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Protein

Formimidoyltransferase-cyclodeaminase

Gene

Ftcd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).By similarity
Binds and promotes bundling of vimentin filaments originating from the Golgi.By similarity

Catalytic activityi

5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.
5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3.

Cofactori

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (transferase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoyltransferase-cyclodeaminase (Ftcd)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (transferase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82For formimidoyltransferase activityBy similarity1
Active sitei412For cyclodeaminase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Multifunctional enzyme, Transferase
Biological processHistidine metabolism
LigandFolate-binding, Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-70921 Histidine catabolism
UniPathwayiUPA00193
UPA00379; UER00555

Names & Taxonomyi

Protein namesi
Recommended name:
Formimidoyltransferase-cyclodeaminase
Alternative name(s):
Formiminotransferase-cyclodeaminase
Short name:
FTCD
Including the following 2 domains:
Glutamate formimidoyltransferase (EC:2.1.2.5)
Alternative name(s):
Glutamate formiminotransferase
Glutamate formyltransferase
Formimidoyltetrahydrofolate cyclodeaminase (EC:4.3.1.4)
Alternative name(s):
Formiminotetrahydrofolate cyclodeaminase
Gene namesi
Name:Ftcd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1339962 Ftcd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873601 – 541Formimidoyltransferase-cyclodeaminaseAdd BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei520PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91XD4
PaxDbiQ91XD4
PeptideAtlasiQ91XD4
PRIDEiQ91XD4

PTM databases

iPTMnetiQ91XD4
PhosphoSitePlusiQ91XD4
SwissPalmiQ91XD4

Expressioni

Gene expression databases

BgeeiENSMUSG00000001155
CleanExiMM_FTCD
GenevisibleiQ91XD4 MM

Interactioni

Subunit structurei

Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199754, 1 interactor
IntActiQ91XD4, 2 interactors
MINTiQ91XD4
STRINGi10090.ENSMUSP00000001183

Structurei

3D structure databases

ProteinModelPortaliQ91XD4
SMRiQ91XD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 181Formiminotransferase N-subdomainBy similarityAdd BLAST181
Regioni163 – 172Folate bindingSequence analysis10
Regioni182 – 326Formiminotransferase C-subdomainBy similarityAdd BLAST145
Regioni327 – 334LinkerBy similarity8
Regioni335 – 541Cyclodeaminase/cyclohydrolaseBy similarityAdd BLAST207

Sequence similaritiesi

In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.Curated
In the N-terminal section; belongs to the formiminotransferase family.Curated

Phylogenomic databases

eggNOGiENOG410IERX Eukaryota
COG3404 LUCA
COG3643 LUCA
GeneTreeiENSGT00390000005581
HOGENOMiHOG000006949
HOVERGENiHBG000168
InParanoidiQ91XD4
KOiK13990
OMAiYGKRQFE
OrthoDBiEOG091G0950
PhylomeDBiQ91XD4
TreeFamiTF333892

Family and domain databases

Gene3Di1.20.120.680, 1 hit
3.30.70.670, 1 hit
3.30.990.10, 1 hit
InterProiView protein in InterPro
IPR007044 Cyclodeamin/CycHdrlase
IPR013802 Formiminotransferase_C
IPR037070 Formiminotransferase_C_sf
IPR004227 Formiminotransferase_cat
IPR012886 Formiminotransferase_N
IPR037064 Formiminotransferase_N_sf
IPR022384 FormiminoTrfase_cat_dom_sf
IPR036178 Formintransfe-cycloase-like_sf
PfamiView protein in Pfam
PF02971 FTCD, 1 hit
PF04961 FTCD_C, 1 hit
PF07837 FTCD_N, 1 hit
SMARTiView protein in SMART
SM01221 FTCD, 1 hit
SM01222 FTCD_N, 1 hit
SUPFAMiSSF101262 SSF101262, 1 hit
SSF55116 SSF55116, 2 hits
TIGRFAMsiTIGR02024 FtcD, 1 hit

Sequencei

Sequence statusi: Complete.

Q91XD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLVECVPN FSEGNNQEVI DAISRAISQT PGCVLLDVDA GPSTNRTVYT
60 70 80 90 100
FVGQPECVVE GALHAARTAS QLIDMSKHKG EHPRMGALDV CPFIPVRGVS
110 120 130 140 150
MEECVLCAKA FGQRLAEELN VPVYLYGEAA QTPSRQTLPA IRAGEYEALP
160 170 180 190 200
EKLKQAEWVP DFGPSSFVPS WGATVTGARK FLIAFNINLL STKEQAHRIA
210 220 230 240 250
LNLREQGRGK DQPGRLKKVQ GIGWYLEEKN LAQVSTNLLD FEVTALHTVF
260 270 280 290 300
EEARREAQEL NLPVVGSQLV GLVPLKALLD AAAFYCDKEK LFVLEEEHRI
310 320 330 340 350
RLVVNRLGLD SLAPFDPKER IIEYLVPDSG PEQSLLDTSL RGFVREVGAR
360 370 380 390 400
SAAPGGGSVA AAVAALGAAL ASMVGQMTYG RRQFDHLDST MRRLIPPFHA
410 420 430 440 450
ASAQLTSLVD ADARAFAACL EAIKLPKNTP EERDRRACAL QEGLRQAVAV
460 470 480 490 500
PLKLAETVSQ LWPALQELAH CGNLSCLSDL QVAAKALETG VFGAYFNVLI
510 520 530 540
NLKDMTDDVF KEKTHHRISS LLQEAKTQAA LVLGSLEARK E
Length:541
Mass (Da):58,939
Last modified:December 1, 2001 - v1
Checksum:i988DDAC3847F5BC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010813 mRNA Translation: AAH10813.1
BC024078 mRNA Translation: AAH24078.1
CCDSiCCDS23950.1
RefSeqiNP_543121.1, NM_080845.2
UniGeneiMm.36278

Genome annotation databases

EnsembliENSMUST00000001183; ENSMUSP00000001183; ENSMUSG00000001155
GeneIDi14317
KEGGimmu:14317
UCSCiuc007fut.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFTCD_MOUSE
AccessioniPrimary (citable) accession number: Q91XD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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