Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91XI2

- Q91XI2_MOUSE

UniProt

Q91XI2 - Q91XI2_MOUSE

Protein

Catalase

Gene

Cat

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.UniRule annotation
    Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide By similarity.

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.

    Cofactori

    Heme group.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751UniRule annotation
    Active sitei148 – 1481UniRule annotation
    Active sitei148 – 1481 By similarity
    Metal bindingi358 – 3581Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. aminoacylase activity Source: MGI
    2. catalase activity Source: MGI
    3. heme binding Source: InterPro
    4. metal ion binding Source: UniProtKB-KW
    5. oxidoreductase activity, acting on peroxide as acceptor Source: MGI

    GO - Biological processi

    1. aerobic respiration Source: MGI
    2. cholesterol metabolic process Source: MGI
    3. hemoglobin metabolic process Source: MGI
    4. hydrogen peroxide catabolic process Source: MGI
    5. negative regulation of NF-kappaB transcription factor activity Source: MGI
    6. positive regulation of NF-kappaB transcription factor activity Source: MGI
    7. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
    8. response to oxidative stress Source: MGI
    9. triglyceride metabolic process Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxideUniRule annotation

    Keywords - Ligandi

    HemeUniRule annotation, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
    Gene namesi
    Name:CatImported
    Synonyms:Cas1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:88271. Cat.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI
    2. peroxisomal membrane Source: MGI
    3. peroxisome Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ91XI2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XI2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XI2.
    SMRiQ91XI2. Positions 4-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.

    Phylogenomic databases

    HOVERGENiHBG003986.
    InParanoidiQ91XI2.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL    50
    LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF 100
    EHIGKRTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT 150
    PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF 200
    SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ GIKNLPVGEA 250
    GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT 300
    KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM 350
    LQGRLFAYPD THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG 400
    APNYYPNSFS APEQQRSALE HSVQCAVDVK RFNSANEDSV TQVRTFYTKV 450
    LNEEERKRLC ENIAGHLKDA QLFIQKKAVK NFTDVHPDYG ARIQALLDKY 500
    NAEKPKNAIH TYTQAGSHMA AKGKANL 527
    Length:527
    Mass (Da):59,738
    Last modified:December 1, 2001 - v1
    Checksum:i31915D443B2339BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040626 mRNA. Translation: AAK73774.1.
    UniGeneiMm.4215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY040626 mRNA. Translation: AAK73774.1 .
    UniGenei Mm.4215.

    3D structure databases

    ProteinModelPortali Q91XI2.
    SMRi Q91XI2. Positions 4-501.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q91XI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:88271. Cat.

    Phylogenomic databases

    HOVERGENi HBG003986.
    InParanoidi Q91XI2.

    Miscellaneous databases

    ChiTaRSi CAT. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q91XI2.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant."
      Wang D.-H., Tsutsui K., Sano K., Masuoka N., Kira S.
      Biochim. Biophys. Acta 1522:217-220(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C3H/AnLImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ91XI2_MOUSE
    AccessioniPrimary (citable) accession number: Q91XI2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)