91XS1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91XS1.
    BgeeiQ91XS1.
    CleanExiMM_MTMR4.
    GenevestigatoriQ91XS1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000112902.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XS1.
    SMRiQ91XS1. Positions 48-571, 1106-1168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini153 – 570418Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni320 – 3234Substrate bindingBy similarity
    Regioni345 – 3462Substrate bindingBy similarity
    Regioni407 – 4137Substrate bindingBy similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1020 – 105233Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1109 – 116961FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG322789.
    GeneTreeiENSGT00670000097670.
    HOGENOMiHOG000004861.
    HOVERGENiHBG052526.
    InParanoidiQ91XS1.
    KOiK18082.
    OMAiGHCTGPG.
    OrthoDBiEOG7PVWNJ.
    PhylomeDBiQ91XS1.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91XS1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRATD     50
    ALIAISNYRL HIKFKDSVIN VPLRMIDSVE SRDMFQLHIA CKDSKVVRCH 100
    FSTFKQCQEW LSRLSRATAR PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ 150
    PGEHIRCRQE AELARMGFDL QNVWRVSHIN SNYKLCPSYP QKLLVPVWIT 200
    DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW WGWRNADDEY 250
    LVTSIAKACA LDPGTRASGG SLSTGTNDAS EACDTDFDSS LTACSGVEST 300
    AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVLF MGMANIHAIR 350
    NSFQYLRAVC SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG 400
    RPVLVHCSDG WDRTPQIVAL AKILLDPYYR TLEGFQVLVE SDWLDFGHKF 450
    GDRCGHQENA EDQNEQCPVF LQWLDSVHQL LKQFPCLFEF NEAFLVKLVQ 500
    HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN FHNFLYTPGS 550
    DVVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR 600
    SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHSQEV RGSLEPWHSS 650
    PEGAETVIDS GVGSPQLTVG EMGLPPPLPS SQKEYLSNKP FKGHKSCSLS 700
    YKLLNTSVSW EMKSNTSDIK VLEETEALAP DPSAQEEQGR TSDGLGKPPE 750
    QFLEKEAVSS LCSVSSKCGG ACDFPEPPQD PLTGTPQQPH LDSMQISPSR 800
    CTPDHSQGSL CNPPSVASQT PEPNTDLLSQ DPPGSTASIS HQEQPSSVPD 850
    LIYKKEDAGK RGSKNGQLLE NPRFGKMPLE LARKPISQSQ ISEFSFLGSN 900
    WDSFQGMMTS FPSGETTPRR LLAYGCCSKR PSNKHIRAAG PCLGGQWAQR 950
    EGMKSPVCSS HSNGHCTGPG GKNNRMWFSS HPKQVSSTKP SLLSCPSPVP 1000
    PLYLDDDGLP FPTDVIQHRL RQIEAGYRQE VEQLRRQVRE LQMRLDIRHC 1050
    CAPPAEPPMD YEDDFTCLKE SDGSDTEDFG SDHSEDCLSE ASWEPVDKKE 1100
    TEVTRWVPDH MASHCFNCDC EFWLAKRRHH CRNCGNVFCA GCCHLKLPIP 1150
    DQQLYDPVLV CNSCYEHIQV SRARELMSQH LKKPIATASS 1190
    Length:1,190
    Mass (Da):132,885
    Last modified:December 1, 2001 - v1
    Checksum:i37E6741227E9DBFF
    GO
    Isoform 2 (identifier: Q91XS1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         497-553: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:1,133
    Mass (Da):126,264
    Checksum:iCE0E99F35F68107E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei497 – 55357Missing in isoform 2. CuratedVSP_028126Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF262986 mRNA. Translation: AAK58180.1.
    AK146641 mRNA. Translation: BAE27324.1.
    AL596086 Genomic DNA. Translation: CAI35136.2.
    AL596086 Genomic DNA. Translation: CAI35138.1.
    CCDSiCCDS25214.1. [Q91XS1-1]
    RefSeqiNP_573478.1. NM_133215.1. [Q91XS1-1]
    XP_006532447.1. XM_006532384.1. [Q91XS1-1]
    XP_006532448.1. XM_006532385.1. [Q91XS1-1]
    XP_006536498.1. XM_006536435.1. [Q91XS1-1]
    XP_006536499.1. XM_006536436.1. [Q91XS1-1]
    UniGeneiMm.399376.

    Genome annotation databases

    EnsembliENSMUST00000092802; ENSMUSP00000090478; ENSMUSG00000018401. [Q91XS1-2]
    ENSMUST00000103179; ENSMUSP00000099468; ENSMUSG00000018401. [Q91XS1-1]
    ENSMUST00000119628; ENSMUSP00000112902; ENSMUSG00000018401. [Q91XS1-1]
    GeneIDi170749.
    KEGGimmu:170749.
    UCSCiuc007ktz.1. mouse. [Q91XS1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF262986 mRNA. Translation: AAK58180.1 .
    AK146641 mRNA. Translation: BAE27324.1 .
    AL596086 Genomic DNA. Translation: CAI35136.2 .
    AL596086 Genomic DNA. Translation: CAI35138.1 .
    CCDSi CCDS25214.1. [Q91XS1-1 ]
    RefSeqi NP_573478.1. NM_133215.1. [Q91XS1-1 ]
    XP_006532447.1. XM_006532384.1. [Q91XS1-1 ]
    XP_006532448.1. XM_006532385.1. [Q91XS1-1 ]
    XP_006536498.1. XM_006536435.1. [Q91XS1-1 ]
    XP_006536499.1. XM_006536436.1. [Q91XS1-1 ]
    UniGenei Mm.399376.

    3D structure databases

    ProteinModelPortali Q91XS1.
    SMRi Q91XS1. Positions 48-571, 1106-1168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000112902.

    PTM databases

    PhosphoSitei Q91XS1.

    Proteomic databases

    PaxDbi Q91XS1.
    PRIDEi Q91XS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092802 ; ENSMUSP00000090478 ; ENSMUSG00000018401 . [Q91XS1-2 ]
    ENSMUST00000103179 ; ENSMUSP00000099468 ; ENSMUSG00000018401 . [Q91XS1-1 ]
    ENSMUST00000119628 ; ENSMUSP00000112902 ; ENSMUSG00000018401 . [Q91XS1-1 ]
    GeneIDi 170749.
    KEGGi mmu:170749.
    UCSCi uc007ktz.1. mouse. [Q91XS1-1 ]

    Organism-specific databases

    CTDi 9110.
    MGIi MGI:2180699. Mtmr4.

    Phylogenomic databases

    eggNOGi NOG322789.
    GeneTreei ENSGT00670000097670.
    HOGENOMi HOG000004861.
    HOVERGENi HBG052526.
    InParanoidi Q91XS1.
    KOi K18082.
    OMAi GHCTGPG.
    OrthoDBi EOG7PVWNJ.
    PhylomeDBi Q91XS1.
    TreeFami TF315197.

    Enzyme and pathway databases

    Reactomei REACT_198972. Synthesis of PIPs at the late endosome membrane.
    REACT_198975. Synthesis of PIPs at the early endosome membrane.
    REACT_215733. Downregulation of TGF-beta receptor signaling.

    Miscellaneous databases

    NextBioi 370322.
    PROi Q91XS1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91XS1.
    Bgeei Q91XS1.
    CleanExi MM_MTMR4.
    Genevestigatori Q91XS1.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR010569. Myotubularin-like_Pase_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a FYVE zinc finger containing phosphatase expressed in mouse bone marrow derived dendritic cells."
      Gorski K.S., Shin T., Otuji M., Suyi T., Pardoll D., Tsuchiya H.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Bone marrow.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Amnion.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiMTMR4_MOUSE
    AccessioniPrimary (citable) accession number: Q91XS1
    Secondary accession number(s): Q5ND06, Q5ND08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3