Q91XM9 (DLG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disks large homolog 2

Alternative name(s):
Channel-associated protein of synapse-110
Short name=Chapsyn-110
Postsynaptic density protein PSD-93

Gene names

Name:	Dlg2
Synonyms:	Dlgh2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	852 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Ref.4
Subunit structure	Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains By similarity. Interacts with FRMPD4 (via C-terminus) By similarity. Interacts through its PDZ domains with Neto1. Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG By similarity. Ref.11
Subcellular location	Membrane; Lipid-anchor By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cell junction › synapse By similarity. Note: Concentrated in soma and postsynaptic density of a subset of neurons By similarity.
Tissue specificity	Brain. Highest levels of isoform 1 in cortex, olfactory bulb, thalamus, hypothalamus, striatum and hippocampus. Highest level of isoform 2 in olfactory bulb. Reduced levels in cortex and hippocampus. Highest level of isoform 4 in spinal cord. Low levels of isoform 4, isoform 6, and isoform 7 in superior cervical ganglion. Ref.4 Ref.5
Domain	Isoform 7 has an L27 domain close to N-terminus.
Post-translational modification	Palmitoylation of isoform 1 and isoform 2 is not required for targeting to postsynaptic density By similarity.
Disruption phenotype	Mice do not respond to persistent pain. Postsynaptic surface expression of NMDA receptors and NMDA receptor-mediated synaptic function are reduced in dorsal horn neurons of the spinal chord. Ref.4
Sequence similarities	Contains 1 guanylate kinase-like domain. Contains 3 PDZ (DHR) domains. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat SH3 domain
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB sensory perception of pain Inferred from mutant phenotype Ref.4. Source: MGI synaptic transmission Inferred from mutant phenotype Ref.4. Source: MGI
Cellular_component	cell junction Inferred from direct assay PubMed 21920314. Source: MGI juxtaparanode region of axon Inferred from direct assay PubMed 19109503. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from direct assay Ref.4. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dlg4	Q62108	5	EBI-400138,EBI-300895

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91XM9-1)

Also known as: PSD93-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91XM9-2)

Also known as: PSD93-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MFFACYCALRTNV → MICHCKVACTNNTLSLMFGC

Isoform 3 (identifier: Q91XM9-3)

Also known as: PSD93-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     62-68: SHISPLK → MQHAFIP

Isoform 4 (identifier: Q91XM9-4)

Also known as: PSD93-delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: MFFACYCALR...VLQSHISPLK → MNAYLTKQHS...CPHGWFSPAQ

Isoform 5 (identifier: Q91XM9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: MFFACYCALR...VLQSHISPLK → MNAYLTKQHS...CPHGWFSPAQ
     394-394: S → RYCMRFLTSSSPVACVSTRMDGWNSSPPTSLALSTFLVERCSASMVRWEKLRTWLFCSFCCAH
     395-852: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q91XM9-6)

Also known as: PSD93 epsilon;

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     43-67: HVSEKNLSQIENVHGYVLQSHISPL → MFASIWYAKKLGRRFVHNARKAKSE

Isoform 7 (identifier: Q91XM9-7)

Also known as: PSD93 zeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MFFACYCALRTNVK → MPVKKKDTDR...PTWMPVHHCT
     69-86: Missing.

Isoform 8 (identifier: Q91XM9-8)

The sequence of this isoform differs from the canonical sequence as follows:
     465-503: DQILSVNGID...VTIIAQYQPE → VINASVNRTG...LPALFPNFVL

Note: Incomplete sequence.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 852

852

Disks large homolog 2

PRO_0000094554

Regions

Domain

98 – 185

88

PDZ 1

Domain

193 – 280

88

PDZ 2

Domain

421 – 502

82

PDZ 3

Domain

536 – 606

71

SH3

Domain

662 – 837

176

Guanylate kinase-like

Amino acid modifications

Modified residue

28

1

Phosphoserine Ref.8

Modified residue

58

1

Phosphotyrosine Ref.9

Modified residue

62

1

Phosphoserine Ref.9

Modified residue

175

1

Phosphoserine Ref.8

Modified residue

340

1

Phosphotyrosine Ref.9

Modified residue

348

1

Phosphotyrosine Ref.9

Modified residue

365

1

Phosphoserine Ref.8

Modified residue

406

1

Phosphoserine Ref.10

Modified residue

414

1

Phosphoserine Ref.7 Ref.8 Ref.10

Modified residue

500

1

Phosphotyrosine Ref.9

Modified residue

505

1

Phosphotyrosine Ref.9

Modified residue

732

1

Phosphotyrosine Ref.9

Modified residue

737

1

Phosphotyrosine Ref.9

Lipidation

5

1

S-palmitoyl cysteine By similarity

Lipidation

7

1

S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence

1 – 68

68

MFFAC…ISPLK → MNAYLTKQHSCSRGSDGMDI GRSAPTLIRDAHCACGWQRN AQGLGYSSQTMPSSGPGGPA SNRTKLVTLWDSVRKSPHKT STKGKGNCGERCACPHGWFS PAQ in isoform 4 and isoform 5.

VSP_012869

Alternative sequence

1 – 61

61

Missing in isoform 3.

VSP_015517

Alternative sequence

1 – 42

42

Missing in isoform 6.

VSP_015518

Alternative sequence

1 – 14

14

MFFAC…RTNVK → MPVKKKDTDRALSLLEEYCK KLRKPEEQLLKNAVKKVMSI FKSSLFQALLDIQEFYEVTL LNSQKSCEQKIEEANHVAQK WEKTLLLDSCRDSLQKSSEH ASCSGPKENALYIEQNKENQ CSENETEEKTCQNQGKCPAQ NCSVEAPTWMPVHHCT in isoform 7.

VSP_015519

Alternative sequence

1 – 13

13

MFFAC…LRTNV → MICHCKVACTNNTLSLMFGC in isoform 2.

VSP_015520

Alternative sequence

43 – 67

25

HVSEK…HISPL → MFASIWYAKKLGRRFVHNAR KAKSE in isoform 6.

VSP_015521

Alternative sequence

62 – 68

7

SHISPLK → MQHAFIP in isoform 3.

VSP_015522

Alternative sequence

69 – 86

18

Missing in isoform 7.

VSP_015523

Alternative sequence

394

1

S → RYCMRFLTSSSPVACVSTRM DGWNSSPPTSLALSTFLVER CSASMVRWEKLRTWLFCSFC CAH in isoform 5.

VSP_012870

Alternative sequence

395 – 852

458

Missing in isoform 5.

VSP_012871

Alternative sequence

465 – 503

39

DQILS…QYQPE → VINASVNRTGDRRIWHQGNG KAASSVSCLLPALFPNFVL in isoform 8.

VSP_015524

Experimental info

Sequence conflict

107

1

G → S in BAC32772. Ref.2

Sequence conflict

123

1

D → G in AAK64496. Ref.1

Sequence conflict

213

1

N → D in AAK64496. Ref.1

Sequence conflict

301

1

M → T in AAK64496. Ref.1

Sequence conflict

323

1

S → P in AAK64496. Ref.1

Sequence conflict

585

1

T → I in AAK64496. Ref.1

Sequence conflict

776

1

I → T in AAK64496. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

852

Helix Strand Turn

Details...

Beta strand

95 – 102

8

Turn

104 – 106

3

Beta strand

110 – 114

5

Beta strand

127 – 132

6

Helix

137 – 141

5

Beta strand

149 – 153

5

Helix

163 – 172

10

Beta strand

175 – 184

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PSD93-alpha) [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 632914AE45ACEBB6	FASTA	852	94,880
	10 20 30 40 50 60 MFFACYCALR TNVKKYRYQD EDGPHDHSLP RLTHEVRGPE LVHVSEKNLS QIENVHGYVL 70 80 90 100 110 120 QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT LERGNSGLGF SIAGGTDNPH 130 140 150 160 170 180 IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY 190 200 210 220 230 240 VRRRRPILET VVEIKLFKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ 250 260 270 280 290 300 VGDRLLMVNN YSLEEVTHEE AVAILKNTSD VVYLKVGKPT TIYMTDPYGP PDITHSYSPP 310 320 330 340 350 360 MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLGEDDY TRPPEPVYST VNKLCDKPAS 370 380 390 400 410 420 PRHYSPVECD KSFLLSTPYP HYHLGLLPDS DMTSHSQHST ATRQPSVTLQ RAISLEGEPR 430 440 450 460 470 480 KVVLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LQRGDQILSV NGIDLRGASH 490 500 510 520 530 540 EQAAAALKGA GQTVTIIAQY QPEDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY 550 560 570 580 590 600 VRAMFDYDKS KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVTLDGDS EEMGVIPSKR 610 620 630 640 650 660 RVERKERARL KTVKFNAKPG VIDSKGDIPG LGDDGYGTKT LRGQEDLILS YEPVTRQEIN 670 680 690 700 710 720 YTRPVIILGP MKDRINDDLI SEFPDKFGSC VPHTTRPKRD YEVDGRDYHF VISREQMEKD 730 740 750 760 770 780 IQEHKFIEAG QYNDNLYGTS VQSVRFVAER GKHCILDVSG NAIKRLQVAQ LYPIAIFIKP 790 800 810 820 830 840 KSLEPLMEMN KRLTEEQAKK TYDRAIKLEQ EFGEYFTAIV QGDTLEDIYN QCKLVIEEQS 850 GPFIWIPSKE KL
	Isoform 2 (PSD93-beta) [UniParc]. Checksum: D3BE703AE529AC57	FASTA	859	95,531
	10 20 30 40 50 60 MICHCKVACT NNTLSLMFGC KKYRYQDEDG PHDHSLPRLT HEVRGPELVH VSEKNLSQIE 70 80 90 100 110 120 NVHGYVLQSH ISPLKASPAP IIVNTDTLDT IPYVNGTEIE YEFEEITLER GNSGLGFSIA 130 140 150 160 170 180 GGTDNPHIGD DPGIFITKII PGGAAAEDGR LRVNDCILRV NEVDVSEVSH SKAVEALKEA 190 200 210 220 230 240 GSIVRLYVRR RRPILETVVE IKLFKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIDGGAA 250 260 270 280 290 300 QKDGRLQVGD RLLMVNNYSL EEVTHEEAVA ILKNTSDVVY LKVGKPTTIY MTDPYGPPDI 310 320 330 340 350 360 THSYSPPMEN HLLSGNNGTL EYKTSLPPIS PGRYSPIPKH MLGEDDYTRP PEPVYSTVNK 370 380 390 400 410 420 LCDKPASPRH YSPVECDKSF LLSTPYPHYH LGLLPDSDMT SHSQHSTATR QPSVTLQRAI 430 440 450 460 470 480 SLEGEPRKVV LHKGSTGLGF NIVGGEDGEG IFVSFILAGG PADLSGELQR GDQILSVNGI 490 500 510 520 530 540 DLRGASHEQA AAALKGAGQT VTIIAQYQPE DYARFEAKIH DLREQMMNHS MSSGSGSLRT 550 560 570 580 590 600 NQKRSLYVRA MFDYDKSKDS GLPSQGLSFK YGDILHVINA SDDEWWQARR VTLDGDSEEM 610 620 630 640 650 660 GVIPSKRRVE RKERARLKTV KFNAKPGVID SKGDIPGLGD DGYGTKTLRG QEDLILSYEP 670 680 690 700 710 720 VTRQEINYTR PVIILGPMKD RINDDLISEF PDKFGSCVPH TTRPKRDYEV DGRDYHFVIS 730 740 750 760 770 780 REQMEKDIQE HKFIEAGQYN DNLYGTSVQS VRFVAERGKH CILDVSGNAI KRLQVAQLYP 790 800 810 820 830 840 IAIFIKPKSL EPLMEMNKRL TEEQAKKTYD RAIKLEQEFG EYFTAIVQGD TLEDIYNQCK 850 LVIEEQSGPF IWIPSKEKL
	Isoform 3 (PSD93-gamma) [UniParc]. Checksum: 645487F4769B1768	FASTA	791	87,790
	10 20 30 40 50 60 MQHAFIPASP APIIVNTDTL DTIPYVNGTE IEYEFEEITL ERGNSGLGFS IAGGTDNPHI 70 80 90 100 110 120 GDDPGIFITK IIPGGAAAED GRLRVNDCIL RVNEVDVSEV SHSKAVEALK EAGSIVRLYV 130 140 150 160 170 180 RRRRPILETV VEIKLFKGPK GLGFSIAGGV GNQHIPGDNS IYVTKIIDGG AAQKDGRLQV 190 200 210 220 230 240 GDRLLMVNNY SLEEVTHEEA VAILKNTSDV VYLKVGKPTT IYMTDPYGPP DITHSYSPPM 250 260 270 280 290 300 ENHLLSGNNG TLEYKTSLPP ISPGRYSPIP KHMLGEDDYT RPPEPVYSTV NKLCDKPASP 310 320 330 340 350 360 RHYSPVECDK SFLLSTPYPH YHLGLLPDSD MTSHSQHSTA TRQPSVTLQR AISLEGEPRK 370 380 390 400 410 420 VVLHKGSTGL GFNIVGGEDG EGIFVSFILA GGPADLSGEL QRGDQILSVN GIDLRGASHE 430 440 450 460 470 480 QAAAALKGAG QTVTIIAQYQ PEDYARFEAK IHDLREQMMN HSMSSGSGSL RTNQKRSLYV 490 500 510 520 530 540 RAMFDYDKSK DSGLPSQGLS FKYGDILHVI NASDDEWWQA RRVTLDGDSE EMGVIPSKRR 550 560 570 580 590 600 VERKERARLK TVKFNAKPGV IDSKGDIPGL GDDGYGTKTL RGQEDLILSY EPVTRQEINY 610 620 630 640 650 660 TRPVIILGPM KDRINDDLIS EFPDKFGSCV PHTTRPKRDY EVDGRDYHFV ISREQMEKDI 670 680 690 700 710 720 QEHKFIEAGQ YNDNLYGTSV QSVRFVAERG KHCILDVSGN AIKRLQVAQL YPIAIFIKPK 730 740 750 760 770 780 SLEPLMEMNK RLTEEQAKKT YDRAIKLEQE FGEYFTAIVQ GDTLEDIYNQ CKLVIEEQSG 790 PFIWIPSKEK L
	Isoform 4 (PSD93-delta) [UniParc]. Checksum: 7416EAB77947D245	FASTA	887	97,928
	10 20 30 40 50 60 MNAYLTKQHS CSRGSDGMDI GRSAPTLIRD AHCACGWQRN AQGLGYSSQT MPSSGPGGPA 70 80 90 100 110 120 SNRTKLVTLW DSVRKSPHKT STKGKGNCGE RCACPHGWFS PAQASPAPII VNTDTLDTIP 130 140 150 160 170 180 YVNGTEIEYE FEEITLERGN SGLGFSIAGG TDNPHIGDDP GIFITKIIPG GAAAEDGRLR 190 200 210 220 230 240 VNDCILRVNE VDVSEVSHSK AVEALKEAGS IVRLYVRRRR PILETVVEIK LFKGPKGLGF 250 260 270 280 290 300 SIAGGVGNQH IPGDNSIYVT KIIDGGAAQK DGRLQVGDRL LMVNNYSLEE VTHEEAVAIL 310 320 330 340 350 360 KNTSDVVYLK VGKPTTIYMT DPYGPPDITH SYSPPMENHL LSGNNGTLEY KTSLPPISPG 370 380 390 400 410 420 RYSPIPKHML GEDDYTRPPE PVYSTVNKLC DKPASPRHYS PVECDKSFLL STPYPHYHLG 430 440 450 460 470 480 LLPDSDMTSH SQHSTATRQP SVTLQRAISL EGEPRKVVLH KGSTGLGFNI VGGEDGEGIF 490 500 510 520 530 540 VSFILAGGPA DLSGELQRGD QILSVNGIDL RGASHEQAAA ALKGAGQTVT IIAQYQPEDY 550 560 570 580 590 600 ARFEAKIHDL REQMMNHSMS SGSGSLRTNQ KRSLYVRAMF DYDKSKDSGL PSQGLSFKYG 610 620 630 640 650 660 DILHVINASD DEWWQARRVT LDGDSEEMGV IPSKRRVERK ERARLKTVKF NAKPGVIDSK 670 680 690 700 710 720 GDIPGLGDDG YGTKTLRGQE DLILSYEPVT RQEINYTRPV IILGPMKDRI NDDLISEFPD 730 740 750 760 770 780 KFGSCVPHTT RPKRDYEVDG RDYHFVISRE QMEKDIQEHK FIEAGQYNDN LYGTSVQSVR 790 800 810 820 830 840 FVAERGKHCI LDVSGNAIKR LQVAQLYPIA IFIKPKSLEP LMEMNKRLTE EQAKKTYDRA 850 860 870 880 IKLEQEFGEY FTAIVQGDTL EDIYNQCKLV IEEQSGPFIW IPSKEKL
	Isoform 5 [UniParc]. Checksum: 0926554D5F3A8FE6	FASTA	491	53,570
	10 20 30 40 50 60 MNAYLTKQHS CSRGSDGMDI GRSAPTLIRD AHCACGWQRN AQGLGYSSQT MPSSGPGGPA 70 80 90 100 110 120 SNRTKLVTLW DSVRKSPHKT STKGKGNCGE RCACPHGWFS PAQASPAPII VNTDTLDTIP 130 140 150 160 170 180 YVNGTEIEYE FEEITLERGN SGLGFSIAGG TDNPHIGDDP GIFITKIIPG GAAAEDGRLR 190 200 210 220 230 240 VNDCILRVNE VDVSEVSHSK AVEALKEAGS IVRLYVRRRR PILETVVEIK LFKGPKGLGF 250 260 270 280 290 300 SIAGGVGNQH IPGDNSIYVT KIIDGGAAQK DGRLQVGDRL LMVNNYSLEE VTHEEAVAIL 310 320 330 340 350 360 KNTSDVVYLK VGKPTTIYMT DPYGPPDITH SYSPPMENHL LSGNNGTLEY KTSLPPISPG 370 380 390 400 410 420 RYSPIPKHML GEDDYTRPPE PVYSTVNKLC DKPASPRHYS PVECDKSFLL STPYPHYHLG 430 440 450 460 470 480 LLPDSDMTRY CMRFLTSSSP VACVSTRMDG WNSSPPTSLA LSTFLVERCS ASMVRWEKLR 490 TWLFCSFCCA H
	Isoform 6 (PSD93 epsilon) [UniParc]. Checksum: E3F3ADB9E5ECA0D5	FASTA	810	90,071
	10 20 30 40 50 60 MFASIWYAKK LGRRFVHNAR KAKSEKASPA PIIVNTDTLD TIPYVNGTEI EYEFEEITLE 70 80 90 100 110 120 RGNSGLGFSI AGGTDNPHIG DDPGIFITKI IPGGAAAEDG RLRVNDCILR VNEVDVSEVS 130 140 150 160 170 180 HSKAVEALKE AGSIVRLYVR RRRPILETVV EIKLFKGPKG LGFSIAGGVG NQHIPGDNSI 190 200 210 220 230 240 YVTKIIDGGA AQKDGRLQVG DRLLMVNNYS LEEVTHEEAV AILKNTSDVV YLKVGKPTTI 250 260 270 280 290 300 YMTDPYGPPD ITHSYSPPME NHLLSGNNGT LEYKTSLPPI SPGRYSPIPK HMLGEDDYTR 310 320 330 340 350 360 PPEPVYSTVN KLCDKPASPR HYSPVECDKS FLLSTPYPHY HLGLLPDSDM TSHSQHSTAT 370 380 390 400 410 420 RQPSVTLQRA ISLEGEPRKV VLHKGSTGLG FNIVGGEDGE GIFVSFILAG GPADLSGELQ 430 440 450 460 470 480 RGDQILSVNG IDLRGASHEQ AAAALKGAGQ TVTIIAQYQP EDYARFEAKI HDLREQMMNH 490 500 510 520 530 540 SMSSGSGSLR TNQKRSLYVR AMFDYDKSKD SGLPSQGLSF KYGDILHVIN ASDDEWWQAR 550 560 570 580 590 600 RVTLDGDSEE MGVIPSKRRV ERKERARLKT VKFNAKPGVI DSKGDIPGLG DDGYGTKTLR 610 620 630 640 650 660 GQEDLILSYE PVTRQEINYT RPVIILGPMK DRINDDLISE FPDKFGSCVP HTTRPKRDYE 670 680 690 700 710 720 VDGRDYHFVI SREQMEKDIQ EHKFIEAGQY NDNLYGTSVQ SVRFVAERGK HCILDVSGNA 730 740 750 760 770 780 IKRLQVAQLY PIAIFIKPKS LEPLMEMNKR LTEEQAKKTY DRAIKLEQEF GEYFTAIVQG 790 800 810 DTLEDIYNQC KLVIEEQSGP FIWIPSKEKL
	Isoform 7 (PSD93 zeta) [UniParc]. Checksum: 137F926A3694DC90	FASTA	976	109,239
	10 20 30 40 50 60 MPVKKKDTDR ALSLLEEYCK KLRKPEEQLL KNAVKKVMSI FKSSLFQALL DIQEFYEVTL 70 80 90 100 110 120 LNSQKSCEQK IEEANHVAQK WEKTLLLDSC RDSLQKSSEH ASCSGPKENA LYIEQNKENQ 130 140 150 160 170 180 CSENETEEKT CQNQGKCPAQ NCSVEAPTWM PVHHCTKYRY QDEDGPHDHS LPRLTHEVRG 190 200 210 220 230 240 PELVHVSEKN LSQIENVHGY VLQSHISPLK VNGTEIEYEF EEITLERGNS GLGFSIAGGT 250 260 270 280 290 300 DNPHIGDDPG IFITKIIPGG AAAEDGRLRV NDCILRVNEV DVSEVSHSKA VEALKEAGSI 310 320 330 340 350 360 VRLYVRRRRP ILETVVEIKL FKGPKGLGFS IAGGVGNQHI PGDNSIYVTK IIDGGAAQKD 370 380 390 400 410 420 GRLQVGDRLL MVNNYSLEEV THEEAVAILK NTSDVVYLKV GKPTTIYMTD PYGPPDITHS 430 440 450 460 470 480 YSPPMENHLL SGNNGTLEYK TSLPPISPGR YSPIPKHMLG EDDYTRPPEP VYSTVNKLCD 490 500 510 520 530 540 KPASPRHYSP VECDKSFLLS TPYPHYHLGL LPDSDMTSHS QHSTATRQPS VTLQRAISLE 550 560 570 580 590 600 GEPRKVVLHK GSTGLGFNIV GGEDGEGIFV SFILAGGPAD LSGELQRGDQ ILSVNGIDLR 610 620 630 640 650 660 GASHEQAAAA LKGAGQTVTI IAQYQPEDYA RFEAKIHDLR EQMMNHSMSS GSGSLRTNQK 670 680 690 700 710 720 RSLYVRAMFD YDKSKDSGLP SQGLSFKYGD ILHVINASDD EWWQARRVTL DGDSEEMGVI 730 740 750 760 770 780 PSKRRVERKE RARLKTVKFN AKPGVIDSKG DIPGLGDDGY GTKTLRGQED LILSYEPVTR 790 800 810 820 830 840 QEINYTRPVI ILGPMKDRIN DDLISEFPDK FGSCVPHTTR PKRDYEVDGR DYHFVISREQ 850 860 870 880 890 900 MEKDIQEHKF IEAGQYNDNL YGTSVQSVRF VAERGKHCIL DVSGNAIKRL QVAQLYPIAI 910 920 930 940 950 960 FIKPKSLEPL MEMNKRLTEE QAKKTYDRAI KLEQEFGEYF TAIVQGDTLE DIYNQCKLVI 970 EEQSGPFIWI PSKEKL
	Isoform 8 [UniParc]. Checksum: ED0E8A1613E89FF5	FASTA	852	95,055
	10 20 30 40 50 60 MFFACYCALR TNVKKYRYQD EDGPHDHSLP RLTHEVRGPE LVHVSEKNLS QIENVHGYVL 70 80 90 100 110 120 QSHISPLKAS PAPIIVNTDT LDTIPYVNGT EIEYEFEEIT LERGNSGLGF SIAGGTDNPH 130 140 150 160 170 180 IGDDPGIFIT KIIPGGAAAE DGRLRVNDCI LRVNEVDVSE VSHSKAVEAL KEAGSIVRLY 190 200 210 220 230 240 VRRRRPILET VVEIKLFKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIDG GAAQKDGRLQ 250 260 270 280 290 300 VGDRLLMVNN YSLEEVTHEE AVAILKNTSD VVYLKVGKPT TIYMTDPYGP PDITHSYSPP 310 320 330 340 350 360 MENHLLSGNN GTLEYKTSLP PISPGRYSPI PKHMLGEDDY TRPPEPVYST VNKLCDKPAS 370 380 390 400 410 420 PRHYSPVECD KSFLLSTPYP HYHLGLLPDS DMTSHSQHST ATRQPSVTLQ RAISLEGEPR 430 440 450 460 470 480 KVVLHKGSTG LGFNIVGGED GEGIFVSFIL AGGPADLSGE LQRGVINASV NRTGDRRIWH 490 500 510 520 530 540 QGNGKAASSV SCLLPALFPN FVLDYARFEA KIHDLREQMM NHSMSSGSGS LRTNQKRSLY 550 560 570 580 590 600 VRAMFDYDKS KDSGLPSQGL SFKYGDILHV INASDDEWWQ ARRVTLDGDS EEMGVIPSKR 610 620 630 640 650 660 RVERKERARL KTVKFNAKPG VIDSKGDIPG LGDDGYGTKT LRGQEDLILS YEPVTRQEIN 670 680 690 700 710 720 YTRPVIILGP MKDRINDDLI SEFPDKFGSC VPHTTRPKRD YEVDGRDYHF VISREQMEKD 730 740 750 760 770 780 IQEHKFIEAG QYNDNLYGTS VQSVRFVAER GKHCILDVSG NAIKRLQVAQ LYPIAIFIKP 790 800 810 820 830 840 KSLEPLMEMN KRLTEEQAKK TYDRAIKLEQ EFGEYFTAIV QGDTLEDIYN QCKLVIEEQS 850 GPFIWIPSKE KL

References

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[1]	"Cloning and sequencing of mouse PSD-93 cDNA." Yamashita T., Mochizuki C., Miyagi Y., Sonoda T., Kawamoto S. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c. Tissue: Cerebellum.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 465-852 (ISOFORM 8). Strain: C57BL/6J. Tissue: Adrenal gland and Spinal cord.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein." Tao Y.-X., Rumbaugh G., Wang G.-D., Petralia R.S., Zhao C., Kauer F.W., Tao F., Zhuo M., Wenthold R.J., Raja S.N., Huganir R.L., Bredt D.S., Johns R.A. J. Neurosci. 23:6703-6712(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[5]	"An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1." Leyland M.L., Dart C. J. Biol. Chem. 279:43427-43436(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"PSD93 regulates synaptic stability at neuronal cholinergic synapses." Parker M.J., Zhao S., Bredt D.S., Sanes J.R., Feng G. J. Neurosci. 24:378-388(2004) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[7]	"Proteomic analysis of in vivo phosphorylated synaptic proteins." Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I., Blackstock W.P., Choudhary J.S., Grant S.G. J. Biol. Chem. 280:5972-5982(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414, MASS SPECTROMETRY. Tissue: Forebrain.
[8]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-175; SER-365 AND SER-414, MASS SPECTROMETRY. Tissue: Brain.
[9]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-58; SER-62; TYR-340; TYR-348; TYR-500; TYR-505; TYR-732 AND TYR-737, MASS SPECTROMETRY. Tissue: Brain.
[10]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND SER-414, MASS SPECTROMETRY. Tissue: Brain cortex.
[11]	"Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning." Ng D., Pitcher G.M., Szilard R.K., Sertie A., Kanisek M., Clapcote S.J., Lipina T., Kalia L.V., Joo D., McKerlie C., Cortez M., Roder J.C., Salter M.W., McInnes R.R. PLoS Biol. 7:E41-E41(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NETO1.
[12]	"Structure of the first PDZ domain of human PSD-93." Fiorentini M., Nielsen A.K., Kristensen O., Kastrup J.S., Gajhede M. Acta Crystallogr. F 65:1254-1257(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 95-188.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF388675 mRNA. Translation: AAK64496.1.
AK046525 mRNA. Translation: BAC32772.1.
AK039754 mRNA. Translation: BAC30440.1.
AC100322 Genomic DNA. No translation available.
AC101784 Genomic DNA. No translation available.
AC108818 Genomic DNA. No translation available.
AC108832 Genomic DNA. No translation available.
AC109506 Genomic DNA. No translation available.
AC112262 Genomic DNA. No translation available.
AC118621 Genomic DNA. No translation available.
AC119218 Genomic DNA. No translation available.
AC121261 Genomic DNA. No translation available.
AC122002 Genomic DNA. No translation available.
AC127299 Genomic DNA. No translation available.
AC127683 Genomic DNA. No translation available.
AC140196 Genomic DNA. No translation available.
AC141890 Genomic DNA. No translation available.
AC161490 Genomic DNA. No translation available.
AC162304 Genomic DNA. No translation available.

IPI

IPI00129282.
IPI00226727.
IPI00466988.
IPI00648194.
IPI00648424.
IPI00649556.
IPI00649990.
IPI01026606.

RefSeq

NP_001229976.1. NM_001243047.1.
NP_035937.2. NM_011807.3.

UniGene

Mm.147213.
Mm.257035.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WL7	X-ray	2.03	A	95-188	[»]

ProteinModelPortal

Q91XM9.

SMR

Q91XM9. Positions 93-283, 418-849.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-31569N.

IntAct

Q91XM9. 4 interactions.

MINT

MINT-136378.

PTM databases

PhosphoSite

Q91XM9.

Proteomic databases

PaxDb

Q91XM9.

PRIDE

Q91XM9.

Protocols and materials databases

DNASU

23859.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000107196; ENSMUSP00000102814; ENSMUSG00000052572.

GeneID

23859.

KEGG

mmu:23859.

UCSC

uc009ihr.2. mouse.
uc009ihs.1. mouse.

Organism-specific databases

CTD

1740.

MGI

MGI:1344351. Dlg2.

Phylogenomic databases

eggNOG

COG0194.

GeneTree

ENSGT00660000095130.

HOGENOM

HOG000232102.

HOVERGEN

HBG107814.

KO

K12075.

OrthoDB

EOG447FSN.

Gene expression databases

CleanEx

MM_DLG2.

Genevestigator

Q91XM9.

GermOnline

ENSMUSG00000052572. Mus musculus.

Family and domain databases

InterPro

IPR008144. Guanylate_kin.
IPR008145. Guanylate_kin/L-typ_Ca_channel.
IPR020590. Guanylate_kinase_CS.
IPR016313. M-assoc_guanylate_kinase.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]

PIRSF

PIRSF001741. MAGUK_DLGH. 1 hit.

SMART

SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 3 hits.
SSF50044. SH3. 1 hit.
SSF52540. SSF52540. 1 hit.

PROSITE

PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

DLG2. mouse.

EvolutionaryTrace

Q91XM9.

NextBio

303569.

SOURCE

Search...

Entry information

Entry name

DLG2_MOUSE

Accession

Primary (citable) accession number: Q91XM9
Secondary accession number(s): F8VQM7, Q8BXK7, Q8BYG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 3, 2012
Last modified:	May 29, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program