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Q91XD7

- CREL1_MOUSE

UniProt

Q91XD7 - CREL1_MOUSE

Protein

Cysteine-rich with EGF-like domain protein 1

Gene

Creld1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich with EGF-like domain protein 1
    Gene namesi
    Name:Creld1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2152539. Creld1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 420391Cysteine-rich with EGF-like domain protein 1PRO_0000042782Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi155 ↔ 169PROSITE-ProRule annotation
    Disulfide bondi163 ↔ 181PROSITE-ProRule annotation
    Disulfide bondi183 ↔ 192PROSITE-ProRule annotation
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi309 ↔ 321PROSITE-ProRule annotation
    Disulfide bondi314 ↔ 330PROSITE-ProRule annotation
    Disulfide bondi332 ↔ 343PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ91XD7.
    PRIDEiQ91XD7.

    Expressioni

    Gene expression databases

    BgeeiQ91XD7.
    CleanExiMM_CRELD1.
    GenevestigatoriQ91XD7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ91XD7. 2 interactions.
    MINTiMINT-4997877.
    STRINGi10090.ENSMUSP00000032422.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XD7.
    SMRiQ91XD7. Positions 133-197, 290-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 362333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini384 – 3841CytoplasmicSequence Analysis
    Topological domaini406 – 42015ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini153 – 19341EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Repeati208 – 25548FU 1Add
    BLAST
    Repeati268 – 31548FU 2Add
    BLAST
    Domaini305 – 34238EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRELD family.Curated
    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 2 FU (furin-like) repeats.Curated

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG315654.
    GeneTreeiENSGT00680000100014.
    HOGENOMiHOG000004778.
    HOVERGENiHBG081344.
    InParanoidiQ91XD7.
    OMAiEPHPCHT.
    OrthoDBiEOG7Z3F4B.
    PhylomeDBiQ91XD7.
    TreeFamiTF316507.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR002049. EGF_laminin.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF11938. DUF3456. 2 hits.
    PF07645. EGF_CA. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    SM00261. FU. 2 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91XD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLPPRGLV PSLLWCLSLF LSLPGPVWLQ PSPPPHPSPR AEPHPCHTCR    50
    ALVDNFNKGL ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSR 100
    SDFECHRLLE LSEELVENWW FHRQQEAPDL FQWLCSDSLK LCCPSGTFGP 150
    SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF 200
    EAERNSSHLV CSACFGPCAR CTGPEESHCL QCKKGWALHH LKCVDIDECG 250
    TEQATCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSRGYQQVG 300
    SKCLDVDECE TVVCPGENEK CENTEGGYRC VCAEGYRQED GICVKEQVPE 350
    SAGFFAEMTE DEMVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM 400
    TGYWLSERSD RVLEGFIKGR 420
    Length:420
    Mass (Da):45,718
    Last modified:December 1, 2001 - v1
    Checksum:i4066BF2D739D3179
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050160 mRNA. Translation: BAC34101.1.
    AK050455 mRNA. Translation: BAC34266.1.
    AK155777 mRNA. Translation: BAE33433.1.
    BC010804 mRNA. Translation: AAH10804.1.
    BC023893 mRNA. Translation: AAH23893.1.
    BC025932 mRNA. Translation: AAH25932.1.
    BC029065 mRNA. Translation: AAH29065.1.
    CCDSiCCDS20423.1.
    RefSeqiNP_598691.1. NM_133930.1.
    UniGeneiMm.41593.

    Genome annotation databases

    EnsembliENSMUST00000032422; ENSMUSP00000032422; ENSMUSG00000030284.
    GeneIDi171508.
    KEGGimmu:171508.
    UCSCiuc009dgo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK050160 mRNA. Translation: BAC34101.1 .
    AK050455 mRNA. Translation: BAC34266.1 .
    AK155777 mRNA. Translation: BAE33433.1 .
    BC010804 mRNA. Translation: AAH10804.1 .
    BC023893 mRNA. Translation: AAH23893.1 .
    BC025932 mRNA. Translation: AAH25932.1 .
    BC029065 mRNA. Translation: AAH29065.1 .
    CCDSi CCDS20423.1.
    RefSeqi NP_598691.1. NM_133930.1.
    UniGenei Mm.41593.

    3D structure databases

    ProteinModelPortali Q91XD7.
    SMRi Q91XD7. Positions 133-197, 290-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91XD7. 2 interactions.
    MINTi MINT-4997877.
    STRINGi 10090.ENSMUSP00000032422.

    Proteomic databases

    PaxDbi Q91XD7.
    PRIDEi Q91XD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032422 ; ENSMUSP00000032422 ; ENSMUSG00000030284 .
    GeneIDi 171508.
    KEGGi mmu:171508.
    UCSCi uc009dgo.1. mouse.

    Organism-specific databases

    CTDi 78987.
    MGIi MGI:2152539. Creld1.

    Phylogenomic databases

    eggNOGi NOG315654.
    GeneTreei ENSGT00680000100014.
    HOGENOMi HOG000004778.
    HOVERGENi HBG081344.
    InParanoidi Q91XD7.
    OMAi EPHPCHT.
    OrthoDBi EOG7Z3F4B.
    PhylomeDBi Q91XD7.
    TreeFami TF316507.

    Miscellaneous databases

    NextBioi 371024.
    PROi Q91XD7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91XD7.
    CleanExi MM_CRELD1.
    Genevestigatori Q91XD7.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR002049. EGF_laminin.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF11938. DUF3456. 2 hits.
    PF07645. EGF_CA. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    SM00261. FU. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins."
      Rupp P.A., Fouad G.T., Egelston C.A., Reifsteck C.A., Olson S.B., Knosp W.M., Glanville R.W., Thornburg K.L., Robinson S.W., Maslen C.L.
      Gene 293:47-57(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fibroblast.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney, Liver and Mammary tumor.

    Entry informationi

    Entry nameiCREL1_MOUSE
    AccessioniPrimary (citable) accession number: Q91XD7
    Secondary accession number(s): Q8BGJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3