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Q91XI2

- Q91XI2_MOUSE

UniProt

Q91XI2 - Q91XI2_MOUSE

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Protein

Catalase

Gene

Cat

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.UniRule annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

Note: Heme group.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751UniRule annotation
Active sitei148 – 1481UniRule annotation
Metal bindingi358 – 3581Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

  1. aminoacylase activity Source: MGI
  2. catalase activity Source: MGI
  3. heme binding Source: InterPro
  4. metal ion binding Source: UniProtKB-KW
  5. oxidoreductase activity, acting on peroxide as acceptor Source: MGI

GO - Biological processi

  1. aerobic respiration Source: MGI
  2. cholesterol metabolic process Source: MGI
  3. hemoglobin metabolic process Source: MGI
  4. hydrogen peroxide catabolic process Source: MGI
  5. negative regulation of NF-kappaB transcription factor activity Source: MGI
  6. positive regulation of NF-kappaB transcription factor activity Source: MGI
  7. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  8. response to oxidative stress Source: MGI
  9. triglyceride metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotation

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
Gene namesi
Name:CatImported
Synonyms:Cas1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88271. Cat.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. peroxisomal membrane Source: MGI
  3. peroxisome Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ91XI2.

Expressioni

Gene expression databases

GenevestigatoriQ91XI2.

Structurei

3D structure databases

ProteinModelPortaliQ91XI2.
SMRiQ91XI2. Positions 4-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG003986.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL
60 70 80 90 100
LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF
110 120 130 140 150
EHIGKRTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT
160 170 180 190 200
PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF
210 220 230 240 250
SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ GIKNLPVGEA
260 270 280 290 300
GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT
310 320 330 340 350
KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM
360 370 380 390 400
LQGRLFAYPD THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG
410 420 430 440 450
APNYYPNSFS APEQQRSALE HSVQCAVDVK RFNSANEDSV TQVRTFYTKV
460 470 480 490 500
LNEEERKRLC ENIAGHLKDA QLFIQKKAVK NFTDVHPDYG ARIQALLDKY
510 520
NAEKPKNAIH TYTQAGSHMA AKGKANL
Length:527
Mass (Da):59,738
Last modified:December 1, 2001 - v1
Checksum:i31915D443B2339BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040626 mRNA. Translation: AAK73774.1.
UniGeneiMm.4215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040626 mRNA. Translation: AAK73774.1 .
UniGenei Mm.4215.

3D structure databases

ProteinModelPortali Q91XI2.
SMRi Q91XI2. Positions 4-501.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q91XI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:88271. Cat.

Phylogenomic databases

HOVERGENi HBG003986.

Miscellaneous databases

ChiTaRSi Cat. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q91XI2.

Family and domain databases

Gene3Di 2.40.180.10. 1 hit.
InterProi IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view ]
PANTHERi PTHR11465. PTHR11465. 1 hit.
Pfami PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view ]
PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSi PR00067. CATALASE.
SMARTi SM01060. Catalase. 1 hit.
[Graphical view ]
SUPFAMi SSF56634. SSF56634. 1 hit.
PROSITEi PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant."
    Wang D.-H., Tsutsui K., Sano K., Masuoka N., Kira S.
    Biochim. Biophys. Acta 1522:217-220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/AnLImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ91XI2_MOUSE
AccessioniPrimary (citable) accession number: Q91XI2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)