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Protein

Oxysterol-binding protein-related protein 1

Gene

Osbpl1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-192105. Synthesis of bile acids and bile salts.
R-MMU-2132295. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 1
Short name:
ORP-1
Short name:
OSBP-related protein 1
Gene namesi
Name:Osbpl1a
Synonyms:Orp1, Orp1a, Orp1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1927551. Osbpl1a.

Subcellular locationi

  • Late endosome By similarity

  • Note: Co-localizes with RAB7A, RAB9A and LAMP1 in late endosomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003681 – 950Oxysterol-binding protein-related protein 1Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei499PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91XL9.
PaxDbiQ91XL9.
PeptideAtlasiQ91XL9.
PRIDEiQ91XL9.

PTM databases

iPTMnetiQ91XL9.
PhosphoSitePlusiQ91XL9.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000044252.
CleanExiMM_OSBPL1A.
ExpressionAtlasiQ91XL9. baseline and differential.
GenevisibleiQ91XL9. MM.

Interactioni

Subunit structurei

Interacts with VAPA (By similarity). Interacts with the GTP-bound form of RAB7A (By similarity). Interacts with OAS1B.By similarity1 Publication

Protein-protein interaction databases

IntActiQ91XL9. 2 interactors.
MINTiMINT-4105908.
STRINGi10090.ENSMUSP00000073957.

Structurei

3D structure databases

ProteinModelPortaliQ91XL9.
SMRiQ91XL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 76ANK 1Add BLAST30
Repeati80 – 109ANK 2Add BLAST30
Repeati175 – 204ANK 3Add BLAST30
Domaini235 – 334PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 237Interaction with RAB7ABy similarityAdd BLAST237

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili430 – 463Sequence analysisAdd BLAST34
Coiled coili879 – 913Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000048711.
HOVERGENiHBG082087.
InParanoidiQ91XL9.
KOiK20174.
OMAiVIADINC.
OrthoDBiEOG091G07RK.
PhylomeDBiQ91XL9.
TreeFamiTF320922.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91XL9-1) [UniParc]FASTAAdd to basket
Also known as: Osbpl1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTEAEQQLL HHARNGNAEE VRKLLAAMAR MEVVADIDCK GRSKSNLGWT
60 70 80 90 100
PLHLACYFGH KQVVEDLLKA GAKVNMLNDM GDTPLHRAAF TGRKELVLLL
110 120 130 140 150
LEYDADSTVV NGSGQTAKEA THDKEIRNML EAVERTQQRK LEELLLGAAR
160 170 180 190 200
EGRTAEVSAL LSRPNPPDVN CSDQLGNTPL HCAAYRAHKQ CVLKLLRSGA
210 220 230 240 250
DPSLKNKNDQ KPLDLAQGAE MKHILVGNKV VHKALKRYEG PLWKSSRFFG
260 270 280 290 300
WKLFWVVLEH GVLSWYRKQP DAVHNSYRQG CKHLTQAVCT VKPTDSCLFS
310 320 330 340 350
IRCFDDTVHC FRVPKNSVQQ SREKWLEAIE EHSAYSTHYC SQDQVTDDEE
360 370 380 390 400
EDVVSAMDLK ESLARAQTCQ QRLDREIYNF LKMIKECDVA KDMLPSFLQK
410 420 430 440 450
ADIVSEASRE TCVALNDCLN LFTKQEGVRN FKLEQEQEKN KILSEALETL
460 470 480 490 500
ATEHHELERS LVEGSPPVSI LSEEEFYDAL SGSESEGSLT CLEAVTAHSF
510 520 530 540 550
EENEVPGSSG KHRMSEGKDC GGGDALSNGI KKHRTSLPSP MFSRNDFSIW
560 570 580 590 600
SILRKCIGME LSKITMPVIF NEPLSFLQRL TEYMEHTYLI HKASSLSDPV
610 620 630 640 650
ERMQCVAAFA VSAVASQWER TGKPFNPLLG ETYELVRDDL GFRLISEQVS
660 670 680 690 700
HHPPISAFHA EGLNNDFIFH GSIYPKLKFW GKSVEAEPKG TITLELLDHN
710 720 730 740 750
EAYTWTNPTC CVHNIIVGKL WIEQYGNVEI INHKTGDKCV LNFKPCGLFG
760 770 780 790 800
KELHKVEGYI QDKSKKKLCA LYGKWTECLY SVDPATFDAY KKNDKKNTEE
810 820 830 840 850
KKNSKQTSSS EESDEMPVPD SESVFIIPGS VLLWRIAPRP PNSAQMYNFT
860 870 880 890 900
SFAMVLNEVD KEMESVIPKT DCRLRPDIRA MENGEIDLAS EEKKRLEEKQ
910 920 930 940 950
RAARKNRSKS EEDWKTRWFH QGPNPYSGAQ DWIYSGSYWD RNYFNLPDIY
Length:950
Mass (Da):107,795
Last modified:March 21, 2006 - v2
Checksum:iAA4F5678999B0EB5
GO
Isoform 2 (identifier: Q91XL9-2) [UniParc]FASTAAdd to basket
Also known as: Osbpl1a

The sequence of this isoform differs from the canonical sequence as follows:
     1-513: Missing.

Show »
Length:437
Mass (Da):50,069
Checksum:i869EDF5199C9C70B
GO
Isoform 3 (identifier: Q91XL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Show »
Length:410
Mass (Da):47,344
Checksum:iD37F5D9161BAC7E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti572E → D in AAH76637 (PubMed:15489334).Curated1
Sequence conflicti599P → L in BAA33012 (Ref. 3) Curated1
Sequence conflicti685E → K in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti697 – 698LD → FV in AAK71661 (PubMed:12215260).Curated2
Sequence conflicti713H → Q in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti732N → T in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti744K → N in AAK71661 (PubMed:12215260).Curated1
Sequence conflicti759Y → S in AAK71661 (PubMed:12215260).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177231 – 540Missing in isoform 3. 1 PublicationAdd BLAST540
Alternative sequenceiVSP_0177241 – 513Missing in isoform 2. 3 PublicationsAdd BLAST513

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394063 mRNA. Translation: AAK71661.2.
AY536214 mRNA. Translation: AAT06024.1.
AB017026 mRNA. Translation: BAA33012.1.
AK168366 mRNA. Translation: BAE40301.1.
BC076637 mRNA. Translation: AAH76637.1.
CCDSiCCDS29067.1. [Q91XL9-1]
CCDS57114.1. [Q91XL9-2]
RefSeqiNP_001239418.1. NM_001252489.1.
NP_001239419.1. NM_001252490.1. [Q91XL9-2]
NP_001239420.1. NM_001252491.1. [Q91XL9-2]
NP_001239421.1. NM_001252492.1. [Q91XL9-2]
NP_001239422.1. NM_001252493.1. [Q91XL9-2]
NP_997413.2. NM_207530.3. [Q91XL9-1]
XP_006526204.1. XM_006526141.3. [Q91XL9-1]
XP_006526205.1. XM_006526142.3. [Q91XL9-1]
XP_006526210.1. XM_006526147.2. [Q91XL9-2]
XP_006526211.1. XM_006526148.2. [Q91XL9-2]
XP_017173451.1. XM_017317962.1. [Q91XL9-2]
XP_017173452.1. XM_017317963.1. [Q91XL9-2]
XP_017173453.1. XM_017317964.1. [Q91XL9-2]
XP_017173454.1. XM_017317965.1. [Q91XL9-2]
UniGeneiMm.259470.

Genome annotation databases

EnsembliENSMUST00000074352; ENSMUSP00000073957; ENSMUSG00000044252. [Q91XL9-1]
ENSMUST00000117361; ENSMUSP00000112681; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000118313; ENSMUSP00000113735; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000119043; ENSMUSP00000113357; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000121774; ENSMUSP00000113268; ENSMUSG00000044252. [Q91XL9-3]
ENSMUST00000121808; ENSMUSP00000113841; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000121888; ENSMUSP00000112895; ENSMUSG00000044252. [Q91XL9-2]
GeneIDi64291.
KEGGimmu:64291.
UCSCiuc008ecp.2. mouse. [Q91XL9-2]
uc008ecu.2. mouse. [Q91XL9-1]
uc012azm.2. mouse. [Q91XL9-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394063 mRNA. Translation: AAK71661.2.
AY536214 mRNA. Translation: AAT06024.1.
AB017026 mRNA. Translation: BAA33012.1.
AK168366 mRNA. Translation: BAE40301.1.
BC076637 mRNA. Translation: AAH76637.1.
CCDSiCCDS29067.1. [Q91XL9-1]
CCDS57114.1. [Q91XL9-2]
RefSeqiNP_001239418.1. NM_001252489.1.
NP_001239419.1. NM_001252490.1. [Q91XL9-2]
NP_001239420.1. NM_001252491.1. [Q91XL9-2]
NP_001239421.1. NM_001252492.1. [Q91XL9-2]
NP_001239422.1. NM_001252493.1. [Q91XL9-2]
NP_997413.2. NM_207530.3. [Q91XL9-1]
XP_006526204.1. XM_006526141.3. [Q91XL9-1]
XP_006526205.1. XM_006526142.3. [Q91XL9-1]
XP_006526210.1. XM_006526147.2. [Q91XL9-2]
XP_006526211.1. XM_006526148.2. [Q91XL9-2]
XP_017173451.1. XM_017317962.1. [Q91XL9-2]
XP_017173452.1. XM_017317963.1. [Q91XL9-2]
XP_017173453.1. XM_017317964.1. [Q91XL9-2]
XP_017173454.1. XM_017317965.1. [Q91XL9-2]
UniGeneiMm.259470.

3D structure databases

ProteinModelPortaliQ91XL9.
SMRiQ91XL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91XL9. 2 interactors.
MINTiMINT-4105908.
STRINGi10090.ENSMUSP00000073957.

PTM databases

iPTMnetiQ91XL9.
PhosphoSitePlusiQ91XL9.

Proteomic databases

EPDiQ91XL9.
PaxDbiQ91XL9.
PeptideAtlasiQ91XL9.
PRIDEiQ91XL9.

Protocols and materials databases

DNASUi64291.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074352; ENSMUSP00000073957; ENSMUSG00000044252. [Q91XL9-1]
ENSMUST00000117361; ENSMUSP00000112681; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000118313; ENSMUSP00000113735; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000119043; ENSMUSP00000113357; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000121774; ENSMUSP00000113268; ENSMUSG00000044252. [Q91XL9-3]
ENSMUST00000121808; ENSMUSP00000113841; ENSMUSG00000044252. [Q91XL9-2]
ENSMUST00000121888; ENSMUSP00000112895; ENSMUSG00000044252. [Q91XL9-2]
GeneIDi64291.
KEGGimmu:64291.
UCSCiuc008ecp.2. mouse. [Q91XL9-2]
uc008ecu.2. mouse. [Q91XL9-1]
uc012azm.2. mouse. [Q91XL9-3]

Organism-specific databases

CTDi114876.
MGIiMGI:1927551. Osbpl1a.

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
GeneTreeiENSGT00760000119155.
HOGENOMiHOG000048711.
HOVERGENiHBG082087.
InParanoidiQ91XL9.
KOiK20174.
OMAiVIADINC.
OrthoDBiEOG091G07RK.
PhylomeDBiQ91XL9.
TreeFamiTF320922.

Enzyme and pathway databases

ReactomeiR-MMU-192105. Synthesis of bile acids and bile salts.
R-MMU-2132295. MHC class II antigen presentation.

Miscellaneous databases

PROiQ91XL9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044252.
CleanExiMM_OSBPL1A.
ExpressionAtlasiQ91XL9. baseline and differential.
GenevisibleiQ91XL9. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL1_MOUSE
AccessioniPrimary (citable) accession number: Q91XL9
Secondary accession number(s): O88318
, Q3TH97, Q673L8, Q6DFU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 21, 2006
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.