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Protein

Dynein heavy chain 8, axonemal

Gene

Dnah8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2087 – 20948ATPSequence analysis
Nucleotide bindingi2369 – 23768ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 8, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 8
Ciliary dynein heavy chain 8
Gene namesi
Name:Dnah8
Synonyms:Dnahc8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:107714. Dnah8.

Subcellular locationi

Isoform 1 :
  • Cell projectionciliumflagellum
  • Cytoplasm

  • Note: Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. Location determined using antibody against peptide common to isoform 1 and isoform 2.
Isoform 2 :
  • Cell projectionciliumflagellum
  • Cytoplasm

  • Note: Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. Location determined using antibody against peptide common to isoform 1 and isoform 2.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • dynein complex Source: MGI
  • microtubule Source: UniProtKB-KW
  • outer dynein arm Source: MGI
  • sperm principal piece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Flagellum, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 47314731Dynein heavy chain 8, axonemalPRO_0000274045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei917 – 9171PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91XQ0.
PaxDbiQ91XQ0.
PRIDEiQ91XQ0.

PTM databases

iPTMnetiQ91XQ0.
PhosphoSiteiQ91XQ0.

Expressioni

Tissue specificityi

Isoform 1 and/or isoform 2 are expressed in spermatocytes and mature sperm (at protein level). Testis-specific. Accumulates exclusively in mid to late spermatocytes.3 Publications

Gene expression databases

BgeeiENSMUSG00000033826.
CleanExiMM_DNAHC8.
GenevisibleiQ91XQ0. MM.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127878.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2049 – 2271223AAA 1By similarityAdd
BLAST
Regioni2331 – 2550220AAA 2By similarityAdd
BLAST
Regioni2657 – 2910254AAA 3By similarityAdd
BLAST
Regioni3021 – 3275255AAA 4By similarityAdd
BLAST
Regioni3290 – 3587298StalkBy similarityAdd
BLAST
Regioni3673 – 3903231AAA 5By similarityAdd
BLAST
Regioni4118 – 4332215AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 16925Sequence analysisAdd
BLAST
Coiled coili1543 – 156725Sequence analysisAdd
BLAST
Coiled coili3313 – 340593Sequence analysisAdd
BLAST
Coiled coili3531 – 358353Sequence analysisAdd
BLAST
Coiled coili3836 – 387136Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 5445Pro-richAdd
BLAST

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00760000118964.
HOVERGENiHBG005543.
InParanoidiQ91XQ0.
KOiK10408.
OMAiLLKDQWE.
OrthoDBiEOG091G001E.
TreeFamiTF316836.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 3 hits.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91XQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESEEGNAEP PPPSEEAPPP VVEEAPPPLP PEDTAPPPPE EQAPPPEGDA
60 70 80 90 100
APPPTGDAFQ LTVEGEAPHP EDPKLLSEQG PATSVTDYRS LIPSDEEVTL
110 120 130 140 150
PEDEESGQAR VRARHTPRPA QSVLSDGISQ SSRRPSKFRR SMTGIPNLQE
160 170 180 190 200
TLKEKQARFR EARENRKMKI GPSHKYIFEV LGEKLGLDLV TVEELILDCP
210 220 230 240 250
SLDPFTSFFE KGGCKTLKFL YQEGEVPGFE CGRTITGVPK GGKMMRIYVD
260 270 280 290 300
NAAPDKLKGL CLFFVRCRND VAINSKTIHE DVLFSFLDAS KGLLEGIKHM
310 320 330 340 350
LKSIFLPAIL ATSNWGALNQ SKQGESEKHI FIETIHRYLA SLDDATISIE
360 370 380 390 400
GTVMLKKVDN IDFSKLHTFE EVTAAASSSE MVHQLEEVLM VWYKQIEQVL
410 420 430 440 450
IESEQMRKEA DDSGPLTELE HWKRMSAKFN FIIEQIKGSN CKAVINVLNV
460 470 480 490 500
AHSKLLKNWR DLDARITDSA NESKDNVRYL YTLEKVCQPL YNYDLVSMAH
510 520 530 540 550
GIQNLINAIR MIHSVSRYYN TSERMTSLFI KVTNQMVTAC KAYITDGGTN
560 570 580 590 600
HVWDQETPAV LKKIQDCIFL FKEYQASFHK TRKQILESSG EKSFEVSEMY
610 620 630 640 650
IFGKFEAFCK RLEKITEMIT IVQTYSALSN STIEGIDILG IKFKNIYQGI
660 670 680 690 700
KKNQYDILDP RRTEFDTDFT EFMGKINILE IQIQAFMNST FGKILSSQQA
710 720 730 740 750
LQLLQRFQKL NIPCLHLEIN HTIERILQCY VAELEFTKKL YLSQKDDPPL
760 770 780 790 800
ARNMPPIAGK ILWVRQLFRR INEPINYFFK NSDILSSTEG KAVIRQYNRI
810 820 830 840 850
AYVLVEFEVA YHTAWFKEVS QLQYALQATL FVRHPETGKL LVNFDPKILE
860 870 880 890 900
VVRETKCMIK MKLDVPEQAK NLLKLESKLK ADKLYLQGLL QYYDDLCQEV
910 920 930 940 950
PSVFVNLMTP KMKKVESVLR QGLTVLTWSS LMLESFFKEV ESVLDMFNQL
960 970 980 990 1000
LKKVNDLCEM HIDTVLKEIA KTLLISLSDS GTTKVEDMLT LNETYTKECA
1010 1020 1030 1040 1050
DILNHKSRHV EEAVKELILI FEQIYEVKYT GKAAKSVKEQ RKRVVFGSEA
1060 1070 1080 1090 1100
EETEGLDFES TTMEVDTNDK EDEFKKECKE VYAFFSHQLL DSLQKATRLS
1110 1120 1130 1140 1150
LDTMKRRIFV GSQGRRRSED IVSFIKTEVH LAIPNVVMVP SLDDIQQAIN
1160 1170 1180 1190 1200
RMIQLTLEVS RGVAHWGQQQ VRQIKSFQNN SRGSDQPPAS GKPLKKEERS
1210 1220 1230 1240 1250
FEETIPARKL KNFYPGVAEH KDISKLVLLL SSSVNSLRKA ATEALQDFQK
1260 1270 1280 1290 1300
YKTLWIEDRH VKVKEFLANN PSLTEIRSEI LHYATLEQEI KELKPIIVVG
1310 1320 1330 1340 1350
SLELHTEPMK LALSIEAKAW KMLLCRYLNE EYKKKMSDMI TFINEYLKKL
1360 1370 1380 1390 1400
SRPIRDLDDV RFAMEALSCI RDNEIQMDMT LGPIEEAYGI LNRFEVKVTK
1410 1420 1430 1440 1450
EESEGVDTLR YSFNKLQSKA VSVQGELVKV QPKFKSNLLE SVKVFCEDVI
1460 1470 1480 1490 1500
NFTEAYETEG PMVPNIPPQE ASNRLQIFQA NFDDLWRKFV TYSSGEQLFG
1510 1520 1530 1540 1550
LPVTDYEVLH KTRKELNLLQ KLYGLYDTVM GSISGYYEIL WGDVDIEKIN
1560 1570 1580 1590 1600
AELQEFQNRC RKLPRALKDW QAFLDLKKRI DDFSESCPLL EMMTNKAMKQ
1610 1620 1630 1640 1650
RHWDRISELT GTPFDVESDT FCLRNIMEAP LLKNKDDIED ICISAIKEKD
1660 1670 1680 1690 1700
IEAKLTQVIE NWTYQNLSFA AFKGKGELLL KGTESGEIIT LMEDSLMVLG
1710 1720 1730 1740 1750
SLLSNRYNTP FKKNIQNWVF KLSTSSDIIE EWLIVQNLWV YLEAVFVGGD
1760 1770 1780 1790 1800
IAKQLPQEAK RFQNIDKSWI KIMQRAHENP NVISCCVGDE TMGQLLPHLH
1810 1820 1830 1840 1850
EQLEVCQKSL TGYLEKKRLL FPRFFFVSDP VLLEILGQAS DSHTIQPHLP
1860 1870 1880 1890 1900
AVSDNINEVT FHAKDYDRMT AVISREGEKI MLDTPVMAKG PVEIWLLDLL
1910 1920 1930 1940 1950
KVQMSSLHNI IRSAFYQISD SGFLLLPFLN HFPAQVGLLG IQMLWTHDSE
1960 1970 1980 1990 2000
EALNNAKDDR KIMQITNQKF LDILNTLISQ TTHDLTKFDR VKFETLITIH
2010 2020 2030 2040 2050
VHQRDIFDDL VKMHIKSVTD FEWLKQSRFY FKEDLDQTVV SITDVDFIYQ
2060 2070 2080 2090 2100
NEFLGCTDRL VITPLTDRCY ITLAQALGMN MGGAPAGPAG TGKTETTKDM
2110 2120 2130 2140 2150
GRCLGKYVVV FNCSDQMDFR GLGRIFKGLA QSGSWGCFDE FNRIELPVLS
2160 2170 2180 2190 2200
VAAQQIYIVL TARKERKKQF IFSDGDCVDL NPEFGIFLTM NPGYAGRQEL
2210 2220 2230 2240 2250
PENLKIQFRT VAMMVPDRQI IMRVKLASCG FLENVILAQK FYVLYKLCEE
2260 2270 2280 2290 2300
QLTKQVHYDF GLRNILSVLR TLGSQKRARP EDSELSTVMR GLRDMNLSKL
2310 2320 2330 2340 2350
VDEDEPLFLS LINDLFPGLQ LDSSTYAELQ SAVDNQVNLE GLINHPPWNL
2360 2370 2380 2390 2400
KLVQLYETSL VRHGLMTLGP SGSGKTTVIT ILMKSLTECG RPHREMRMNP
2410 2420 2430 2440 2450
KAITAPQMFG RLDTATNDWT DGIFSTLWRK TLKAKKGENI FLILDGPVDA
2460 2470 2480 2490 2500
IWIENLNSVL DDNKTLTLAN GDRIPMAPTC KLLFEVHNIE NASPATVSRM
2510 2520 2530 2540 2550
GMVYISSSAL SWRPILQAWL KKRSQQEASV FLSLYDKVFE DAYTYMKLSL
2560 2570 2580 2590 2600
NPKMQLLECN YIMQSLNLLE GLIPSKEEGG VSSGDHLHKL FVFGLMWSLG
2610 2620 2630 2640 2650
ALLELDSREK LEVFLRGHGS KLNLPEIPKG SQQTMYEFYV TDYGDWEHWN
2660 2670 2680 2690 2700
KRIQPYFYPT DSIPEYSSIL VPNVDNIRTN FLIDTIAKQH KAVLLTGEQG
2710 2720 2730 2740 2750
TAKTVMVKAY LKKYDPEVQL SKSLNFSSAT EPMMFQRTIE SYVDKRMGST
2760 2770 2780 2790 2800
YGPPGGRKMT VFIDDINMPV INEWGDQITN EIVRQMMEME GMYSLDKPGD
2810 2820 2830 2840 2850
FTTIVDVQLI AAMIHPGGGR NDIPQRLKRQ FTVFNCTLPS NTSIDKIFGI
2860 2870 2880 2890 2900
IGCGYFDPCR KFRPEICDMV GNLVSVSRVL WQWTKVKMLP TPSKFHYIFN
2910 2920 2930 2940 2950
LRDLSRIWQG MLTVKAEECS SIPILLSLFK HECNRVIADR FITPDDEQWF
2960 2970 2980 2990 3000
NSQLIRAVEE NISPEVAANI LPEPYFVDFL RDMPEPTGDE PEDTMFEVPK
3010 3020 3030 3040 3050
IYELVPSFEF LSEKLQFYQR QFNEIIRGTS LDLVFFKDAM THLVKISRII
3060 3070 3080 3090 3100
RTSCGNALLV GVGGSGKQSL SKLASFIAGY QIFQITLTRS YNVSNLIEDL
3110 3120 3130 3140 3150
KNLYKVAGAE GKGITFIFTD NEIKDEAFLE YLNNLLSSGE ISNLFARDEM
3160 3170 3180 3190 3200
DEITQGLISV MKRELPRHPP TFDNLYEYFI TRSRKNLHVV LCFSPVGEKF
3210 3220 3230 3240 3250
RARSLKFPGL ISGCTMDWFS RWPKEALIAV ASYFLLDYNI VCSIETKRHV
3260 3270 3280 3290 3300
VETMGLFHDM VSESCENYFQ RYRRRAHVTP KSYLSFINGY KSIYTDKVKY
3310 3320 3330 3340 3350
INEQAERMNI GLDKLMEASE SVAKLSQDLA VKEKELAVAS IKADEVLAEV
3360 3370 3380 3390 3400
TVSAQASAKV KNEVQEVKDK AQKIVDEIDS EKVKAETKLE AAKPALEEAE
3410 3420 3430 3440 3450
AALNTIKPND IATVRKLAKP PHLIMRIMDC VLLLFQKKID PVTMDPEKPC
3460 3470 3480 3490 3500
CKPSWGESLK LMSATGFLFS LQQFPKDTIN EETVELLQPY FNMDDYTFES
3510 3520 3530 3540 3550
AKKVCGNVAG LLSWTLAMVI FYGINREVLP LKANLAKQEG RLAVANVELG
3560 3570 3580 3590 3600
KAQALLDEKQ AELDKVQAKF DAAMKEKMDL LNDADMCRKK MQAASTLIDG
3610 3620 3630 3640 3650
LSGEKVRWTQ QSKEFKTQIN RLVGDVLLCT GFLSYLGPFN QIFRNYLLKD
3660 3670 3680 3690 3700
QWELELKARK IPFTENLNLI AMLVDPPTIG EWGLQGLPGD DLSIQNGIIV
3710 3720 3730 3740 3750
TKATRYPLLI DPQTQGKTWI KSKEKENDLQ VTSLNHKYFR THLEDSLSLG
3760 3770 3780 3790 3800
RPLLIEDIRE ELDPALDNVL EKNFIKSGTA FKVKVGDKEC DIMDTFKLYI
3810 3820 3830 3840 3850
TTKLPNPAFT PEINAKTSVI DFTVTMKGLE NQLLRRVILT EKQELESERV
3860 3870 3880 3890 3900
KLLEDVTFNK RKMKELEDNL LYKLSATKGS LVDDESLIGV LRITKQTAAE
3910 3920 3930 3940 3950
VSEKLHVAAE TEIKINTAQE EFRPAATRGS ILYFLITEMS MVNIMYQTSL
3960 3970 3980 3990 4000
AQFLKLFDQS MARSEKSPLP QKRITNIIEY LTYEVFTYSV RGLYENHKFL
4010 4020 4030 4040 4050
FVLLMTLKID LQRGTVKHKE FQALIKGGAA LDLKACPPKP FRWILDMTWL
4060 4070 4080 4090 4100
NLVELSKLPQ FAEIMNQISR NEKGWKNWFD KDAPEEEIIP DGYNDSLDTC
4110 4120 4130 4140 4150
RKLLLIRSWC PDRTVFQARK YIADSLEEKY TEPVILNLEK TWEESDTHTP
4160 4170 4180 4190 4200
LICFLSMGSD PTIQIDALAK KLKLECRTIS MGQGQEVHAR KLIQLSMQQG
4210 4220 4230 4240 4250
GWVLLQNCHL GLEFMEELLE MLMVTETTED SFRVWITTEP HDRFPITLLQ
4260 4270 4280 4290 4300
TSIKFTNEPP QGVRAGLKRT FAGINQDLLD ISNLPMWKPM LYTVAFLHST
4310 4320 4330 4340 4350
VQERRKFGPL GWNIPYEFNS ADFSASVQFI QNHLDECDIK KGVSWSTVRY
4360 4370 4380 4390 4400
MIGEVQYGGR VTDDFDKRLL NCFARVWFSE KMFEPSFCFY TGYKIPICKT
4410 4420 4430 4440 4450
LDQYFEFIQS LPSLDNPEVF GLHPNADITY QSNTASDVLE TITNIQPKES
4460 4470 4480 4490 4500
GGGVGETREA IVYRLSEDML SKLPPNYVPH EVKARLMKMG HLNSMNIFLR
4510 4520 4530 4540 4550
QEIDRMQKVI SILRSSLSDL KLAIEGTIIM SENLRDALDN MYDARIPQLW
4560 4570 4580 4590 4600
KRVSWDSSTL GFWFTELLER NAQFSTWIFE GRPNVFWMTG FFNPQGFLTA
4610 4620 4630 4640 4650
MRQEVTRAHK GWALDTVTIH NEVLRQTKEE IITPPAEGVY IYGLYMDGAS
4660 4670 4680 4690 4700
WDRRNGKLTE STPKVLFTQL PVLHIFAINS TAPKDPKLYV CPIYKKPRRT
4710 4720 4730
DLTFITVVYL RTVLSPDHWI LRGVALLCDI K
Length:4,731
Mass (Da):541,238
Last modified:July 27, 2011 - v2
Checksum:i37711771223CEC0A
GO
Isoform 2 (identifier: Q91XQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4200-4202: GGW → VCN
     4203-4731: Missing.

Show »
Length:4,202
Mass (Da):480,155
Checksum:iC46E40CEBA790E1C
GO
Isoform 3 (identifier: Q91XQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3671: Missing.

Note: No experimental confirmation available.
Show »
Length:1,060
Mass (Da):122,032
Checksum:i170D1FF0414445D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1282GI → RL in AAK60623 (PubMed:12297094).Curated
Sequence conflicti127 – 1282GI → RL in AAK60624 (PubMed:12297094).Curated
Sequence conflicti127 – 1282GI → RL in AAK60632 (PubMed:12297094).Curated
Sequence conflicti424 – 4241R → C in AAK60623 (PubMed:12297094).Curated
Sequence conflicti424 – 4241R → C in AAK60624 (PubMed:12297094).Curated
Sequence conflicti424 – 4241R → C in AAK60632 (PubMed:12297094).Curated
Sequence conflicti567 – 5671C → R in AAK60621 (PubMed:12297094).Curated
Sequence conflicti567 – 5671C → R in AAK60622 (PubMed:12297094).Curated
Sequence conflicti813 – 8131T → R in AAK60623 (PubMed:12297094).Curated
Sequence conflicti813 – 8131T → R in AAK60624 (PubMed:12297094).Curated
Sequence conflicti813 – 8131T → R in AAK60632 (PubMed:12297094).Curated
Sequence conflicti963 – 9631D → N in AAK60623 (PubMed:12297094).Curated
Sequence conflicti963 – 9631D → N in AAK60624 (PubMed:12297094).Curated
Sequence conflicti963 – 9631D → N in AAK60632 (PubMed:12297094).Curated
Sequence conflicti982 – 9821T → A in AAK60623 (PubMed:12297094).Curated
Sequence conflicti982 – 9821T → A in AAK60624 (PubMed:12297094).Curated
Sequence conflicti982 – 9821T → A in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1051 – 10511E → K in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1051 – 10511E → K in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1051 – 10511E → K in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1291 – 12911K → E in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1291 – 12911K → E in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1291 – 12911K → E in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1421 – 14211V → I in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1421 – 14211V → I in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1421 – 14211V → I in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1429 – 14291K → Q in AAK60621 (PubMed:12297094).Curated
Sequence conflicti1429 – 14291K → Q in AAK60622 (PubMed:12297094).Curated
Sequence conflicti1429 – 14291K → Q in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1429 – 14291K → Q in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1429 – 14291K → Q in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1429 – 14291K → Q in AAK18309 (PubMed:12297094).Curated
Sequence conflicti1437 – 14371N → S in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1437 – 14371N → S in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1437 – 14371N → S in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1463 – 14631V → E in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1463 – 14631V → E in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1463 – 14631V → E in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1566 – 15661A → G in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1566 – 15661A → G in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1566 – 15661A → G in AAK60632 (PubMed:12297094).Curated
Sequence conflicti1569 – 15691D → N in AAK60623 (PubMed:12297094).Curated
Sequence conflicti1569 – 15691D → N in AAK60624 (PubMed:12297094).Curated
Sequence conflicti1569 – 15691D → N in AAK60632 (PubMed:12297094).Curated
Sequence conflicti2060 – 20601L → F in CAB06071 (PubMed:9373155).Curated
Sequence conflicti2157 – 21571Y → N in CAB06071 (PubMed:9373155).Curated
Sequence conflicti2164 – 21641K → R in CAB06071 (PubMed:9373155).Curated
Sequence conflicti2167 – 21671K → T in CAB06071 (PubMed:9373155).Curated
Sequence conflicti2224 – 22241V → A in AAK60623 (PubMed:12297094).Curated
Sequence conflicti2224 – 22241V → A in AAK60624 (PubMed:12297094).Curated
Sequence conflicti2224 – 22241V → A in AAK60632 (PubMed:12297094).Curated
Sequence conflicti2264 – 22641N → A in CAB06071 (PubMed:9373155).Curated
Sequence conflicti3408 – 34081P → T in AAK60623 (PubMed:12297094).Curated
Sequence conflicti3408 – 34081P → T in AAK60624 (PubMed:12297094).Curated
Sequence conflicti3408 – 34081P → T in AAK60632 (PubMed:12297094).Curated
Sequence conflicti3893 – 38931I → V in AAK60623 (PubMed:12297094).Curated
Sequence conflicti3893 – 38931I → V in AAK60624 (PubMed:12297094).Curated
Sequence conflicti3893 – 38931I → V in AAK60632 (PubMed:12297094).Curated
Sequence conflicti4229 – 42291E → K in AAK60623 (PubMed:12297094).Curated
Sequence conflicti4310 – 43101L → W in BAE21572 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 36713671Missing in isoform 3. 1 PublicationVSP_022615Add
BLAST
Alternative sequencei4200 – 42023GGW → VCN in isoform 2. 1 PublicationVSP_022616
Alternative sequencei4203 – 4731529Missing in isoform 2. 1 PublicationVSP_022617Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356520 mRNA. Translation: AAK60621.1.
AF356521 mRNA. Translation: AAK60622.1.
AF356522 mRNA. Translation: AAK60623.1.
AF356523 mRNA. Translation: AAK60624.1.
AF363577 mRNA. Translation: AAK60632.1.
AF342999 Genomic DNA. Translation: AAK18309.1.
AK133238 mRNA. Translation: BAE21572.1.
AC165951 Genomic DNA. No translation available.
AC165962 Genomic DNA. No translation available.
AC166166 Genomic DNA. No translation available.
AC174471 Genomic DNA. No translation available.
AF117305 mRNA. Translation: AAF20213.1.
Z83817 mRNA. Translation: CAB06071.1.
CCDSiCCDS37541.1. [Q91XQ0-1]
RefSeqiNP_038839.2. NM_013811.3. [Q91XQ0-1]
XP_006523651.1. XM_006523588.2. [Q91XQ0-1]
UniGeneiMm.426017.
Mm.446558.

Genome annotation databases

EnsembliENSMUST00000170651; ENSMUSP00000127878; ENSMUSG00000033826. [Q91XQ0-1]
GeneIDi13417.
KEGGimmu:13417.
UCSCiuc008bua.1. mouse. [Q91XQ0-2]
uc008bub.1. mouse. [Q91XQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356520 mRNA. Translation: AAK60621.1.
AF356521 mRNA. Translation: AAK60622.1.
AF356522 mRNA. Translation: AAK60623.1.
AF356523 mRNA. Translation: AAK60624.1.
AF363577 mRNA. Translation: AAK60632.1.
AF342999 Genomic DNA. Translation: AAK18309.1.
AK133238 mRNA. Translation: BAE21572.1.
AC165951 Genomic DNA. No translation available.
AC165962 Genomic DNA. No translation available.
AC166166 Genomic DNA. No translation available.
AC174471 Genomic DNA. No translation available.
AF117305 mRNA. Translation: AAF20213.1.
Z83817 mRNA. Translation: CAB06071.1.
CCDSiCCDS37541.1. [Q91XQ0-1]
RefSeqiNP_038839.2. NM_013811.3. [Q91XQ0-1]
XP_006523651.1. XM_006523588.2. [Q91XQ0-1]
UniGeneiMm.426017.
Mm.446558.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127878.

PTM databases

iPTMnetiQ91XQ0.
PhosphoSiteiQ91XQ0.

Proteomic databases

MaxQBiQ91XQ0.
PaxDbiQ91XQ0.
PRIDEiQ91XQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170651; ENSMUSP00000127878; ENSMUSG00000033826. [Q91XQ0-1]
GeneIDi13417.
KEGGimmu:13417.
UCSCiuc008bua.1. mouse. [Q91XQ0-2]
uc008bub.1. mouse. [Q91XQ0-1]

Organism-specific databases

CTDi1769.
MGIiMGI:107714. Dnah8.

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
GeneTreeiENSGT00760000118964.
HOVERGENiHBG005543.
InParanoidiQ91XQ0.
KOiK10408.
OMAiLLKDQWE.
OrthoDBiEOG091G001E.
TreeFamiTF316836.

Miscellaneous databases

PROiQ91XQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033826.
CleanExiMM_DNAHC8.
GenevisibleiQ91XQ0. MM.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 3 hits.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 3 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDYH8_MOUSE
AccessioniPrimary (citable) accession number: Q91XQ0
Secondary accession number(s): E9Q010
, O08830, Q3V0D2, Q91V63, Q91XP8, Q91XP9, Q99MH8, Q9QY72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.