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Protein

Feline leukemia virus subgroup C receptor-related protein 2

Gene

Flvcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Feline leukemia virus subgroup C receptor-related protein 2
Alternative name(s):
Calcium-chelate transporter
Short name:
CCT
Gene namesi
Name:Flvcr2
Synonyms:Mfsd7c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384974. Mfsd7c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence analysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei401 – 42121HelicalSequence analysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence analysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence analysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Feline leukemia virus subgroup C receptor-related protein 2PRO_0000084847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei541 – 5411PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X85.
PaxDbiQ91X85.
PRIDEiQ91X85.

PTM databases

iPTMnetiQ91X85.
PhosphoSiteiQ91X85.

Expressioni

Tissue specificityi

Found in the kidney and in cells implicated in rapid calcium exchange, namely the CNS, the eye, cardiomyocytes and placenta in late term.

Developmental stagei

Found in fetal chondrocytes and osteoclasts.

Gene expression databases

BgeeiQ91X85.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035569.

Structurei

3D structure databases

ProteinModelPortaliQ91X85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 3661
Repeati37 – 4262
Repeati43 – 4863
Repeati49 – 5464
Repeati55 – 6065
Repeati61 – 6666
Repeati67 – 7267
Repeati73 – 7868

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni31 – 78488 X 6 AA tandem repeats of P-S-[VSG]-S-[VIAG]-[HDRL]Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi530 – 5367Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
HOGENOMiHOG000019717.
HOVERGENiHBG051631.
InParanoidiQ91X85.
KOiK08220.
OrthoDBiEOG7KQ21D.
PhylomeDBiQ91X85.
TreeFamiTF314292.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91X85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNESLNQEE SNDRPAPESE FQMDTSYSTQ PSGSIHPSVS GHPSVSGHPS
60 70 80 90 100
VSGHPSVSIH PSVSIDPSVS VRPSSSALPS TLAQPSGLTH HSSLVREDSV
110 120 130 140 150
IKVSKRRWVV VLVFSCYSLC NAFQWIQYGS INNIFMNFYG VSAFAIDWLS
160 170 180 190 200
MCYMLTYIPL LLPVAWMLEK FGLRTIAITG SALNCLGAWV KLGSLEPHLF
210 220 230 240 250
PVTMVGQVIC SVAQVFILGM PSRIASVWFG ADEVSTACSV AVFGNQLGIA
260 270 280 290 300
IGFLVPPVLV PNIKDPEKLA YHISIMFYII GGVATFLFIL VIIVFKEKPK
310 320 330 340 350
HPPSRAQSLS YALATTDASY LSSIVRLFKN LNFVLLVITY GLNAGAFYAL
360 370 380 390 400
STLLNRMVIL HFPGEEVNAG RIGLTIVIAG MFGAMISGIW LDKSKTYKET
410 420 430 440 450
TLVVYIMTLV GMVVYTFTLN LNHLWIVFIT AGTLGFFMTG YLPLGFEFAV
460 470 480 490 500
EFTYPESEGV SSGLLNVSAQ VFGIVFTISQ GQIIDNHGTM FGNIFLCVFL
510 520 530 540 550
ALGSALTAFI KSDLRRQRAN KDAPETKVQE EEEEEEGSNT SKVPVVSEAH

L
Length:551
Mass (Da):60,107
Last modified:April 13, 2004 - v2
Checksum:i968F46696EEAE416
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti426 – 4261I → V in AAH11209 (PubMed:15489334).Curated
Sequence conflicti452 – 4521F → L in AAH11209 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260574 mRNA. Translation: AAP86635.1.
AY260576 mRNA. Translation: AAP86637.1.
AY260575 mRNA. Translation: AAP86636.1.
BC011209 mRNA. Translation: AAH11209.1.
CCDSiCCDS26062.1.
RefSeqiNP_663422.1. NM_145447.2.
UniGeneiMm.301076.

Genome annotation databases

GeneIDi217721.
KEGGimmu:217721.
UCSCiuc007ohe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260574 mRNA. Translation: AAP86635.1.
AY260576 mRNA. Translation: AAP86637.1.
AY260575 mRNA. Translation: AAP86636.1.
BC011209 mRNA. Translation: AAH11209.1.
CCDSiCCDS26062.1.
RefSeqiNP_663422.1. NM_145447.2.
UniGeneiMm.301076.

3D structure databases

ProteinModelPortaliQ91X85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035569.

PTM databases

iPTMnetiQ91X85.
PhosphoSiteiQ91X85.

Proteomic databases

MaxQBiQ91X85.
PaxDbiQ91X85.
PRIDEiQ91X85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi217721.
KEGGimmu:217721.
UCSCiuc007ohe.1. mouse.

Organism-specific databases

CTDi217721.
MGIiMGI:2384974. Mfsd7c.

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
HOGENOMiHOG000019717.
HOVERGENiHBG051631.
InParanoidiQ91X85.
KOiK08220.
OrthoDBiEOG7KQ21D.
PhylomeDBiQ91X85.
TreeFamiTF314292.

Miscellaneous databases

PROiQ91X85.
SOURCEiSearch...

Gene expression databases

BgeeiQ91X85.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis."
    Brasier G., Tikellis C., Xuereb L., Craigie J., Casley D., Kovacs C.S., Fudge N.J., Kalnins R., Cooper M.E., Wookey P.J.
    Exp. Cell Res. 293:31-42(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Testis.

Entry informationi

Entry nameiFLVC2_MOUSE
AccessioniPrimary (citable) accession number: Q91X85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.