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Q91XC9

- PEX16_MOUSE

UniProt

Q91XC9 - PEX16_MOUSE

Protein

Peroxisomal membrane protein PEX16

Gene

Pex16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 By similarity.By similarity

    GO - Biological processi

    1. ER-dependent peroxisome organization Source: Ensembl
    2. peroxisome membrane biogenesis Source: Ensembl
    3. protein import into peroxisome matrix Source: Ensembl
    4. protein import into peroxisome membrane Source: Ensembl
    5. protein localization to endoplasmic reticulum Source: Ensembl
    6. protein to membrane docking Source: Ensembl

    Keywords - Biological processi

    Peroxisome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX16
    Alternative name(s):
    Peroxin-16
    Peroxisomal biogenesis factor 16
    Gene namesi
    Name:Pex16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1338829. Pex16.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Ensembl
    2. integral component of peroxisomal membrane Source: Ensembl
    3. peroxisomal membrane Source: HGNC

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Peroxisomal membrane protein PEX16PRO_0000366961Add
    BLAST

    Proteomic databases

    PaxDbiQ91XC9.
    PRIDEiQ91XC9.

    PTM databases

    PhosphoSiteiQ91XC9.

    Expressioni

    Gene expression databases

    BgeeiQ91XC9.
    GenevestigatoriQ91XC9.

    Interactioni

    Subunit structurei

    Interacts with PEX19.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8484CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 1105PeroxisomalSequence Analysis
    Topological domaini132 – 336205CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 8116Required for peroxisomal locationBy similarityAdd
    BLAST
    Regioni221 – 336116Interaction with PEX19By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxin-16 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289038.
    GeneTreeiENSGT00390000017790.
    HOGENOMiHOG000008062.
    HOVERGENiHBG053572.
    InParanoidiQ3UPY2.
    KOiK13335.
    OMAiPLNREQQ.
    OrthoDBiEOG7XWPNZ.
    PhylomeDBiQ91XC9.
    TreeFamiTF324139.

    Family and domain databases

    InterProiIPR013919. Pex16.
    [Graphical view]
    PfamiPF08610. Pex16. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLRLLSLR YQEYVTRHPA ATAQLETAVR GLSYLLAGRF SDSHELSELV    50
    YSASNLLVLL NDGILRKELR KKLPVSLSQQ KLLTWLSVLE CVEVFMEMGA 100
    AKVWGEVGRW LVIALIQLAK AVLRMLLLIW FKAGIQTSPP IVPLDRETQA 150
    QPLDGDHNPG SQEPSYVGKR SHRVVRTLQN SPSLHSRYWG APQQREIRQK 200
    QQQEELSTPP TPLGLQETIA ESLYIARPLL HLLSLGLWGQ RSWTPWLLSG 250
    VVDMTSLSLL SDRKNLTRRE RLELRRRTIL LLYYLLRSPF YDRFSEAKIL 300
    FLLQLLTDHI PGVGLVARPL MDYLPSWQKI YFYSWG 336
    Length:336
    Mass (Da):38,677
    Last modified:March 24, 2009 - v2
    Checksum:iC7507C8B482EC8F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti268 – 2681R → Q in AAH10822. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK143073 mRNA. Translation: BAE25262.1.
    AL731709 Genomic DNA. Translation: CAM20621.1.
    CH466519 Genomic DNA. Translation: EDL27597.1.
    BC010822 mRNA. Translation: AAH10822.1.
    CCDSiCCDS16444.1.
    RefSeqiNP_660104.2. NM_145122.2.
    UniGeneiMm.202782.

    Genome annotation databases

    EnsembliENSMUST00000028650; ENSMUSP00000028650; ENSMUSG00000027222.
    GeneIDi18633.
    KEGGimmu:18633.
    UCSCiuc008kxs.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK143073 mRNA. Translation: BAE25262.1 .
    AL731709 Genomic DNA. Translation: CAM20621.1 .
    CH466519 Genomic DNA. Translation: EDL27597.1 .
    BC010822 mRNA. Translation: AAH10822.1 .
    CCDSi CCDS16444.1.
    RefSeqi NP_660104.2. NM_145122.2.
    UniGenei Mm.202782.

    3D structure databases

    ProteinModelPortali Q91XC9.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91XC9.

    Proteomic databases

    PaxDbi Q91XC9.
    PRIDEi Q91XC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028650 ; ENSMUSP00000028650 ; ENSMUSG00000027222 .
    GeneIDi 18633.
    KEGGi mmu:18633.
    UCSCi uc008kxs.2. mouse.

    Organism-specific databases

    CTDi 9409.
    MGIi MGI:1338829. Pex16.

    Phylogenomic databases

    eggNOGi NOG289038.
    GeneTreei ENSGT00390000017790.
    HOGENOMi HOG000008062.
    HOVERGENi HBG053572.
    InParanoidi Q3UPY2.
    KOi K13335.
    OMAi PLNREQQ.
    OrthoDBi EOG7XWPNZ.
    PhylomeDBi Q91XC9.
    TreeFami TF324139.

    Miscellaneous databases

    NextBioi 294600.
    PROi Q91XC9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91XC9.
    Genevestigatori Q91XC9.

    Family and domain databases

    InterProi IPR013919. Pex16.
    [Graphical view ]
    Pfami PF08610. Pex16. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiPEX16_MOUSE
    AccessioniPrimary (citable) accession number: Q91XC9
    Secondary accession number(s): Q3UPY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3