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Protein
Submitted name:

Complement component 6

Gene

C6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • immune response Source: InterPro
  • in utero embryonic development Source: MGI
  • positive regulation of activation of membrane attack complex Source: BHF-UCL
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of complement activation Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-166665. Terminal pathway of complement.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 6Imported
Submitted name:
Protein C6Imported
Gene namesi
Name:C6Imported
ORF Names:mCG_1041Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88233. C6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 769748Sequence analysisPRO_5007215438Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022788.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 522347MACPFInterPro annotationAdd
BLAST
Domaini642 – 70160Sushi (CCP/SCR)InterPro annotationAdd
BLAST
Domaini702 – 76362Sushi (CCP/SCR)InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
HOGENOMiHOG000111865.
HOVERGENiHBG005366.
KOiK03995.

Family and domain databases

InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91X70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHLTLCFI LLVMLIDKSE ACFCDHYPWT HWSSCSKSCN SGTQSRQRQV
60 70 80 90 100
VVNDYYWKNL CDKLCIKQET RECNLQTCPI NCVLGDYGTW SDCDPCTEKQ
110 120 130 140 150
VKVKSVLRPS QFGGQPCTEP LVTFQPCVPS KLCKIEETNC KNKFLCDSGR
160 170 180 190 200
CIPSKLECNG ENDCGDNSDE RNCGRTKPVC TRIYTPIPSV QLMGTGFHFL
210 220 230 240 250
AGEPRGEVLD NSFTGGICKL VKTSRASNPY RVSANLENVN FEVQTIEDDL
260 270 280 290 300
KTEFYKNLIS FEKNKNEDSL SVDERTKFFP IPIFHFSEKN EHSHYSSAFN
310 320 330 340 350
KVIKASHKKD SSFIRIHKLI KVLNFTMKAT DLQLSDVFLK ALVHLPLEYN
360 370 380 390 400
SAVYSRIFDD FGTHYFTSGS LGGKYDLIYQ FSRQELQNSG LTEEEAQNCV
410 420 430 440 450
QYETKKLKFL YMEIHKEDTC TKNKLSEKYG GSFLQGSEKS ISLVQGGRSQ
460 470 480 490 500
QAAALAWEKG TSGPEENVYS EWLESVKENP AVVDYKLAPI TDLVRNIPCA
510 520 530 540 550
VTKRNNLRRA LQEYAAKFDP CQCAPCPNNG RPRLSGTECL CVCQSGTYGE
560 570 580 590 600
NCERRSPGYK SDAVDGNWGC WSSWSACNAA YRRSRTRECN NPAPQRGGQS
610 620 630 640 650
CGGKDQQEED CTVSIMENVG QPCINDDEEM KEVDLAEPEA ESGCSQPPLP
660 670 680 690 700
ENAFTWNEKK LYSVGEEVEI SCLTGFTAVG FQYLRCLPDR TWSQGDVECQ
710 720 730 740 750
RTSCLKPVVQ DVLTISPFQR VYQIGESIEL TCPRGFVVAG PSRYTCKEDS
760
WTPPISNSLT CEQGVRDHP
Length:769
Mass (Da):86,631
Last modified:December 1, 2001 - v1
Checksum:i84EE204CC8D048BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102033 Genomic DNA. No translation available.
AC117588 Genomic DNA. No translation available.
BC011251 mRNA. Translation: AAH11251.1.
CH466581 Genomic DNA. Translation: EDL03393.1.
RefSeqiNP_057913.2. NM_016704.2.
XP_011243624.1. XM_011245322.1.
UniGeneiMm.20247.

Genome annotation databases

EnsembliENSMUST00000022788; ENSMUSP00000022788; ENSMUSG00000022181.
ENSMUST00000162585; ENSMUSP00000124417; ENSMUSG00000022181.
GeneIDi12274.
KEGGimmu:12274.
UCSCiuc007vco.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102033 Genomic DNA. No translation available.
AC117588 Genomic DNA. No translation available.
BC011251 mRNA. Translation: AAH11251.1.
CH466581 Genomic DNA. Translation: EDL03393.1.
RefSeqiNP_057913.2. NM_016704.2.
XP_011243624.1. XM_011245322.1.
UniGeneiMm.20247.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022788; ENSMUSP00000022788; ENSMUSG00000022181.
ENSMUST00000162585; ENSMUSP00000124417; ENSMUSG00000022181.
GeneIDi12274.
KEGGimmu:12274.
UCSCiuc007vco.2. mouse.

Organism-specific databases

CTDi729.
MGIiMGI:88233. C6.

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
HOGENOMiHOG000111865.
HOVERGENiHBG005366.
KOiK03995.

Enzyme and pathway databases

ReactomeiR-MMU-166665. Terminal pathway of complement.
R-MMU-977606. Regulation of Complement cascade.

Miscellaneous databases

NextBioi280736.
SOURCEiSearch...

Family and domain databases

InterProiIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ91X70_MOUSE
AccessioniPrimary (citable) accession number: Q91X70
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.