Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Death-associated protein 1

Gene

Dap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Gene namesi
Name:Dap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1918190. Dap.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000797832 – 102Death-associated protein 1Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei3Phosphoserine; by MTORBy similarity1
Modified residuei29N6-acetyllysineCombined sources1
Modified residuei49PhosphoserineBy similarity1
Modified residuei51PhosphoserineCombined sources1
Modified residuei91PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91XC8.
MaxQBiQ91XC8.
PaxDbiQ91XC8.
PRIDEiQ91XC8.

PTM databases

iPTMnetiQ91XC8.
PhosphoSitePlusiQ91XC8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039168.
CleanExiMM_DAP.
ExpressionAtlasiQ91XC8. baseline and differential.
GenevisibleiQ91XC8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91XC8. 2 interactors.
MINTiMINT-4092830.
STRINGi10090.ENSMUSP00000047186.

Structurei

3D structure databases

ProteinModelPortaliQ91XC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ91XC8.
OMAiAQHINQH.
OrthoDBiEOG091G14AS.
PhylomeDBiQ91XC8.
TreeFamiTF329716.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiPF15228. DAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDGKEER DKDDQEWEST
60 70 80 90 100
SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP

RK
Length:102
Mass (Da):11,155
Last modified:January 23, 2007 - v3
Checksum:iE6ECD12BEA21A557
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010828 mRNA. Translation: AAH10828.1.
BC024876 mRNA. Translation: AAH24876.1.
BC057669 mRNA. Translation: AAH57669.1.
CCDSiCCDS27406.1.
RefSeqiNP_666169.1. NM_146057.3.
UniGeneiMm.222867.

Genome annotation databases

EnsembliENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
GeneIDi223453.
KEGGimmu:223453.
UCSCiuc007vkc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010828 mRNA. Translation: AAH10828.1.
BC024876 mRNA. Translation: AAH24876.1.
BC057669 mRNA. Translation: AAH57669.1.
CCDSiCCDS27406.1.
RefSeqiNP_666169.1. NM_146057.3.
UniGeneiMm.222867.

3D structure databases

ProteinModelPortaliQ91XC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91XC8. 2 interactors.
MINTiMINT-4092830.
STRINGi10090.ENSMUSP00000047186.

PTM databases

iPTMnetiQ91XC8.
PhosphoSitePlusiQ91XC8.

Proteomic databases

EPDiQ91XC8.
MaxQBiQ91XC8.
PaxDbiQ91XC8.
PRIDEiQ91XC8.

Protocols and materials databases

DNASUi223453.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
GeneIDi223453.
KEGGimmu:223453.
UCSCiuc007vkc.2. mouse.

Organism-specific databases

CTDi1611.
MGIiMGI:1918190. Dap.

Phylogenomic databases

eggNOGiENOG410IZ5N. Eukaryota.
ENOG41122SE. LUCA.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ91XC8.
OMAiAQHINQH.
OrthoDBiEOG091G14AS.
PhylomeDBiQ91XC8.
TreeFamiTF329716.

Miscellaneous databases

ChiTaRSiDap. mouse.
PROiQ91XC8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039168.
CleanExiMM_DAP.
ExpressionAtlasiQ91XC8. baseline and differential.
GenevisibleiQ91XC8. MM.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
PfamiPF15228. DAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAP1_MOUSE
AccessioniPrimary (citable) accession number: Q91XC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.