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Protein

Peroxisomal membrane protein PEX16

Gene

Pex16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX16
Alternative name(s):
Peroxin-16
Peroxisomal biogenesis factor 16
Gene namesi
Name:Pex16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1338829 Pex16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 84CytoplasmicSequence analysisAdd BLAST84
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 110PeroxisomalSequence analysis5
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 336CytoplasmicSequence analysisAdd BLAST205

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003669611 – 336Peroxisomal membrane protein PEX16Add BLAST336

Proteomic databases

EPDiQ91XC9
MaxQBiQ91XC9
PaxDbiQ91XC9
PeptideAtlasiQ91XC9
PRIDEiQ91XC9

PTM databases

iPTMnetiQ91XC9
PhosphoSitePlusiQ91XC9

Expressioni

Gene expression databases

BgeeiENSMUSG00000027222
GenevisibleiQ91XC9 MM

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028650

Structurei

3D structure databases

ProteinModelPortaliQ91XC9
SMRiQ91XC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 81Required for peroxisomal locationBy similarityAdd BLAST16
Regioni221 – 336Interaction with PEX19By similarityAdd BLAST116

Sequence similaritiesi

Belongs to the peroxin-16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4546 Eukaryota
ENOG4111GEA LUCA
GeneTreeiENSGT00390000017790
HOGENOMiHOG000008062
HOVERGENiHBG053572
InParanoidiQ91XC9
KOiK13335
OMAiKIYFYSW
OrthoDBiEOG091G0GH4
PhylomeDBiQ91XC9
TreeFamiTF324139

Family and domain databases

InterProiView protein in InterPro
IPR013919 Pex16
PANTHERiPTHR13299 PTHR13299, 1 hit
PfamiView protein in Pfam
PF08610 Pex16, 1 hit

Sequencei

Sequence statusi: Complete.

Q91XC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLRLLSLR YQEYVTRHPA ATAQLETAVR GLSYLLAGRF SDSHELSELV
60 70 80 90 100
YSASNLLVLL NDGILRKELR KKLPVSLSQQ KLLTWLSVLE CVEVFMEMGA
110 120 130 140 150
AKVWGEVGRW LVIALIQLAK AVLRMLLLIW FKAGIQTSPP IVPLDRETQA
160 170 180 190 200
QPLDGDHNPG SQEPSYVGKR SHRVVRTLQN SPSLHSRYWG APQQREIRQK
210 220 230 240 250
QQQEELSTPP TPLGLQETIA ESLYIARPLL HLLSLGLWGQ RSWTPWLLSG
260 270 280 290 300
VVDMTSLSLL SDRKNLTRRE RLELRRRTIL LLYYLLRSPF YDRFSEAKIL
310 320 330
FLLQLLTDHI PGVGLVARPL MDYLPSWQKI YFYSWG
Length:336
Mass (Da):38,677
Last modified:March 24, 2009 - v2
Checksum:iC7507C8B482EC8F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268R → Q in AAH10822 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143073 mRNA Translation: BAE25262.1
AL731709 Genomic DNA Translation: CAM20621.1
CH466519 Genomic DNA Translation: EDL27597.1
BC010822 mRNA Translation: AAH10822.1
CCDSiCCDS16444.1
RefSeqiNP_660104.2, NM_145122.2
UniGeneiMm.202782

Genome annotation databases

EnsembliENSMUST00000028650; ENSMUSP00000028650; ENSMUSG00000027222
GeneIDi18633
KEGGimmu:18633
UCSCiuc008kxs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPEX16_MOUSE
AccessioniPrimary (citable) accession number: Q91XC9
Secondary accession number(s): Q3UPY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health