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Q91XP5

- GLRA3_MOUSE

UniProt

Q91XP5 - GLRA3_MOUSE

Protein

Glycine receptor subunit alpha-3

Gene

Glra3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (24 May 2005)
      Previous versions | rss
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    Functioni

    The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) By similarity.By similarity

    GO - Molecular functioni

    1. extracellular-glycine-gated chloride channel activity Source: InterPro
    2. glycine binding Source: InterPro
    3. transmitter-gated ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Enzyme and pathway databases

    ReactomeiREACT_198558. Ligand-gated ion channel transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine receptor subunit alpha-3
    Gene namesi
    Name:Glra3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:95749. Glra3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. chloride channel complex Source: UniProtKB-KW
    3. integral component of plasma membrane Source: InterPro
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 464431Glycine receptor subunit alpha-3PRO_0000000420Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi171 ↔ 185By similarity
    Disulfide bondi231 ↔ 242By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ91XP5.
    PRIDEiQ91XP5.

    PTM databases

    PhosphoSiteiQ91XP5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91XP5.
    BgeeiQ91XP5.
    CleanExiMM_GLRA3.
    GenevestigatoriQ91XP5.

    Interactioni

    Subunit structurei

    Pentamer composed of alpha and beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000000275.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XP5.
    SMRiQ91XP5. Positions 54-345, 421-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 252219ExtracellularCuratedAdd
    BLAST
    Topological domaini342 – 43392CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei253 – 27927HelicalCuratedAdd
    BLAST
    Transmembranei286 – 30318HelicalCuratedAdd
    BLAST
    Transmembranei315 – 34127HelicalCuratedAdd
    BLAST
    Transmembranei434 – 45118HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265706.
    HOGENOMiHOG000231336.
    HOVERGENiHBG051707.
    InParanoidiQ91XP5.
    KOiK05195.
    PhylomeDBiQ91XP5.

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006028. GABAA/Glycine_rcpt.
    IPR008127. Glycine_rcpt_A.
    IPR008130. Glycine_rcpt_A3.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00253. GABAARECEPTR.
    PR01673. GLYRALPHA.
    PR01676. GLYRALPHA3.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91XP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHVRHFRTL VSGFYFWEAA LLLSLVATKE TNSARSRSAP MSPSDFLDKL    50
    MGRTSGYDAR IRPNFKGPPV NVTCNIFINS FGSIAETTMD YRVNIFLRQK 100
    WNDPRLAYSE YPDDSLDLDP SMLDSIWKPD LFFANEKGAN FHEVTTDNKL 150
    LRIFKNGNVL YSIRLTLTLS CPMDLKNFPM DVQTCIMQLE SFGYTMNDLI 200
    FEWQDEAPVQ VAEGLTLPQF LLKEEKDLRY CTKHYNTGKF TCIEVRFHLE 250
    RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI TTVLTMTTQS 300
    SGSRASLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRF 350
    RRKRKNKTEA FALEKFYRFS DTDDEVRESR FSFTAYGMGP CLQAKDGVVP 400
    KGPNHAVQVM PKSPDEMRKV FIDRAKKIDT ISRACFPLAF LIFNIFYWVI 450
    YKILRHEDIH QQQD 464
    Length:464
    Mass (Da):53,709
    Last modified:May 24, 2005 - v2
    Checksum:i0963FD4A3727AA1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101Missing in AAK51962. 1 PublicationCurated
    Sequence conflicti293 – 2931V → D in AAK51962. 1 PublicationCurated
    Sequence conflicti461 – 4611Q → H in AAK51962. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF362764 mRNA. Translation: AAK51962.1.
    AY230204 mRNA. Translation: AAP22967.1.
    RefSeqiNP_536686.2. NM_080438.2.
    UniGeneiMm.307061.

    Genome annotation databases

    GeneIDi110304.
    KEGGimmu:110304.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF362764 mRNA. Translation: AAK51962.1 .
    AY230204 mRNA. Translation: AAP22967.1 .
    RefSeqi NP_536686.2. NM_080438.2.
    UniGenei Mm.307061.

    3D structure databases

    ProteinModelPortali Q91XP5.
    SMRi Q91XP5. Positions 54-345, 421-458.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000000275.

    Chemistry

    GuidetoPHARMACOLOGYi 425.

    PTM databases

    PhosphoSitei Q91XP5.

    Proteomic databases

    PaxDbi Q91XP5.
    PRIDEi Q91XP5.

    Protocols and materials databases

    DNASUi 110304.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 110304.
    KEGGi mmu:110304.

    Organism-specific databases

    CTDi 8001.
    MGIi MGI:95749. Glra3.

    Phylogenomic databases

    eggNOGi NOG265706.
    HOGENOMi HOG000231336.
    HOVERGENi HBG051707.
    InParanoidi Q91XP5.
    KOi K05195.
    PhylomeDBi Q91XP5.

    Enzyme and pathway databases

    Reactomei REACT_198558. Ligand-gated ion channel transport.

    Miscellaneous databases

    NextBioi 363729.
    PROi Q91XP5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91XP5.
    Bgeei Q91XP5.
    CleanExi MM_GLRA3.
    Genevestigatori Q91XP5.

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006028. GABAA/Glycine_rcpt.
    IPR008127. Glycine_rcpt_A.
    IPR008130. Glycine_rcpt_A3.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00253. GABAARECEPTR.
    PR01673. GLYRALPHA.
    PR01676. GLYRALPHA3.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Different glycine receptor isoforms are expressed in murine cerebellum."
      Noegel S., Becker C., Becker K.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal cord.
    2. "Diversity of glycine receptors in the mouse retina: localization of the alpha 3 subunit."
      Haverkamp S., Mueller U., Harvey K., Harvey R.J., Betz H., Waessle H.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.

    Entry informationi

    Entry nameiGLRA3_MOUSE
    AccessioniPrimary (citable) accession number: Q91XP5
    Secondary accession number(s): Q7TSQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The alpha subunit binds strychnine.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3