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Protein

Chymotrypsin-like elastase family member 1

Gene

Cela1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts upon elastin.By similarity

Catalytic activityi

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Charge relay systemBy similarity
Metal bindingi85 – 851CalciumBy similarity
Metal bindingi90 – 901Calcium; via carbonyl oxygenBy similarity
Metal bindingi95 – 951CalciumBy similarity
Active sitei119 – 1191Charge relay systemBy similarity
Active sitei214 – 2141Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

  • digestive system development Source: MGI
  • elastin catabolic process Source: MGI
  • exocrine pancreas development Source: MGI
  • inflammatory response Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • pancreas morphogenesis Source: MGI
  • positive regulation of angiogenesis Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • post-embryonic development Source: MGI
  • regulation of cell differentiation Source: MGI
  • regulation of cell proliferation Source: MGI
  • tissue remodeling Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.153.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 1 (EC:3.4.21.36)
Alternative name(s):
Elastase-1
Gene namesi
Name:Cela1
Synonyms:Ela1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:95314. Cela1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Propeptidei17 – 2610Activation peptideBy similarityPRO_0000416103
Chaini27 – 266240Chymotrypsin-like elastase family member 1PRO_0000416104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 220PROSITE-ProRule annotation
Disulfide bondi184 ↔ 200PROSITE-ProRule annotation
Disulfide bondi210 ↔ 240PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiQ91X79.
PaxDbiQ91X79.
PeptideAtlasiQ91X79.
PRIDEiQ91X79.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023031.
GenevisibleiQ91X79. MM.

Interactioni

Protein-protein interaction databases

BioGridi225137. 1 interaction.
STRINGi10090.ENSMUSP00000023775.

Structurei

3D structure databases

ProteinModelPortaliQ91X79.
SMRiQ91X79. Positions 27-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 264238Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ91X79.
KOiK01326.
OMAiLANNTPC.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ91X79.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91X79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFLVFASL VLCGHSTEDV PETDARVVGG AEARRNSWPS QISLQYQYGG
60 70 80 90 100
SWHHTCGGTL IRSNWVMTAA HCVDSPMTYR VVVGEHNLSQ NDGTEQYVNV
110 120 130 140 150
QKIVSHPYWN KNNVVAGYDI ALLRLAKSVT LNNYVQLGVL PREGTILANN
160 170 180 190 200
SPCYITGWGR TRTNGELAQT LQQAYLPSVS YSICSSSSYW GSSVKNTMVC
210 220 230 240 250
AGGDGVRSGC QGDSGGPLHC MVNGQYAVHG VTSFVSSMGC NVARKPTVFT
260
RVSAYISWMN NVIASN
Length:266
Mass (Da):28,901
Last modified:December 1, 2001 - v1
Checksum:i27C50812E8804F5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121L → P in BAB25008 (PubMed:16141072).Curated
Sequence conflicti27 – 271V → M in BAB25008 (PubMed:16141072).Curated
Sequence conflicti31 – 333AEA → EFP in AAA39901 (PubMed:3493908).Curated
Sequence conflicti123 – 1231L → V in AAA39901 (PubMed:3493908).Curated
Sequence conflicti194 – 1941V → L in AAA39901 (PubMed:3493908).Curated
Sequence conflicti202 – 2021G → C in AAA39901 (PubMed:3493908).Curated
Sequence conflicti229 – 2291H → D in AAA39901 (PubMed:3493908).Curated
Sequence conflicti252 – 2521V → L in AAA39901 (PubMed:3493908).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007392 mRNA. Translation: BAB25008.1.
AC123724 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04074.1.
BC011218 mRNA. Translation: AAH11218.1.
M27347 mRNA. Translation: AAA39901.1.
CCDSiCCDS37213.1.
RefSeqiNP_291090.2. NM_033612.2.
UniGeneiMm.2131.

Genome annotation databases

EnsembliENSMUST00000023775; ENSMUSP00000023775; ENSMUSG00000023031.
GeneIDi109901.
KEGGimmu:109901.
UCSCiuc007xrx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007392 mRNA. Translation: BAB25008.1.
AC123724 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04074.1.
BC011218 mRNA. Translation: AAH11218.1.
M27347 mRNA. Translation: AAA39901.1.
CCDSiCCDS37213.1.
RefSeqiNP_291090.2. NM_033612.2.
UniGeneiMm.2131.

3D structure databases

ProteinModelPortaliQ91X79.
SMRiQ91X79. Positions 27-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225137. 1 interaction.
STRINGi10090.ENSMUSP00000023775.

Protein family/group databases

MEROPSiS01.153.

Proteomic databases

MaxQBiQ91X79.
PaxDbiQ91X79.
PeptideAtlasiQ91X79.
PRIDEiQ91X79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023775; ENSMUSP00000023775; ENSMUSG00000023031.
GeneIDi109901.
KEGGimmu:109901.
UCSCiuc007xrx.2. mouse.

Organism-specific databases

CTDi1990.
MGIiMGI:95314. Cela1.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ91X79.
KOiK01326.
OMAiLANNTPC.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ91X79.
TreeFamiTF330455.

Miscellaneous databases

ChiTaRSiCela1. mouse.
PROiQ91X79.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023031.
GenevisibleiQ91X79. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCELA1_MOUSE
AccessioniPrimary (citable) accession number: Q91X79
Secondary accession number(s): Q9D936, Q9Z1H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.