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Protein

Glycine N-acyltransferase

Gene

Glyat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.By similarity

Catalytic activityi

Acyl-CoA + glycine = CoA + N-acylglycine.By similarity
Benzoyl-CoA + glycine = CoA + hippurate.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processDetoxification

Enzyme and pathway databases

ReactomeiR-MMU-177128 Conjugation of salicylate with glycine
R-MMU-177135 Conjugation of benzoate with glycine

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase (EC:2.3.1.13By similarity)
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase
Short name:
AAc
Aralkyl acyl-CoA N-acyltransferase
Aralkyl acyl-CoA:amino acid N-acyltransferase
Benzoyl-coenzyme A:glycine N-acyltransferase
Glycine N-benzoyltransferase (EC:2.3.1.71By similarity)
Gene namesi
Name:Glyat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147502 Glyat

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818701 – 296Glycine N-acyltransferaseAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16N6-acetyllysine; alternateCombined sources1
Modified residuei16N6-succinyllysine; alternateCombined sources1
Modified residuei113N6-acetyllysineCombined sources1
Modified residuei127N6-acetyllysine; alternateCombined sources1
Modified residuei127N6-succinyllysine; alternateCombined sources1
Modified residuei141N6-acetyllysine; alternateCombined sources1
Modified residuei141N6-succinyllysine; alternateCombined sources1
Modified residuei142N6-acetyllysine; alternateCombined sources1
Modified residuei142N6-succinyllysine; alternateCombined sources1
Modified residuei159N6-acetyllysineCombined sources1
Modified residuei167N6-acetyllysineCombined sources1
Modified residuei169N6-succinyllysineCombined sources1
Modified residuei183N6-acetyllysine; alternateCombined sources1
Modified residuei183N6-succinyllysine; alternateCombined sources1
Modified residuei256N6-acetyllysine; alternateCombined sources1
Modified residuei256N6-succinyllysine; alternateCombined sources1
Modified residuei267N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ91XE0
PeptideAtlasiQ91XE0
PRIDEiQ91XE0

PTM databases

iPTMnetiQ91XE0
PhosphoSitePlusiQ91XE0

Expressioni

Gene expression databases

BgeeiENSMUSG00000063683
CleanExiMM_GLYAT
GenevisibleiQ91XE0 MM

Interactioni

Protein-protein interaction databases

IntActiQ91XE0, 2 interactors
MINTiQ91XE0
STRINGi10090.ENSMUSP00000043308

Structurei

3D structure databases

ProteinModelPortaliQ91XE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IJUM Eukaryota
ENOG4111428 LUCA
GeneTreeiENSGT00390000004997
HOGENOMiHOG000263599
HOVERGENiHBG107953
InParanoidiQ91XE0
KOiK00628
OMAiHVDKSNI
OrthoDBiEOG091G0ESR
PhylomeDBiQ91XE0
TreeFamiTF353258

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR010313 Glycine_N-acyltransferase
IPR013652 Glycine_N-acyltransferase_C
IPR015938 Glycine_N-acyltransferase_N
PANTHERiPTHR15298 PTHR15298, 1 hit
PfamiView protein in Pfam
PF08444 Gly_acyl_tr_C, 1 hit
PF06021 Gly_acyl_tr_N, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91XE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIVPLQGAQM LQMLEKSLRK YLPESLKVYG TVYHMIHGNP FNLKALVDKW
60 70 80 90 100
PDFNTVVVRP QEQEMTDDLD FYINTYQVYS KDPQNCQEFL ESSEVINWKQ
110 120 130 140 150
HLQIQSSQSH LNKTIQNLAS IQSFQIKHSE NILYVSSETI KKLFPSLLDT
160 170 180 190 200
KNLSTGSGKP KAIDQDKFKL SSLDVVHAAL VNKFWLFGGN ERSQRFIERC
210 220 230 240 250
IKNFPSSCVL GPEGTPASWT LMDQTGEMRM GGTMPEYRLQ GLVSFVVHSQ
260 270 280 290
DQIMTKRGYP VYSHTEKSNI AMQKMSYTLQ HLPMPCAWNQ WKCMPM
Length:296
Mass (Da):34,098
Last modified:December 1, 2001 - v1
Checksum:i2825F8C6F7BA2C96
GO
Isoform 2 (identifier: Q91XE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):30,150
Checksum:i6DA04B8D9A92AC01
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0240751 – 34Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039262 mRNA Translation: BAC30297.1
AK143901 mRNA Translation: BAE25590.1
AK143803 mRNA Translation: BAE25544.1
BC010799 mRNA Translation: AAH10799.1
BC015294 mRNA Translation: AAH15294.1
BC024434 mRNA Translation: AAH24434.1
CCDSiCCDS29633.1 [Q91XE0-1]
RefSeqiNP_666047.1, NM_145935.3 [Q91XE0-1]
UniGeneiMm.39974

Genome annotation databases

EnsembliENSMUST00000044976; ENSMUSP00000043308; ENSMUSG00000063683 [Q91XE0-1]
ENSMUST00000119960; ENSMUSP00000114002; ENSMUSG00000063683 [Q91XE0-2]
GeneIDi107146
KEGGimmu:107146
UCSCiuc008guh.1 mouse [Q91XE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGLYAT_MOUSE
AccessioniPrimary (citable) accession number: Q91XE0
Secondary accession number(s): Q05DG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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