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Q91X60

- ACHA2_MOUSE

UniProt

Q91X60 - ACHA2_MOUSE

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Protein

Neuronal acetylcholine receptor subunit alpha-2

Gene

Chrna2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.By similarity

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: Ensembl
  2. acetylcholine binding Source: Ensembl
  3. acetylcholine receptor activity Source: Ensembl
  4. drug binding Source: Ensembl

GO - Biological processi

  1. protein heterooligomerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
REACT_198585. Highly calcium permeable nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-2
Gene namesi
Name:Chrna2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:87886. Chrna2.

Subcellular locationi

GO - Cellular componenti

  1. acetylcholine-gated channel complex Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. cell periphery Source: MGI
  4. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 512485Neuronal acetylcholine receptor subunit alpha-2PRO_0000000341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi160 ↔ 174By similarity
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi224 ↔ 225Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ91X60.

PTM databases

PhosphoSiteiQ91X60.

Expressioni

Gene expression databases

BgeeiQ91X60.
ExpressionAtlasiQ91X60. baseline and differential.
GenevestigatoriQ91X60.

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ91X60.
SMRiQ91X60. Positions 36-338, 483-510.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 241214ExtracellularSequence AnalysisAdd
BLAST
Topological domaini330 – 485156CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei242 – 26625HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29219HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 32922HelicalSequence AnalysisAdd
BLAST
Transmembranei486 – 50419HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi391 – 40313Poly-GluAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290206.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ91X60.
KOiK04804.
OMAiEDENICM.
OrthoDBiEOG72JWGV.
PhylomeDBiQ91X60.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91X60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPSHPAFQF WIHLYLWCLL LMPAVLAQQG SHTHAEDRLF KHLFGGYNRW
60 70 80 90 100
ARPVPNTSDV VIVRFGLSIA QLIDVDEKNQ MMTTNVWLKQ EWNDYKLRWD
110 120 130 140 150
PAEFGNITSL RVPSEMIWIP DIVLYNNADG EFAVTHMTKA HLFFTGTVHW
160 170 180 190 200
VPPAIYKSSC SIDVTFFPFD QQNCKMKFGS WTYDKAKIDL EQMERTVDLK
210 220 230 240 250
DYWESGEWAI INATGTYNSK KYDCCAEIYP DVTYYFVIRR LPLFYTINLI
260 270 280 290 300
IPCLLISCLT VLVFYLPSEC GEKITLCISV LLSLTVFLLL ITEIIPSTSL
310 320 330 340 350
VIPLIGEYLL FTMIFVTLSI VITVFVLNVH HRSPSTHNMP NWVRVALLGR
360 370 380 390 400
VPRWLMMNRP LPPMELHGSP GLKLSPTYHW LETNMDAEER EETEEEEEEE
410 420 430 440 450
EDENICMCAG LPDSSMGVLY GHGSLHLRAM GPEAKTPSQA SEILLSPQIQ
460 470 480 490 500
KALEGVHYIA DHLRSEDADS SVKEDWKYVA MVVDRIFLWL FIIVCFLGTI
510
GLFLPPFLAG MI
Length:512
Mass (Da):58,735
Last modified:December 1, 2001 - v1
Checksum:iAC0C6CC398B69C6C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY574261 mRNA. Translation: AAS90357.1.
BC011490 mRNA. Translation: AAH11490.1.
CCDSiCCDS27219.1.
RefSeqiNP_659052.1. NM_144803.2.
XP_006518497.1. XM_006518434.1.
XP_006518498.1. XM_006518435.1.
XP_006518499.1. XM_006518436.1.
XP_006518500.1. XM_006518437.1.
XP_006518501.1. XM_006518438.1.
UniGeneiMm.57350.

Genome annotation databases

EnsembliENSMUST00000022620; ENSMUSP00000022620; ENSMUSG00000022041.
GeneIDi110902.
KEGGimmu:110902.
UCSCiuc007ujx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY574261 mRNA. Translation: AAS90357.1 .
BC011490 mRNA. Translation: AAH11490.1 .
CCDSi CCDS27219.1.
RefSeqi NP_659052.1. NM_144803.2.
XP_006518497.1. XM_006518434.1.
XP_006518498.1. XM_006518435.1.
XP_006518499.1. XM_006518436.1.
XP_006518500.1. XM_006518437.1.
XP_006518501.1. XM_006518438.1.
UniGenei Mm.57350.

3D structure databases

ProteinModelPortali Q91X60.
SMRi Q91X60. Positions 36-338, 483-510.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 463.

PTM databases

PhosphoSitei Q91X60.

Proteomic databases

PRIDEi Q91X60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022620 ; ENSMUSP00000022620 ; ENSMUSG00000022041 .
GeneIDi 110902.
KEGGi mmu:110902.
UCSCi uc007ujx.1. mouse.

Organism-specific databases

CTDi 1135.
MGIi MGI:87886. Chrna2.

Phylogenomic databases

eggNOGi NOG290206.
GeneTreei ENSGT00760000118930.
HOGENOMi HOG000006756.
HOVERGENi HBG003756.
InParanoidi Q91X60.
KOi K04804.
OMAi EDENICM.
OrthoDBi EOG72JWGV.
PhylomeDBi Q91X60.
TreeFami TF315605.

Enzyme and pathway databases

Reactomei REACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
REACT_198585. Highly calcium permeable nicotinic acetylcholine receptors.

Miscellaneous databases

NextBioi 364901.
PROi Q91X60.
SOURCEi Search...

Gene expression databases

Bgeei Q91X60.
ExpressionAtlasi Q91X60. baseline and differential.
Genevestigatori Q91X60.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Groot-Kormelink P.J.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.

Entry informationi

Entry nameiACHA2_MOUSE
AccessioniPrimary (citable) accession number: Q91X60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3