Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-directed RNA polymerase II subunit GRINL1A

Gene

Polr2m

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator-dependent regulation of transcription activation. In vitro, acts as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase II subunit GRINL1A
Alternative name(s):
DNA-directed RNA polymerase II subunit M
Glutamate receptor-like protein 1A
Gene namesi
Name:Polr2m
Synonyms:Grinl1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi619847. Polr2m.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003262321 – 364DNA-directed RNA polymerase II subunit GRINL1AAdd BLAST364

Proteomic databases

PaxDbiQ91XQ4.
PRIDEiQ91XQ4.

PTM databases

PhosphoSitePlusiQ91XQ4.

Expressioni

Gene expression databases

ExpressionAtlasiQ91XQ4. baseline.
GenevisibleiQ91XQ4. RN.

Interactioni

Subunit structurei

Component of the Pol II(G) complex, which contains the RNA polymerase II (Pol II) core complex subunits and Polr2m and appears to be an abundant form of Pol II.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054052.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 39Sequence analysisAdd BLAST25
Coiled coili297 – 331Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the GRINL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVF6. Eukaryota.
ENOG410ZKMZ. LUCA.
GeneTreeiENSGT00530000063232.
HOGENOMiHOG000112815.
HOVERGENiHBG098324.
InParanoidiQ91XQ4.
PhylomeDBiQ91XQ4.
TreeFamiTF332945.

Family and domain databases

InterProiIPR026213. GRINL1.
[Graphical view]
PfamiPF15328. GCOM2. 1 hit.
[Graphical view]
PRINTSiPR02085. POLR2GRINL1.

Sequencei

Sequence statusi: Complete.

Q91XQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSLPRGFEP PAPEDLGRQS SAELRERLRR QERLLRNEKF ICKLPDKGKK
60 70 80 90 100
ISDTIAKLKA AISEREEVRG RTELFHPVSV DCKLRHKATT RVDTDIDKAQ
110 120 130 140 150
NSDLMLDTSS LVPECSSVDI ESSKTTSETQ GPTHLTHKGN EETLATGCTV
160 170 180 190 200
NTCPSARITT QDPSSEVNEH LPQHSSQVEE ISSSVDSLFI TKLQKITIAD
210 220 230 240 250
QTEPSEENTS TENFPGLQSE TPKKPHYMKV LEMRAKNPVP PPHKFKTNVL
260 270 280 290 300
PTQQSDSSSH CHKGQSPASS EEHRRRARQH LDDVTAARLL PLHHLPAQLL
310 320 330 340 350
SIEESLALQK EQKQNYEEMQ AKLAAQKLAE RLNIKMQSFN PEGESSGRYR
360
EVRDEDDAQS SDEC
Length:364
Mass (Da):40,874
Last modified:March 1, 2003 - v2
Checksum:i5EC07061B9F917EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326772 mRNA. Translation: AAK92283.2.
BC079379 mRNA. Translation: AAH79379.1.
RefSeqiNP_899652.1. NM_183402.1.
UniGeneiRn.144666.

Genome annotation databases

EnsembliENSRNOT00000085843; ENSRNOP00000072186; ENSRNOG00000057676.
GeneIDi192147.
KEGGirno:192147.
UCSCiRGD:619847. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326772 mRNA. Translation: AAK92283.2.
BC079379 mRNA. Translation: AAH79379.1.
RefSeqiNP_899652.1. NM_183402.1.
UniGeneiRn.144666.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054052.

PTM databases

PhosphoSitePlusiQ91XQ4.

Proteomic databases

PaxDbiQ91XQ4.
PRIDEiQ91XQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085843; ENSRNOP00000072186; ENSRNOG00000057676.
GeneIDi192147.
KEGGirno:192147.
UCSCiRGD:619847. rat.

Organism-specific databases

CTDi81488.
RGDi619847. Polr2m.

Phylogenomic databases

eggNOGiENOG410IVF6. Eukaryota.
ENOG410ZKMZ. LUCA.
GeneTreeiENSGT00530000063232.
HOGENOMiHOG000112815.
HOVERGENiHBG098324.
InParanoidiQ91XQ4.
PhylomeDBiQ91XQ4.
TreeFamiTF332945.

Miscellaneous databases

PROiQ91XQ4.

Gene expression databases

ExpressionAtlasiQ91XQ4. baseline.
GenevisibleiQ91XQ4. RN.

Family and domain databases

InterProiIPR026213. GRINL1.
[Graphical view]
PfamiPF15328. GCOM2. 1 hit.
[Graphical view]
PRINTSiPR02085. POLR2GRINL1.
ProtoNetiSearch...

Entry informationi

Entry nameiGRL1A_RAT
AccessioniPrimary (citable) accession number: Q91XQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.