Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Death-associated protein 1

Gene

Dap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Gene namesi
Name:Dap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1918190. Dap.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000797832 – 102Death-associated protein 1Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei3Phosphoserine; by MTORBy similarity1
Modified residuei29N6-acetyllysineCombined sources1
Modified residuei49PhosphoserineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91XC8.
MaxQBiQ91XC8.
PaxDbiQ91XC8.
PRIDEiQ91XC8.

PTM databases

iPTMnetiQ91XC8.
PhosphoSitePlusiQ91XC8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039168.
CleanExiMM_DAP.
ExpressionAtlasiQ91XC8. baseline and differential.
GenevisibleiQ91XC8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91XC8. 2 interactors.
MINTiMINT-4092830.
STRINGi10090.ENSMUSP00000047186.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ91XC8.
OMAiVQKHPHS.
OrthoDBiEOG091G14AS.
PhylomeDBiQ91XC8.
TreeFamiTF329716.

Family and domain databases

InterProiView protein in InterPro
IPR024130. DAP1/DAPL1.
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiView protein in Pfam
PF15228. DAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDGKEER DKDDQEWEST
60 70 80 90 100
SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP

RK
Length:102
Mass (Da):11,155
Last modified:January 23, 2007 - v3
Checksum:iE6ECD12BEA21A557
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010828 mRNA. Translation: AAH10828.1.
BC024876 mRNA. Translation: AAH24876.1.
BC057669 mRNA. Translation: AAH57669.1.
CCDSiCCDS27406.1.
RefSeqiNP_666169.1. NM_146057.3.
UniGeneiMm.222867.

Genome annotation databases

EnsembliENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
GeneIDi223453.
KEGGimmu:223453.
UCSCiuc007vkc.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiDAP1_MOUSE
AccessioniPrimary (citable) accession number: Q91XC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot