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Protein

Death-associated protein 1

Gene

Dap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity).By similarity

GO - Molecular functioni

  1. death domain binding Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. apoptotic process Source: MGI
  3. apoptotic signaling pathway Source: MGI
  4. autophagy Source: UniProtKB-KW
  5. cellular response to amino acid starvation Source: MGI
  6. negative regulation of autophagy Source: MGI
  7. negative regulation of NF-kappaB transcription factor activity Source: MGI
  8. negative regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Gene namesi
Name:Dap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1918190. Dap.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 102101Death-associated protein 1PRO_0000079783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei3 – 31Phosphoserine; by MTORBy similarity
Modified residuei29 – 291N6-acetyllysine1 Publication
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei51 – 511Phosphoserine; alternate2 Publications
Modified residuei51 – 511Phosphoserine; by MTOR; alternateBy similarity
Modified residuei91 – 911PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91XC8.
PaxDbiQ91XC8.
PRIDEiQ91XC8.

PTM databases

PhosphoSiteiQ91XC8.

Expressioni

Gene expression databases

BgeeiQ91XC8.
CleanExiMM_DAP.
ExpressionAtlasiQ91XC8. baseline and differential.
GenevestigatoriQ91XC8.

Interactioni

Protein-protein interaction databases

BioGridi230149. 1 interaction.
IntActiQ91XC8. 2 interactions.
MINTiMINT-4092830.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG84666.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ91XC8.
OMAiVEKLPHP.
OrthoDBiEOG757D0J.
PhylomeDBiQ91XC8.
TreeFamiTF329716.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDGKEER DKDDQEWEST
60 70 80 90 100
SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP

RK
Length:102
Mass (Da):11,155
Last modified:January 23, 2007 - v3
Checksum:iE6ECD12BEA21A557
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010828 mRNA. Translation: AAH10828.1.
BC024876 mRNA. Translation: AAH24876.1.
BC057669 mRNA. Translation: AAH57669.1.
CCDSiCCDS27406.1.
RefSeqiNP_666169.1. NM_146057.3.
UniGeneiMm.222867.

Genome annotation databases

EnsembliENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
GeneIDi223453.
KEGGimmu:223453.
UCSCiuc007vkc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010828 mRNA. Translation: AAH10828.1.
BC024876 mRNA. Translation: AAH24876.1.
BC057669 mRNA. Translation: AAH57669.1.
CCDSiCCDS27406.1.
RefSeqiNP_666169.1. NM_146057.3.
UniGeneiMm.222867.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230149. 1 interaction.
IntActiQ91XC8. 2 interactions.
MINTiMINT-4092830.

PTM databases

PhosphoSiteiQ91XC8.

Proteomic databases

MaxQBiQ91XC8.
PaxDbiQ91XC8.
PRIDEiQ91XC8.

Protocols and materials databases

DNASUi223453.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
GeneIDi223453.
KEGGimmu:223453.
UCSCiuc007vkc.2. mouse.

Organism-specific databases

CTDi1611.
MGIiMGI:1918190. Dap.

Phylogenomic databases

eggNOGiNOG84666.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ91XC8.
OMAiVEKLPHP.
OrthoDBiEOG757D0J.
PhylomeDBiQ91XC8.
TreeFamiTF329716.

Miscellaneous databases

ChiTaRSiDap. mouse.
NextBioi376722.
PROiQ91XC8.
SOURCEiSearch...

Gene expression databases

BgeeiQ91XC8.
CleanExiMM_DAP.
ExpressionAtlasiQ91XC8. baseline and differential.
GenevestigatoriQ91XC8.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129, FVB/N and FVB/N-3.
    Tissue: Colon and Mammary tumor.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiDAP1_MOUSE
AccessioniPrimary (citable) accession number: Q91XC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.