Q91XI2 (Q91XI2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Catalase RuleBase RU000498
EC=1.11.1.6 RuleBase RU000498

Gene names

Name:	Cat MGI 88271
Synonyms:	Cas1 EMBL AAK73774.1

Organism

Mus musculus (Mouse) EMBL AAK73774.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide By similarity. RuleBase RU004142
Catalytic activity	2 H2O2 = O2 + 2 H2O. RuleBase RU000498
Sequence similarities	Belongs to the catalase family. RuleBase RU000498

Ontologies

Keywords
Biological process	Hydrogen peroxide RuleBase RU000498
Ligand	Heme RuleBase RU000498 Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological_process	aerobic respiration Inferred from mutant phenotype PubMed 15178682. Source: MGI cholesterol metabolic process Inferred from mutant phenotype PubMed 5087482. Source: MGI hemoglobin metabolic process Inferred from mutant phenotype PubMed 8153151. Source: MGI hydrogen peroxide catabolic process Inferred from direct assay PubMed 10617683PubMed 17275685PubMed 9600348. Source: MGI negative regulation of NF-kappaB transcription factor activity Inferred from direct assay PubMed 9600348. Source: MGI positive regulation of NF-kappaB transcription factor activity Inferred from direct assay PubMed 15020231. Source: MGI positive regulation of phosphatidylinositol 3-kinase cascade Inferred from direct assay PubMed 15020231. Source: MGI triglyceride metabolic process Inferred from mutant phenotype PubMed 5087482. Source: MGI
Cellular_component	mitochondrion Inferred from direct assay PubMed 14651853. Source: MGI peroxisomal membrane Inferred from direct assay PubMed 12915479. Source: MGI
Molecular_function	aminoacylase activity Inferred from mutant phenotype PubMed 15178682. Source: MGI catalase activity Inferred from direct assay PubMed 10617683PubMed 12521604PubMed 12646716PubMed 15317809PubMed 17275685PubMed 9600348. Source: MGI heme binding Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q91XI2 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 31915D443B2339BF	FASTA	527	59,738
	10 20 30 40 50 60 MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL LVQDVVFTDE 70 80 90 100 110 120 MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF EHIGKRTPIA VRFSTVAGES 130 140 150 160 170 180 GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD 190 200 210 220 230 240 MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ 250 260 270 280 290 300 GIKNLPVGEA GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT 310 320 330 340 350 360 KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM LQGRLFAYPD 370 380 390 400 410 420 THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG APNYYPNSFS APEQQRSALE 430 440 450 460 470 480 HSVQCAVDVK RFNSANEDSV TQVRTFYTKV LNEEERKRLC ENIAGHLKDA QLFIQKKAVK 490 500 510 520 NFTDVHPDYG ARIQALLDKY NAEKPKNAIH TYTQAGSHMA AKGKANL

References

[1]	"cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant." Wang D.-H., Tsutsui K., Sano K., Masuoka N., Kira S. Biochim. Biophys. Acta 1522:217-220(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C3H/AnL EMBL AAK73774.1. Tissue: Liver EMBL AAK73774.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY040626 mRNA. Translation: AAK73774.1.
IPI	IPI00312058.
UniGene	Mm.4215.
3D structure databases
HSSP	HSSP built from PDB template 4BLC based on UniProtKB P00432.
ProteinModelPortal	Q91XI2.
SMR	Q91XI2. Positions 4-501.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91XI2.
Proteomic databases
PRIDE	Q91XI2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:88271. Cat.
Phylogenomic databases
HOVERGEN	HBG003986.
InParanoid	Q91XI2.
Gene expression databases
ArrayExpress	Q91XI2.
Genevestigator	Q91XI2.
Family and domain databases
Gene3D	2.40.180.10. 1 hit.
InterPro	IPR018028. Catalase. IPR020835. Catalase-like_dom. IPR024708. Catalase_AS. IPR024711. Catalase_clade1/3. IPR011614. Catalase_core. IPR002226. Catalase_haem_BS. IPR010582. Catalase_immune_responsive. [Graphical view]
PANTHER	PTHR11465. PTHR11465. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PIRSF	PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTS	PR00067. CATALASE.
SMART	SM01060. Catalase. 1 hit. [Graphical view]
SUPFAM	SSF56634. Catalase_N. 1 hit.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CAT. mouse.
SOURCE	Search...

Entry information

Entry name

Q91XI2_MOUSE

Accession

Primary (citable) accession number: Q91XI2

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)