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Protein

Neuronal acetylcholine receptor subunit alpha-2

Gene

Chrna2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-MMU-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-2
Gene namesi
Name:Chrna2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:87886. Chrna2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 241ExtracellularSequence analysisAdd BLAST214
Transmembranei242 – 266HelicalSequence analysisAdd BLAST25
Transmembranei274 – 292HelicalSequence analysisAdd BLAST19
Transmembranei308 – 329HelicalSequence analysisAdd BLAST22
Topological domaini330 – 485CytoplasmicSequence analysisAdd BLAST156
Transmembranei486 – 504HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3350222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000034128 – 512Neuronal acetylcholine receptor subunit alpha-2Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 174By similarity
Glycosylationi212N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi224 ↔ 225Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91X60.
PRIDEiQ91X60.

PTM databases

iPTMnetiQ91X60.
PhosphoSitePlusiQ91X60.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022041.
GenevisibleiQ91X60. MM.

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022620.

Structurei

3D structure databases

ProteinModelPortaliQ91X60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi391 – 403Poly-GluAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ91X60.
KOiK04804.
OMAiAQQGSHT.
OrthoDBiEOG091G0R20.
PhylomeDBiQ91X60.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91X60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSHPAFQF WIHLYLWCLL LMPAVLAQQG SHTHAEDRLF KHLFGGYNRW
60 70 80 90 100
ARPVPNTSDV VIVRFGLSIA QLIDVDEKNQ MMTTNVWLKQ EWNDYKLRWD
110 120 130 140 150
PAEFGNITSL RVPSEMIWIP DIVLYNNADG EFAVTHMTKA HLFFTGTVHW
160 170 180 190 200
VPPAIYKSSC SIDVTFFPFD QQNCKMKFGS WTYDKAKIDL EQMERTVDLK
210 220 230 240 250
DYWESGEWAI INATGTYNSK KYDCCAEIYP DVTYYFVIRR LPLFYTINLI
260 270 280 290 300
IPCLLISCLT VLVFYLPSEC GEKITLCISV LLSLTVFLLL ITEIIPSTSL
310 320 330 340 350
VIPLIGEYLL FTMIFVTLSI VITVFVLNVH HRSPSTHNMP NWVRVALLGR
360 370 380 390 400
VPRWLMMNRP LPPMELHGSP GLKLSPTYHW LETNMDAEER EETEEEEEEE
410 420 430 440 450
EDENICMCAG LPDSSMGVLY GHGSLHLRAM GPEAKTPSQA SEILLSPQIQ
460 470 480 490 500
KALEGVHYIA DHLRSEDADS SVKEDWKYVA MVVDRIFLWL FIIVCFLGTI
510
GLFLPPFLAG MI
Length:512
Mass (Da):58,735
Last modified:December 1, 2001 - v1
Checksum:iAC0C6CC398B69C6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574261 mRNA. Translation: AAS90357.1.
BC011490 mRNA. Translation: AAH11490.1.
CCDSiCCDS27219.1.
RefSeqiNP_659052.1. NM_144803.2.
XP_006518497.1. XM_006518434.3.
XP_006518498.1. XM_006518435.3.
XP_006518499.1. XM_006518436.3.
UniGeneiMm.57350.

Genome annotation databases

EnsembliENSMUST00000022620; ENSMUSP00000022620; ENSMUSG00000022041.
ENSMUST00000206455; ENSMUSP00000145896; ENSMUSG00000022041.
GeneIDi110902.
KEGGimmu:110902.
UCSCiuc007ujx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY574261 mRNA. Translation: AAS90357.1.
BC011490 mRNA. Translation: AAH11490.1.
CCDSiCCDS27219.1.
RefSeqiNP_659052.1. NM_144803.2.
XP_006518497.1. XM_006518434.3.
XP_006518498.1. XM_006518435.3.
XP_006518499.1. XM_006518436.3.
UniGeneiMm.57350.

3D structure databases

ProteinModelPortaliQ91X60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022620.

Chemistry databases

ChEMBLiCHEMBL3350222.

PTM databases

iPTMnetiQ91X60.
PhosphoSitePlusiQ91X60.

Proteomic databases

PaxDbiQ91X60.
PRIDEiQ91X60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022620; ENSMUSP00000022620; ENSMUSG00000022041.
ENSMUST00000206455; ENSMUSP00000145896; ENSMUSG00000022041.
GeneIDi110902.
KEGGimmu:110902.
UCSCiuc007ujx.1. mouse.

Organism-specific databases

CTDi1135.
MGIiMGI:87886. Chrna2.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ91X60.
KOiK04804.
OMAiAQQGSHT.
OrthoDBiEOG091G0R20.
PhylomeDBiQ91X60.
TreeFamiTF315605.

Enzyme and pathway databases

ReactomeiR-MMU-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-MMU-629597. Highly calcium permeable nicotinic acetylcholine receptors.

Miscellaneous databases

PROiQ91X60.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022041.
GenevisibleiQ91X60. MM.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA2_MOUSE
AccessioniPrimary (citable) accession number: Q91X60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.