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Q91X84

- CRTC3_MOUSE

UniProt

Q91X84 - CRTC3_MOUSE

Protein

CREB-regulated transcription coactivator 3

Gene

Crtc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells By similarity.By similarity

    GO - Molecular functioni

    1. cAMP response element binding protein binding Source: InterPro

    GO - Biological processi

    1. energy homeostasis Source: MGI
    2. negative regulation of cAMP-mediated signaling Source: MGI
    3. negative regulation of lipid catabolic process Source: MGI
    4. positive regulation of CREB transcription factor activity Source: InterPro
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    6. protein homotetramerization Source: InterPro
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CREB-regulated transcription coactivator 3
    Alternative name(s):
    Transducer of regulated cAMP response element-binding protein 3
    Short name:
    TORC-3
    Short name:
    Transducer of CREB protein 3
    Gene namesi
    Name:Crtc3
    Synonyms:Torc3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1917711. Crtc3.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Appears to be mainly nuclear.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619CREB-regulated transcription coactivator 3PRO_0000318532Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei4 – 41PhosphoserineBy similarity
    Modified residuei62 – 621PhosphoserineBy similarity
    Modified residuei162 – 1621Phosphoserine; by SIK2By similarity
    Modified residuei329 – 3291PhosphoserineBy similarity
    Modified residuei370 – 3701PhosphoserineBy similarity
    Modified residuei391 – 3911PhosphoserineBy similarity
    Modified residuei443 – 4431PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ91X84.
    PRIDEiQ91X84.

    PTM databases

    PhosphoSiteiQ91X84.

    Expressioni

    Gene expression databases

    BgeeiQ91X84.
    CleanExiMM_CRTC3.
    GenevestigatoriQ91X84.

    Interactioni

    Subunit structurei

    Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000113540.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91X84.
    SMRiQ91X84. Positions 13-40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TORC family.Curated

    Phylogenomic databases

    eggNOGiNOG74259.
    GeneTreeiENSGT00390000010652.
    HOGENOMiHOG000111980.
    HOVERGENiHBG058314.
    InParanoidiQ91X84.
    KOiK16334.
    OMAiYMGFCDG.
    OrthoDBiEOG7MKW5P.
    PhylomeDBiQ91X84.
    TreeFamiTF321571.

    Family and domain databases

    InterProiIPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view]
    PANTHERiPTHR13589. PTHR13589. 1 hit.
    PfamiPF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91X84-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL    50
    QQLRLTQYHG GSLPNVSQLR NSAPEFQPSL HQADNVRGTR HHGLVERPAR 100
    NRFHPLHRRS GDKPGRQFDG NAFAASYSSQ HLDESWPRQQ PPWKEEKHPG 150
    FRLTSALNRT NSDSALHTSA LSTKPQDPYG GGGQSAWPAP YMGFCDGEND 200
    GHAEVAAFPG PLKEENLLNV PKPLPKHLWE SKEIQSLSGR PRSCDVGGGN 250
    AFPHNGQNTG LSPFLGTLNT GGSLPDLTNL HYSAPLPASL DTSDHLFGSM 300
    SVGNSVGNLP AAMTHLGIRT SSGLQSSRSN PSIQATLSKM ALSSSLKCHP 350
    QPSVANASAL HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE 400
    AHQGFSRQLS ATSPLNPYPA SQMVTSEQSP LSFLPTDAQA QVSPPPPYPT 450
    PQELPQPLLQ QPHAQEPPTQ QPQAAPSLPQ SDFQLLTAQG SALTSFFPDV 500
    RFDQQPMRPS PAFPQQVPLV QQSHREPQDS FHLRPNPYSS CGSFPGTILT 550
    EDTNSNLFKG LSGGLSGMPE VSLDMDTPFP LEEELQIEPL SLDGLNMLSD 600
    SSMGLLDPSV EETFRADRL 619
    Length:619
    Mass (Da):67,027
    Last modified:February 5, 2008 - v2
    Checksum:iFBBE723F186CD60E
    GO
    Isoform 2 (identifier: Q91X84-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-299: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:320
    Mass (Da):34,300
    Checksum:iEED0509307E413DC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 299299Missing in isoform 2. 1 PublicationVSP_031221Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK144840 mRNA. No translation available.
    BC011210 mRNA. Translation: AAH11210.1.
    CCDSiCCDS21398.2. [Q91X84-1]
    RefSeqiNP_776288.2. NM_173863.2. [Q91X84-1]
    XP_006541259.1. XM_006541196.1. [Q91X84-2]
    UniGeneiMm.392175.

    Genome annotation databases

    EnsembliENSMUST00000122255; ENSMUSP00000113540; ENSMUSG00000030527. [Q91X84-1]
    GeneIDi70461.
    KEGGimmu:70461.
    UCSCiuc009iaz.1. mouse. [Q91X84-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK144840 mRNA. No translation available.
    BC011210 mRNA. Translation: AAH11210.1 .
    CCDSi CCDS21398.2. [Q91X84-1 ]
    RefSeqi NP_776288.2. NM_173863.2. [Q91X84-1 ]
    XP_006541259.1. XM_006541196.1. [Q91X84-2 ]
    UniGenei Mm.392175.

    3D structure databases

    ProteinModelPortali Q91X84.
    SMRi Q91X84. Positions 13-40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000113540.

    PTM databases

    PhosphoSitei Q91X84.

    Proteomic databases

    PaxDbi Q91X84.
    PRIDEi Q91X84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000122255 ; ENSMUSP00000113540 ; ENSMUSG00000030527 . [Q91X84-1 ]
    GeneIDi 70461.
    KEGGi mmu:70461.
    UCSCi uc009iaz.1. mouse. [Q91X84-1 ]

    Organism-specific databases

    CTDi 64784.
    MGIi MGI:1917711. Crtc3.

    Phylogenomic databases

    eggNOGi NOG74259.
    GeneTreei ENSGT00390000010652.
    HOGENOMi HOG000111980.
    HOVERGENi HBG058314.
    InParanoidi Q91X84.
    KOi K16334.
    OMAi YMGFCDG.
    OrthoDBi EOG7MKW5P.
    PhylomeDBi Q91X84.
    TreeFami TF321571.

    Miscellaneous databases

    ChiTaRSi CRTC3. mouse.
    NextBioi 331677.
    PROi Q91X84.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91X84.
    CleanExi MM_CRTC3.
    Genevestigatori Q91X84.

    Family and domain databases

    InterProi IPR024786. TORC.
    IPR024785. TORC_C.
    IPR024784. TORC_M.
    IPR024783. TORC_N.
    [Graphical view ]
    PANTHERi PTHR13589. PTHR13589. 1 hit.
    Pfami PF12886. TORC_C. 1 hit.
    PF12885. TORC_M. 1 hit.
    PF12884. TORC_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiCRTC3_MOUSE
    AccessioniPrimary (citable) accession number: Q91X84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3