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Protein

Peroxisomal membrane protein PEX16

Gene

Pex16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX16
Alternative name(s):
Peroxin-16
Peroxisomal biogenesis factor 16
Gene namesi
Name:Pex16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1338829. Pex16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 84CytoplasmicSequence analysisAdd BLAST84
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 110PeroxisomalSequence analysis5
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 336CytoplasmicSequence analysisAdd BLAST205

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003669611 – 336Peroxisomal membrane protein PEX16Add BLAST336

Proteomic databases

EPDiQ91XC9.
MaxQBiQ91XC9.
PaxDbiQ91XC9.
PeptideAtlasiQ91XC9.
PRIDEiQ91XC9.

PTM databases

iPTMnetiQ91XC9.
PhosphoSitePlusiQ91XC9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027222.
GenevisibleiQ91XC9. MM.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028650.

Structurei

3D structure databases

ProteinModelPortaliQ91XC9.
SMRiQ91XC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 81Required for peroxisomal locationBy similarityAdd BLAST16
Regioni221 – 336Interaction with PEX19By similarityAdd BLAST116

Sequence similaritiesi

Belongs to the peroxin-16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4546. Eukaryota.
ENOG4111GEA. LUCA.
GeneTreeiENSGT00390000017790.
HOGENOMiHOG000008062.
HOVERGENiHBG053572.
InParanoidiQ91XC9.
KOiK13335.
OMAiANGLTWI.
OrthoDBiEOG091G0GH4.
PhylomeDBiQ91XC9.
TreeFamiTF324139.

Family and domain databases

InterProiIPR013919. Pex16.
[Graphical view]
PfamiPF08610. Pex16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLRLLSLR YQEYVTRHPA ATAQLETAVR GLSYLLAGRF SDSHELSELV
60 70 80 90 100
YSASNLLVLL NDGILRKELR KKLPVSLSQQ KLLTWLSVLE CVEVFMEMGA
110 120 130 140 150
AKVWGEVGRW LVIALIQLAK AVLRMLLLIW FKAGIQTSPP IVPLDRETQA
160 170 180 190 200
QPLDGDHNPG SQEPSYVGKR SHRVVRTLQN SPSLHSRYWG APQQREIRQK
210 220 230 240 250
QQQEELSTPP TPLGLQETIA ESLYIARPLL HLLSLGLWGQ RSWTPWLLSG
260 270 280 290 300
VVDMTSLSLL SDRKNLTRRE RLELRRRTIL LLYYLLRSPF YDRFSEAKIL
310 320 330
FLLQLLTDHI PGVGLVARPL MDYLPSWQKI YFYSWG
Length:336
Mass (Da):38,677
Last modified:March 24, 2009 - v2
Checksum:iC7507C8B482EC8F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268R → Q in AAH10822 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143073 mRNA. Translation: BAE25262.1.
AL731709 Genomic DNA. Translation: CAM20621.1.
CH466519 Genomic DNA. Translation: EDL27597.1.
BC010822 mRNA. Translation: AAH10822.1.
CCDSiCCDS16444.1.
RefSeqiNP_660104.2. NM_145122.2.
UniGeneiMm.202782.

Genome annotation databases

EnsembliENSMUST00000028650; ENSMUSP00000028650; ENSMUSG00000027222.
GeneIDi18633.
KEGGimmu:18633.
UCSCiuc008kxs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143073 mRNA. Translation: BAE25262.1.
AL731709 Genomic DNA. Translation: CAM20621.1.
CH466519 Genomic DNA. Translation: EDL27597.1.
BC010822 mRNA. Translation: AAH10822.1.
CCDSiCCDS16444.1.
RefSeqiNP_660104.2. NM_145122.2.
UniGeneiMm.202782.

3D structure databases

ProteinModelPortaliQ91XC9.
SMRiQ91XC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028650.

PTM databases

iPTMnetiQ91XC9.
PhosphoSitePlusiQ91XC9.

Proteomic databases

EPDiQ91XC9.
MaxQBiQ91XC9.
PaxDbiQ91XC9.
PeptideAtlasiQ91XC9.
PRIDEiQ91XC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028650; ENSMUSP00000028650; ENSMUSG00000027222.
GeneIDi18633.
KEGGimmu:18633.
UCSCiuc008kxs.2. mouse.

Organism-specific databases

CTDi9409.
MGIiMGI:1338829. Pex16.

Phylogenomic databases

eggNOGiKOG4546. Eukaryota.
ENOG4111GEA. LUCA.
GeneTreeiENSGT00390000017790.
HOGENOMiHOG000008062.
HOVERGENiHBG053572.
InParanoidiQ91XC9.
KOiK13335.
OMAiANGLTWI.
OrthoDBiEOG091G0GH4.
PhylomeDBiQ91XC9.
TreeFamiTF324139.

Miscellaneous databases

PROiQ91XC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027222.
GenevisibleiQ91XC9. MM.

Family and domain databases

InterProiIPR013919. Pex16.
[Graphical view]
PfamiPF08610. Pex16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX16_MOUSE
AccessioniPrimary (citable) accession number: Q91XC9
Secondary accession number(s): Q3UPY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.