Neuronal acetylcholine receptor subunit alpha-2 precursor

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Q91X60 (ACHA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Neuronal acetylcholine receptor subunit alpha-2

Gene names

Name:

Chrna2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane By similarity.
Subunit structure	Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors By similarity.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	acetylcholine-gated channel complex Inferred from electronic annotation. Source: Compara cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell periphery Inferred from direct assay PubMed 21884692. Source: MGI postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetylcholine receptor activity Inferred from electronic annotation. Source: Compara acetylcholine-activated cation-selective channel activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 27

Potential

Chain

28 – 512

485

Neuronal acetylcholine receptor subunit alpha-2

PRO_0000000341

Regions

Topological domain

28 – 241

214

Extracellular Potential

Transmembrane

242 – 266

Helical; Potential

Transmembrane

274 – 292

Helical; Potential

Transmembrane

308 – 329

Helical; Potential

Topological domain

330 – 485

156

Cytoplasmic Potential

Transmembrane

486 – 504

Helical; Potential

Compositional bias

391 – 403

Poly-Glu

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

106

N-linked (GlcNAc...) Potential

Glycosylation

212

N-linked (GlcNAc...) Potential

Disulfide bond

160 ↔ 174

By similarity

Disulfide bond

224 ↔ 225

Associated with receptor activation By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q91X60 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: AC0C6CC398B69C6C
Show »

FASTA

512

58,735

        10         20         30         40         50         60 
MAPSHPAFQF WIHLYLWCLL LMPAVLAQQG SHTHAEDRLF KHLFGGYNRW ARPVPNTSDV 

        70         80         90        100        110        120 
VIVRFGLSIA QLIDVDEKNQ MMTTNVWLKQ EWNDYKLRWD PAEFGNITSL RVPSEMIWIP 

       130        140        150        160        170        180 
DIVLYNNADG EFAVTHMTKA HLFFTGTVHW VPPAIYKSSC SIDVTFFPFD QQNCKMKFGS 

       190        200        210        220        230        240 
WTYDKAKIDL EQMERTVDLK DYWESGEWAI INATGTYNSK KYDCCAEIYP DVTYYFVIRR 

       250        260        270        280        290        300 
LPLFYTINLI IPCLLISCLT VLVFYLPSEC GEKITLCISV LLSLTVFLLL ITEIIPSTSL 

       310        320        330        340        350        360 
VIPLIGEYLL FTMIFVTLSI VITVFVLNVH HRSPSTHNMP NWVRVALLGR VPRWLMMNRP 

       370        380        390        400        410        420 
LPPMELHGSP GLKLSPTYHW LETNMDAEER EETEEEEEEE EDENICMCAG LPDSSMGVLY 

       430        440        450        460        470        480 
GHGSLHLRAM GPEAKTPSQA SEILLSPQIQ KALEGVHYIA DHLRSEDADS SVKEDWKYVA 

       490        500        510 
MVVDRIFLWL FIIVCFLGTI GLFLPPFLAG MI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Groot-Kormelink P.J. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Salivary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY574261 mRNA. Translation: AAS90357.1. BC011490 mRNA. Translation: AAH11490.1.
IPI	IPI00128446.
RefSeq	NP_659052.1. NM_144803.2.
UniGene	Mm.57350.
3D structure databases
ProteinModelPortal	Q91X60.
SMR	Q91X60. Positions 36-363, 483-510.
ModBase	Search...
PTM databases
PhosphoSite	Q91X60.
Proteomic databases
PRIDE	Q91X60.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022620; ENSMUSP00000022620; ENSMUSG00000022041.
GeneID	110902.
KEGG	mmu:110902.
UCSC	uc007ujx.1. mouse.
Organism-specific databases
CTD	1135.
MGI	MGI:87886. Chrna2.
Phylogenomic databases
eggNOG	NOG290206.
GeneTree	ENSGT00620000087732.
HOGENOM	HOG000006756.
HOVERGEN	HBG003756.
InParanoid	Q91X60.
KO	K04804.
OMA	EDENICM.
OrthoDB	EOG480HWN.
Gene expression databases
ArrayExpress	Q91X60.
Bgee	Q91X60.
Genevestigator	Q91X60.
GermOnline	ENSMUSG00000022041. Mus musculus.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. IPR002394. Nicotinic_acetylcholine_rcpt. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00254. NICOTINICR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	364901.
SOURCE	Search...

Entry information

Entry name

ACHA2_MOUSE

Accession

Primary (citable) accession number: Q91X60

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents