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Q91XA2

- GOLM1_MOUSE

UniProt

Q91XA2 - GOLM1_MOUSE

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Protein

Golgi membrane protein 1

Gene

Golm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Unknown. Cellular response protein to viral infection (By similarity).By similarity

GO - Biological processi

  1. nucleus organization Source: MGI
  2. regulation of lipid metabolic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi membrane protein 1
Alternative name(s):
Golgi membrane protein GP73
Golgi phosphoprotein 2
Gene namesi
Name:Golm1
Synonyms:Golph2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1917329. Golm1.

Subcellular locationi

Golgi apparatuscis-Golgi network membrane By similarity; Single-pass type II membrane protein By similarity
Note: Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption (By similarity).By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. Golgi apparatus Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Golgi membrane protein 1PRO_0000087553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...); atypical1 Publication
Glycosylationi109 – 1091N-linked (GlcNAc...)1 Publication
Glycosylationi144 – 1441N-linked (GlcNAc...)1 Publication
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ91XA2.
PaxDbiQ91XA2.
PRIDEiQ91XA2.

PTM databases

PhosphoSiteiQ91XA2.

Expressioni

Inductioni

Up-regulated in response to viral infection.By similarity

Gene expression databases

CleanExiMM_GOLM1.
GenevestigatoriQ91XA2.

Interactioni

Subunit structurei

Interacts with DYM.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91XA2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini36 – 393358LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3523Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 183144Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the GOLM1/CASC4 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39658.
GeneTreeiENSGT00530000063675.
HOGENOMiHOG000065682.
HOVERGENiHBG062332.
InParanoidiQ91XA2.
OMAiKFSYDLN.
OrthoDBiEOG7992QP.
TreeFamiTF331127.

Family and domain databases

InterProiIPR026143. GOLM1.
IPR026139. GOLM1/CASC4.
[Graphical view]
PANTHERiPTHR15896. PTHR15896. 1 hit.
PTHR15896:SF8. PTHR15896:SF8. 1 hit.
PRINTSiPR02084. GOLM1CASC4.

Sequencei

Sequence statusi: Complete.

Q91XA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMGLGNGRRS MKSPPLILAA LVACVIVLGF NYWIASSRSV ELQTRIVELE
60 70 80 90 100
GRVRRAAAER GAVELKKNEF QGELQKQREQ LDRIQSSHSF QLENVNKLHQ
110 120 130 140 150
DEKAVLVNNI TTGEKLIRDL QDQLKALQRS YSSLQQDIFQ FQKNQTSLEK
160 170 180 190 200
KFSYDLNQCI SQMTEVKEQC DERIEEVIRK RNEAPGSRDL AETNNQHQQA
210 220 230 240 250
LKPQPKLQEE VPSEEQMPQE KGDVPRNKSQ IPAPNSESLG LKPQVQNEET
260 270 280 290 300
NEIQAVGEEH QQASIQGQAV ADGTRVGAEK LDQHTQLPAG LLARPEEDSQ
310 320 330 340 350
YPEREQLVIR DRQEQQRASE EGGGQKNPGD EYDMDENEAE SEREKQAALA
360 370 380 390
GNDRNINVLN ADAQKRGIIN VPVGSERQSH ILNQVGIHIP QQA
Length:393
Mass (Da):44,326
Last modified:October 3, 2012 - v2
Checksum:iB19881050CC5AD55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti319 – 3191S → A in AAH11152. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC134869 Genomic DNA. No translation available.
CH466546 Genomic DNA. Translation: EDL41283.1.
CH466546 Genomic DNA. Translation: EDL41284.1.
BC011152 mRNA. Translation: AAH11152.1.
CCDSiCCDS26576.1.
RefSeqiNP_001030294.1. NM_001035122.2.
NP_081583.3. NM_027307.4.
UniGeneiMm.171335.

Genome annotation databases

EnsembliENSMUST00000022039; ENSMUSP00000022039; ENSMUSG00000021556.
ENSMUST00000095739; ENSMUSP00000093410; ENSMUSG00000021556.
GeneIDi105348.
KEGGimmu:105348.
UCSCiuc007quw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC134869 Genomic DNA. No translation available.
CH466546 Genomic DNA. Translation: EDL41283.1 .
CH466546 Genomic DNA. Translation: EDL41284.1 .
BC011152 mRNA. Translation: AAH11152.1 .
CCDSi CCDS26576.1.
RefSeqi NP_001030294.1. NM_001035122.2.
NP_081583.3. NM_027307.4.
UniGenei Mm.171335.

3D structure databases

ProteinModelPortali Q91XA2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91XA2.

Proteomic databases

MaxQBi Q91XA2.
PaxDbi Q91XA2.
PRIDEi Q91XA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022039 ; ENSMUSP00000022039 ; ENSMUSG00000021556 .
ENSMUST00000095739 ; ENSMUSP00000093410 ; ENSMUSG00000021556 .
GeneIDi 105348.
KEGGi mmu:105348.
UCSCi uc007quw.1. mouse.

Organism-specific databases

CTDi 51280.
MGIi MGI:1917329. Golm1.

Phylogenomic databases

eggNOGi NOG39658.
GeneTreei ENSGT00530000063675.
HOGENOMi HOG000065682.
HOVERGENi HBG062332.
InParanoidi Q91XA2.
OMAi KFSYDLN.
OrthoDBi EOG7992QP.
TreeFami TF331127.

Miscellaneous databases

NextBioi 357610.
PROi Q91XA2.
SOURCEi Search...

Gene expression databases

CleanExi MM_GOLM1.
Genevestigatori Q91XA2.

Family and domain databases

InterProi IPR026143. GOLM1.
IPR026139. GOLM1/CASC4.
[Graphical view ]
PANTHERi PTHR15896. PTHR15896. 1 hit.
PTHR15896:SF8. PTHR15896:SF8. 1 hit.
PRINTSi PR02084. GOLM1CASC4.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-108; ASN-109 AND ASN-144.

Entry informationi

Entry nameiGOLM1_MOUSE
AccessioniPrimary (citable) accession number: Q91XA2
Secondary accession number(s): G3X8U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3