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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 3

Gene

Creb3l3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds to the cAMP response element (CRE). Activates transcription through box-B element (By similarity). Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Enzyme and pathway databases

ReactomeiR-MMU-8874211. CREB3 factors activate genes.
R-MMU-8963889. Assembly of active LPL and LIPC lipase complexes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 3
Short name:
cAMP-responsive element-binding protein 3-like protein 3
Alternative name(s):
Transcription factor CREB-H
Cleaved into the following chain:
Gene namesi
Name:Creb3l3
Synonyms:Crebh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2384786. Creb3l3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 317CytoplasmicSequence analysisAdd BLAST317
Transmembranei318 – 338Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini339 – 479LumenalSequence analysisAdd BLAST141

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880751 – 479Cyclic AMP-responsive element-binding protein 3-like protein 3Add BLAST479
ChainiPRO_00003071231 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (By similarity).By similarity
N-glycosylation is required for optimal proteolytic activation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei359 – 360Cleavage; by PS1By similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91XE9.
PaxDbiQ91XE9.
PRIDEiQ91XE9.

PTM databases

iPTMnetiQ91XE9.
PhosphoSitePlusiQ91XE9.

Miscellaneous databases

PMAP-CutDBiQ91XE9.

Expressioni

Tissue specificityi

Exclusively expressed in adult liver. Differentially expressed in cancer cell lines.1 Publication

Inductioni

By IL6. Proinflammatory cytokines and lipopolysaccharide activate the UPR and induce cleavage of CREBH in the liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000035041.
CleanExiMM_CREB3L3.
GenevisibleiQ91XE9. MM.

Interactioni

Subunit structurei

Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229005. 1 interactor.
STRINGi10090.ENSMUSP00000112836.

Structurei

3D structure databases

ProteinModelPortaliQ91XE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 302bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 270Basic motifPROSITE-ProRule annotationAdd BLAST30
Regioni281 – 302Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0709. Eukaryota.
ENOG410ZZQM. LUCA.
GeneTreeiENSGT00520000055538.
HOGENOMiHOG000059566.
HOVERGENiHBG090496.
InParanoidiQ91XE9.
KOiK09048.
OMAiDLEMWSP.
OrthoDBiEOG091G07QR.
PhylomeDBiQ91XE9.
TreeFamiTF316079.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR029806. CREBH.
IPR008917. TF_DNA-bd.
PANTHERiPTHR22952:SF98. PTHR22952:SF98. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDIAAGKM ASPVCAMAPL DSMEVLDLLF DRQDGILRNV ELAEGWILAR
60 70 80 90 100
EEQKVLLNSD SDEFLNCILG PGDSDPSSPL WSPADSDSGI SEDLPSDPQD
110 120 130 140 150
TPPRSGTEPA NTVARCHTRE QGKGPCPSYL PSTPCPEPPR TQVQESSVAI
160 170 180 190 200
DLDMWSTDTL YPEEPAGSPS RFNLTVKELL LSGGSGDLQQ HSLAASQLLG
210 220 230 240 250
PGSGHCQELV LTEDEKKLLA KEGVTLPTQL PLTKYEERVL KKIRRKIRNK
260 270 280 290 300
QSAQESRKKK KEYIDGLENR MSACTAQNQE LQRKVLHLEK QNLSLLEQLK
310 320 330 340 350
HLQALVVQST SKPAHAGTCI AVLLLSFALI ILPSISPFNS NKVDSPGDFV
360 370 380 390 400
PVRVFSRTLH NHAASRVAPD VTPGSEVPGP WPDVGTPHKG PSSGGLSADW
410 420 430 440 450
GNFLEIPMLD NLTEELDNST LVLANSTEDL GRATLLDWVA SEPLLSPGRV
460 470
GLEIPGEMWL SWVPRWLRVR LVQDALGVL
Length:479
Mass (Da):52,145
Last modified:December 1, 2001 - v1
Checksum:i948A06FE79DB3779
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270R → L in BAC34115 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392874 mRNA. Translation: AAM73673.1.
AK050186 mRNA. Translation: BAC34115.1.
AK077258 mRNA. Translation: BAC36714.1.
BC010786 mRNA. Translation: AAH10786.1.
BC028820 mRNA. Translation: AAH28820.1.
CCDSiCCDS24043.1.
RefSeqiNP_663340.1. NM_145365.3.
UniGeneiMm.294693.

Genome annotation databases

EnsembliENSMUST00000117422; ENSMUSP00000112836; ENSMUSG00000035041.
GeneIDi208677.
KEGGimmu:208677.
UCSCiuc007gfw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCR3L3_MOUSE
AccessioniPrimary (citable) accession number: Q91XE9
Secondary accession number(s): Q8BWS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families