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Q91X60

- ACHA2_MOUSE

UniProt

Q91X60 - ACHA2_MOUSE

Protein

Neuronal acetylcholine receptor subunit alpha-2

Gene

Chrna2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: Ensembl
    2. acetylcholine binding Source: Ensembl
    3. acetylcholine receptor activity Source: Ensembl
    4. drug binding Source: Ensembl

    GO - Biological processi

    1. protein heterooligomerization Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_198585. Highly calcium permeable nicotinic acetylcholine receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-2
    Gene namesi
    Name:Chrna2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:87886. Chrna2.

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. cell periphery Source: MGI
    4. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 512485Neuronal acetylcholine receptor subunit alpha-2PRO_0000000341Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi160 ↔ 174By similarity
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi224 ↔ 225Associated with receptor activationBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ91X60.

    PTM databases

    PhosphoSiteiQ91X60.

    Expressioni

    Gene expression databases

    BgeeiQ91X60.
    GenevestigatoriQ91X60.

    Interactioni

    Subunit structurei

    Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ91X60.
    SMRiQ91X60. Positions 36-363, 483-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 241214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini330 – 485156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei242 – 26625HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50419HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi391 – 40313Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290206.
    GeneTreeiENSGT00750000117277.
    HOGENOMiHOG000006756.
    HOVERGENiHBG003756.
    InParanoidiQ91X60.
    KOiK04804.
    OMAiEDENICM.
    OrthoDBiEOG72JWGV.
    PhylomeDBiQ91X60.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91X60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSHPAFQF WIHLYLWCLL LMPAVLAQQG SHTHAEDRLF KHLFGGYNRW    50
    ARPVPNTSDV VIVRFGLSIA QLIDVDEKNQ MMTTNVWLKQ EWNDYKLRWD 100
    PAEFGNITSL RVPSEMIWIP DIVLYNNADG EFAVTHMTKA HLFFTGTVHW 150
    VPPAIYKSSC SIDVTFFPFD QQNCKMKFGS WTYDKAKIDL EQMERTVDLK 200
    DYWESGEWAI INATGTYNSK KYDCCAEIYP DVTYYFVIRR LPLFYTINLI 250
    IPCLLISCLT VLVFYLPSEC GEKITLCISV LLSLTVFLLL ITEIIPSTSL 300
    VIPLIGEYLL FTMIFVTLSI VITVFVLNVH HRSPSTHNMP NWVRVALLGR 350
    VPRWLMMNRP LPPMELHGSP GLKLSPTYHW LETNMDAEER EETEEEEEEE 400
    EDENICMCAG LPDSSMGVLY GHGSLHLRAM GPEAKTPSQA SEILLSPQIQ 450
    KALEGVHYIA DHLRSEDADS SVKEDWKYVA MVVDRIFLWL FIIVCFLGTI 500
    GLFLPPFLAG MI 512
    Length:512
    Mass (Da):58,735
    Last modified:December 1, 2001 - v1
    Checksum:iAC0C6CC398B69C6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY574261 mRNA. Translation: AAS90357.1.
    BC011490 mRNA. Translation: AAH11490.1.
    CCDSiCCDS27219.1.
    RefSeqiNP_659052.1. NM_144803.2.
    XP_006518497.1. XM_006518434.1.
    XP_006518498.1. XM_006518435.1.
    XP_006518499.1. XM_006518436.1.
    XP_006518500.1. XM_006518437.1.
    XP_006518501.1. XM_006518438.1.
    UniGeneiMm.57350.

    Genome annotation databases

    EnsembliENSMUST00000022620; ENSMUSP00000022620; ENSMUSG00000022041.
    GeneIDi110902.
    KEGGimmu:110902.
    UCSCiuc007ujx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY574261 mRNA. Translation: AAS90357.1 .
    BC011490 mRNA. Translation: AAH11490.1 .
    CCDSi CCDS27219.1.
    RefSeqi NP_659052.1. NM_144803.2.
    XP_006518497.1. XM_006518434.1.
    XP_006518498.1. XM_006518435.1.
    XP_006518499.1. XM_006518436.1.
    XP_006518500.1. XM_006518437.1.
    XP_006518501.1. XM_006518438.1.
    UniGenei Mm.57350.

    3D structure databases

    ProteinModelPortali Q91X60.
    SMRi Q91X60. Positions 36-363, 483-510.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 463.

    PTM databases

    PhosphoSitei Q91X60.

    Proteomic databases

    PRIDEi Q91X60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022620 ; ENSMUSP00000022620 ; ENSMUSG00000022041 .
    GeneIDi 110902.
    KEGGi mmu:110902.
    UCSCi uc007ujx.1. mouse.

    Organism-specific databases

    CTDi 1135.
    MGIi MGI:87886. Chrna2.

    Phylogenomic databases

    eggNOGi NOG290206.
    GeneTreei ENSGT00750000117277.
    HOGENOMi HOG000006756.
    HOVERGENi HBG003756.
    InParanoidi Q91X60.
    KOi K04804.
    OMAi EDENICM.
    OrthoDBi EOG72JWGV.
    PhylomeDBi Q91X60.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_198585. Highly calcium permeable nicotinic acetylcholine receptors.

    Miscellaneous databases

    NextBioi 364901.
    PROi Q91X60.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91X60.
    Genevestigatori Q91X60.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 2 hits.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Groot-Kormelink P.J.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiACHA2_MOUSE
    AccessioniPrimary (citable) accession number: Q91X60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3