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Q91XP5 (GLRA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine receptor subunit alpha-3
Gene names
Name:Glra3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) By similarity.

Subunit structure

Pentamer composed of alpha and beta subunits By similarity.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Miscellaneous

The alpha subunit binds strychnine By similarity.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 464431Glycine receptor subunit alpha-3
PRO_0000000420

Regions

Topological domain34 – 252219Extracellular Probable
Transmembrane253 – 27927Helical; Probable
Transmembrane286 – 30318Helical; Probable
Transmembrane315 – 34127Helical; Probable
Topological domain342 – 43392Cytoplasmic Probable
Transmembrane434 – 45118Helical; Probable

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Disulfide bond171 ↔ 185 By similarity
Disulfide bond231 ↔ 242 By similarity

Experimental info

Sequence conflict1101Missing in AAK51962. Ref.1
Sequence conflict2931V → D in AAK51962. Ref.1
Sequence conflict4611Q → H in AAK51962. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91XP5 [UniParc].

Last modified May 24, 2005. Version 2.
Checksum: 0963FD4A3727AA1D

FASTA46453,709
        10         20         30         40         50         60 
MAHVRHFRTL VSGFYFWEAA LLLSLVATKE TNSARSRSAP MSPSDFLDKL MGRTSGYDAR 

        70         80         90        100        110        120 
IRPNFKGPPV NVTCNIFINS FGSIAETTMD YRVNIFLRQK WNDPRLAYSE YPDDSLDLDP 

       130        140        150        160        170        180 
SMLDSIWKPD LFFANEKGAN FHEVTTDNKL LRIFKNGNVL YSIRLTLTLS CPMDLKNFPM 

       190        200        210        220        230        240 
DVQTCIMQLE SFGYTMNDLI FEWQDEAPVQ VAEGLTLPQF LLKEEKDLRY CTKHYNTGKF 

       250        260        270        280        290        300 
TCIEVRFHLE RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI TTVLTMTTQS 

       310        320        330        340        350        360 
SGSRASLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRF RRKRKNKTEA 

       370        380        390        400        410        420 
FALEKFYRFS DTDDEVRESR FSFTAYGMGP CLQAKDGVVP KGPNHAVQVM PKSPDEMRKV 

       430        440        450        460 
FIDRAKKIDT ISRACFPLAF LIFNIFYWVI YKILRHEDIH QQQD 

« Hide

References

[1]"Different glycine receptor isoforms are expressed in murine cerebellum."
Noegel S., Becker C., Becker K.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Spinal cord.
[2]"Diversity of glycine receptors in the mouse retina: localization of the alpha 3 subunit."
Haverkamp S., Mueller U., Harvey K., Harvey R.J., Betz H., Waessle H.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF362764 mRNA. Translation: AAK51962.1.
AY230204 mRNA. Translation: AAP22967.1.
RefSeqNP_536686.2. NM_080438.2.
UniGeneMm.307061.

3D structure databases

ProteinModelPortalQ91XP5.
SMRQ91XP5. Positions 54-345, 421-458.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000000275.

Chemistry

GuidetoPHARMACOLOGY425.

PTM databases

PhosphoSiteQ91XP5.

Proteomic databases

PaxDbQ91XP5.
PRIDEQ91XP5.

Protocols and materials databases

DNASU110304.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID110304.
KEGGmmu:110304.

Organism-specific databases

CTD8001.
MGIMGI:95749. Glra3.

Phylogenomic databases

eggNOGNOG265706.
HOGENOMHOG000231336.
HOVERGENHBG051707.
InParanoidQ91XP5.
KOK05195.
PhylomeDBQ91XP5.

Gene expression databases

ArrayExpressQ91XP5.
BgeeQ91XP5.
CleanExMM_GLRA3.
GenevestigatorQ91XP5.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006028. GABAA/Glycine_rcpt.
IPR008127. Glycine_rcpt_A.
IPR008130. Glycine_rcpt_A3.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00253. GABAARECEPTR.
PR01673. GLYRALPHA.
PR01676. GLYRALPHA3.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio363729.
PROQ91XP5.
SOURCESearch...

Entry information

Entry nameGLRA3_MOUSE
AccessionPrimary (citable) accession number: Q91XP5
Secondary accession number(s): Q7TSQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: May 24, 2005
Last modified: June 11, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot