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Protein

DNA-directed RNA polymerase II subunit GRINL1A

Gene

Polr2m

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator-dependent regulation of transcription activation. In vitro, acts as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit GRINL1A
Alternative name(s):
DNA-directed RNA polymerase II subunit M
Glutamate receptor-like protein 1A
Gene namesi
Name:Polr2m
Synonyms:Grinl1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi619847. Polr2m.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262321 – 364DNA-directed RNA polymerase II subunit GRINL1AAdd BLAST364

Proteomic databases

PaxDbiQ91XQ4.
PRIDEiQ91XQ4.

PTM databases

PhosphoSitePlusiQ91XQ4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000057676.
ExpressionAtlasiQ91XQ4. differential.
GenevisibleiQ91XQ4. RN.

Interactioni

Subunit structurei

Component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and Polr2m and appears to be an abundant form of Pol II.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054052.

Structurei

3D structure databases

SMRiQ91XQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 39Sequence analysisAdd BLAST25
Coiled coili297 – 331Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the GRINL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVF6. Eukaryota.
ENOG410ZKMZ. LUCA.
GeneTreeiENSGT00530000063232.
HOGENOMiHOG000112815.
HOVERGENiHBG098324.
InParanoidiQ91XQ4.
PhylomeDBiQ91XQ4.
TreeFamiTF332945.

Family and domain databases

InterProiView protein in InterPro
IPR026213. GRINL1.
PfamiView protein in Pfam
PF15328. GCOM2. 1 hit.
PRINTSiPR02085. POLR2GRINL1.

Sequencei

Sequence statusi: Complete.

Q91XQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSLPRGFEP PAPEDLGRQS SAELRERLRR QERLLRNEKF ICKLPDKGKK
60 70 80 90 100
ISDTIAKLKA AISEREEVRG RTELFHPVSV DCKLRHKATT RVDTDIDKAQ
110 120 130 140 150
NSDLMLDTSS LVPECSSVDI ESSKTTSETQ GPTHLTHKGN EETLATGCTV
160 170 180 190 200
NTCPSARITT QDPSSEVNEH LPQHSSQVEE ISSSVDSLFI TKLQKITIAD
210 220 230 240 250
QTEPSEENTS TENFPGLQSE TPKKPHYMKV LEMRAKNPVP PPHKFKTNVL
260 270 280 290 300
PTQQSDSSSH CHKGQSPASS EEHRRRARQH LDDVTAARLL PLHHLPAQLL
310 320 330 340 350
SIEESLALQK EQKQNYEEMQ AKLAAQKLAE RLNIKMQSFN PEGESSGRYR
360
EVRDEDDAQS SDEC
Length:364
Mass (Da):40,874
Last modified:March 1, 2003 - v2
Checksum:i5EC07061B9F917EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326772 mRNA. Translation: AAK92283.2.
BC079379 mRNA. Translation: AAH79379.1.
RefSeqiNP_899652.1. NM_183402.1.
UniGeneiRn.144666.

Genome annotation databases

EnsembliENSRNOT00000085843; ENSRNOP00000072186; ENSRNOG00000057676.
GeneIDi192147.
KEGGirno:192147.
UCSCiRGD:619847. rat.

Similar proteinsi

Entry informationi

Entry nameiGRL1A_RAT
AccessioniPrimary (citable) accession number: Q91XQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families