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Q91XC8

- DAP1_MOUSE

UniProt

Q91XC8 - DAP1_MOUSE

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Protein
Death-associated protein 1
Gene
Dap
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death By similarity.

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. apoptotic signaling pathway Source: Ensembl
  3. autophagy Source: UniProtKB-KW
  4. cellular response to amino acid starvation Source: Ensembl
  5. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
  6. negative regulation of autophagy Source: Ensembl
  7. negative regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein 1
Short name:
DAP-1
Gene namesi
Name:Dap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1918190. Dap.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 102101Death-associated protein 1
PRO_0000079783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei3 – 31Phosphoserine; by MTOR By similarity
Modified residuei29 – 291N6-acetyllysine1 Publication
Modified residuei49 – 491Phosphoserine By similarity
Modified residuei51 – 511Phosphoserine; alternate2 Publications
Modified residuei51 – 511Phosphoserine; by MTOR; alternate By similarity
Modified residuei91 – 911Phosphoserine By similarity

Post-translational modificationi

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91XC8.
PaxDbiQ91XC8.
PRIDEiQ91XC8.

PTM databases

PhosphoSiteiQ91XC8.

Expressioni

Gene expression databases

ArrayExpressiQ91XC8.
BgeeiQ91XC8.
CleanExiMM_DAP.
GenevestigatoriQ91XC8.

Interactioni

Protein-protein interaction databases

IntActiQ91XC8. 2 interactions.
MINTiMINT-4092830.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG84666.
GeneTreeiENSGT00510000049345.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiQ91XC8.
OMAiVEKLPHP.
OrthoDBiEOG757D0J.
PhylomeDBiQ91XC8.
TreeFamiTF329716.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XC8-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDGKEER DKDDQEWEST    50
SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP 100
RK 102
Length:102
Mass (Da):11,155
Last modified:January 23, 2007 - v3
Checksum:iE6ECD12BEA21A557
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC010828 mRNA. Translation: AAH10828.1.
BC024876 mRNA. Translation: AAH24876.1.
BC057669 mRNA. Translation: AAH57669.1.
CCDSiCCDS27406.1.
RefSeqiNP_666169.1. NM_146057.3.
UniGeneiMm.222867.

Genome annotation databases

EnsembliENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
GeneIDi223453.
KEGGimmu:223453.
UCSCiuc007vkc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC010828 mRNA. Translation: AAH10828.1 .
BC024876 mRNA. Translation: AAH24876.1 .
BC057669 mRNA. Translation: AAH57669.1 .
CCDSi CCDS27406.1.
RefSeqi NP_666169.1. NM_146057.3.
UniGenei Mm.222867.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91XC8. 2 interactions.
MINTi MINT-4092830.

PTM databases

PhosphoSitei Q91XC8.

Proteomic databases

MaxQBi Q91XC8.
PaxDbi Q91XC8.
PRIDEi Q91XC8.

Protocols and materials databases

DNASUi 223453.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044524 ; ENSMUSP00000047186 ; ENSMUSG00000039168 .
GeneIDi 223453.
KEGGi mmu:223453.
UCSCi uc007vkc.2. mouse.

Organism-specific databases

CTDi 1611.
MGIi MGI:1918190. Dap.

Phylogenomic databases

eggNOGi NOG84666.
GeneTreei ENSGT00510000049345.
HOGENOMi HOG000039719.
HOVERGENi HBG005451.
InParanoidi Q91XC8.
OMAi VEKLPHP.
OrthoDBi EOG757D0J.
PhylomeDBi Q91XC8.
TreeFami TF329716.

Miscellaneous databases

ChiTaRSi DAP. mouse.
NextBioi 376722.
PROi Q91XC8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91XC8.
Bgeei Q91XC8.
CleanExi MM_DAP.
Genevestigatori Q91XC8.

Family and domain databases

InterProi IPR024130. DAP1/DAPL1.
[Graphical view ]
PANTHERi PTHR13177. PTHR13177. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129, FVB/N and FVB/N-3.
    Tissue: Colon and Mammary tumor.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiDAP1_MOUSE
AccessioniPrimary (citable) accession number: Q91XC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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