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Q91XA2

- GOLM1_MOUSE

UniProt

Q91XA2 - GOLM1_MOUSE

Protein

Golgi membrane protein 1

Gene

Golm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Unknown. Cellular response protein to viral infection By similarity.By similarity

    GO - Biological processi

    1. nucleus organization Source: MGI
    2. regulation of lipid metabolic process Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi membrane protein 1
    Alternative name(s):
    Golgi membrane protein GP73
    Golgi phosphoprotein 2
    Gene namesi
    Name:Golm1
    Synonyms:Golph2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1917329. Golm1.

    Subcellular locationi

    Golgi apparatuscis-Golgi network membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption By similarity.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Golgi membrane protein 1PRO_0000087553Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi108 – 1081N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi109 – 1091N-linked (GlcNAc...)1 Publication
    Glycosylationi144 – 1441N-linked (GlcNAc...)1 Publication
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ91XA2.
    PaxDbiQ91XA2.
    PRIDEiQ91XA2.

    PTM databases

    PhosphoSiteiQ91XA2.

    Expressioni

    Inductioni

    Up-regulated in response to viral infection.By similarity

    Gene expression databases

    CleanExiMM_GOLM1.
    GenevestigatoriQ91XA2.

    Interactioni

    Subunit structurei

    Interacts with DYM.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini36 – 393358LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3523Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili40 – 183144Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GOLM1/CASC4 family.Curated

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39658.
    GeneTreeiENSGT00530000063675.
    HOGENOMiHOG000065682.
    HOVERGENiHBG062332.
    InParanoidiQ91XA2.
    OMAiKFSYDLN.
    OrthoDBiEOG7992QP.
    TreeFamiTF331127.

    Family and domain databases

    InterProiIPR026143. GOLM1.
    IPR026139. GOLM1/CASC4.
    [Graphical view]
    PANTHERiPTHR15896. PTHR15896. 1 hit.
    PTHR15896:SF8. PTHR15896:SF8. 1 hit.
    PRINTSiPR02084. GOLM1CASC4.

    Sequencei

    Sequence statusi: Complete.

    Q91XA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMGLGNGRRS MKSPPLILAA LVACVIVLGF NYWIASSRSV ELQTRIVELE    50
    GRVRRAAAER GAVELKKNEF QGELQKQREQ LDRIQSSHSF QLENVNKLHQ 100
    DEKAVLVNNI TTGEKLIRDL QDQLKALQRS YSSLQQDIFQ FQKNQTSLEK 150
    KFSYDLNQCI SQMTEVKEQC DERIEEVIRK RNEAPGSRDL AETNNQHQQA 200
    LKPQPKLQEE VPSEEQMPQE KGDVPRNKSQ IPAPNSESLG LKPQVQNEET 250
    NEIQAVGEEH QQASIQGQAV ADGTRVGAEK LDQHTQLPAG LLARPEEDSQ 300
    YPEREQLVIR DRQEQQRASE EGGGQKNPGD EYDMDENEAE SEREKQAALA 350
    GNDRNINVLN ADAQKRGIIN VPVGSERQSH ILNQVGIHIP QQA 393
    Length:393
    Mass (Da):44,326
    Last modified:October 3, 2012 - v2
    Checksum:iB19881050CC5AD55
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti319 – 3191S → A in AAH11152. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC134869 Genomic DNA. No translation available.
    CH466546 Genomic DNA. Translation: EDL41283.1.
    CH466546 Genomic DNA. Translation: EDL41284.1.
    BC011152 mRNA. Translation: AAH11152.1.
    CCDSiCCDS26576.1.
    RefSeqiNP_001030294.1. NM_001035122.2.
    NP_081583.3. NM_027307.4.
    UniGeneiMm.171335.

    Genome annotation databases

    EnsembliENSMUST00000022039; ENSMUSP00000022039; ENSMUSG00000021556.
    ENSMUST00000095739; ENSMUSP00000093410; ENSMUSG00000021556.
    GeneIDi105348.
    KEGGimmu:105348.
    UCSCiuc007quw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC134869 Genomic DNA. No translation available.
    CH466546 Genomic DNA. Translation: EDL41283.1 .
    CH466546 Genomic DNA. Translation: EDL41284.1 .
    BC011152 mRNA. Translation: AAH11152.1 .
    CCDSi CCDS26576.1.
    RefSeqi NP_001030294.1. NM_001035122.2.
    NP_081583.3. NM_027307.4.
    UniGenei Mm.171335.

    3D structure databases

    ProteinModelPortali Q91XA2.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91XA2.

    Proteomic databases

    MaxQBi Q91XA2.
    PaxDbi Q91XA2.
    PRIDEi Q91XA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022039 ; ENSMUSP00000022039 ; ENSMUSG00000021556 .
    ENSMUST00000095739 ; ENSMUSP00000093410 ; ENSMUSG00000021556 .
    GeneIDi 105348.
    KEGGi mmu:105348.
    UCSCi uc007quw.1. mouse.

    Organism-specific databases

    CTDi 51280.
    MGIi MGI:1917329. Golm1.

    Phylogenomic databases

    eggNOGi NOG39658.
    GeneTreei ENSGT00530000063675.
    HOGENOMi HOG000065682.
    HOVERGENi HBG062332.
    InParanoidi Q91XA2.
    OMAi KFSYDLN.
    OrthoDBi EOG7992QP.
    TreeFami TF331127.

    Miscellaneous databases

    NextBioi 357610.
    PROi Q91XA2.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GOLM1.
    Genevestigatori Q91XA2.

    Family and domain databases

    InterProi IPR026143. GOLM1.
    IPR026139. GOLM1/CASC4.
    [Graphical view ]
    PANTHERi PTHR15896. PTHR15896. 1 hit.
    PTHR15896:SF8. PTHR15896:SF8. 1 hit.
    PRINTSi PR02084. GOLM1CASC4.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-108; ASN-109 AND ASN-144.

    Entry informationi

    Entry nameiGOLM1_MOUSE
    AccessioniPrimary (citable) accession number: Q91XA2
    Secondary accession number(s): G3X8U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-2 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3