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Protein
Submitted name:

Complement component 6

Gene

C6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

  • complement activation Source: InterPro
  • in utero embryonic development Source: MGI
  • positive regulation of activation of membrane attack complex Source: BHF-UCL
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of complement activation Source: BHF-UCL

Enzyme and pathway databases

ReactomeiR-MMU-166665 Terminal pathway of complement
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 6Imported
Gene namesi
Name:C6Imported
ORF Names:mCG_1041Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88233 C6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501509950922 – 769Sequence analysisAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi146 ↔ 164PROSITE-ProRule annotation
Disulfide bondi158 ↔ 173PROSITE-ProRule annotation
Disulfide bondi672 ↔ 699PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000022181

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022788

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 522MACPFInterPro annotationAdd BLAST347
Domaini642 – 701SushiInterPro annotationAdd BLAST60
Domaini702 – 763SushiInterPro annotationAdd BLAST62

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IDXP Eukaryota
ENOG410YJ70 LUCA
GeneTreeiENSGT00550000074478
HOGENOMiHOG000111865
HOVERGENiHBG005366
KOiK03995

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 3 hits
InterProiView protein in InterPro
IPR037563 Complement_C6
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR19325:SF23 PTHR19325:SF23, 1 hit
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00084 Sushi, 2 hits
PF00090 TSP_1, 3 hits
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 3 hits
SUPFAMiSSF57424 SSF57424, 1 hit
SSF57535 SSF57535, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50923 SUSHI, 2 hits
PS50092 TSP1, 3 hits

Sequencei

Sequence statusi: Complete.

Q91X70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHLTLCFI LLVMLIDKSE ACFCDHYPWT HWSSCSKSCN SGTQSRQRQV
60 70 80 90 100
VVNDYYWKNL CDKLCIKQET RECNLQTCPI NCVLGDYGTW SDCDPCTEKQ
110 120 130 140 150
VKVKSVLRPS QFGGQPCTEP LVTFQPCVPS KLCKIEETNC KNKFLCDSGR
160 170 180 190 200
CIPSKLECNG ENDCGDNSDE RNCGRTKPVC TRIYTPIPSV QLMGTGFHFL
210 220 230 240 250
AGEPRGEVLD NSFTGGICKL VKTSRASNPY RVSANLENVN FEVQTIEDDL
260 270 280 290 300
KTEFYKNLIS FEKNKNEDSL SVDERTKFFP IPIFHFSEKN EHSHYSSAFN
310 320 330 340 350
KVIKASHKKD SSFIRIHKLI KVLNFTMKAT DLQLSDVFLK ALVHLPLEYN
360 370 380 390 400
SAVYSRIFDD FGTHYFTSGS LGGKYDLIYQ FSRQELQNSG LTEEEAQNCV
410 420 430 440 450
QYETKKLKFL YMEIHKEDTC TKNKLSEKYG GSFLQGSEKS ISLVQGGRSQ
460 470 480 490 500
QAAALAWEKG TSGPEENVYS EWLESVKENP AVVDYKLAPI TDLVRNIPCA
510 520 530 540 550
VTKRNNLRRA LQEYAAKFDP CQCAPCPNNG RPRLSGTECL CVCQSGTYGE
560 570 580 590 600
NCERRSPGYK SDAVDGNWGC WSSWSACNAA YRRSRTRECN NPAPQRGGQS
610 620 630 640 650
CGGKDQQEED CTVSIMENVG QPCINDDEEM KEVDLAEPEA ESGCSQPPLP
660 670 680 690 700
ENAFTWNEKK LYSVGEEVEI SCLTGFTAVG FQYLRCLPDR TWSQGDVECQ
710 720 730 740 750
RTSCLKPVVQ DVLTISPFQR VYQIGESIEL TCPRGFVVAG PSRYTCKEDS
760
WTPPISNSLT CEQGVRDHP
Length:769
Mass (Da):86,631
Last modified:December 1, 2001 - v1
Checksum:i84EE204CC8D048BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102033 Genomic DNA No translation available.
AC117588 Genomic DNA No translation available.
BC011251 mRNA Translation: AAH11251.1
CH466581 Genomic DNA Translation: EDL03393.1
RefSeqiNP_057913.2, NM_016704.2
UniGeneiMm.20247

Genome annotation databases

EnsembliENSMUST00000022788; ENSMUSP00000022788; ENSMUSG00000022181
ENSMUST00000162585; ENSMUSP00000124417; ENSMUSG00000022181
GeneIDi12274
KEGGimmu:12274
UCSCiuc007vco.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ91X70_MOUSE
AccessioniPrimary (citable) accession number: Q91X70
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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