Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysosomal-associated transmembrane protein 4B

Gene

Laptm4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4B
Gene namesi
Name:Laptm4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1890494. Laptm4b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002497231 – 227Lysosomal-associated transmembrane protein 4BAdd BLAST227

Proteomic databases

PaxDbiQ91XQ6.
PRIDEiQ91XQ6.

PTM databases

iPTMnetiQ91XQ6.
PhosphoSitePlusiQ91XQ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022257.
CleanExiMM_LAPTM4B.
ExpressionAtlasiQ91XQ6. baseline and differential.
GenevisibleiQ91XQ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022867.

Structurei

3D structure databases

ProteinModelPortaliQ91XQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGWG. Eukaryota.
ENOG4111K1Z. LUCA.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ91XQ6.
KOiK12387.
OMAiMSTNNMC.
OrthoDBiEOG091G0MA5.
PhylomeDBiQ91XQ6.
TreeFamiTF330843.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMVAPWTRF YSHSCCLCCH VRTGTILLGV WYLIINAVVL LILLSALADP
60 70 80 90 100
NQYHFSGSEL GGEFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQHAAW
110 120 130 140 150
IIPFFCYQIF DFALNTLVAI TVLVYPNSIQ EYIRQLPPSF PYRDDIMSVN
160 170 180 190 200
PTCLVLIILL FIGILLTLKG YLISCVWSCY RYINGRNSSD VLVYVTSNDT
210 220
TVLLPPYDDA TAVPSTAKEP PPPYVSA
Length:227
Mass (Da):25,395
Last modified:December 1, 2001 - v1
Checksum:iFD3DC53C2682818D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317418 mRNA. Translation: AAK69596.1.
AK077269 mRNA. Translation: BAC36721.1.
AK077933 mRNA. Translation: BAC37072.1.
AK079581 mRNA. Translation: BAC37691.1.
AK082807 mRNA. Translation: BAC38630.1.
BC019120 mRNA. Translation: AAH19120.1.
CCDSiCCDS27416.1.
RefSeqiNP_277056.1. NM_033521.3.
UniGeneiMm.197518.

Genome annotation databases

EnsembliENSMUST00000022867; ENSMUSP00000022867; ENSMUSG00000022257.
GeneIDi114128.
KEGGimmu:114128.
UCSCiuc007vlj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317418 mRNA. Translation: AAK69596.1.
AK077269 mRNA. Translation: BAC36721.1.
AK077933 mRNA. Translation: BAC37072.1.
AK079581 mRNA. Translation: BAC37691.1.
AK082807 mRNA. Translation: BAC38630.1.
BC019120 mRNA. Translation: AAH19120.1.
CCDSiCCDS27416.1.
RefSeqiNP_277056.1. NM_033521.3.
UniGeneiMm.197518.

3D structure databases

ProteinModelPortaliQ91XQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022867.

PTM databases

iPTMnetiQ91XQ6.
PhosphoSitePlusiQ91XQ6.

Proteomic databases

PaxDbiQ91XQ6.
PRIDEiQ91XQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022867; ENSMUSP00000022867; ENSMUSG00000022257.
GeneIDi114128.
KEGGimmu:114128.
UCSCiuc007vlj.1. mouse.

Organism-specific databases

CTDi55353.
MGIiMGI:1890494. Laptm4b.

Phylogenomic databases

eggNOGiENOG410IGWG. Eukaryota.
ENOG4111K1Z. LUCA.
GeneTreeiENSGT00390000013359.
HOGENOMiHOG000007698.
HOVERGENiHBG000908.
InParanoidiQ91XQ6.
KOiK12387.
OMAiMSTNNMC.
OrthoDBiEOG091G0MA5.
PhylomeDBiQ91XQ6.
TreeFamiTF330843.

Miscellaneous databases

ChiTaRSiLaptm4b. mouse.
PROiQ91XQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022257.
CleanExiMM_LAPTM4B.
ExpressionAtlasiQ91XQ6. baseline and differential.
GenevisibleiQ91XQ6. MM.

Family and domain databases

InterProiIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERiPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamiPF03821. Mtp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAP4B_MOUSE
AccessioniPrimary (citable) accession number: Q91XQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.