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Q91XH5

- Q91XH5_MOUSE

UniProt

Q91XH5 - Q91XH5_MOUSE

Protein
Submitted name:

Sepiapterin reductase

Gene

Spr

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sepiapterin reductase activity Source: InterPro

    GO - Biological processi

    1. cell morphogenesis involved in neuron differentiation Source: MGI
    2. death Source: MGI
    3. dopamine metabolic process Source: MGI
    4. L-phenylalanine metabolic process Source: MGI
    5. norepinephrine metabolic process Source: MGI
    6. pteridine metabolic process Source: MGI
    7. regulation of multicellular organism growth Source: MGI
    8. serotonin metabolic process Source: MGI
    9. tetrahydrobiopterin biosynthetic process Source: InterPro
    10. tetrahydrobiopterin metabolic process Source: MGI
    11. voluntary musculoskeletal movement Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_199047. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Sepiapterin reductaseImported
    Submitted name:
    Sepiapterin reductase, isoform CRA_bImported
    Gene namesi
    Name:SprImported
    ORF Names:mCG_128676Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:103078. Spr.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XH5.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00440000033609.
    HOVERGENiHBG006973.
    InParanoidiQ91XH5.
    KOiK00072.
    OMAiFRSWALY.
    OrthoDBiEOG7327PS.
    TreeFamiTF326358.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR006393. Sepiapterin_red.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    TIGRFAMsiTIGR01500. sepiapter_red. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q91XH5-1 [UniParc]FASTAAdd to Basket

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    MEAGGLGCAV CVLTGASRGF GRALAPQLAR LLSPGSVMLV SARSESMLRQ    50
    LKEELGAQQP DLKVVLAAAD LGTEAGVQRL LSAVRELPRP EGLQRLLLIN 100
    NAATLGDVSK GFLNVNDLAE VNNYWALNLT SMLCLTSGTL NAFQDSPGLS 150
    KTVVNISSLC ALQPYKGWGL YCAGKAARDM LYQVLAAEEP SVRVLSYAPG 200
    PLDNDMQQLA RETSKDPELR SKLQKLKSDG ALVDCGTSAQ KLLGLLQKDT 250
    FQSGAHVDFY DC 262
    Length:262
    Mass (Da):27,928
    Last modified:December 1, 2001 - v1
    Checksum:iE78022297439CA95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC153373 Genomic DNA. No translation available.
    BC010400 mRNA. Translation: AAH10400.1.
    BC054423 mRNA. Translation: AAH54423.1.
    CH466523 Genomic DNA. Translation: EDK99121.1.
    RefSeqiNP_035597.2. NM_011467.2.
    UniGeneiMm.28393.

    Genome annotation databases

    EnsembliENSMUST00000045986; ENSMUSP00000048111; ENSMUSG00000033735.
    GeneIDi20751.
    KEGGimmu:20751.
    UCSCiuc012eod.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC153373 Genomic DNA. No translation available.
    BC010400 mRNA. Translation: AAH10400.1 .
    BC054423 mRNA. Translation: AAH54423.1 .
    CH466523 Genomic DNA. Translation: EDK99121.1 .
    RefSeqi NP_035597.2. NM_011467.2.
    UniGenei Mm.28393.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045986 ; ENSMUSP00000048111 ; ENSMUSG00000033735 .
    GeneIDi 20751.
    KEGGi mmu:20751.
    UCSCi uc012eod.1. mouse.

    Organism-specific databases

    CTDi 6697.
    MGIi MGI:103078. Spr.

    Phylogenomic databases

    GeneTreei ENSGT00440000033609.
    HOVERGENi HBG006973.
    InParanoidi Q91XH5.
    KOi K00072.
    OMAi FRSWALY.
    OrthoDBi EOG7327PS.
    TreeFami TF326358.

    Enzyme and pathway databases

    Reactomei REACT_199047. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.

    Miscellaneous databases

    ChiTaRSi SPR. mouse.
    NextBioi 299415.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q91XH5.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR006393. Sepiapterin_red.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    TIGRFAMsi TIGR01500. sepiapter_red. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: ColonImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ91XH5_MOUSE
    AccessioniPrimary (citable) accession number: Q91XH5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3