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Q91XQ6 (LAP4B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosomal-associated transmembrane protein 4B
Gene names
Name:Laptm4b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Endomembrane system; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the LAPTM4/LAPTM5 transporter family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendomembrane system

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227Lysosomal-associated transmembrane protein 4B
PRO_0000249723

Regions

Transmembrane26 – 4621Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane153 – 17321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q91XQ6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FD3DC53C2682818D

FASTA22725,395
        10         20         30         40         50         60 
MKMVAPWTRF YSHSCCLCCH VRTGTILLGV WYLIINAVVL LILLSALADP NQYHFSGSEL 

        70         80         90        100        110        120 
GGEFEFMDDA NMCIAIAISL LMILICAMAT YGAYKQHAAW IIPFFCYQIF DFALNTLVAI 

       130        140        150        160        170        180 
TVLVYPNSIQ EYIRQLPPSF PYRDDIMSVN PTCLVLIILL FIGILLTLKG YLISCVWSCY 

       190        200        210        220 
RYINGRNSSD VLVYVTSNDT TVLLPPYDDA TAVPSTAKEP PPPYVSA 

« Hide

References

« Hide 'large scale' references
[1]Hogue D.L.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hypothalamus and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF317418 mRNA. Translation: AAK69596.1.
AK077269 mRNA. Translation: BAC36721.1.
AK077933 mRNA. Translation: BAC37072.1.
AK079581 mRNA. Translation: BAC37691.1.
AK082807 mRNA. Translation: BAC38630.1.
BC019120 mRNA. Translation: AAH19120.1.
CCDSCCDS27416.1.
RefSeqNP_277056.1. NM_033521.3.
UniGeneMm.197518.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91XQ6.

Proteomic databases

PRIDEQ91XQ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022867; ENSMUSP00000022867; ENSMUSG00000022257.
GeneID114128.
KEGGmmu:114128.
UCSCuc007vlj.1. mouse.

Organism-specific databases

CTD55353.
MGIMGI:1890494. Laptm4b.

Phylogenomic databases

eggNOGNOG46169.
GeneTreeENSGT00390000013359.
HOGENOMHOG000007698.
HOVERGENHBG000908.
InParanoidQ91XQ6.
KOK12387.
OMATIILGIW.
OrthoDBEOG7QC7X3.
PhylomeDBQ91XQ6.
TreeFamTF330843.

Gene expression databases

ArrayExpressQ91XQ6.
BgeeQ91XQ6.
CleanExMM_LAPTM4B.
GenevestigatorQ91XQ6.

Family and domain databases

InterProIPR004687. LAPTM4/5.
IPR018401. Lysosomal-assoc_TM_prot4B.
[Graphical view]
PANTHERPTHR12479. PTHR12479. 1 hit.
PTHR12479:SF6. PTHR12479:SF6. 1 hit.
PfamPF03821. Mtp. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLAPTM4B. mouse.
NextBio368129.
PROQ91XQ6.
SOURCESearch...

Entry information

Entry nameLAP4B_MOUSE
AccessionPrimary (citable) accession number: Q91XQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot