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Protein

Glycine receptor subunit alpha-3

Gene

Glra3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) (By similarity).By similarity

GO - Molecular functioni

  1. extracellular-glycine-gated chloride channel activity Source: InterPro
  2. glycine binding Source: InterPro
  3. transmitter-gated ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine receptor subunit alpha-3
Gene namesi
Name:Glra3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:95749. Glra3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 252219ExtracellularCuratedAdd
BLAST
Transmembranei253 – 27927HelicalCuratedAdd
BLAST
Transmembranei286 – 30318HelicalCuratedAdd
BLAST
Transmembranei315 – 34127HelicalCuratedAdd
BLAST
Topological domaini342 – 43392CytoplasmicCuratedAdd
BLAST
Transmembranei434 – 45118HelicalCuratedAdd
BLAST

GO - Cellular componenti

  1. axon terminus Source: MGI
  2. cell junction Source: UniProtKB-KW
  3. chloride channel complex Source: UniProtKB-KW
  4. external side of plasma membrane Source: MGI
  5. integral component of plasma membrane Source: InterPro
  6. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 464431Glycine receptor subunit alpha-3PRO_0000000420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi171 ↔ 185By similarity
Disulfide bondi231 ↔ 242By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91XP5.
PRIDEiQ91XP5.

PTM databases

PhosphoSiteiQ91XP5.

Expressioni

Gene expression databases

BgeeiQ91XP5.
CleanExiMM_GLRA3.
ExpressionAtlasiQ91XP5. baseline.
GenevestigatoriQ91XP5.

Interactioni

Subunit structurei

Pentamer composed of alpha and beta subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000275.

Structurei

3D structure databases

ProteinModelPortaliQ91XP5.
SMRiQ91XP5. Positions 47-345, 421-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265706.
HOGENOMiHOG000231336.
HOVERGENiHBG051707.
InParanoidiQ91XP5.
KOiK05195.
PhylomeDBiQ91XP5.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHVRHFRTL VSGFYFWEAA LLLSLVATKE TNSARSRSAP MSPSDFLDKL
60 70 80 90 100
MGRTSGYDAR IRPNFKGPPV NVTCNIFINS FGSIAETTMD YRVNIFLRQK
110 120 130 140 150
WNDPRLAYSE YPDDSLDLDP SMLDSIWKPD LFFANEKGAN FHEVTTDNKL
160 170 180 190 200
LRIFKNGNVL YSIRLTLTLS CPMDLKNFPM DVQTCIMQLE SFGYTMNDLI
210 220 230 240 250
FEWQDEAPVQ VAEGLTLPQF LLKEEKDLRY CTKHYNTGKF TCIEVRFHLE
260 270 280 290 300
RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI TTVLTMTTQS
310 320 330 340 350
SGSRASLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRF
360 370 380 390 400
RRKRKNKTEA FALEKFYRFS DTDDEVRESR FSFTAYGMGP CLQAKDGVVP
410 420 430 440 450
KGPNHAVQVM PKSPDEMRKV FIDRAKKIDT ISRACFPLAF LIFNIFYWVI
460
YKILRHEDIH QQQD
Length:464
Mass (Da):53,709
Last modified:May 24, 2005 - v2
Checksum:i0963FD4A3727AA1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101Missing in AAK51962 (Ref. 1) Curated
Sequence conflicti293 – 2931V → D in AAK51962 (Ref. 1) Curated
Sequence conflicti461 – 4611Q → H in AAK51962 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362764 mRNA. Translation: AAK51962.1.
AY230204 mRNA. Translation: AAP22967.1.
RefSeqiNP_536686.2. NM_080438.2.
UniGeneiMm.307061.

Genome annotation databases

GeneIDi110304.
KEGGimmu:110304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362764 mRNA. Translation: AAK51962.1.
AY230204 mRNA. Translation: AAP22967.1.
RefSeqiNP_536686.2. NM_080438.2.
UniGeneiMm.307061.

3D structure databases

ProteinModelPortaliQ91XP5.
SMRiQ91XP5. Positions 47-345, 421-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000275.

Chemistry

GuidetoPHARMACOLOGYi425.

PTM databases

PhosphoSiteiQ91XP5.

Proteomic databases

PaxDbiQ91XP5.
PRIDEiQ91XP5.

Protocols and materials databases

DNASUi110304.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi110304.
KEGGimmu:110304.

Organism-specific databases

CTDi8001.
MGIiMGI:95749. Glra3.

Phylogenomic databases

eggNOGiNOG265706.
HOGENOMiHOG000231336.
HOVERGENiHBG051707.
InParanoidiQ91XP5.
KOiK05195.
PhylomeDBiQ91XP5.

Enzyme and pathway databases

ReactomeiREACT_198558. Ligand-gated ion channel transport.

Miscellaneous databases

NextBioi363729.
PROiQ91XP5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91XP5.
CleanExiMM_GLRA3.
ExpressionAtlasiQ91XP5. baseline.
GenevestigatoriQ91XP5.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Different glycine receptor isoforms are expressed in murine cerebellum."
    Noegel S., Becker C., Becker K.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. "Diversity of glycine receptors in the mouse retina: localization of the alpha 3 subunit."
    Haverkamp S., Mueller U., Harvey K., Harvey R.J., Betz H., Waessle H.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.

Entry informationi

Entry nameiGLRA3_MOUSE
AccessioniPrimary (citable) accession number: Q91XP5
Secondary accession number(s): Q7TSQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: May 24, 2005
Last modified: January 7, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The alpha subunit binds strychnine.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.