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Protein

Feline leukemia virus subgroup C receptor-related protein 2

Gene

Flvcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Feline leukemia virus subgroup C receptor-related protein 2
Alternative name(s):
Calcium-chelate transporter
Short name:
CCT
Gene namesi
Name:Flvcr2
Synonyms:Mfsd7c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2384974. Mfsd7c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848471 – 551Feline leukemia virus subgroup C receptor-related protein 2Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei541PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X85.
PaxDbiQ91X85.
PRIDEiQ91X85.

PTM databases

iPTMnetiQ91X85.
PhosphoSitePlusiQ91X85.

Expressioni

Tissue specificityi

Found in the kidney and in cells implicated in rapid calcium exchange, namely the CNS, the eye, cardiomyocytes and placenta in late term.

Developmental stagei

Found in fetal chondrocytes and osteoclasts.

Gene expression databases

BgeeiENSMUSG00000034258.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035569.

Structurei

3D structure databases

ProteinModelPortaliQ91X85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 3616
Repeati37 – 4226
Repeati43 – 4836
Repeati49 – 5446
Repeati55 – 6056
Repeati61 – 6666
Repeati67 – 7276
Repeati73 – 7886

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 788 X 6 AA tandem repeats of P-S-[VSG]-S-[VIAG]-[HDRL]Add BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 536Poly-Glu7

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
HOGENOMiHOG000019717.
HOVERGENiHBG051631.
InParanoidiQ91X85.
KOiK08220.
PhylomeDBiQ91X85.
TreeFamiTF314292.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91X85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNESLNQEE SNDRPAPESE FQMDTSYSTQ PSGSIHPSVS GHPSVSGHPS
60 70 80 90 100
VSGHPSVSIH PSVSIDPSVS VRPSSSALPS TLAQPSGLTH HSSLVREDSV
110 120 130 140 150
IKVSKRRWVV VLVFSCYSLC NAFQWIQYGS INNIFMNFYG VSAFAIDWLS
160 170 180 190 200
MCYMLTYIPL LLPVAWMLEK FGLRTIAITG SALNCLGAWV KLGSLEPHLF
210 220 230 240 250
PVTMVGQVIC SVAQVFILGM PSRIASVWFG ADEVSTACSV AVFGNQLGIA
260 270 280 290 300
IGFLVPPVLV PNIKDPEKLA YHISIMFYII GGVATFLFIL VIIVFKEKPK
310 320 330 340 350
HPPSRAQSLS YALATTDASY LSSIVRLFKN LNFVLLVITY GLNAGAFYAL
360 370 380 390 400
STLLNRMVIL HFPGEEVNAG RIGLTIVIAG MFGAMISGIW LDKSKTYKET
410 420 430 440 450
TLVVYIMTLV GMVVYTFTLN LNHLWIVFIT AGTLGFFMTG YLPLGFEFAV
460 470 480 490 500
EFTYPESEGV SSGLLNVSAQ VFGIVFTISQ GQIIDNHGTM FGNIFLCVFL
510 520 530 540 550
ALGSALTAFI KSDLRRQRAN KDAPETKVQE EEEEEEGSNT SKVPVVSEAH

L
Length:551
Mass (Da):60,107
Last modified:April 13, 2004 - v2
Checksum:i968F46696EEAE416
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti426I → V in AAH11209 (PubMed:15489334).Curated1
Sequence conflicti452F → L in AAH11209 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260574 mRNA. Translation: AAP86635.1.
AY260576 mRNA. Translation: AAP86637.1.
AY260575 mRNA. Translation: AAP86636.1.
BC011209 mRNA. Translation: AAH11209.1.
CCDSiCCDS26062.1.
RefSeqiNP_663422.1. NM_145447.2.
UniGeneiMm.301076.

Genome annotation databases

GeneIDi217721.
KEGGimmu:217721.
UCSCiuc007ohe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY260574 mRNA. Translation: AAP86635.1.
AY260576 mRNA. Translation: AAP86637.1.
AY260575 mRNA. Translation: AAP86636.1.
BC011209 mRNA. Translation: AAH11209.1.
CCDSiCCDS26062.1.
RefSeqiNP_663422.1. NM_145447.2.
UniGeneiMm.301076.

3D structure databases

ProteinModelPortaliQ91X85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035569.

PTM databases

iPTMnetiQ91X85.
PhosphoSitePlusiQ91X85.

Proteomic databases

MaxQBiQ91X85.
PaxDbiQ91X85.
PRIDEiQ91X85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi217721.
KEGGimmu:217721.
UCSCiuc007ohe.1. mouse.

Organism-specific databases

CTDi217721.
MGIiMGI:2384974. Mfsd7c.

Phylogenomic databases

eggNOGiKOG2563. Eukaryota.
ENOG410XSTK. LUCA.
HOGENOMiHOG000019717.
HOVERGENiHBG051631.
InParanoidiQ91X85.
KOiK08220.
PhylomeDBiQ91X85.
TreeFamiTF314292.

Miscellaneous databases

PROiQ91X85.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034258.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLVC2_MOUSE
AccessioniPrimary (citable) accession number: Q91X85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.