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Q91XC8

- DAP1_MOUSE

UniProt

Q91XC8 - DAP1_MOUSE

Protein

Death-associated protein 1

Gene

Dap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death By similarity.By similarity

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. apoptotic signaling pathway Source: Ensembl
    3. autophagy Source: UniProtKB-KW
    4. cellular response to amino acid starvation Source: Ensembl
    5. negative regulation of autophagy Source: Ensembl
    6. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
    7. negative regulation of transcription, DNA-templated Source: Ensembl

    Keywords - Biological processi

    Apoptosis, Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Death-associated protein 1
    Short name:
    DAP-1
    Gene namesi
    Name:Dap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1918190. Dap.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 102101Death-associated protein 1PRO_0000079783Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei3 – 31Phosphoserine; by MTORBy similarity
    Modified residuei29 – 291N6-acetyllysine1 Publication
    Modified residuei49 – 491PhosphoserineBy similarity
    Modified residuei51 – 511Phosphoserine; alternate2 Publications
    Modified residuei51 – 511Phosphoserine; by MTOR; alternateBy similarity
    Modified residuei91 – 911PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ91XC8.
    PaxDbiQ91XC8.
    PRIDEiQ91XC8.

    PTM databases

    PhosphoSiteiQ91XC8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91XC8.
    BgeeiQ91XC8.
    CleanExiMM_DAP.
    GenevestigatoriQ91XC8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ91XC8. 2 interactions.
    MINTiMINT-4092830.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG84666.
    GeneTreeiENSGT00510000049345.
    HOGENOMiHOG000039719.
    HOVERGENiHBG005451.
    InParanoidiQ91XC8.
    OMAiVEKLPHP.
    OrthoDBiEOG757D0J.
    PhylomeDBiQ91XC8.
    TreeFamiTF329716.

    Family and domain databases

    InterProiIPR024130. DAP1/DAPL1.
    [Graphical view]
    PANTHERiPTHR13177. PTHR13177. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91XC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDGKEER DKDDQEWEST    50
    SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP 100
    RK 102
    Length:102
    Mass (Da):11,155
    Last modified:January 23, 2007 - v3
    Checksum:iE6ECD12BEA21A557
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC010828 mRNA. Translation: AAH10828.1.
    BC024876 mRNA. Translation: AAH24876.1.
    BC057669 mRNA. Translation: AAH57669.1.
    CCDSiCCDS27406.1.
    RefSeqiNP_666169.1. NM_146057.3.
    UniGeneiMm.222867.

    Genome annotation databases

    EnsembliENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
    GeneIDi223453.
    KEGGimmu:223453.
    UCSCiuc007vkc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC010828 mRNA. Translation: AAH10828.1 .
    BC024876 mRNA. Translation: AAH24876.1 .
    BC057669 mRNA. Translation: AAH57669.1 .
    CCDSi CCDS27406.1.
    RefSeqi NP_666169.1. NM_146057.3.
    UniGenei Mm.222867.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91XC8. 2 interactions.
    MINTi MINT-4092830.

    PTM databases

    PhosphoSitei Q91XC8.

    Proteomic databases

    MaxQBi Q91XC8.
    PaxDbi Q91XC8.
    PRIDEi Q91XC8.

    Protocols and materials databases

    DNASUi 223453.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044524 ; ENSMUSP00000047186 ; ENSMUSG00000039168 .
    GeneIDi 223453.
    KEGGi mmu:223453.
    UCSCi uc007vkc.2. mouse.

    Organism-specific databases

    CTDi 1611.
    MGIi MGI:1918190. Dap.

    Phylogenomic databases

    eggNOGi NOG84666.
    GeneTreei ENSGT00510000049345.
    HOGENOMi HOG000039719.
    HOVERGENi HBG005451.
    InParanoidi Q91XC8.
    OMAi VEKLPHP.
    OrthoDBi EOG757D0J.
    PhylomeDBi Q91XC8.
    TreeFami TF329716.

    Miscellaneous databases

    ChiTaRSi DAP. mouse.
    NextBioi 376722.
    PROi Q91XC8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91XC8.
    Bgeei Q91XC8.
    CleanExi MM_DAP.
    Genevestigatori Q91XC8.

    Family and domain databases

    InterProi IPR024130. DAP1/DAPL1.
    [Graphical view ]
    PANTHERi PTHR13177. PTHR13177. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129, FVB/N and FVB/N-3.
      Tissue: Colon and Mammary tumor.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiDAP1_MOUSE
    AccessioniPrimary (citable) accession number: Q91XC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3