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Q91XC9

- PEX16_MOUSE

UniProt

Q91XC9 - PEX16_MOUSE

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Protein

Peroxisomal membrane protein PEX16

Gene

Pex16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity).By similarity

GO - Biological processi

  1. ER-dependent peroxisome organization Source: Ensembl
  2. peroxisome membrane biogenesis Source: Ensembl
  3. protein import into peroxisome matrix Source: Ensembl
  4. protein import into peroxisome membrane Source: Ensembl
  5. protein localization to endoplasmic reticulum Source: Ensembl
  6. protein to membrane docking Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX16
Alternative name(s):
Peroxin-16
Peroxisomal biogenesis factor 16
Gene namesi
Name:Pex16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1338829. Pex16.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Ensembl
  2. integral component of peroxisomal membrane Source: Ensembl
  3. peroxisomal membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Peroxisomal membrane protein PEX16PRO_0000366961Add
BLAST

Proteomic databases

MaxQBiQ91XC9.
PaxDbiQ91XC9.
PRIDEiQ91XC9.

PTM databases

PhosphoSiteiQ91XC9.

Expressioni

Gene expression databases

BgeeiQ91XC9.
GenevestigatoriQ91XC9.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91XC9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini106 – 1105PeroxisomalSequence Analysis
Topological domaini132 – 336205CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 8116Required for peroxisomal locationBy similarityAdd
BLAST
Regioni221 – 336116Interaction with PEX19By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peroxin-16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289038.
GeneTreeiENSGT00390000017790.
HOGENOMiHOG000008062.
HOVERGENiHBG053572.
InParanoidiQ91XC9.
KOiK13335.
OMAiPLNREQQ.
OrthoDBiEOG7XWPNZ.
PhylomeDBiQ91XC9.
TreeFamiTF324139.

Family and domain databases

InterProiIPR013919. Pex16.
[Graphical view]
PfamiPF08610. Pex16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLRLLSLR YQEYVTRHPA ATAQLETAVR GLSYLLAGRF SDSHELSELV
60 70 80 90 100
YSASNLLVLL NDGILRKELR KKLPVSLSQQ KLLTWLSVLE CVEVFMEMGA
110 120 130 140 150
AKVWGEVGRW LVIALIQLAK AVLRMLLLIW FKAGIQTSPP IVPLDRETQA
160 170 180 190 200
QPLDGDHNPG SQEPSYVGKR SHRVVRTLQN SPSLHSRYWG APQQREIRQK
210 220 230 240 250
QQQEELSTPP TPLGLQETIA ESLYIARPLL HLLSLGLWGQ RSWTPWLLSG
260 270 280 290 300
VVDMTSLSLL SDRKNLTRRE RLELRRRTIL LLYYLLRSPF YDRFSEAKIL
310 320 330
FLLQLLTDHI PGVGLVARPL MDYLPSWQKI YFYSWG
Length:336
Mass (Da):38,677
Last modified:March 24, 2009 - v2
Checksum:iC7507C8B482EC8F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti268 – 2681R → Q in AAH10822. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK143073 mRNA. Translation: BAE25262.1.
AL731709 Genomic DNA. Translation: CAM20621.1.
CH466519 Genomic DNA. Translation: EDL27597.1.
BC010822 mRNA. Translation: AAH10822.1.
CCDSiCCDS16444.1.
RefSeqiNP_660104.2. NM_145122.2.
UniGeneiMm.202782.

Genome annotation databases

EnsembliENSMUST00000028650; ENSMUSP00000028650; ENSMUSG00000027222.
GeneIDi18633.
KEGGimmu:18633.
UCSCiuc008kxs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK143073 mRNA. Translation: BAE25262.1 .
AL731709 Genomic DNA. Translation: CAM20621.1 .
CH466519 Genomic DNA. Translation: EDL27597.1 .
BC010822 mRNA. Translation: AAH10822.1 .
CCDSi CCDS16444.1.
RefSeqi NP_660104.2. NM_145122.2.
UniGenei Mm.202782.

3D structure databases

ProteinModelPortali Q91XC9.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91XC9.

Proteomic databases

MaxQBi Q91XC9.
PaxDbi Q91XC9.
PRIDEi Q91XC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028650 ; ENSMUSP00000028650 ; ENSMUSG00000027222 .
GeneIDi 18633.
KEGGi mmu:18633.
UCSCi uc008kxs.2. mouse.

Organism-specific databases

CTDi 9409.
MGIi MGI:1338829. Pex16.

Phylogenomic databases

eggNOGi NOG289038.
GeneTreei ENSGT00390000017790.
HOGENOMi HOG000008062.
HOVERGENi HBG053572.
InParanoidi Q91XC9.
KOi K13335.
OMAi PLNREQQ.
OrthoDBi EOG7XWPNZ.
PhylomeDBi Q91XC9.
TreeFami TF324139.

Miscellaneous databases

NextBioi 294600.
PROi Q91XC9.
SOURCEi Search...

Gene expression databases

Bgeei Q91XC9.
Genevestigatori Q91XC9.

Family and domain databases

InterProi IPR013919. Pex16.
[Graphical view ]
Pfami PF08610. Pex16. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiPEX16_MOUSE
AccessioniPrimary (citable) accession number: Q91XC9
Secondary accession number(s): Q3UPY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3