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Protein

LIM and senescent cell antigen-like-containing domain protein 2

Gene

Lims2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell-cell adhesion Source: MGI
  • cell-cell junction organization Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of hepatocyte proliferation Source: MGI
  • negative regulation of neural precursor cell proliferation Source: MGI
  • positive regulation of integrin-mediated signaling pathway Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain protein 2
Alternative name(s):
Particularly interesting new Cys-His protein 2
Short name:
PINCH-2
Gene namesi
Name:Lims2
Synonyms:Pinch2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2385067 Lims2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002660121 – 341LIM and senescent cell antigen-like-containing domain protein 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei328PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91XD2
PaxDbiQ91XD2
PeptideAtlasiQ91XD2
PRIDEiQ91XD2

PTM databases

iPTMnetiQ91XD2
PhosphoSitePlusiQ91XD2

Expressioni

Tissue specificityi

Detected in heart, lung, kidney, liver, urinary bladder, fat, skin, skeletal muscle, uterus, large intestine and testis.1 Publication

Developmental stagei

Not detectable during early stages of embryogenesis. Detected at low levels at E14.5 and E15.5. Highly expressed at E17.5.

Gene expression databases

BgeeiENSMUSG00000024395
CleanExiMM_LIMS2
GenevisibleiQ91XD2 MM

Interactioni

Subunit structurei

Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA (By similarity). Interacts with TGFB1I1.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025254

Structurei

3D structure databases

ProteinModelPortaliQ91XD2
SMRiQ91XD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 74LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini76 – 133LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini138 – 195LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST58
Domaini196 – 255LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST60
Domaini256 – 315LIM zinc-binding 5PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
HOVERGENiHBG000053
InParanoidiQ91XD2
OMAiTHCGKEL
OrthoDBiEOG091G08K3
PhylomeDBiQ91XD2
TreeFamiTF314113

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q91XD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSNMSECL ADAMCQRCQA RFAPTERIVN SNGELYHEHC FVCAQCFRPF
60 70 80 90 100
PEGLFYEFEG RKYCEHDFQM LFAPCCGFCG EFVIGRVIKA MNANWHPGCF
110 120 130 140 150
RCELCDVELA DLGFVKNAGR HLCRPCHNRE KAKGLGKFIC QRCHLAIDEQ
160 170 180 190 200
PLMFKNDPYH PDHFSCSNCG KELTSDAREL KGELYCLPCH DKMGIPICGA
210 220 230 240 250
CRRPIEGRVV NALGKQWHVE HFVCAKCEKP FLGHRHYEKK GLAYCETHYN
260 270 280 290 300
QLFGDVCYNC SHVIEGDVVS ALSKAWCVNC FSCSTCNMKL TLKNKFVEFD
310 320 330 340
MKPVCKRCYE RFPLELKKRL KKLSDLSSRK AQPKSVDVNS L
Length:341
Mass (Da):39,031
Last modified:December 1, 2001 - v1
Checksum:i7A93F9845BDAED91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ420860
, AJ420861, AJ420863, AJ420862 Genomic DNA Translation: CAD12820.1
BC010816 mRNA Translation: AAH10816.1
CCDSiCCDS29113.1
RefSeqiNP_659111.1, NM_144862.3
UniGeneiMm.24551

Genome annotation databases

EnsembliENSMUST00000025254; ENSMUSP00000025254; ENSMUSG00000024395
GeneIDi225341
KEGGimmu:225341
UCSCiuc008eiv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLIMS2_MOUSE
AccessioniPrimary (citable) accession number: Q91XD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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