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Q91X72

- HEMO_MOUSE

UniProt

Q91X72 - HEMO_MOUSE

Protein

Hemopexin

Gene

Hpx

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Iron (heme 1 axial ligand)By similarity
    Metal bindingi149 – 1491Iron (heme 1 axial ligand)By similarity
    Metal bindingi235 – 2351Iron (heme 2 axial ligand)By similarity
    Metal bindingi291 – 2911Iron (heme 2 axial ligand)By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme metabolic process Source: MGI
    2. hemoglobin metabolic process Source: MGI
    3. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
    4. positive regulation of immunoglobulin production Source: MGI
    5. positive regulation of interferon-gamma-mediated signaling pathway Source: MGI
    6. positive regulation of response to interferon-gamma Source: MGI
    7. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
    8. regulation of protein metabolic process Source: MGI
    9. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196575. Scavenging of heme from plasma.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemopexin
    Gene namesi
    Name:Hpx
    Synonyms:Hpxn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:105112. Hpx.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 460437HemopexinPRO_0000021407Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)1 Publication
    Disulfide bondi50 ↔ 230By similarity
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 153By similarity
    Glycosylationi186 – 1861N-linked (GlcNAc...)1 Publication
    Disulfide bondi187 ↔ 199By similarity
    Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi255 ↔ 458By similarity
    Disulfide bondi364 ↔ 406By similarity
    Disulfide bondi416 ↔ 433By similarity
    Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ91X72.
    PaxDbiQ91X72.
    PRIDEiQ91X72.

    PTM databases

    PhosphoSiteiQ91X72.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    BgeeiQ91X72.
    CleanExiMM_HPX.
    GenevestigatoriQ91X72.

    Interactioni

    Protein-protein interaction databases

    IntActiQ91X72. 4 interactions.
    MINTiMINT-1862286.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91X72.
    SMRiQ91X72. Positions 48-460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati53 – 9341Hemopexin 1Add
    BLAST
    Repeati94 – 13845Hemopexin 2Add
    BLAST
    Repeati139 – 18345Hemopexin 3Add
    BLAST
    Repeati184 – 23047Hemopexin 4Add
    BLAST
    Repeati257 – 30246Hemopexin 5Add
    BLAST
    Repeati303 – 35048Hemopexin 6Add
    BLAST
    Repeati355 – 39440Hemopexin 7Add
    BLAST
    Repeati398 – 44851Hemopexin 8Add
    BLAST

    Sequence similaritiesi

    Belongs to the hemopexin family.Curated
    Contains 8 hemopexin repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG251805.
    GeneTreeiENSGT00390000009178.
    HOGENOMiHOG000112887.
    HOVERGENiHBG005956.
    InParanoidiQ3UKP2.
    OMAiAVECHRG.
    OrthoDBiEOG7Q8CN5.
    TreeFamiTF331201.

    Family and domain databases

    Gene3Di2.110.10.10. 2 hits.
    InterProiIPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR016358. Hemopexin_chordata.
    IPR018486. Hemopexin_CS.
    [Graphical view]
    PfamiPF00045. Hemopexin. 5 hits.
    [Graphical view]
    PIRSFiPIRSF002551. Hemopexin_chordata. 1 hit.
    SMARTiSM00120. HX. 6 hits.
    [Graphical view]
    SUPFAMiSSF50923. SSF50923. 2 hits.
    PROSITEiPS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91X72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARTAVALNI LVLLGLCWSL AVASPLPTAN GRVAEVENGT KPDSDVPEHC    50
    LDTWSFDAAT MDHNGTMLFF KGEFVWRGHS GTRELISARW KNPITSVDAA 100
    FRGPDSVFLI KEDKVWVYPP EKKENGYPKL FQEEFPGIPY PPDAAVECHR 150
    GECQSEGVLF FQGNRKWFWD FATRTQKERS WSTVGNCTAA LRWLERYYCF 200
    QGNKFLRFNP VTGEVPPRYP LDARDYFVSC PGRGHGRPRN GTAHGNSTHP 250
    MHSRCSPDPG LTALLSDHRG ATYAFTGSHY WRLDSSRDGW HSWPIAHHWP 300
    QGPSTVDAAF SWDDKVYLIQ GTQVYVFLTK GGNNLVSGYP KRLEKELGSP 350
    PGISLETIDA AFSCPGSSRL YVSSGRRLWW LDLKSGAQAT WTEVSWPHEK 400
    VDGALCLDKS LGPNTCSSNG SSLYFIHGPN LYCYSSIDKL NAAKSLPQPQ 450
    KVNSILGCSQ 460
    Length:460
    Mass (Da):51,318
    Last modified:July 27, 2011 - v2
    Checksum:i5DF86BA50CC23B48
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301N → H in AAH11246. (PubMed:15489334)Curated
    Sequence conflicti30 – 301N → H in AAH19901. (PubMed:15489334)Curated
    Sequence conflicti233 – 2331R → Q in AAB49490. 1 PublicationCurated
    Sequence conflicti453 – 4531Missing in AAB49490. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145928 mRNA. Translation: BAE26759.1.
    CH466531 Genomic DNA. Translation: EDL16785.1.
    BC011246 mRNA. Translation: AAH11246.1.
    BC019901 mRNA. Translation: AAH19901.1.
    U89889 mRNA. Translation: AAB49490.1.
    CCDSiCCDS21654.1.
    RefSeqiNP_059067.2. NM_017371.2.
    UniGeneiMm.3485.

    Genome annotation databases

    EnsembliENSMUST00000033185; ENSMUSP00000033185; ENSMUSG00000030895.
    GeneIDi15458.
    KEGGimmu:15458.
    UCSCiuc009iyl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145928 mRNA. Translation: BAE26759.1 .
    CH466531 Genomic DNA. Translation: EDL16785.1 .
    BC011246 mRNA. Translation: AAH11246.1 .
    BC019901 mRNA. Translation: AAH19901.1 .
    U89889 mRNA. Translation: AAB49490.1 .
    CCDSi CCDS21654.1.
    RefSeqi NP_059067.2. NM_017371.2.
    UniGenei Mm.3485.

    3D structure databases

    ProteinModelPortali Q91X72.
    SMRi Q91X72. Positions 48-460.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91X72. 4 interactions.
    MINTi MINT-1862286.

    PTM databases

    PhosphoSitei Q91X72.

    Proteomic databases

    MaxQBi Q91X72.
    PaxDbi Q91X72.
    PRIDEi Q91X72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033185 ; ENSMUSP00000033185 ; ENSMUSG00000030895 .
    GeneIDi 15458.
    KEGGi mmu:15458.
    UCSCi uc009iyl.2. mouse.

    Organism-specific databases

    CTDi 3263.
    MGIi MGI:105112. Hpx.

    Phylogenomic databases

    eggNOGi NOG251805.
    GeneTreei ENSGT00390000009178.
    HOGENOMi HOG000112887.
    HOVERGENi HBG005956.
    InParanoidi Q3UKP2.
    OMAi AVECHRG.
    OrthoDBi EOG7Q8CN5.
    TreeFami TF331201.

    Enzyme and pathway databases

    Reactomei REACT_196575. Scavenging of heme from plasma.

    Miscellaneous databases

    ChiTaRSi HPX. mouse.
    NextBioi 288270.
    PROi Q91X72.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91X72.
    CleanExi MM_HPX.
    Genevestigatori Q91X72.

    Family and domain databases

    Gene3Di 2.110.10.10. 2 hits.
    InterProi IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR016358. Hemopexin_chordata.
    IPR018486. Hemopexin_CS.
    [Graphical view ]
    Pfami PF00045. Hemopexin. 5 hits.
    [Graphical view ]
    PIRSFi PIRSF002551. Hemopexin_chordata. 1 hit.
    SMARTi SM00120. HX. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50923. SSF50923. 2 hits.
    PROSITEi PS00024. HEMOPEXIN. 1 hit.
    PS51642. HEMOPEXIN_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. Koepsel R.R., Rohrbach D.H., Brekheiser B.B.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-460.
      Tissue: Liver.
    5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38.
      Strain: C57BL/6.
      Tissue: Plasma.
    6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-186.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiHEMO_MOUSE
    AccessioniPrimary (citable) accession number: Q91X72
    Secondary accession number(s): P97824, Q3UKP2, Q8WUP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3