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Q91XI2 (Q91XI2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Catalase RuleBase RU000498

EC=1.11.1.6 RuleBase RU000498
Gene names
Name:Cat MGI 88271
Synonyms:Cas1 EMBL AAK73774.1
OrganismMus musculus (Mouse) EMBL AAK73774.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide By similarity.

Catalytic activity

2 H2O2 = O2 + 2 H2O. RuleBase RU000498

Cofactor

Heme group By similarity. PIRSR PIRSR038928-2

Sequence similarities

Belongs to the catalase family. RuleBase RU000498

Ontologies

Keywords
   Biological processHydrogen peroxide RuleBase RU000498
   LigandHeme RuleBase RU000498 PIRSR PIRSR038928-2
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
Gene Ontology (GO)
   Biological_processaerobic respiration

Inferred from mutant phenotype PubMed 15178682. Source: MGI

cholesterol metabolic process

Inferred from mutant phenotype PubMed 5087482. Source: MGI

hemoglobin metabolic process

Inferred from mutant phenotype PubMed 8153151. Source: MGI

hydrogen peroxide catabolic process

Inferred from direct assay PubMed 10617683PubMed 17275685PubMed 9600348. Source: MGI

negative regulation of NF-kappaB transcription factor activity

Inferred from direct assay PubMed 9600348. Source: MGI

positive regulation of NF-kappaB transcription factor activity

Inferred from direct assay PubMed 15020231. Source: MGI

positive regulation of phosphatidylinositol 3-kinase signaling

Inferred from direct assay PubMed 15020231. Source: MGI

response to oxidative stress

Inferred from direct assay PubMed 17275685. Source: MGI

triglyceride metabolic process

Inferred from mutant phenotype PubMed 5087482. Source: MGI

   Cellular_componentmitochondrion

Inferred from direct assay PubMed 14651853. Source: MGI

peroxisomal membrane

Inferred from direct assay PubMed 12915479. Source: MGI

peroxisome

Inferred from direct assay PubMed 11156684PubMed 11829486PubMed 17275685PubMed 21460186. Source: MGI

   Molecular_functionaminoacylase activity

Inferred from mutant phenotype PubMed 15178682. Source: MGI

catalase activity

Inferred from direct assay PubMed 10617683PubMed 12521604PubMed 12646716PubMed 15317809PubMed 17275685PubMed 9600348. Source: MGI

heme binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

oxidoreductase activity, acting on peroxide as acceptor

Inferred from direct assay PubMed 11792727. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site751 By similarity PIRSR PIRSR038928-1
Active site1481 By similarity PIRSR PIRSR038928-1
Metal binding3581Iron (heme axial ligand) By similarity PIRSR PIRSR038928-2

Sequences

Sequence LengthMass (Da)Tools
Q91XI2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 31915D443B2339BF

FASTA52759,738
        10         20         30         40         50         60 
MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL LVQDVVFTDE 

        70         80         90        100        110        120 
MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF EHIGKRTPIA VRFSTVAGES 

       130        140        150        160        170        180 
GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD 

       190        200        210        220        230        240 
MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ 

       250        260        270        280        290        300 
GIKNLPVGEA GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT 

       310        320        330        340        350        360 
KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM LQGRLFAYPD 

       370        380        390        400        410        420 
THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG APNYYPNSFS APEQQRSALE 

       430        440        450        460        470        480 
HSVQCAVDVK RFNSANEDSV TQVRTFYTKV LNEEERKRLC ENIAGHLKDA QLFIQKKAVK 

       490        500        510        520 
NFTDVHPDYG ARIQALLDKY NAEKPKNAIH TYTQAGSHMA AKGKANL 

« Hide

References

[1]"cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant."
Wang D.-H., Tsutsui K., Sano K., Masuoka N., Kira S.
Biochim. Biophys. Acta 1522:217-220(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C3H/AnL EMBL AAK73774.1.
Tissue: Liver EMBL AAK73774.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY040626 mRNA. Translation: AAK73774.1.
UniGeneMm.4215.

3D structure databases

ProteinModelPortalQ91XI2.
SMRQ91XI2. Positions 4-501.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ91XI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:88271. Cat.

Phylogenomic databases

HOVERGENHBG003986.
InParanoidQ91XI2.

Gene expression databases

GenevestigatorQ91XI2.

Family and domain databases

Gene3D2.40.180.10. 1 hit.
InterProIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERPTHR11465. PTHR11465. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSPR00067. CATALASE.
SMARTSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMSSF56634. SSF56634. 1 hit.
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCAT. mouse.
SOURCESearch...

Entry information

Entry nameQ91XI2_MOUSE
AccessionPrimary (citable) accession number: Q91XI2
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)