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Protein

Hemopexin

Gene

Hpx

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Iron (heme 1 axial ligand)By similarity1
Metal bindingi149Iron (heme 1 axial ligand)By similarity1
Metal bindingi235Iron (heme 2 axial ligand)By similarity1
Metal bindingi291Iron (heme 2 axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular iron ion homeostasis Source: InterPro
  • heme metabolic process Source: MGI
  • hemoglobin metabolic process Source: MGI
  • positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
  • positive regulation of immunoglobulin production Source: MGI
  • positive regulation of interferon-gamma-mediated signaling pathway Source: MGI
  • positive regulation of response to interferon-gamma Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  • regulation of protein metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-2168880. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemopexin
Gene namesi
Name:Hpx
Synonyms:Hpxn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105112. Hpx.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002140724 – 460HemopexinAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)1 Publication1
Disulfide bondi50 ↔ 230By similarity
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi148 ↔ 153By similarity
Glycosylationi186N-linked (GlcNAc...)1 Publication1
Disulfide bondi187 ↔ 199By similarity
Glycosylationi240N-linked (GlcNAc...)Sequence analysis1
Glycosylationi246N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi255 ↔ 458By similarity
Disulfide bondi364 ↔ 406By similarity
Disulfide bondi416 ↔ 433By similarity
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ91X72.
PaxDbiQ91X72.
PeptideAtlasiQ91X72.
PRIDEiQ91X72.

PTM databases

iPTMnetiQ91X72.
PhosphoSitePlusiQ91X72.
SwissPalmiQ91X72.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000030895.
CleanExiMM_HPX.
GenevisibleiQ91X72. MM.

Interactioni

Protein-protein interaction databases

BioGridi200414. 1 interactor.
IntActiQ91X72. 4 interactors.
MINTiMINT-1862286.
STRINGi10090.ENSMUSP00000033185.

Structurei

3D structure databases

ProteinModelPortaliQ91X72.
SMRiQ91X72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 93Hemopexin 1Add BLAST41
Repeati94 – 138Hemopexin 2Add BLAST45
Repeati139 – 183Hemopexin 3Add BLAST45
Repeati184 – 230Hemopexin 4Add BLAST47
Repeati257 – 302Hemopexin 5Add BLAST46
Repeati303 – 350Hemopexin 6Add BLAST48
Repeati355 – 394Hemopexin 7Add BLAST40
Repeati398 – 448Hemopexin 8Add BLAST51

Sequence similaritiesi

Belongs to the hemopexin family.Curated
Contains 8 hemopexin repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00390000009178.
HOGENOMiHOG000112887.
HOVERGENiHBG005956.
InParanoidiQ91X72.
KOiK18977.
OMAiAVECHRG.
OrthoDBiEOG091G052J.
TreeFamiTF331201.

Family and domain databases

CDDicd00094. HX. 2 hits.
Gene3Di2.110.10.10. 2 hits.
InterProiIPR016358. Hemopexin.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
[Graphical view]
PfamiPF00045. Hemopexin. 5 hits.
[Graphical view]
PIRSFiPIRSF002551. Hemopexin_chordata. 1 hit.
SMARTiSM00120. HX. 6 hits.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 2 hits.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91X72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTAVALNI LVLLGLCWSL AVASPLPTAN GRVAEVENGT KPDSDVPEHC
60 70 80 90 100
LDTWSFDAAT MDHNGTMLFF KGEFVWRGHS GTRELISARW KNPITSVDAA
110 120 130 140 150
FRGPDSVFLI KEDKVWVYPP EKKENGYPKL FQEEFPGIPY PPDAAVECHR
160 170 180 190 200
GECQSEGVLF FQGNRKWFWD FATRTQKERS WSTVGNCTAA LRWLERYYCF
210 220 230 240 250
QGNKFLRFNP VTGEVPPRYP LDARDYFVSC PGRGHGRPRN GTAHGNSTHP
260 270 280 290 300
MHSRCSPDPG LTALLSDHRG ATYAFTGSHY WRLDSSRDGW HSWPIAHHWP
310 320 330 340 350
QGPSTVDAAF SWDDKVYLIQ GTQVYVFLTK GGNNLVSGYP KRLEKELGSP
360 370 380 390 400
PGISLETIDA AFSCPGSSRL YVSSGRRLWW LDLKSGAQAT WTEVSWPHEK
410 420 430 440 450
VDGALCLDKS LGPNTCSSNG SSLYFIHGPN LYCYSSIDKL NAAKSLPQPQ
460
KVNSILGCSQ
Length:460
Mass (Da):51,318
Last modified:July 27, 2011 - v2
Checksum:i5DF86BA50CC23B48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30N → H in AAH11246 (PubMed:15489334).Curated1
Sequence conflicti30N → H in AAH19901 (PubMed:15489334).Curated1
Sequence conflicti233R → Q in AAB49490 (Ref. 4) Curated1
Sequence conflicti453Missing in AAB49490 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145928 mRNA. Translation: BAE26759.1.
CH466531 Genomic DNA. Translation: EDL16785.1.
BC011246 mRNA. Translation: AAH11246.1.
BC019901 mRNA. Translation: AAH19901.1.
U89889 mRNA. Translation: AAB49490.1.
CCDSiCCDS21654.1.
RefSeqiNP_059067.2. NM_017371.2.
UniGeneiMm.3485.

Genome annotation databases

EnsembliENSMUST00000033185; ENSMUSP00000033185; ENSMUSG00000030895.
GeneIDi15458.
KEGGimmu:15458.
UCSCiuc009iyl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145928 mRNA. Translation: BAE26759.1.
CH466531 Genomic DNA. Translation: EDL16785.1.
BC011246 mRNA. Translation: AAH11246.1.
BC019901 mRNA. Translation: AAH19901.1.
U89889 mRNA. Translation: AAB49490.1.
CCDSiCCDS21654.1.
RefSeqiNP_059067.2. NM_017371.2.
UniGeneiMm.3485.

3D structure databases

ProteinModelPortaliQ91X72.
SMRiQ91X72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200414. 1 interactor.
IntActiQ91X72. 4 interactors.
MINTiMINT-1862286.
STRINGi10090.ENSMUSP00000033185.

PTM databases

iPTMnetiQ91X72.
PhosphoSitePlusiQ91X72.
SwissPalmiQ91X72.

Proteomic databases

MaxQBiQ91X72.
PaxDbiQ91X72.
PeptideAtlasiQ91X72.
PRIDEiQ91X72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033185; ENSMUSP00000033185; ENSMUSG00000030895.
GeneIDi15458.
KEGGimmu:15458.
UCSCiuc009iyl.2. mouse.

Organism-specific databases

CTDi3263.
MGIiMGI:105112. Hpx.

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00390000009178.
HOGENOMiHOG000112887.
HOVERGENiHBG005956.
InParanoidiQ91X72.
KOiK18977.
OMAiAVECHRG.
OrthoDBiEOG091G052J.
TreeFamiTF331201.

Enzyme and pathway databases

ReactomeiR-MMU-2168880. Scavenging of heme from plasma.

Miscellaneous databases

ChiTaRSiHpx. mouse.
PROiQ91X72.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030895.
CleanExiMM_HPX.
GenevisibleiQ91X72. MM.

Family and domain databases

CDDicd00094. HX. 2 hits.
Gene3Di2.110.10.10. 2 hits.
InterProiIPR016358. Hemopexin.
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
[Graphical view]
PfamiPF00045. Hemopexin. 5 hits.
[Graphical view]
PIRSFiPIRSF002551. Hemopexin_chordata. 1 hit.
SMARTiSM00120. HX. 6 hits.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 2 hits.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMO_MOUSE
AccessioniPrimary (citable) accession number: Q91X72
Secondary accession number(s): P97824, Q3UKP2, Q8WUP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.