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Protein

Cysteine-rich with EGF-like domain protein 1

Gene

Creld1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 1
Gene namesi
Name:Creld1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2152539. Creld1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 362ExtracellularSequence analysisAdd BLAST333
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384CytoplasmicSequence analysis1
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 420ExtracellularSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004278230 – 420Cysteine-rich with EGF-like domain protein 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi155 ↔ 169PROSITE-ProRule annotation
Disulfide bondi163 ↔ 181PROSITE-ProRule annotation
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi309 ↔ 321PROSITE-ProRule annotation
Disulfide bondi314 ↔ 330PROSITE-ProRule annotation
Disulfide bondi332 ↔ 343PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ91XD7.
PaxDbiQ91XD7.
PRIDEiQ91XD7.

PTM databases

PhosphoSitePlusiQ91XD7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030284.
CleanExiMM_CRELD1.
ExpressionAtlasiQ91XD7. baseline and differential.
GenevisibleiQ91XD7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91XD7. 2 interactors.
MINTiMINT-4997877.
STRINGi10090.ENSMUSP00000032422.

Structurei

3D structure databases

ProteinModelPortaliQ91XD7.
SMRiQ91XD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 193EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Repeati208 – 255FU 1Add BLAST48
Repeati268 – 315FU 2Add BLAST48
Domaini305 – 342EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST38

Sequence similaritiesi

Belongs to the CRELD family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 2 FU (furin-like) repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
GeneTreeiENSGT00680000100014.
HOGENOMiHOG000004778.
HOVERGENiHBG081344.
InParanoidiQ91XD7.
OMAiEPHPCHT.
OrthoDBiEOG091G09AA.
PhylomeDBiQ91XD7.
TreeFamiTF316507.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLPPRGLV PSLLWCLSLF LSLPGPVWLQ PSPPPHPSPR AEPHPCHTCR
60 70 80 90 100
ALVDNFNKGL ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSR
110 120 130 140 150
SDFECHRLLE LSEELVENWW FHRQQEAPDL FQWLCSDSLK LCCPSGTFGP
160 170 180 190 200
SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF
210 220 230 240 250
EAERNSSHLV CSACFGPCAR CTGPEESHCL QCKKGWALHH LKCVDIDECG
260 270 280 290 300
TEQATCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSRGYQQVG
310 320 330 340 350
SKCLDVDECE TVVCPGENEK CENTEGGYRC VCAEGYRQED GICVKEQVPE
360 370 380 390 400
SAGFFAEMTE DEMVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM
410 420
TGYWLSERSD RVLEGFIKGR
Length:420
Mass (Da):45,718
Last modified:December 1, 2001 - v1
Checksum:i4066BF2D739D3179
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050160 mRNA. Translation: BAC34101.1.
AK050455 mRNA. Translation: BAC34266.1.
AK155777 mRNA. Translation: BAE33433.1.
BC010804 mRNA. Translation: AAH10804.1.
BC023893 mRNA. Translation: AAH23893.1.
BC025932 mRNA. Translation: AAH25932.1.
BC029065 mRNA. Translation: AAH29065.1.
CCDSiCCDS20423.1.
RefSeqiNP_598691.1. NM_133930.1.
UniGeneiMm.41593.

Genome annotation databases

EnsembliENSMUST00000032422; ENSMUSP00000032422; ENSMUSG00000030284.
GeneIDi171508.
KEGGimmu:171508.
UCSCiuc009dgo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050160 mRNA. Translation: BAC34101.1.
AK050455 mRNA. Translation: BAC34266.1.
AK155777 mRNA. Translation: BAE33433.1.
BC010804 mRNA. Translation: AAH10804.1.
BC023893 mRNA. Translation: AAH23893.1.
BC025932 mRNA. Translation: AAH25932.1.
BC029065 mRNA. Translation: AAH29065.1.
CCDSiCCDS20423.1.
RefSeqiNP_598691.1. NM_133930.1.
UniGeneiMm.41593.

3D structure databases

ProteinModelPortaliQ91XD7.
SMRiQ91XD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91XD7. 2 interactors.
MINTiMINT-4997877.
STRINGi10090.ENSMUSP00000032422.

PTM databases

PhosphoSitePlusiQ91XD7.

Proteomic databases

MaxQBiQ91XD7.
PaxDbiQ91XD7.
PRIDEiQ91XD7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032422; ENSMUSP00000032422; ENSMUSG00000030284.
GeneIDi171508.
KEGGimmu:171508.
UCSCiuc009dgo.1. mouse.

Organism-specific databases

CTDi78987.
MGIiMGI:2152539. Creld1.

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
GeneTreeiENSGT00680000100014.
HOGENOMiHOG000004778.
HOVERGENiHBG081344.
InParanoidiQ91XD7.
OMAiEPHPCHT.
OrthoDBiEOG091G09AA.
PhylomeDBiQ91XD7.
TreeFamiTF316507.

Miscellaneous databases

PROiQ91XD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030284.
CleanExiMM_CRELD1.
ExpressionAtlasiQ91XD7. baseline and differential.
GenevisibleiQ91XD7. MM.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCREL1_MOUSE
AccessioniPrimary (citable) accession number: Q91XD7
Secondary accession number(s): Q8BGJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.