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Protein

Catalase

Gene

Cat

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.UniRule annotation

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75UniRule annotation1
Active sitei148UniRule annotation1
Metal bindingi358Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxideUniRule annotation
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
Gene namesi
Name:CatImported
Synonyms:Cas1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:88271. Cat.

PTM / Processingi

Proteomic databases

PaxDbiQ91XI2.
PeptideAtlasiQ91XI2.

Structurei

3D structure databases

ProteinModelPortaliQ91XI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 413CatalaseInterPro annotationAdd BLAST386

Sequence similaritiesi

Belongs to the catalase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
HOVERGENiHBG003986.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiView protein in InterPro
IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiView protein in Pfam
PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiView protein in SMART
SM01060. Catalase. 1 hit.
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiView protein in PROSITE
PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91XI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSRDPASD QMKQWKEQRA SQRPDVLTTG GGNPIGDKLN IMTAGSRGPL
60 70 80 90 100
LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF
110 120 130 140 150
EHIGKRTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT
160 170 180 190 200
PIFFIRDAIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF
210 220 230 240 250
SDRGIPDGHR HMNGYGSHTF KLVNADGEAV YCKFHYKTDQ GIKNLPVGEA
260 270 280 290 300
GRLAQEDPDY GLRDLFNAIA NGNYPSWTFY IQVMTFKEAE TFPFNPFDLT
310 320 330 340 350
KVWPHKDYPL IPVGKLVLNK NPVNYFAEVE QMAFDPSNMP PGIEPSPDKM
360 370 380 390 400
LQGRLFAYPD THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMHDNQGG
410 420 430 440 450
APNYYPNSFS APEQQRSALE HSVQCAVDVK RFNSANEDSV TQVRTFYTKV
460 470 480 490 500
LNEEERKRLC ENIAGHLKDA QLFIQKKAVK NFTDVHPDYG ARIQALLDKY
510 520
NAEKPKNAIH TYTQAGSHMA AKGKANL
Length:527
Mass (Da):59,738
Last modified:December 1, 2001 - v1
Checksum:i31915D443B2339BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040626 mRNA. Translation: AAK73774.1.
UniGeneiMm.4215.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ91XI2_MOUSE
AccessioniPrimary (citable) accession number: Q91XI2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)