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Protein

CREB-regulated transcription coactivator 3

Gene

Crtc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).By similarity

GO - Molecular functioni

  1. cAMP response element binding protein binding Source: InterPro

GO - Biological processi

  1. energy homeostasis Source: MGI
  2. negative regulation of cAMP-mediated signaling Source: MGI
  3. negative regulation of lipid catabolic process Source: MGI
  4. positive regulation of CREB transcription factor activity Source: InterPro
  5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  6. protein homotetramerization Source: InterPro
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 3
Alternative name(s):
Transducer of regulated cAMP response element-binding protein 3
Short name:
TORC-3
Short name:
Transducer of CREB protein 3
Gene namesi
Name:Crtc3
Synonyms:Torc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1917711. Crtc3.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Appears to be mainly nuclear.By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619CREB-regulated transcription coactivator 3PRO_0000318532Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei162 – 1621Phosphoserine; by SIK2By similarity
Modified residuei329 – 3291PhosphoserineBy similarity
Modified residuei370 – 3701PhosphoserineBy similarity
Modified residuei391 – 3911PhosphoserineBy similarity
Modified residuei443 – 4431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X84.
PaxDbiQ91X84.
PRIDEiQ91X84.

PTM databases

PhosphoSiteiQ91X84.

Expressioni

Gene expression databases

BgeeiQ91X84.
CleanExiMM_CRTC3.
GenevestigatoriQ91X84.

Interactioni

Subunit structurei

Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113540.

Structurei

3D structure databases

ProteinModelPortaliQ91X84.
SMRiQ91X84. Positions 13-40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

eggNOGiNOG74259.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ91X84.
KOiK16334.
OMAiYMGFCDG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ91X84.
TreeFamiTF321571.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91X84-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL
60 70 80 90 100
QQLRLTQYHG GSLPNVSQLR NSAPEFQPSL HQADNVRGTR HHGLVERPAR
110 120 130 140 150
NRFHPLHRRS GDKPGRQFDG NAFAASYSSQ HLDESWPRQQ PPWKEEKHPG
160 170 180 190 200
FRLTSALNRT NSDSALHTSA LSTKPQDPYG GGGQSAWPAP YMGFCDGEND
210 220 230 240 250
GHAEVAAFPG PLKEENLLNV PKPLPKHLWE SKEIQSLSGR PRSCDVGGGN
260 270 280 290 300
AFPHNGQNTG LSPFLGTLNT GGSLPDLTNL HYSAPLPASL DTSDHLFGSM
310 320 330 340 350
SVGNSVGNLP AAMTHLGIRT SSGLQSSRSN PSIQATLSKM ALSSSLKCHP
360 370 380 390 400
QPSVANASAL HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE
410 420 430 440 450
AHQGFSRQLS ATSPLNPYPA SQMVTSEQSP LSFLPTDAQA QVSPPPPYPT
460 470 480 490 500
PQELPQPLLQ QPHAQEPPTQ QPQAAPSLPQ SDFQLLTAQG SALTSFFPDV
510 520 530 540 550
RFDQQPMRPS PAFPQQVPLV QQSHREPQDS FHLRPNPYSS CGSFPGTILT
560 570 580 590 600
EDTNSNLFKG LSGGLSGMPE VSLDMDTPFP LEEELQIEPL SLDGLNMLSD
610
SSMGLLDPSV EETFRADRL
Length:619
Mass (Da):67,027
Last modified:February 5, 2008 - v2
Checksum:iFBBE723F186CD60E
GO
Isoform 2 (identifier: Q91X84-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Note: No experimental confirmation available.

Show »
Length:320
Mass (Da):34,300
Checksum:iEED0509307E413DC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 299299Missing in isoform 2. 1 PublicationVSP_031221Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144840 mRNA. No translation available.
BC011210 mRNA. Translation: AAH11210.1.
CCDSiCCDS21398.2. [Q91X84-1]
RefSeqiNP_776288.2. NM_173863.2. [Q91X84-1]
XP_006541259.1. XM_006541196.1. [Q91X84-2]
UniGeneiMm.392175.

Genome annotation databases

EnsembliENSMUST00000122255; ENSMUSP00000113540; ENSMUSG00000030527. [Q91X84-1]
GeneIDi70461.
KEGGimmu:70461.
UCSCiuc009iaz.1. mouse. [Q91X84-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144840 mRNA. No translation available.
BC011210 mRNA. Translation: AAH11210.1.
CCDSiCCDS21398.2. [Q91X84-1]
RefSeqiNP_776288.2. NM_173863.2. [Q91X84-1]
XP_006541259.1. XM_006541196.1. [Q91X84-2]
UniGeneiMm.392175.

3D structure databases

ProteinModelPortaliQ91X84.
SMRiQ91X84. Positions 13-40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113540.

PTM databases

PhosphoSiteiQ91X84.

Proteomic databases

MaxQBiQ91X84.
PaxDbiQ91X84.
PRIDEiQ91X84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000122255; ENSMUSP00000113540; ENSMUSG00000030527. [Q91X84-1]
GeneIDi70461.
KEGGimmu:70461.
UCSCiuc009iaz.1. mouse. [Q91X84-1]

Organism-specific databases

CTDi64784.
MGIiMGI:1917711. Crtc3.

Phylogenomic databases

eggNOGiNOG74259.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ91X84.
KOiK16334.
OMAiYMGFCDG.
OrthoDBiEOG7MKW5P.
PhylomeDBiQ91X84.
TreeFamiTF321571.

Miscellaneous databases

ChiTaRSiCrtc3. mouse.
NextBioi331677.
PROiQ91X84.
SOURCEiSearch...

Gene expression databases

BgeeiQ91X84.
CleanExiMM_CRTC3.
GenevestigatoriQ91X84.

Family and domain databases

InterProiIPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
[Graphical view]
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiPF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiCRTC3_MOUSE
AccessioniPrimary (citable) accession number: Q91X84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 7, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.