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Q91XD7

- CREL1_MOUSE

UniProt

Q91XD7 - CREL1_MOUSE

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Protein
Cysteine-rich with EGF-like domain protein 1
Gene
Creld1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 1
Gene namesi
Name:Creld1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2152539. Creld1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 362333Extracellular Reviewed prediction
Add
BLAST
Transmembranei363 – 38321Helical; Reviewed prediction
Add
BLAST
Topological domaini384 – 3841Cytoplasmic Reviewed prediction
Transmembranei385 – 40521Helical; Reviewed prediction
Add
BLAST
Topological domaini406 – 42015Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 420391Cysteine-rich with EGF-like domain protein 1
PRO_0000042782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi155 ↔ 169 By similarity
Disulfide bondi163 ↔ 181 By similarity
Disulfide bondi183 ↔ 192 By similarity
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi309 ↔ 321 By similarity
Disulfide bondi314 ↔ 330 By similarity
Disulfide bondi332 ↔ 343 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91XD7.
PRIDEiQ91XD7.

Expressioni

Gene expression databases

BgeeiQ91XD7.
CleanExiMM_CRELD1.
GenevestigatoriQ91XD7.

Interactioni

Protein-protein interaction databases

IntActiQ91XD7. 2 interactions.
MINTiMINT-4997877.
STRINGi10090.ENSMUSP00000032422.

Structurei

3D structure databases

ProteinModelPortaliQ91XD7.
SMRiQ91XD7. Positions 133-197, 290-345.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 19341EGF-like 1
Add
BLAST
Repeati208 – 25548FU 1
Add
BLAST
Repeati268 – 31548FU 2
Add
BLAST
Domaini305 – 34238EGF-like 2; calcium-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the CRELD family.
Contains 2 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG315654.
GeneTreeiENSGT00680000100014.
HOGENOMiHOG000004778.
HOVERGENiHBG081344.
InParanoidiQ91XD7.
OMAiEPHPCHT.
OrthoDBiEOG7Z3F4B.
PhylomeDBiQ91XD7.
TreeFamiTF316507.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF11938. DUF3456. 2 hits.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XD7-1 [UniParc]FASTAAdd to Basket

« Hide

MAPLPPRGLV PSLLWCLSLF LSLPGPVWLQ PSPPPHPSPR AEPHPCHTCR    50
ALVDNFNKGL ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSR 100
SDFECHRLLE LSEELVENWW FHRQQEAPDL FQWLCSDSLK LCCPSGTFGP 150
SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF 200
EAERNSSHLV CSACFGPCAR CTGPEESHCL QCKKGWALHH LKCVDIDECG 250
TEQATCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSRGYQQVG 300
SKCLDVDECE TVVCPGENEK CENTEGGYRC VCAEGYRQED GICVKEQVPE 350
SAGFFAEMTE DEMVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM 400
TGYWLSERSD RVLEGFIKGR 420
Length:420
Mass (Da):45,718
Last modified:December 1, 2001 - v1
Checksum:i4066BF2D739D3179
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050160 mRNA. Translation: BAC34101.1.
AK050455 mRNA. Translation: BAC34266.1.
AK155777 mRNA. Translation: BAE33433.1.
BC010804 mRNA. Translation: AAH10804.1.
BC023893 mRNA. Translation: AAH23893.1.
BC025932 mRNA. Translation: AAH25932.1.
BC029065 mRNA. Translation: AAH29065.1.
CCDSiCCDS20423.1.
RefSeqiNP_598691.1. NM_133930.1.
UniGeneiMm.41593.

Genome annotation databases

EnsembliENSMUST00000032422; ENSMUSP00000032422; ENSMUSG00000030284.
GeneIDi171508.
KEGGimmu:171508.
UCSCiuc009dgo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK050160 mRNA. Translation: BAC34101.1 .
AK050455 mRNA. Translation: BAC34266.1 .
AK155777 mRNA. Translation: BAE33433.1 .
BC010804 mRNA. Translation: AAH10804.1 .
BC023893 mRNA. Translation: AAH23893.1 .
BC025932 mRNA. Translation: AAH25932.1 .
BC029065 mRNA. Translation: AAH29065.1 .
CCDSi CCDS20423.1.
RefSeqi NP_598691.1. NM_133930.1.
UniGenei Mm.41593.

3D structure databases

ProteinModelPortali Q91XD7.
SMRi Q91XD7. Positions 133-197, 290-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91XD7. 2 interactions.
MINTi MINT-4997877.
STRINGi 10090.ENSMUSP00000032422.

Proteomic databases

PaxDbi Q91XD7.
PRIDEi Q91XD7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032422 ; ENSMUSP00000032422 ; ENSMUSG00000030284 .
GeneIDi 171508.
KEGGi mmu:171508.
UCSCi uc009dgo.1. mouse.

Organism-specific databases

CTDi 78987.
MGIi MGI:2152539. Creld1.

Phylogenomic databases

eggNOGi NOG315654.
GeneTreei ENSGT00680000100014.
HOGENOMi HOG000004778.
HOVERGENi HBG081344.
InParanoidi Q91XD7.
OMAi EPHPCHT.
OrthoDBi EOG7Z3F4B.
PhylomeDBi Q91XD7.
TreeFami TF316507.

Miscellaneous databases

NextBioi 371024.
PROi Q91XD7.
SOURCEi Search...

Gene expression databases

Bgeei Q91XD7.
CleanExi MM_CRELD1.
Genevestigatori Q91XD7.

Family and domain databases

InterProi IPR021852. DUF3456.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR002049. EGF_laminin.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF11938. DUF3456. 2 hits.
PF07645. EGF_CA. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00261. FU. 2 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins."
    Rupp P.A., Fouad G.T., Egelston C.A., Reifsteck C.A., Olson S.B., Knosp W.M., Glanville R.W., Thornburg K.L., Robinson S.W., Maslen C.L.
    Gene 293:47-57(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney, Liver and Mammary tumor.

Entry informationi

Entry nameiCREL1_MOUSE
AccessioniPrimary (citable) accession number: Q91XD7
Secondary accession number(s): Q8BGJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi