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Protein

Neurocalcin-delta

Gene

Ncald

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi157 – 168123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • calcium-mediated signaling Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocalcin-delta
Gene namesi
Name:Ncald
Synonyms:D15Ertd412e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1196326. Ncald.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 193192Neurocalcin-deltaPRO_0000073783Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ91X97.
MaxQBiQ91X97.
PaxDbiQ91X97.
PRIDEiQ91X97.

PTM databases

iPTMnetiQ91X97.
PhosphoSiteiQ91X97.

Expressioni

Gene expression databases

BgeeiQ91X97.
CleanExiMM_NCALD.
ExpressionAtlasiQ91X97. baseline and differential.
GenevisibleiQ91X97. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91X97. 3 interactions.
MINTiMINT-4103174.
STRINGi10090.ENSMUSP00000087611.

Structurei

3D structure databases

ProteinModelPortaliQ91X97.
SMRiQ91X97. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 5836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 17936EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiQ91X97.
KOiK19695.
OMAiQCDPSAQ.
OrthoDBiEOG7GJ6F3.
PhylomeDBiQ91X97.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91X97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK
60 70 80 90 100
IYGNFFPYGD ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK
110 120 130 140 150
LKWAFSMYDL DGNGYISKAE MLEIVQAIYK MVSSVMKMPE DESTPEKRTE
160 170 180 190
KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA GQF
Length:193
Mass (Da):22,245
Last modified:January 23, 2007 - v4
Checksum:i20DD8B6FF47C4CBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511K → N in AAH11162 (PubMed:15489334).Curated
Sequence conflicti186 – 1861D → N in BAC28553 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034031 mRNA. Translation: BAC28553.1.
AK048440 mRNA. Translation: BAC33338.1.
AK167313 mRNA. Translation: BAE39416.1.
BC011162 mRNA. Translation: AAH11162.1.
BC026979 mRNA. Translation: AAH26979.1.
CCDSiCCDS27435.1.
RefSeqiNP_001164337.1. NM_001170866.1.
NP_001164338.1. NM_001170867.1.
NP_001164339.1. NM_001170868.1.
NP_598855.2. NM_134094.4.
XP_006520170.1. XM_006520107.2.
XP_006520171.1. XM_006520108.1.
XP_006520172.1. XM_006520109.1.
XP_006520174.1. XM_006520111.2.
XP_006520175.1. XM_006520112.2.
XP_006520176.1. XM_006520113.2.
XP_011243664.1. XM_011245362.1.
XP_011243665.1. XM_011245363.1.
XP_011243666.1. XM_011245364.1.
XP_011243667.1. XM_011245365.1.
XP_011243668.1. XM_011245366.1.
UniGeneiMm.283370.

Genome annotation databases

EnsembliENSMUST00000090150; ENSMUSP00000087611; ENSMUSG00000051359.
ENSMUST00000116445; ENSMUSP00000112146; ENSMUSG00000051359.
ENSMUST00000119730; ENSMUSP00000113858; ENSMUSG00000051359.
ENSMUST00000120746; ENSMUSP00000112898; ENSMUSG00000051359.
ENSMUST00000168992; ENSMUSP00000130126; ENSMUSG00000051359.
GeneIDi52589.
KEGGimmu:52589.
UCSCiuc007vng.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034031 mRNA. Translation: BAC28553.1.
AK048440 mRNA. Translation: BAC33338.1.
AK167313 mRNA. Translation: BAE39416.1.
BC011162 mRNA. Translation: AAH11162.1.
BC026979 mRNA. Translation: AAH26979.1.
CCDSiCCDS27435.1.
RefSeqiNP_001164337.1. NM_001170866.1.
NP_001164338.1. NM_001170867.1.
NP_001164339.1. NM_001170868.1.
NP_598855.2. NM_134094.4.
XP_006520170.1. XM_006520107.2.
XP_006520171.1. XM_006520108.1.
XP_006520172.1. XM_006520109.1.
XP_006520174.1. XM_006520111.2.
XP_006520175.1. XM_006520112.2.
XP_006520176.1. XM_006520113.2.
XP_011243664.1. XM_011245362.1.
XP_011243665.1. XM_011245363.1.
XP_011243666.1. XM_011245364.1.
XP_011243667.1. XM_011245365.1.
XP_011243668.1. XM_011245366.1.
UniGeneiMm.283370.

3D structure databases

ProteinModelPortaliQ91X97.
SMRiQ91X97. Positions 5-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91X97. 3 interactions.
MINTiMINT-4103174.
STRINGi10090.ENSMUSP00000087611.

PTM databases

iPTMnetiQ91X97.
PhosphoSiteiQ91X97.

Proteomic databases

EPDiQ91X97.
MaxQBiQ91X97.
PaxDbiQ91X97.
PRIDEiQ91X97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090150; ENSMUSP00000087611; ENSMUSG00000051359.
ENSMUST00000116445; ENSMUSP00000112146; ENSMUSG00000051359.
ENSMUST00000119730; ENSMUSP00000113858; ENSMUSG00000051359.
ENSMUST00000120746; ENSMUSP00000112898; ENSMUSG00000051359.
ENSMUST00000168992; ENSMUSP00000130126; ENSMUSG00000051359.
GeneIDi52589.
KEGGimmu:52589.
UCSCiuc007vng.2. mouse.

Organism-specific databases

CTDi83988.
MGIiMGI:1196326. Ncald.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiQ91X97.
KOiK19695.
OMAiQCDPSAQ.
OrthoDBiEOG7GJ6F3.
PhylomeDBiQ91X97.
TreeFamiTF300009.

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

ChiTaRSiNcald. mouse.
NextBioi309183.
PROiQ91X97.
SOURCEiSearch...

Gene expression databases

BgeeiQ91X97.
CleanExiMM_NCALD.
ExpressionAtlasiQ91X97. baseline and differential.
GenevisibleiQ91X97. MM.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon, Head and Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Salivary gland.
  3. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 51-63, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver and Lung.

Entry informationi

Entry nameiNCALD_MOUSE
AccessioniPrimary (citable) accession number: Q91X97
Secondary accession number(s): Q3TJS9, Q8BZN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.