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Protein

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Gene

Qprt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the catabolism of quinolinic acid (QA).By similarity

Catalytic activityi

Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Qprt)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateBy similarity1
Binding sitei161SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Binding sitei201SubstrateBy similarity1
Binding sitei222SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-196807. Nicotinate metabolism.
UniPathwayiUPA00253; UER00331.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)
Alternative name(s):
Quinolinate phosphoribosyltransferase [decarboxylating]
Short name:
QAPRTase
Short name:
QPRTase
Gene namesi
Name:Qprt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914625. Qprt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559551 – 299Nicotinate-nucleotide pyrophosphorylase [carboxylating]Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei291PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X91.
PaxDbiQ91X91.
PeptideAtlasiQ91X91.
PRIDEiQ91X91.

PTM databases

iPTMnetiQ91X91.
PhosphoSitePlusiQ91X91.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030674.
CleanExiMM_QPRT.
GenevisibleiQ91X91. MM.

Interactioni

Subunit structurei

Hexamer formed by 3 homodimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91X91. 5 interactors.
MINTiMINT-1855546.
STRINGi10090.ENSMUSP00000032912.

Structurei

3D structure databases

ProteinModelPortaliQ91X91.
SMRiQ91X91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 139Substrate bindingBy similarity3
Regioni248 – 250Substrate bindingBy similarity3
Regioni269 – 271Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the NadC/ModD family.Curated

Phylogenomic databases

eggNOGiKOG3008. Eukaryota.
COG0157. LUCA.
GeneTreeiENSGT00390000002761.
HOGENOMiHOG000224023.
HOVERGENiHBG031727.
InParanoidiQ91X91.
KOiK00767.
OMAiDMIMLKD.
OrthoDBiEOG091G10SF.
PhylomeDBiQ91X91.
TreeFamiTF300845.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamiPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006250. NadC_ModD. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR00078. nadC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91X91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEGLQLLL PPTTLAALAN SWLQEDCPGL NFASLVTGSA PSQAVLWAKS
60 70 80 90 100
PGVLAGRPFF DAIFTQLNCQ VSWFLPEGSK LVPVVKVAEV KGPAHHLLLG
110 120 130 140 150
ERVALNTLAR CSGIASAAAT AVEVARSTGW TGHVAGTRKT TPGFRLVEKY
160 170 180 190 200
GLQVGGAACH RYDLGGMVMV KDNHVVAAGS MERAVLKARQ AAGFSLKVEV
210 220 230 240 250
ECSSLEEAFR AAEAGADLVM LDNFKPEELH PTAATLKARF PSVSVEASGG
260 270 280 290
VTLDNLTQFC GTHIDVISLG MLTQAAPALD FSLKLFAEGD TPVPHARRF
Length:299
Mass (Da):31,530
Last modified:December 1, 2001 - v1
Checksum:i4CF7FD0E6E290AAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011191 mRNA. Translation: AAH11191.1.
CCDSiCCDS40138.1.
RefSeqiNP_598447.1. NM_133686.1.
UniGeneiMm.26928.

Genome annotation databases

EnsembliENSMUST00000032912; ENSMUSP00000032912; ENSMUSG00000030674.
GeneIDi67375.
KEGGimmu:67375.
UCSCiuc009jug.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011191 mRNA. Translation: AAH11191.1.
CCDSiCCDS40138.1.
RefSeqiNP_598447.1. NM_133686.1.
UniGeneiMm.26928.

3D structure databases

ProteinModelPortaliQ91X91.
SMRiQ91X91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91X91. 5 interactors.
MINTiMINT-1855546.
STRINGi10090.ENSMUSP00000032912.

PTM databases

iPTMnetiQ91X91.
PhosphoSitePlusiQ91X91.

Proteomic databases

MaxQBiQ91X91.
PaxDbiQ91X91.
PeptideAtlasiQ91X91.
PRIDEiQ91X91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032912; ENSMUSP00000032912; ENSMUSG00000030674.
GeneIDi67375.
KEGGimmu:67375.
UCSCiuc009jug.1. mouse.

Organism-specific databases

CTDi23475.
MGIiMGI:1914625. Qprt.

Phylogenomic databases

eggNOGiKOG3008. Eukaryota.
COG0157. LUCA.
GeneTreeiENSGT00390000002761.
HOGENOMiHOG000224023.
HOVERGENiHBG031727.
InParanoidiQ91X91.
KOiK00767.
OMAiDMIMLKD.
OrthoDBiEOG091G10SF.
PhylomeDBiQ91X91.
TreeFamiTF300845.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00331.
ReactomeiR-MMU-196807. Nicotinate metabolism.

Miscellaneous databases

PROiQ91X91.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030674.
CleanExiMM_QPRT.
GenevisibleiQ91X91. MM.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.90.1170.20. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR004393. NadC.
IPR027277. NadC/ModD.
IPR002638. Quinolinate_PRibosylTrfase_C.
IPR022412. Quinolinate_PRibosylTrfase_N.
[Graphical view]
PfamiPF01729. QRPTase_C. 1 hit.
PF02749. QRPTase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006250. NadC_ModD. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR00078. nadC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADC_MOUSE
AccessioniPrimary (citable) accession number: Q91X91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.