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Protein

Solute carrier family 25 member 38

Gene

Slc25a38

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38UniRule annotation
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2384782. Slc25a38.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei51 – 76Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei109 – 135Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei147 – 172Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei200 – 223Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei241 – 267Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei296 – 314Helical; Name=6UniRule annotationAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918031 – 326Solute carrier family 25 member 38Add BLAST326

Proteomic databases

PaxDbiQ91XD8.
PRIDEiQ91XD8.

PTM databases

PhosphoSitePlusiQ91XD8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032519.
CleanExiMM_SLC25A38.
ExpressionAtlasiQ91XD8. baseline and differential.
GenevisibleiQ91XD8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035106.

Structurei

3D structure databases

ProteinModelPortaliQ91XD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 134Solcar 1Add BLAST90
Repeati141 – 225Solcar 2Add BLAST85
Repeati237 – 321Solcar 3Add BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
Contains 3 Solcar repeats.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
HOVERGENiHBG054682.
InParanoidiQ91XD8.
KOiK15118.
OMAiRWIGQAV.
OrthoDBiEOG091G0IR1.
PhylomeDBiQ91XD8.
TreeFamiTF332793.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVSAEPRSL SVAGAGLASP VIEKARSALL QSQDVEDTVE TLMLHPVIKA
60 70 80 90 100
FLCGSISGTC STLLFQPLDL LKTRLQALQP SDLGPRRVGM LAVFLKVVRT
110 120 130 140 150
ESLLGLWKGM SPSIVRCVPG VGIYFGTLYS SKQYFLRGHP PTALESVILG
160 170 180 190 200
MGSRSVAGVC MSPITVIKTR YESGTYSYES IYAALRSIYC SEGHRGLFRG
210 220 230 240 250
LTATLLRDAP FSGLYLMFYS QTRTAVLHGT AQLDAALIPL INFSCGIFAG
260 270 280 290 300
VLASLVTQPA DVIKTHMQLS PVKFQWIGQA ATLIFKNHGL RGFFHGSVPR
310 320
ALRRTLMAAM AWTVYEEMMA RMGLKS
Length:326
Mass (Da):35,390
Last modified:December 1, 2001 - v1
Checksum:i9C895EBD7A87A9F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078385 mRNA. Translation: BAC37246.1.
BC010801 mRNA. Translation: AAH10801.1.
CCDSiCCDS23622.1.
RefSeqiNP_659042.1. NM_144793.1.
UniGeneiMm.236656.

Genome annotation databases

EnsembliENSMUST00000035106; ENSMUSP00000035106; ENSMUSG00000032519.
GeneIDi208638.
KEGGimmu:208638.
UCSCiuc009scc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK078385 mRNA. Translation: BAC37246.1.
BC010801 mRNA. Translation: AAH10801.1.
CCDSiCCDS23622.1.
RefSeqiNP_659042.1. NM_144793.1.
UniGeneiMm.236656.

3D structure databases

ProteinModelPortaliQ91XD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035106.

PTM databases

PhosphoSitePlusiQ91XD8.

Proteomic databases

PaxDbiQ91XD8.
PRIDEiQ91XD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035106; ENSMUSP00000035106; ENSMUSG00000032519.
GeneIDi208638.
KEGGimmu:208638.
UCSCiuc009scc.1. mouse.

Organism-specific databases

CTDi54977.
MGIiMGI:2384782. Slc25a38.

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
HOVERGENiHBG054682.
InParanoidiQ91XD8.
KOiK15118.
OMAiRWIGQAV.
OrthoDBiEOG091G0IR1.
PhylomeDBiQ91XD8.
TreeFamiTF332793.

Miscellaneous databases

PROiQ91XD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032519.
CleanExiMM_SLC25A38.
ExpressionAtlasiQ91XD8. baseline and differential.
GenevisibleiQ91XD8. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2538_MOUSE
AccessioniPrimary (citable) accession number: Q91XD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.