Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91X60 (ACHA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal acetylcholine receptor subunit alpha-2
Gene names
Name:Chrna2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane By similarity.

Subunit structure

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors By similarity.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 512485Neuronal acetylcholine receptor subunit alpha-2
PRO_0000000341

Regions

Topological domain28 – 241214Extracellular Potential
Transmembrane242 – 26625Helical; Potential
Transmembrane274 – 29219Helical; Potential
Transmembrane308 – 32922Helical; Potential
Topological domain330 – 485156Cytoplasmic Potential
Transmembrane486 – 50419Helical; Potential
Compositional bias391 – 40313Poly-Glu

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Disulfide bond160 ↔ 174 By similarity
Disulfide bond224 ↔ 225Associated with receptor activation By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91X60 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: AC0C6CC398B69C6C

FASTA51258,735
        10         20         30         40         50         60 
MAPSHPAFQF WIHLYLWCLL LMPAVLAQQG SHTHAEDRLF KHLFGGYNRW ARPVPNTSDV 

        70         80         90        100        110        120 
VIVRFGLSIA QLIDVDEKNQ MMTTNVWLKQ EWNDYKLRWD PAEFGNITSL RVPSEMIWIP 

       130        140        150        160        170        180 
DIVLYNNADG EFAVTHMTKA HLFFTGTVHW VPPAIYKSSC SIDVTFFPFD QQNCKMKFGS 

       190        200        210        220        230        240 
WTYDKAKIDL EQMERTVDLK DYWESGEWAI INATGTYNSK KYDCCAEIYP DVTYYFVIRR 

       250        260        270        280        290        300 
LPLFYTINLI IPCLLISCLT VLVFYLPSEC GEKITLCISV LLSLTVFLLL ITEIIPSTSL 

       310        320        330        340        350        360 
VIPLIGEYLL FTMIFVTLSI VITVFVLNVH HRSPSTHNMP NWVRVALLGR VPRWLMMNRP 

       370        380        390        400        410        420 
LPPMELHGSP GLKLSPTYHW LETNMDAEER EETEEEEEEE EDENICMCAG LPDSSMGVLY 

       430        440        450        460        470        480 
GHGSLHLRAM GPEAKTPSQA SEILLSPQIQ KALEGVHYIA DHLRSEDADS SVKEDWKYVA 

       490        500        510 
MVVDRIFLWL FIIVCFLGTI GLFLPPFLAG MI 

« Hide

References

« Hide 'large scale' references
[1]Groot-Kormelink P.J.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY574261 mRNA. Translation: AAS90357.1.
BC011490 mRNA. Translation: AAH11490.1.
CCDSCCDS27219.1.
RefSeqNP_659052.1. NM_144803.2.
XP_006518497.1. XM_006518434.1.
XP_006518498.1. XM_006518435.1.
XP_006518499.1. XM_006518436.1.
XP_006518500.1. XM_006518437.1.
XP_006518501.1. XM_006518438.1.
UniGeneMm.57350.

3D structure databases

ProteinModelPortalQ91X60.
SMRQ91X60. Positions 36-363, 483-510.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY463.

PTM databases

PhosphoSiteQ91X60.

Proteomic databases

PRIDEQ91X60.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022620; ENSMUSP00000022620; ENSMUSG00000022041.
GeneID110902.
KEGGmmu:110902.
UCSCuc007ujx.1. mouse.

Organism-specific databases

CTD1135.
MGIMGI:87886. Chrna2.

Phylogenomic databases

eggNOGNOG290206.
GeneTreeENSGT00750000117277.
HOGENOMHOG000006756.
HOVERGENHBG003756.
InParanoidQ91X60.
KOK04804.
OMAEDENICM.
OrthoDBEOG72JWGV.
PhylomeDBQ91X60.
TreeFamTF315605.

Gene expression databases

BgeeQ91X60.
GenevestigatorQ91X60.

Family and domain databases

Gene3D1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio364901.
PROQ91X60.
SOURCESearch...

Entry information

Entry nameACHA2_MOUSE
AccessionPrimary (citable) accession number: Q91X60
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot