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Q91XQ6

- LAP4B_MOUSE

UniProt

Q91XQ6 - LAP4B_MOUSE

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Protein

Lysosomal-associated transmembrane protein 4B

Gene

Laptm4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4B
Gene namesi
Name:Laptm4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1890494. Laptm4b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Lysosomal-associated transmembrane protein 4BPRO_0000249723Add
BLAST

Proteomic databases

PRIDEiQ91XQ6.

PTM databases

PhosphoSiteiQ91XQ6.

Expressioni

Gene expression databases

BgeeiQ91XQ6.
CleanExiMM_LAPTM4B.
ExpressionAtlasiQ91XQ6. baseline and differential.
GenevestigatoriQ91XQ6.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46169.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ91XQ6.
KOiK12387.
OMAiTIILGIW.
OrthoDBiEOG7QC7X3.
PhylomeDBiQ91XQ6.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XQ6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMVAPWTRF YSHSCCLCCH VRTGTILLGV WYLIINAVVL LILLSALADP
60 70 80 90 100
NQYHFSGSEL GGEFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQHAAW
110 120 130 140 150
IIPFFCYQIF DFALNTLVAI TVLVYPNSIQ EYIRQLPPSF PYRDDIMSVN
160 170 180 190 200
PTCLVLIILL FIGILLTLKG YLISCVWSCY RYINGRNSSD VLVYVTSNDT
210 220
TVLLPPYDDA TAVPSTAKEP PPPYVSA
Length:227
Mass (Da):25,395
Last modified:December 1, 2001 - v1
Checksum:iFD3DC53C2682818D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317418 mRNA. Translation: AAK69596.1.
AK077269 mRNA. Translation: BAC36721.1.
AK077933 mRNA. Translation: BAC37072.1.
AK079581 mRNA. Translation: BAC37691.1.
AK082807 mRNA. Translation: BAC38630.1.
BC019120 mRNA. Translation: AAH19120.1.
CCDSiCCDS27416.1.
RefSeqiNP_277056.1. NM_033521.3.
UniGeneiMm.197518.

Genome annotation databases

EnsembliENSMUST00000022867; ENSMUSP00000022867; ENSMUSG00000022257.
GeneIDi114128.
KEGGimmu:114128.
UCSCiuc007vlj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317418 mRNA. Translation: AAK69596.1 .
AK077269 mRNA. Translation: BAC36721.1 .
AK077933 mRNA. Translation: BAC37072.1 .
AK079581 mRNA. Translation: BAC37691.1 .
AK082807 mRNA. Translation: BAC38630.1 .
BC019120 mRNA. Translation: AAH19120.1 .
CCDSi CCDS27416.1.
RefSeqi NP_277056.1. NM_033521.3.
UniGenei Mm.197518.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91XQ6.

Proteomic databases

PRIDEi Q91XQ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022867 ; ENSMUSP00000022867 ; ENSMUSG00000022257 .
GeneIDi 114128.
KEGGi mmu:114128.
UCSCi uc007vlj.1. mouse.

Organism-specific databases

CTDi 55353.
MGIi MGI:1890494. Laptm4b.

Phylogenomic databases

eggNOGi NOG46169.
GeneTreei ENSGT00390000013359.
HOGENOMi HOG000007698.
HOVERGENi HBG000908.
InParanoidi Q91XQ6.
KOi K12387.
OMAi TIILGIW.
OrthoDBi EOG7QC7X3.
PhylomeDBi Q91XQ6.
TreeFami TF330843.

Miscellaneous databases

ChiTaRSi LAPTM4B. mouse.
NextBioi 368129.
PROi Q91XQ6.
SOURCEi Search...

Gene expression databases

Bgeei Q91XQ6.
CleanExi MM_LAPTM4B.
ExpressionAtlasi Q91XQ6. baseline and differential.
Genevestigatori Q91XQ6.

Family and domain databases

InterProi IPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view ]
PANTHERi PTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
Pfami PF03821. Mtp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Hogue D.L.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiLAP4B_MOUSE
AccessioniPrimary (citable) accession number: Q91XQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3