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Protein
Submitted name:

Leucine-rich HEV glycoprotein

Gene

Lrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  • brown fat cell differentiation Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine-rich HEV glycoproteinImported
Submitted name:
Leucine-rich alpha-2-glycoproteinImported
Submitted name:
Leucine-rich alpha-2-glycoprotein 1Imported
Submitted name:
Protein Lrg1Imported
Gene namesi
Name:Lrg1Imported
Synonyms:LrgImported, lrhgImported
ORF Names:mCG_22979Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1924155. Lrg1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_500878523733 – 342Sequence analysisAdd BLAST310

Expressioni

Gene expression databases

BgeeiENSMUSG00000037095.

Interactioni

GO - Molecular functioni

  • transforming growth factor beta receptor binding Source: MGI

Protein-protein interaction databases

DIPiDIP-60318N.
STRINGi10090.ENSMUSP00000038048.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 342LRRCTInterPro annotationAdd BLAST51

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000234378.
HOVERGENiHBG000045.
OMAiDTRCAGP.
OrthoDBiEOG091G0RZG.
TreeFamiTF351919.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSWQHQGSL QDLKTCLART LFLLALLGRV SSLKECLILQ SAEGSTVSCH
60 70 80 90 100
GPTEFPSSLP ADTVHLSVEF SNLTQLPAAA LQGCPGLREL HLSSNRLQAL
110 120 130 140 150
SPELLAPVPR LRALDLTRNA LRSLPPGLFS TSANLSTLVL RENQLREVSA
160 170 180 190 200
QWLQGLDALG HLDLAENQLS SLPSGLLASL GALHTLDLGY NLLESLPEGL
210 220 230 240 250
LRGPRRLQRL HLEGNRLQRL EDSLLAPQPF LRVLFLNDNQ LVGVATGSFQ
260 270 280 290 300
GLQHLDMLDL SNNSLSSTPP GLWAFLGRPT RDMQDGFDIS HNPWICDKNL
310 320 330 340
ADLCRWLVAN RNKMFSQNDT RCAGPEAMKG QRLLDVAELG SL
Length:342
Mass (Da):37,431
Last modified:December 1, 2001 - v1
Checksum:iC47D826F57677747
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009719 Genomic DNA. No translation available.
BC030733 mRNA. Translation: AAH30733.1.
BC092077 mRNA. Translation: AAH92077.1.
AF403429 mRNA. Translation: AAK95352.1.
AB055885 mRNA. Translation: BAB83091.1.
CH466559 Genomic DNA. Translation: EDL23719.1.
RefSeqiNP_084072.1. NM_029796.2.
UniGeneiMm.348025.

Genome annotation databases

EnsembliENSMUST00000041357; ENSMUSP00000038048; ENSMUSG00000037095.
GeneIDi76905.
KEGGimmu:76905.
UCSCiuc008dbb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009719 Genomic DNA. No translation available.
BC030733 mRNA. Translation: AAH30733.1.
BC092077 mRNA. Translation: AAH92077.1.
AF403429 mRNA. Translation: AAK95352.1.
AB055885 mRNA. Translation: BAB83091.1.
CH466559 Genomic DNA. Translation: EDL23719.1.
RefSeqiNP_084072.1. NM_029796.2.
UniGeneiMm.348025.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60318N.
STRINGi10090.ENSMUSP00000038048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041357; ENSMUSP00000038048; ENSMUSG00000037095.
GeneIDi76905.
KEGGimmu:76905.
UCSCiuc008dbb.1. mouse.

Organism-specific databases

CTDi116844.
MGIiMGI:1924155. Lrg1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000234378.
HOVERGENiHBG000045.
OMAiDTRCAGP.
OrthoDBiEOG091G0RZG.
TreeFamiTF351919.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiLrg1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037095.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91XL1_MOUSE
AccessioniPrimary (citable) accession number: Q91XL1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.