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Q91XC8 (DAP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Death-associated protein 1

Short name=DAP-1
Gene names
Name:Dap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length102 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death By similarity.

Post-translational modification

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 102101Death-associated protein 1
PRO_0000079783

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue31Phosphoserine; by MTOR By similarity
Modified residue291N6-acetyllysine Ref.4
Modified residue491Phosphoserine By similarity
Modified residue511Phosphoserine; alternate Ref.2 Ref.3
Modified residue511Phosphoserine; by MTOR; alternate By similarity
Modified residue911Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91XC8 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: E6ECD12BEA21A557

FASTA10211,155
        10         20         30         40         50         60 
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDGKEER DKDDQEWEST SPPKPTVFIS 

        70         80         90        100 
GVIARGDKDF PPAAAQVAHQ KPHASMDKHV SPRTQHIQQP RK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129, FVB/N and FVB/N-3.
Tissue: Colon and Mammary tumor.
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[3]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC010828 mRNA. Translation: AAH10828.1.
BC024876 mRNA. Translation: AAH24876.1.
BC057669 mRNA. Translation: AAH57669.1.
CCDSCCDS27406.1.
RefSeqNP_666169.1. NM_146057.3.
UniGeneMm.222867.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91XC8. 2 interactions.
MINTMINT-4092830.

PTM databases

PhosphoSiteQ91XC8.

Proteomic databases

MaxQBQ91XC8.
PaxDbQ91XC8.
PRIDEQ91XC8.

Protocols and materials databases

DNASU223453.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044524; ENSMUSP00000047186; ENSMUSG00000039168.
GeneID223453.
KEGGmmu:223453.
UCSCuc007vkc.2. mouse.

Organism-specific databases

CTD1611.
MGIMGI:1918190. Dap.

Phylogenomic databases

eggNOGNOG84666.
GeneTreeENSGT00510000049345.
HOGENOMHOG000039719.
HOVERGENHBG005451.
InParanoidQ91XC8.
OMAVEKLPHP.
OrthoDBEOG757D0J.
PhylomeDBQ91XC8.
TreeFamTF329716.

Gene expression databases

ArrayExpressQ91XC8.
BgeeQ91XC8.
CleanExMM_DAP.
GenevestigatorQ91XC8.

Family and domain databases

InterProIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERPTHR13177. PTHR13177. 1 hit.
ProtoNetSearch...

Other

ChiTaRSDAP. mouse.
NextBio376722.
PROQ91XC8.
SOURCESearch...

Entry information

Entry nameDAP1_MOUSE
AccessionPrimary (citable) accession number: Q91XC8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot