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Q91XQ6

- LAP4B_MOUSE

UniProt

Q91XQ6 - LAP4B_MOUSE

Protein

Lysosomal-associated transmembrane protein 4B

Gene

Laptm4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal-associated transmembrane protein 4B
    Gene namesi
    Name:Laptm4b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1890494. Laptm4b.

    Subcellular locationi

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Lysosomal-associated transmembrane protein 4BPRO_0000249723Add
    BLAST

    Proteomic databases

    PRIDEiQ91XQ6.

    PTM databases

    PhosphoSiteiQ91XQ6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91XQ6.
    BgeeiQ91XQ6.
    CleanExiMM_LAPTM4B.
    GenevestigatoriQ91XQ6.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAPTM4/LAPTM5 transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46169.
    GeneTreeiENSGT00390000013359.
    HOGENOMiHOG000007698.
    HOVERGENiHBG000908.
    InParanoidiQ91XQ6.
    KOiK12387.
    OMAiTIILGIW.
    OrthoDBiEOG7QC7X3.
    PhylomeDBiQ91XQ6.
    TreeFamiTF330843.

    Family and domain databases

    InterProiIPR004687. LAPTM4/5.
    IPR018401. Lysosomal-assoc_TM_prot4B.
    [Graphical view]
    PANTHERiPTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF6. PTHR12479:SF6. 1 hit.
    PfamiPF03821. Mtp. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMVAPWTRF YSHSCCLCCH VRTGTILLGV WYLIINAVVL LILLSALADP    50
    NQYHFSGSEL GGEFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQHAAW 100
    IIPFFCYQIF DFALNTLVAI TVLVYPNSIQ EYIRQLPPSF PYRDDIMSVN 150
    PTCLVLIILL FIGILLTLKG YLISCVWSCY RYINGRNSSD VLVYVTSNDT 200
    TVLLPPYDDA TAVPSTAKEP PPPYVSA 227
    Length:227
    Mass (Da):25,395
    Last modified:December 1, 2001 - v1
    Checksum:iFD3DC53C2682818D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317418 mRNA. Translation: AAK69596.1.
    AK077269 mRNA. Translation: BAC36721.1.
    AK077933 mRNA. Translation: BAC37072.1.
    AK079581 mRNA. Translation: BAC37691.1.
    AK082807 mRNA. Translation: BAC38630.1.
    BC019120 mRNA. Translation: AAH19120.1.
    CCDSiCCDS27416.1.
    RefSeqiNP_277056.1. NM_033521.3.
    UniGeneiMm.197518.

    Genome annotation databases

    EnsembliENSMUST00000022867; ENSMUSP00000022867; ENSMUSG00000022257.
    GeneIDi114128.
    KEGGimmu:114128.
    UCSCiuc007vlj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317418 mRNA. Translation: AAK69596.1 .
    AK077269 mRNA. Translation: BAC36721.1 .
    AK077933 mRNA. Translation: BAC37072.1 .
    AK079581 mRNA. Translation: BAC37691.1 .
    AK082807 mRNA. Translation: BAC38630.1 .
    BC019120 mRNA. Translation: AAH19120.1 .
    CCDSi CCDS27416.1.
    RefSeqi NP_277056.1. NM_033521.3.
    UniGenei Mm.197518.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91XQ6.

    Proteomic databases

    PRIDEi Q91XQ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022867 ; ENSMUSP00000022867 ; ENSMUSG00000022257 .
    GeneIDi 114128.
    KEGGi mmu:114128.
    UCSCi uc007vlj.1. mouse.

    Organism-specific databases

    CTDi 55353.
    MGIi MGI:1890494. Laptm4b.

    Phylogenomic databases

    eggNOGi NOG46169.
    GeneTreei ENSGT00390000013359.
    HOGENOMi HOG000007698.
    HOVERGENi HBG000908.
    InParanoidi Q91XQ6.
    KOi K12387.
    OMAi TIILGIW.
    OrthoDBi EOG7QC7X3.
    PhylomeDBi Q91XQ6.
    TreeFami TF330843.

    Miscellaneous databases

    ChiTaRSi LAPTM4B. mouse.
    NextBioi 368129.
    PROi Q91XQ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91XQ6.
    Bgeei Q91XQ6.
    CleanExi MM_LAPTM4B.
    Genevestigatori Q91XQ6.

    Family and domain databases

    InterProi IPR004687. LAPTM4/5.
    IPR018401. Lysosomal-assoc_TM_prot4B.
    [Graphical view ]
    PANTHERi PTHR12479. PTHR12479. 1 hit.
    PTHR12479:SF6. PTHR12479:SF6. 1 hit.
    Pfami PF03821. Mtp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hogue D.L.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hypothalamus and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiLAP4B_MOUSE
    AccessioniPrimary (citable) accession number: Q91XQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3