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Protein

CREB-regulated transcription coactivator 3

Gene

Crtc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • energy homeostasis Source: MGI
  • macrophage activation Source: MGI
  • negative regulation of cAMP-mediated signaling Source: MGI
  • negative regulation of lipid catabolic process Source: MGI
  • positive regulation of CREB transcription factor activity Source: GO_Central
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein homotetramerization Source: InterPro
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CREB-regulated transcription coactivator 3
Alternative name(s):
Transducer of regulated cAMP response element-binding protein 3
Short name:
TORC-3
Short name:
Transducer of CREB protein 3
Gene namesi
Name:Crtc3
Synonyms:Torc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917711. Crtc3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi162S → A: Up-regulates CREB transcription factor activity. Reduces interaction with 14-3-3 proteins. 1 Publication1
Mutagenesisi273S → A: Reduces interaction with 14-3-3 proteins. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185321 – 619CREB-regulated transcription coactivator 3Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei62PhosphoserineCombined sources1 Publication1
Modified residuei160Phosphothreonine1 Publication1
Modified residuei162Phosphoserine; by SIK21 Publication1
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei273Phosphoserine1 Publication1
Modified residuei329PhosphoserineBy similarity1
Modified residuei332PhosphoserineBy similarity1
Modified residuei370PhosphoserineCombined sources1
Modified residuei391PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei443PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ91X84.
PeptideAtlasiQ91X84.
PRIDEiQ91X84.

PTM databases

iPTMnetiQ91X84.
PhosphoSitePlusiQ91X84.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030527.
CleanExiMM_CRTC3.
ExpressionAtlasiQ91X84. baseline and differential.
GenevisibleiQ91X84. MM.

Interactioni

Subunit structurei

Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interacts with 14-3-3 proteins (PubMed:28235073).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113540.

Structurei

3D structure databases

ProteinModelPortaliQ91X84.
SMRiQ91X84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

eggNOGiENOG410IGNT. Eukaryota.
ENOG410XPDQ. LUCA.
GeneTreeiENSGT00390000010652.
HOGENOMiHOG000111980.
HOVERGENiHBG058314.
InParanoidiQ91X84.
KOiK16334.
OMAiGFCDGEN.
OrthoDBiEOG091G03YN.
PhylomeDBiQ91X84.
TreeFamiTF321571.

Family and domain databases

InterProiView protein in InterPro
IPR024786. TORC.
IPR024785. TORC_C.
IPR024784. TORC_M.
IPR024783. TORC_N.
PANTHERiPTHR13589. PTHR13589. 1 hit.
PfamiView protein in Pfam
PF12886. TORC_C. 1 hit.
PF12885. TORC_M. 1 hit.
PF12884. TORC_N. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91X84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL
60 70 80 90 100
QQLRLTQYHG GSLPNVSQLR NSAPEFQPSL HQADNVRGTR HHGLVERPAR
110 120 130 140 150
NRFHPLHRRS GDKPGRQFDG NAFAASYSSQ HLDESWPRQQ PPWKEEKHPG
160 170 180 190 200
FRLTSALNRT NSDSALHTSA LSTKPQDPYG GGGQSAWPAP YMGFCDGEND
210 220 230 240 250
GHAEVAAFPG PLKEENLLNV PKPLPKHLWE SKEIQSLSGR PRSCDVGGGN
260 270 280 290 300
AFPHNGQNTG LSPFLGTLNT GGSLPDLTNL HYSAPLPASL DTSDHLFGSM
310 320 330 340 350
SVGNSVGNLP AAMTHLGIRT SSGLQSSRSN PSIQATLSKM ALSSSLKCHP
360 370 380 390 400
QPSVANASAL HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE
410 420 430 440 450
AHQGFSRQLS ATSPLNPYPA SQMVTSEQSP LSFLPTDAQA QVSPPPPYPT
460 470 480 490 500
PQELPQPLLQ QPHAQEPPTQ QPQAAPSLPQ SDFQLLTAQG SALTSFFPDV
510 520 530 540 550
RFDQQPMRPS PAFPQQVPLV QQSHREPQDS FHLRPNPYSS CGSFPGTILT
560 570 580 590 600
EDTNSNLFKG LSGGLSGMPE VSLDMDTPFP LEEELQIEPL SLDGLNMLSD
610
SSMGLLDPSV EETFRADRL
Length:619
Mass (Da):67,027
Last modified:February 5, 2008 - v2
Checksum:iFBBE723F186CD60E
GO
Isoform 2 (identifier: Q91X84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):34,300
Checksum:iEED0509307E413DC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0312211 – 299Missing in isoform 2. 1 PublicationAdd BLAST299

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144840 mRNA. No translation available.
BC011210 mRNA. Translation: AAH11210.1.
CCDSiCCDS21398.2. [Q91X84-1]
RefSeqiNP_776288.2. NM_173863.2. [Q91X84-1]
XP_006541259.1. XM_006541196.1. [Q91X84-2]
UniGeneiMm.392175.

Genome annotation databases

EnsembliENSMUST00000122255; ENSMUSP00000113540; ENSMUSG00000030527. [Q91X84-1]
GeneIDi70461.
KEGGimmu:70461.
UCSCiuc009iaz.1. mouse. [Q91X84-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCRTC3_MOUSE
AccessioniPrimary (citable) accession number: Q91X84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 25, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families