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Protein

Kelch domain-containing protein 8A

Gene

Klhdc8a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 8A
Gene namesi
Name:Klhdc8a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2442630. Klhdc8a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Kelch domain-containing protein 8APRO_0000229002Add
BLAST

Proteomic databases

MaxQBiQ91XA8.
PaxDbiQ91XA8.
PRIDEiQ91XA8.

PTM databases

iPTMnetiQ91XA8.
PhosphoSiteiQ91XA8.

Expressioni

Gene expression databases

BgeeiQ91XA8.
CleanExiMM_KLHDC8A.
GenevisibleiQ91XA8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038297.

Structurei

3D structure databases

ProteinModelPortaliQ91XA8.
SMRiQ91XA8. Positions 10-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 3131Kelch 1Add
BLAST
Repeati32 – 7948Kelch 2Add
BLAST
Repeati81 – 12747Kelch 3Add
BLAST
Repeati128 – 17548Kelch 4Add
BLAST
Repeati176 – 22247Kelch 5Add
BLAST
Repeati224 – 27855Kelch 6Add
BLAST
Repeati279 – 32648Kelch 7Add
BLAST

Sequence similaritiesi

Contains 7 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000065733.
HOVERGENiHBG055245.
InParanoidiQ91XA8.
OMAiPMPTPRH.
OrthoDBiEOG7W41C3.
PhylomeDBiQ91XA8.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
InterProiIPR015916. Gal_Oxidase_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00612. Kelch. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVPNVKDFQ WKRLAPLPSR RVYCSLLETG GQVYAIGGCD DNGVPMDCFE
60 70 80 90 100
VYSPEADQWT SLPSLPTARA GVAITALGKR IMVIGGVGTN QLPVKVVEMY
110 120 130 140 150
NIDEGKWKKR SVLREAAMGI SVTAKDYRVY AAGGMGLDLR PHNYLQHYDM
160 170 180 190 200
LKDMWVSLAP MPTPRYAATS FLRGSKIYVL GGRQSKYAVN AFEVFDIESR
210 220 230 240 250
SWTKFPNIPC KRAFSSFVTL DNHLYSLGGL RQGRLYRQPK FLRTMDVFDM
260 270 280 290 300
EQGGWLKMER SFFLKKRRAD FVAGGLSGRV IVAGGLGNQP TVLETAEAFH
310 320 330 340 350
PEKNKWEALP PMPTPRCACS SIVFKNCLLA VGGVSQGLSD AVEALFVSDS
Length:350
Mass (Da):38,817
Last modified:December 1, 2001 - v1
Checksum:i92F1BC7C9870C261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044318 mRNA. Translation: BAC31864.1.
AK080356 mRNA. Translation: BAC37888.1.
BC011135 mRNA. Translation: AAH11135.1.
CCDSiCCDS35706.1.
RefSeqiNP_659059.1. NM_144810.5.
XP_006529417.1. XM_006529354.2.
UniGeneiMm.39723.

Genome annotation databases

EnsembliENSMUST00000046071; ENSMUSP00000038297; ENSMUSG00000042115.
GeneIDi213417.
KEGGimmu:213417.
UCSCiuc007con.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044318 mRNA. Translation: BAC31864.1.
AK080356 mRNA. Translation: BAC37888.1.
BC011135 mRNA. Translation: AAH11135.1.
CCDSiCCDS35706.1.
RefSeqiNP_659059.1. NM_144810.5.
XP_006529417.1. XM_006529354.2.
UniGeneiMm.39723.

3D structure databases

ProteinModelPortaliQ91XA8.
SMRiQ91XA8. Positions 10-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038297.

PTM databases

iPTMnetiQ91XA8.
PhosphoSiteiQ91XA8.

Proteomic databases

MaxQBiQ91XA8.
PaxDbiQ91XA8.
PRIDEiQ91XA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046071; ENSMUSP00000038297; ENSMUSG00000042115.
GeneIDi213417.
KEGGimmu:213417.
UCSCiuc007con.1. mouse.

Organism-specific databases

CTDi55220.
MGIiMGI:2442630. Klhdc8a.

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00760000119153.
HOGENOMiHOG000065733.
HOVERGENiHBG055245.
InParanoidiQ91XA8.
OMAiPMPTPRH.
OrthoDBiEOG7W41C3.
PhylomeDBiQ91XA8.

Miscellaneous databases

PROiQ91XA8.
SOURCEiSearch...

Gene expression databases

BgeeiQ91XA8.
CleanExiMM_KLHDC8A.
GenevisibleiQ91XA8. MM.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
InterProiIPR015916. Gal_Oxidase_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00612. Kelch. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiKLD8A_MOUSE
AccessioniPrimary (citable) accession number: Q91XA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.