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Q91X84

- CRTC3_MOUSE

UniProt

Q91X84 - CRTC3_MOUSE

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Protein

CREB-regulated transcription coactivator 3

Gene
Crtc3, Torc3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells By similarity.

GO - Molecular functioni

  1. cAMP response element binding protein binding Source: InterPro

GO - Biological processi

  1. energy homeostasis Source: MGI
  2. negative regulation of cAMP-mediated signaling Source: MGI
  3. negative regulation of lipid catabolic process Source: MGI
  4. positive regulation of CREB transcription factor activity Source: InterPro
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  6. protein homotetramerization Source: InterPro
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 3
Alternative name(s):
Transducer of regulated cAMP response element-binding protein 3
Short name:
TORC-3
Short name:
Transducer of CREB protein 3
Gene namesi
Name:Crtc3
Synonyms:Torc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1917711. Crtc3.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Appears to be mainly nuclear By similarity.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619CREB-regulated transcription coactivator 3PRO_0000318532Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Phosphoserine By similarity
Modified residuei62 – 621Phosphoserine By similarity
Modified residuei162 – 1621Phosphoserine; by SIK2 By similarity
Modified residuei329 – 3291Phosphoserine By similarity
Modified residuei370 – 3701Phosphoserine By similarity
Modified residuei391 – 3911Phosphoserine By similarity
Modified residuei443 – 4431Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91X84.
PRIDEiQ91X84.

PTM databases

PhosphoSiteiQ91X84.

Expressioni

Gene expression databases

BgeeiQ91X84.
CleanExiMM_CRTC3.
GenevestigatoriQ91X84.

Interactioni

Subunit structurei

Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113540.

Structurei

3D structure databases

ProteinModelPortaliQ91X84.
SMRiQ91X84. Positions 13-40.

Family & Domainsi

Sequence similaritiesi

Belongs to the TORC family.

Phylogenomic databases

eggNOGiNOG74259.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ91X84.
KOiK16334.
OMAiYMGFCDG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ91X84.
TreeFamiTF321571.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91X84-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL    50
QQLRLTQYHG GSLPNVSQLR NSAPEFQPSL HQADNVRGTR HHGLVERPAR 100
NRFHPLHRRS GDKPGRQFDG NAFAASYSSQ HLDESWPRQQ PPWKEEKHPG 150
FRLTSALNRT NSDSALHTSA LSTKPQDPYG GGGQSAWPAP YMGFCDGEND 200
GHAEVAAFPG PLKEENLLNV PKPLPKHLWE SKEIQSLSGR PRSCDVGGGN 250
AFPHNGQNTG LSPFLGTLNT GGSLPDLTNL HYSAPLPASL DTSDHLFGSM 300
SVGNSVGNLP AAMTHLGIRT SSGLQSSRSN PSIQATLSKM ALSSSLKCHP 350
QPSVANASAL HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE 400
AHQGFSRQLS ATSPLNPYPA SQMVTSEQSP LSFLPTDAQA QVSPPPPYPT 450
PQELPQPLLQ QPHAQEPPTQ QPQAAPSLPQ SDFQLLTAQG SALTSFFPDV 500
RFDQQPMRPS PAFPQQVPLV QQSHREPQDS FHLRPNPYSS CGSFPGTILT 550
EDTNSNLFKG LSGGLSGMPE VSLDMDTPFP LEEELQIEPL SLDGLNMLSD 600
SSMGLLDPSV EETFRADRL 619
Length:619
Mass (Da):67,027
Last modified:February 5, 2008 - v2
Checksum:iFBBE723F186CD60E
GO
Isoform 2 (identifier: Q91X84-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Note: No experimental confirmation available.

Show »
Length:320
Mass (Da):34,300
Checksum:iEED0509307E413DC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 299299Missing in isoform 2. VSP_031221Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK144840 mRNA. No translation available.
BC011210 mRNA. Translation: AAH11210.1.
CCDSiCCDS21398.2. [Q91X84-1]
RefSeqiNP_776288.2. NM_173863.2. [Q91X84-1]
XP_006541259.1. XM_006541196.1. [Q91X84-2]
UniGeneiMm.392175.

Genome annotation databases

EnsembliENSMUST00000122255; ENSMUSP00000113540; ENSMUSG00000030527. [Q91X84-1]
GeneIDi70461.
KEGGimmu:70461.
UCSCiuc009iaz.1. mouse. [Q91X84-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK144840 mRNA. No translation available.
BC011210 mRNA. Translation: AAH11210.1 .
CCDSi CCDS21398.2. [Q91X84-1 ]
RefSeqi NP_776288.2. NM_173863.2. [Q91X84-1 ]
XP_006541259.1. XM_006541196.1. [Q91X84-2 ]
UniGenei Mm.392175.

3D structure databases

ProteinModelPortali Q91X84.
SMRi Q91X84. Positions 13-40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000113540.

PTM databases

PhosphoSitei Q91X84.

Proteomic databases

PaxDbi Q91X84.
PRIDEi Q91X84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000122255 ; ENSMUSP00000113540 ; ENSMUSG00000030527 . [Q91X84-1 ]
GeneIDi 70461.
KEGGi mmu:70461.
UCSCi uc009iaz.1. mouse. [Q91X84-1 ]

Organism-specific databases

CTDi 64784.
MGIi MGI:1917711. Crtc3.

Phylogenomic databases

eggNOGi NOG74259.
GeneTreei ENSGT00390000010652.
HOGENOMi HOG000111980.
HOVERGENi HBG058314.
InParanoidi Q91X84.
KOi K16334.
OMAi YMGFCDG.
OrthoDBi EOG7MKW5P.
PhylomeDBi Q91X84.
TreeFami TF321571.

Miscellaneous databases

ChiTaRSi CRTC3. mouse.
NextBioi 331677.
PROi Q91X84.
SOURCEi Search...

Gene expression databases

Bgeei Q91X84.
CleanExi MM_CRTC3.
Genevestigatori Q91X84.

Family and domain databases

InterProi IPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view ]
PANTHERi PTHR13589. PTHR13589. 1 hit.
Pfami PF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiCRTC3_MOUSE
AccessioniPrimary (citable) accession number: Q91X84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi