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Q91XP5

- GLRA3_MOUSE

UniProt

Q91XP5 - GLRA3_MOUSE

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Protein

Glycine receptor subunit alpha-3

Gene
Glra3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) By similarity.

GO - Molecular functioni

  1. extracellular-glycine-gated chloride channel activity Source: InterPro
  2. glycine binding Source: InterPro
  3. transmitter-gated ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine receptor subunit alpha-3
Gene namesi
Name:Glra3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:95749. Glra3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 252219Extracellular InferredAdd
BLAST
Transmembranei253 – 27927Helical; InferredAdd
BLAST
Transmembranei286 – 30318Helical; InferredAdd
BLAST
Transmembranei315 – 34127Helical; InferredAdd
BLAST
Topological domaini342 – 43392Cytoplasmic InferredAdd
BLAST
Transmembranei434 – 45118Helical; InferredAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. chloride channel complex Source: UniProtKB-KW
  3. integral component of plasma membrane Source: InterPro
  4. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed predictionAdd
BLAST
Chaini34 – 464431Glycine receptor subunit alpha-3PRO_0000000420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi171 ↔ 185 By similarity
Disulfide bondi231 ↔ 242 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91XP5.
PRIDEiQ91XP5.

PTM databases

PhosphoSiteiQ91XP5.

Expressioni

Gene expression databases

ArrayExpressiQ91XP5.
BgeeiQ91XP5.
CleanExiMM_GLRA3.
GenevestigatoriQ91XP5.

Interactioni

Subunit structurei

Pentamer composed of alpha and beta subunits By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000275.

Structurei

3D structure databases

ProteinModelPortaliQ91XP5.
SMRiQ91XP5. Positions 54-345, 421-458.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265706.
HOGENOMiHOG000231336.
HOVERGENiHBG051707.
InParanoidiQ91XP5.
KOiK05195.
PhylomeDBiQ91XP5.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XP5-1 [UniParc]FASTAAdd to Basket

« Hide

MAHVRHFRTL VSGFYFWEAA LLLSLVATKE TNSARSRSAP MSPSDFLDKL    50
MGRTSGYDAR IRPNFKGPPV NVTCNIFINS FGSIAETTMD YRVNIFLRQK 100
WNDPRLAYSE YPDDSLDLDP SMLDSIWKPD LFFANEKGAN FHEVTTDNKL 150
LRIFKNGNVL YSIRLTLTLS CPMDLKNFPM DVQTCIMQLE SFGYTMNDLI 200
FEWQDEAPVQ VAEGLTLPQF LLKEEKDLRY CTKHYNTGKF TCIEVRFHLE 250
RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI TTVLTMTTQS 300
SGSRASLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRF 350
RRKRKNKTEA FALEKFYRFS DTDDEVRESR FSFTAYGMGP CLQAKDGVVP 400
KGPNHAVQVM PKSPDEMRKV FIDRAKKIDT ISRACFPLAF LIFNIFYWVI 450
YKILRHEDIH QQQD 464
Length:464
Mass (Da):53,709
Last modified:May 24, 2005 - v2
Checksum:i0963FD4A3727AA1D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101Missing in AAK51962. 1 Publication
Sequence conflicti293 – 2931V → D in AAK51962. 1 Publication
Sequence conflicti461 – 4611Q → H in AAK51962. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF362764 mRNA. Translation: AAK51962.1.
AY230204 mRNA. Translation: AAP22967.1.
RefSeqiNP_536686.2. NM_080438.2.
UniGeneiMm.307061.

Genome annotation databases

GeneIDi110304.
KEGGimmu:110304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF362764 mRNA. Translation: AAK51962.1 .
AY230204 mRNA. Translation: AAP22967.1 .
RefSeqi NP_536686.2. NM_080438.2.
UniGenei Mm.307061.

3D structure databases

ProteinModelPortali Q91XP5.
SMRi Q91XP5. Positions 54-345, 421-458.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000000275.

Chemistry

GuidetoPHARMACOLOGYi 425.

PTM databases

PhosphoSitei Q91XP5.

Proteomic databases

PaxDbi Q91XP5.
PRIDEi Q91XP5.

Protocols and materials databases

DNASUi 110304.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 110304.
KEGGi mmu:110304.

Organism-specific databases

CTDi 8001.
MGIi MGI:95749. Glra3.

Phylogenomic databases

eggNOGi NOG265706.
HOGENOMi HOG000231336.
HOVERGENi HBG051707.
InParanoidi Q91XP5.
KOi K05195.
PhylomeDBi Q91XP5.

Enzyme and pathway databases

Reactomei REACT_198558. Ligand-gated ion channel transport.

Miscellaneous databases

NextBioi 363729.
PROi Q91XP5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91XP5.
Bgeei Q91XP5.
CleanExi MM_GLRA3.
Genevestigatori Q91XP5.

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Different glycine receptor isoforms are expressed in murine cerebellum."
    Noegel S., Becker C., Becker K.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. "Diversity of glycine receptors in the mouse retina: localization of the alpha 3 subunit."
    Haverkamp S., Mueller U., Harvey K., Harvey R.J., Betz H., Waessle H.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiGLRA3_MOUSE
AccessioniPrimary (citable) accession number: Q91XP5
Secondary accession number(s): Q7TSQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The alpha subunit binds strychnine By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi