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Protein

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene

Qprt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the catabolism of quinolinic acid (QA).By similarity

Catalytic activityi

Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Qprt)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateBy similarity1
Binding sitei161SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Binding sitei201SubstrateBy similarity1
Binding sitei222SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-196807 Nicotinate metabolism
UniPathwayiUPA00253; UER00331

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]
Short name:
QAPRTase
Short name:
QPRTase
Gene namesi
Name:Qprt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914625 Qprt

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559551 – 299Nicotinate-nucleotide pyrophosphorylase [carboxylating]Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei291PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X91
PaxDbiQ91X91
PeptideAtlasiQ91X91
PRIDEiQ91X91

PTM databases

iPTMnetiQ91X91
PhosphoSitePlusiQ91X91
SwissPalmiQ91X91

Expressioni

Gene expression databases

BgeeiENSMUSG00000030674
CleanExiMM_QPRT
GenevisibleiQ91X91 MM

Interactioni

Subunit structurei

Hexamer formed by 3 homodimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91X91, 5 interactors
MINTiQ91X91
STRINGi10090.ENSMUSP00000032912

Structurei

3D structure databases

ProteinModelPortaliQ91X91
SMRiQ91X91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 139Substrate bindingBy similarity3
Regioni248 – 250Substrate bindingBy similarity3
Regioni269 – 271Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the NadC/ModD family.Curated

Phylogenomic databases

eggNOGiKOG3008 Eukaryota
COG0157 LUCA
GeneTreeiENSGT00390000002761
HOGENOMiHOG000224023
HOVERGENiHBG031727
InParanoidiQ91X91
KOiK00767
OMAiVIMLDNM
OrthoDBiEOG091G10SF
PhylomeDBiQ91X91
TreeFamiTF300845

Family and domain databases

CDDicd01572 QPRTase, 1 hit
Gene3Di3.20.20.70, 1 hit
3.90.1170.20, 2 hits
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR004393 NadC
IPR027277 NadC/ModD
IPR036068 Nicotinate_pribotase_like_C
IPR037128 Quinolinate_PRibosylTase_N_sf
IPR002638 Quinolinate_PRibosylTrfase_C
IPR022412 Quinolinate_PRibosylTrfase_N
PANTHERiPTHR32179 PTHR32179, 1 hit
PfamiView protein in Pfam
PF01729 QRPTase_C, 1 hit
PF02749 QRPTase_N, 1 hit
PIRSFiPIRSF006250 NadC_ModD, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR00078 nadC, 1 hit

Sequencei

Sequence statusi: Complete.

Q91X91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEGLQLLL PPTTLAALAN SWLQEDCPGL NFASLVTGSA PSQAVLWAKS
60 70 80 90 100
PGVLAGRPFF DAIFTQLNCQ VSWFLPEGSK LVPVVKVAEV KGPAHHLLLG
110 120 130 140 150
ERVALNTLAR CSGIASAAAT AVEVARSTGW TGHVAGTRKT TPGFRLVEKY
160 170 180 190 200
GLQVGGAACH RYDLGGMVMV KDNHVVAAGS MERAVLKARQ AAGFSLKVEV
210 220 230 240 250
ECSSLEEAFR AAEAGADLVM LDNFKPEELH PTAATLKARF PSVSVEASGG
260 270 280 290
VTLDNLTQFC GTHIDVISLG MLTQAAPALD FSLKLFAEGD TPVPHARRF
Length:299
Mass (Da):31,530
Last modified:December 1, 2001 - v1
Checksum:i4CF7FD0E6E290AAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011191 mRNA Translation: AAH11191.1
CCDSiCCDS40138.1
RefSeqiNP_598447.1, NM_133686.1
UniGeneiMm.26928

Genome annotation databases

EnsembliENSMUST00000032912; ENSMUSP00000032912; ENSMUSG00000030674
GeneIDi67375
KEGGimmu:67375
UCSCiuc009jug.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNADC_MOUSE
AccessioniPrimary (citable) accession number: Q91X91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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