Q91XS1 (MTMR4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myotubularin-related protein 4
EC=3.1.3.48

Gene names

Name:

Mtmr4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1190 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Note: Localized to perinuclear region By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Contains 1 FYVE-type zinc finger. Contains 1 myotubularin phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91XS1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91XS1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     497-553: Missing.

Note: Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1190	1190	Myotubularin-related protein 4		PRO_0000304810
Regions
	Domain	153 – 570	418	Myotubularin phosphatase
	Zinc finger	1109 – 1169	61	FYVE-type
	Region	320 – 323	4	Substrate binding By similarity
	Region	345 – 346	2	Substrate binding By similarity
	Region	407 – 413	7	Substrate binding By similarity
	Coiled coil	1020 – 1052	33	Potential
Sites
	Active site	407	1	Phosphocysteine intermediate By similarity
	Binding site	453	1	Substrate By similarity
Amino acid modifications
	Modified residue	637	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	497 – 553	57	Missing in isoform 2.		VSP_028126

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 37E6741227E9DBFF	FASTA	1,190	132,885
	10 20 30 40 50 60 MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRATD ALIAISNYRL 70 80 90 100 110 120 HIKFKDSVIN VPLRMIDSVE SRDMFQLHIA CKDSKVVRCH FSTFKQCQEW LSRLSRATAR 130 140 150 160 170 180 PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ PGEHIRCRQE AELARMGFDL QNVWRVSHIN 190 200 210 220 230 240 SNYKLCPSYP QKLLVPVWIT DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW 250 260 270 280 290 300 WGWRNADDEY LVTSIAKACA LDPGTRASGG SLSTGTNDAS EACDTDFDSS LTACSGVEST 310 320 330 340 350 360 AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVLF MGMANIHAIR NSFQYLRAVC 370 380 390 400 410 420 SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG RPVLVHCSDG WDRTPQIVAL 430 440 450 460 470 480 AKILLDPYYR TLEGFQVLVE SDWLDFGHKF GDRCGHQENA EDQNEQCPVF LQWLDSVHQL 490 500 510 520 530 540 LKQFPCLFEF NEAFLVKLVQ HTYSCLYGTF LANNPCEREK RNIYKRTCSV WALLRAGNKN 550 560 570 580 590 600 FHNFLYTPGS DVVLHPVCHV RALHLWTAVY LPASSPCTLG EENMDLYLSP VAQSQEFSGR 610 620 630 640 650 660 SLDRLPKTRS MDDLLSACDT SSPLTRTSSD PNLNNHSQEV RGSLEPWHSS PEGAETVIDS 670 680 690 700 710 720 GVGSPQLTVG EMGLPPPLPS SQKEYLSNKP FKGHKSCSLS YKLLNTSVSW EMKSNTSDIK 730 740 750 760 770 780 VLEETEALAP DPSAQEEQGR TSDGLGKPPE QFLEKEAVSS LCSVSSKCGG ACDFPEPPQD 790 800 810 820 830 840 PLTGTPQQPH LDSMQISPSR CTPDHSQGSL CNPPSVASQT PEPNTDLLSQ DPPGSTASIS 850 860 870 880 890 900 HQEQPSSVPD LIYKKEDAGK RGSKNGQLLE NPRFGKMPLE LARKPISQSQ ISEFSFLGSN 910 920 930 940 950 960 WDSFQGMMTS FPSGETTPRR LLAYGCCSKR PSNKHIRAAG PCLGGQWAQR EGMKSPVCSS 970 980 990 1000 1010 1020 HSNGHCTGPG GKNNRMWFSS HPKQVSSTKP SLLSCPSPVP PLYLDDDGLP FPTDVIQHRL 1030 1040 1050 1060 1070 1080 RQIEAGYRQE VEQLRRQVRE LQMRLDIRHC CAPPAEPPMD YEDDFTCLKE SDGSDTEDFG 1090 1100 1110 1120 1130 1140 SDHSEDCLSE ASWEPVDKKE TEVTRWVPDH MASHCFNCDC EFWLAKRRHH CRNCGNVFCA 1150 1160 1170 1180 1190 GCCHLKLPIP DQQLYDPVLV CNSCYEHIQV SRARELMSQH LKKPIATASS
	Isoform 2 [UniParc]. Checksum: CE0E99F35F68107E	FASTA	1,133	126,264
	10 20 30 40 50 60 MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRATD ALIAISNYRL 70 80 90 100 110 120 HIKFKDSVIN VPLRMIDSVE SRDMFQLHIA CKDSKVVRCH FSTFKQCQEW LSRLSRATAR 130 140 150 160 170 180 PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ PGEHIRCRQE AELARMGFDL QNVWRVSHIN 190 200 210 220 230 240 SNYKLCPSYP QKLLVPVWIT DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW 250 260 270 280 290 300 WGWRNADDEY LVTSIAKACA LDPGTRASGG SLSTGTNDAS EACDTDFDSS LTACSGVEST 310 320 330 340 350 360 AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVLF MGMANIHAIR NSFQYLRAVC 370 380 390 400 410 420 SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG RPVLVHCSDG WDRTPQIVAL 430 440 450 460 470 480 AKILLDPYYR TLEGFQVLVE SDWLDFGHKF GDRCGHQENA EDQNEQCPVF LQWLDSVHQL 490 500 510 520 530 540 LKQFPCLFEF NEAFLVLHPV CHVRALHLWT AVYLPASSPC TLGEENMDLY LSPVAQSQEF 550 560 570 580 590 600 SGRSLDRLPK TRSMDDLLSA CDTSSPLTRT SSDPNLNNHS QEVRGSLEPW HSSPEGAETV 610 620 630 640 650 660 IDSGVGSPQL TVGEMGLPPP LPSSQKEYLS NKPFKGHKSC SLSYKLLNTS VSWEMKSNTS 670 680 690 700 710 720 DIKVLEETEA LAPDPSAQEE QGRTSDGLGK PPEQFLEKEA VSSLCSVSSK CGGACDFPEP 730 740 750 760 770 780 PQDPLTGTPQ QPHLDSMQIS PSRCTPDHSQ GSLCNPPSVA SQTPEPNTDL LSQDPPGSTA 790 800 810 820 830 840 SISHQEQPSS VPDLIYKKED AGKRGSKNGQ LLENPRFGKM PLELARKPIS QSQISEFSFL 850 860 870 880 890 900 GSNWDSFQGM MTSFPSGETT PRRLLAYGCC SKRPSNKHIR AAGPCLGGQW AQREGMKSPV 910 920 930 940 950 960 CSSHSNGHCT GPGGKNNRMW FSSHPKQVSS TKPSLLSCPS PVPPLYLDDD GLPFPTDVIQ 970 980 990 1000 1010 1020 HRLRQIEAGY RQEVEQLRRQ VRELQMRLDI RHCCAPPAEP PMDYEDDFTC LKESDGSDTE 1030 1040 1050 1060 1070 1080 DFGSDHSEDC LSEASWEPVD KKETEVTRWV PDHMASHCFN CDCEFWLAKR RHHCRNCGNV 1090 1100 1110 1120 1130 FCAGCCHLKL PIPDQQLYDP VLVCNSCYEH IQVSRARELM SQHLKKPIAT ASS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a FYVE zinc finger containing phosphatase expressed in mouse bone marrow derived dendritic cells." Gorski K.S., Shin T., Otuji M., Suyi T., Pardoll D., Tsuchiya H. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c. Tissue: Bone marrow.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Amnion.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-637, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF262986 mRNA. Translation: AAK58180.1. AK146641 mRNA. Translation: BAE27324.1. AL596086 Genomic DNA. Translation: CAI35136.2. AL596086 Genomic DNA. Translation: CAI35138.1.
IPI	IPI00129408. IPI00461622.
RefSeq	NP_573478.1. NM_133215.1.
UniGene	Mm.399376.
3D structure databases
HSSP	HSSP built from PDB template 1VFY based on UniProtKB P40343.
ProteinModelPortal	Q91XS1.
SMR	Q91XS1. Positions 48-571, 1106-1168.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000112902.
PTM databases
PhosphoSite	Q91XS1.
Proteomic databases
PaxDb	Q91XS1.
PRIDE	Q91XS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092802; ENSMUSP00000090478; ENSMUSG00000018401. ENSMUST00000103179; ENSMUSP00000099468; ENSMUSG00000018401. ENSMUST00000119628; ENSMUSP00000112902; ENSMUSG00000018401.
GeneID	170749.
KEGG	mmu:170749.
Organism-specific databases
CTD	9110.
MGI	MGI:2180699. Mtmr4.
Phylogenomic databases
eggNOG	NOG322789.
GeneTree	ENSGT00670000097670.
HOGENOM	HOG000004861.
HOVERGEN	HBG052526.
InParanoid	Q91XS1.
OMA	GHCTGPG.
OrthoDB	EOG4R501X.
Gene expression databases
ArrayExpress	Q91XS1.
Bgee	Q91XS1.
CleanEx	MM_MTMR4.
Genevestigator	Q91XS1.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR010569. Myotub-related. IPR017906. Myotubularin_phosphatase_dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF01363. FYVE. 1 hit. PF06602. Myotub-related. 1 hit. [Graphical view]
SMART	SM00064. FYVE. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS51339. PPASE_MYOTUBULARIN. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50178. ZF_FYVE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	370322.
SOURCE	Search...

Entry information

Entry name

MTMR4_MOUSE

Accession

Primary (citable) accession number: Q91XS1
Secondary accession number(s): Q5ND06, Q5ND08

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program