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Protein

Catalase

Gene

Cat

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.UniRule annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

  1. aminoacylase activity Source: MGI
  2. antioxidant activity Source: MGI
  3. catalase activity Source: MGI
  4. enzyme binding Source: MGI
  5. heme binding Source: MGI
  6. metal ion binding Source: UniProtKB-KW
  7. NADP binding Source: MGI
  8. oxidoreductase activity, acting on peroxide as acceptor Source: MGI
  9. protein homodimerization activity Source: MGI
  10. receptor binding Source: MGI

GO - Biological processi

  1. aerobic respiration Source: MGI
  2. cholesterol metabolic process Source: MGI
  3. hemoglobin metabolic process Source: MGI
  4. hydrogen peroxide catabolic process Source: MGI
  5. negative regulation of apoptotic process Source: MGI
  6. negative regulation of NF-kappaB transcription factor activity Source: MGI
  7. osteoblast differentiation Source: MGI
  8. positive regulation of NF-kappaB transcription factor activity Source: MGI
  9. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  10. protein homotetramerization Source: MGI
  11. protein tetramerization Source: MGI
  12. response to oxidative stress Source: MGI
  13. response to reactive oxygen species Source: MGI
  14. triglyceride metabolic process Source: MGI
  15. UV protection Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotation

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
Gene namesi
Name:CatImported
Synonyms:Cas1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88271. Cat.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. focal adhesion Source: MGI
  3. intracellular membrane-bounded organelle Source: MGI
  4. membrane Source: MGI
  5. mitochondrion Source: MGI
  6. peroxisomal membrane Source: MGI
  7. peroxisome Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ91XI2.

Expressioni

Gene expression databases

GenevestigatoriQ91XI2.

Structurei

3D structure databases

ProteinModelPortaliQ91XI2.
SMRiQ91XI2. Positions 4-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG003986.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL
60 70 80 90 100
LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF
110 120 130 140 150
EHIGKRTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT
160 170 180 190 200
PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF
210 220 230 240 250
SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ GIKNLPVGEA
260 270 280 290 300
GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT
310 320 330 340 350
KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM
360 370 380 390 400
LQGRLFAYPD THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG
410 420 430 440 450
APNYYPNSFS APEQQRSALE HSVQCAVDVK RFNSANEDSV TQVRTFYTKV
460 470 480 490 500
LNEEERKRLC ENIAGHLKDA QLFIQKKAVK NFTDVHPDYG ARIQALLDKY
510 520
NAEKPKNAIH TYTQAGSHMA AKGKANL
Length:527
Mass (Da):59,738
Last modified:December 1, 2001 - v1
Checksum:i31915D443B2339BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040626 mRNA. Translation: AAK73774.1.
UniGeneiMm.4215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040626 mRNA. Translation: AAK73774.1.
UniGeneiMm.4215.

3D structure databases

ProteinModelPortaliQ91XI2.
SMRiQ91XI2. Positions 4-501.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ91XI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88271. Cat.

Phylogenomic databases

HOVERGENiHBG003986.

Miscellaneous databases

ChiTaRSiCat. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ91XI2.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant."
    Wang D.-H., Tsutsui K., Sano K., Masuoka N., Kira S.
    Biochim. Biophys. Acta 1522:217-220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/AnLImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ91XI2_MOUSE
AccessioniPrimary (citable) accession number: Q91XI2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.