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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

Bambi

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates TGF-beta signaling.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2173788. Downregulation of TGF-beta receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Kinase-deficient TGFbeta superfamily receptor subunit
Gene namesi
Name:Bambi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621831. Bambi.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 152126ExtracellularSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Topological domaini174 – 26087CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 260234BMP and activin membrane-bound inhibitor homologPRO_0000020781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91XN4.
PRIDEiQ91XN4.

Expressioni

Tissue specificityi

Detected in granulosa and thecal cells of adult ovaries and in spermatogonia, spermatocytes, round spermatids, and Sertoli cells of adult testes.1 Publication

Gene expression databases

GenevisibleiQ91XN4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021801.

Structurei

3D structure databases

ProteinModelPortaliQ91XN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAMBI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU1. Eukaryota.
ENOG4110R2C. LUCA.
GeneTreeiENSGT00390000014168.
HOGENOMiHOG000095174.
HOVERGENiHBG050659.
InParanoidiQ91XN4.
KOiK10162.
OMAiAKQAQNH.
OrthoDBiEOG7CZK6Q.
PhylomeDBiQ91XN4.
TreeFamiTF333466.

Family and domain databases

InterProiIPR009345. BAMBI.
[Graphical view]
PfamiPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFiPIRSF037456. BAMBI. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN TNSPLTHGCL DSLASTADIC RAKQAQNHSG PTMPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLSPPKSEA SGQGNRYQHD SSRNLITKVQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQADLSNE KILSLVHWGM
260
YSGHGKLEFV
Length:260
Mass (Da):29,143
Last modified:December 1, 2001 - v1
Checksum:iE33CC1729DE260A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387513 mRNA. Translation: AAK67353.1.
BC070516 mRNA. Translation: AAH70516.1.
RefSeqiNP_620782.1. NM_139082.3.
UniGeneiRn.25267.

Genome annotation databases

EnsembliENSRNOT00000021801; ENSRNOP00000021801; ENSRNOG00000016066.
GeneIDi83837.
KEGGirno:83837.
UCSCiRGD:621831. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387513 mRNA. Translation: AAK67353.1.
BC070516 mRNA. Translation: AAH70516.1.
RefSeqiNP_620782.1. NM_139082.3.
UniGeneiRn.25267.

3D structure databases

ProteinModelPortaliQ91XN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021801.

Proteomic databases

PaxDbiQ91XN4.
PRIDEiQ91XN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021801; ENSRNOP00000021801; ENSRNOG00000016066.
GeneIDi83837.
KEGGirno:83837.
UCSCiRGD:621831. rat.

Organism-specific databases

CTDi25805.
RGDi621831. Bambi.

Phylogenomic databases

eggNOGiENOG410IIU1. Eukaryota.
ENOG4110R2C. LUCA.
GeneTreeiENSGT00390000014168.
HOGENOMiHOG000095174.
HOVERGENiHBG050659.
InParanoidiQ91XN4.
KOiK10162.
OMAiAKQAQNH.
OrthoDBiEOG7CZK6Q.
PhylomeDBiQ91XN4.
TreeFamiTF333466.

Enzyme and pathway databases

ReactomeiR-RNO-2173788. Downregulation of TGF-beta receptor signaling.

Miscellaneous databases

NextBioi616487.
PROiQ91XN4.

Gene expression databases

GenevisibleiQ91XN4. RN.

Family and domain databases

InterProiIPR009345. BAMBI.
[Graphical view]
PfamiPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFiPIRSF037456. BAMBI. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells."
    Loveland K.L., Bakker M., Meehan T., Christy E., von Schonfeldt V., Drummond A., de Kretser D.
    Endocrinology 144:4180-4186(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiBAMBI_RAT
AccessioniPrimary (citable) accession number: Q91XN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.