Q91X84 (CRTC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CREB-regulated transcription coactivator 3

Alternative name(s):
Transducer of regulated cAMP response element-binding protein 3
Short name=TORC-3
Short name=Transducer of CREB protein 3

Gene names

Name:	Crtc3
Synonyms:	Torc3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	619 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells By similarity.
Subunit structure	Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Appears to be mainly nuclear By similarity.
Sequence similarities	Belongs to the TORC family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of CREB transcription factor activity Inferred from electronic annotation. Source: InterPro protein homotetramerization Inferred from electronic annotation. Source: InterPro transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cAMP response element binding protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91X84-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91X84-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-299: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 619	619	CREB-regulated transcription coactivator 3		PRO_0000318532
Amino acid modifications
	Modified residue	4	1	Phosphoserine By similarity
	Modified residue	62	1	Phosphoserine By similarity
	Modified residue	162	1	Phosphoserine; by SIK2 By similarity
	Modified residue	329	1	Phosphoserine By similarity
	Modified residue	370	1	Phosphoserine By similarity
	Modified residue	391	1	Phosphoserine By similarity
	Modified residue	443	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 299	299	Missing in isoform 2.		VSP_031221

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: FBBE723F186CD60E	FASTA	619	67,027
	10 20 30 40 50 60 MAASPGSGSA NPRKFSEKIA LHTQRQAEET RAFEQLMTDL TLSRVQFQKL QQLRLTQYHG 70 80 90 100 110 120 GSLPNVSQLR NSAPEFQPSL HQADNVRGTR HHGLVERPAR NRFHPLHRRS GDKPGRQFDG 130 140 150 160 170 180 NAFAASYSSQ HLDESWPRQQ PPWKEEKHPG FRLTSALNRT NSDSALHTSA LSTKPQDPYG 190 200 210 220 230 240 GGGQSAWPAP YMGFCDGEND GHAEVAAFPG PLKEENLLNV PKPLPKHLWE SKEIQSLSGR 250 260 270 280 290 300 PRSCDVGGGN AFPHNGQNTG LSPFLGTLNT GGSLPDLTNL HYSAPLPASL DTSDHLFGSM 310 320 330 340 350 360 SVGNSVGNLP AAMTHLGIRT SSGLQSSRSN PSIQATLSKM ALSSSLKCHP QPSVANASAL 370 380 390 400 410 420 HPSLRLFSLS NPSLSTTNLS GPSRRRQPPV SPLTLSPGPE AHQGFSRQLS ATSPLNPYPA 430 440 450 460 470 480 SQMVTSEQSP LSFLPTDAQA QVSPPPPYPT PQELPQPLLQ QPHAQEPPTQ QPQAAPSLPQ 490 500 510 520 530 540 SDFQLLTAQG SALTSFFPDV RFDQQPMRPS PAFPQQVPLV QQSHREPQDS FHLRPNPYSS 550 560 570 580 590 600 CGSFPGTILT EDTNSNLFKG LSGGLSGMPE VSLDMDTPFP LEEELQIEPL SLDGLNMLSD 610 SSMGLLDPSV EETFRADRL
	Isoform 2 [UniParc]. Checksum: EED0509307E413DC	FASTA	320	34,300
	10 20 30 40 50 60 MSVGNSVGNL PAAMTHLGIR TSSGLQSSRS NPSIQATLSK MALSSSLKCH PQPSVANASA 70 80 90 100 110 120 LHPSLRLFSL SNPSLSTTNL SGPSRRRQPP VSPLTLSPGP EAHQGFSRQL SATSPLNPYP 130 140 150 160 170 180 ASQMVTSEQS PLSFLPTDAQ AQVSPPPPYP TPQELPQPLL QQPHAQEPPT QQPQAAPSLP 190 200 210 220 230 240 QSDFQLLTAQ GSALTSFFPD VRFDQQPMRP SPAFPQQVPL VQQSHREPQD SFHLRPNPYS 250 260 270 280 290 300 SCGSFPGTIL TEDTNSNLFK GLSGGLSGMP EVSLDMDTPF PLEEELQIEP LSLDGLNMLS 310 320 DSSMGLLDPS VEETFRADRL

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK144840 mRNA. No translation available. BC011210 mRNA. Translation: AAH11210.1.
IPI	IPI00128519. IPI00885423.
RefSeq	NP_776288.2. NM_173863.2.
UniGene	Mm.392175.
3D structure databases
SMR	Q91X84. Positions 13-40.
ModBase	Search...
PTM databases
PhosphoSite	Q91X84.
Proteomic databases
PaxDb	Q91X84.
PRIDE	Q91X84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000122255; ENSMUSP00000113540; ENSMUSG00000030527.
GeneID	70461.
KEGG	mmu:70461.
UCSC	uc009iaz.1. mouse.
Organism-specific databases
CTD	64784.
MGI	MGI:1917711. Crtc3.
Phylogenomic databases
eggNOG	NOG74259.
GeneTree	ENSGT00390000010652.
HOGENOM	HOG000111980.
HOVERGEN	HBG058314.
InParanoid	Q91X84.
KO	K16334.
OMA	YMGFCDG.
OrthoDB	EOG437RDJ.
Gene expression databases
Bgee	Q91X84.
CleanEx	MM_CRTC3.
Genevestigator	Q91X84.
Family and domain databases
InterPro	IPR024786. TORC. IPR024785. TORC_C. IPR024784. TORC_M. IPR024783. TORC_N. [Graphical view]
PANTHER	PTHR13589. PTHR13589. 1 hit.
Pfam	PF12886. TORC_C. 1 hit. PF12885. TORC_M. 1 hit. PF12884. TORC_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CRTC3. mouse.
NextBio	331677.
SOURCE	Search...

Entry information

Entry name

CRTC3_MOUSE

Accession

Primary (citable) accession number: Q91X84

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program