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Protein

Sphingosine 1-phosphate receptor 5

Gene

S1pr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell.By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • regulation of neuron differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 5
Short name:
S1P receptor 5
Short name:
S1P5
Alternative name(s):
Endothelial differentiation G-protein-coupled receptor 8
Lysophospholipid receptor B4
Sphingosine 1-phosphate receptor Edg-8
Short name:
S1P receptor Edg-8
Gene namesi
Name:S1pr5
Synonyms:Edg8, Lpb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2150641. S1pr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularBy similarityAdd
BLAST
Transmembranei42 – 6221Helical; Name=1By similarityAdd
BLAST
Topological domaini63 – 686CytoplasmicBy similarity
Transmembranei69 – 8921Helical; Name=2By similarityAdd
BLAST
Topological domaini90 – 11122ExtracellularBy similarityAdd
BLAST
Transmembranei112 – 13221Helical; Name=3By similarityAdd
BLAST
Topological domaini133 – 15119CytoplasmicBy similarityAdd
BLAST
Transmembranei152 – 17221Helical; Name=4By similarityAdd
BLAST
Topological domaini173 – 19220ExtracellularBy similarityAdd
BLAST
Transmembranei193 – 21321Helical; Name=5By similarityAdd
BLAST
Topological domaini214 – 25340CytoplasmicBy similarityAdd
BLAST
Transmembranei254 – 27421Helical; Name=6By similarityAdd
BLAST
Topological domaini275 – 28814ExtracellularBy similarityAdd
BLAST
Transmembranei289 – 30921Helical; Name=7By similarityAdd
BLAST
Topological domaini310 – 40091CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi279.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Sphingosine 1-phosphate receptor 5PRO_0000069437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Lipidationi324 – 3241S-palmitoyl cysteineBy similarity
Modified residuei340 – 3401PhosphoserineCombined sources
Modified residuei342 – 3421PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ91X56.
PaxDbiQ91X56.
PRIDEiQ91X56.

PTM databases

PhosphoSiteiQ91X56.

Expressioni

Tissue specificityi

Expressed in spleen and brain. In the CNS expression is restricted to oligodendrocytes.2 Publications

Developmental stagei

Expressed in 7-day and 17-day embryos, but not in 11-day and 15-day embryos, implying its role in mammalian development. In oligodendrocytes, expressed throughout development from the immature stages to the mature myelin-froming cell.1 Publication

Gene expression databases

BgeeiQ91X56.
GenevisibleiQ91X56. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113843.

Structurei

3D structure databases

ProteinModelPortaliQ91X56.
SMRiQ91X56. Positions 13-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIK8. Eukaryota.
ENOG4111FBV. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ91X56.
KOiK04295.
OMAiYMANILM.
OrthoDBiEOG708W0B.
PhylomeDBiQ91X56.
TreeFamiTF330052.

Family and domain databases

InterProiIPR005386. EDG8_S1P_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01561. EDG8RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91X56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGLLRPAP VSEVIVLHYN YTGKLRGARY QPGAGLRADA AVCLAVCAFI
60 70 80 90 100
VLENLAVLLV LVRHPRFHAP MFLLLGSLTL SDLLAGAAYA TNILLSGPLT
110 120 130 140 150
LRLSPALWFA REGGVFVALA ASVLSLLAIA LERHLTMARR GPAPAASRAR
160 170 180 190 200
TLAMAVAAWG ASLLLGLLPA LGWNCLGRLE TCSTVLPLYA KAYVLFCVLA
210 220 230 240 250
FLGILAAICA LYARIYCQVR ANARRLRAGP GSRRATSSSR SRHTPRSLAL
260 270 280 290 300
LRTLSVVLLA FVACWGPLFL LLLLDVACPA RACPVLLQAD PFLGLAMANS
310 320 330 340 350
LLNPIIYTFT NRDLRHALLR LLCCGRGPCN QDSSNSLQRS PSAAGPSGGG
360 370 380 390 400
LRRCLPPTLD RSSSPSEHLS PQQDGVDTSC STGSPGVATA NRSLVPTATD
Length:400
Mass (Da):42,331
Last modified:December 1, 2001 - v1
Checksum:iA4311B8E8515F3F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012232 mRNA. Translation: AAH12232.1.
AF327535 mRNA. Translation: AAK15485.1.
AK081126 mRNA. Translation: BAC38142.1.
CCDSiCCDS22898.1.
RefSeqiNP_444420.1. NM_053190.2.
XP_011240934.1. XM_011242632.1.
UniGeneiMm.190619.

Genome annotation databases

EnsembliENSMUST00000122088; ENSMUSP00000113843; ENSMUSG00000045087.
GeneIDi94226.
KEGGimmu:94226.
UCSCiuc009oks.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012232 mRNA. Translation: AAH12232.1.
AF327535 mRNA. Translation: AAK15485.1.
AK081126 mRNA. Translation: BAC38142.1.
CCDSiCCDS22898.1.
RefSeqiNP_444420.1. NM_053190.2.
XP_011240934.1. XM_011242632.1.
UniGeneiMm.190619.

3D structure databases

ProteinModelPortaliQ91X56.
SMRiQ91X56. Positions 13-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113843.

Chemistry

GuidetoPHARMACOLOGYi279.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ91X56.

Proteomic databases

MaxQBiQ91X56.
PaxDbiQ91X56.
PRIDEiQ91X56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000122088; ENSMUSP00000113843; ENSMUSG00000045087.
GeneIDi94226.
KEGGimmu:94226.
UCSCiuc009oks.2. mouse.

Organism-specific databases

CTDi53637.
MGIiMGI:2150641. S1pr5.

Phylogenomic databases

eggNOGiENOG410IIK8. Eukaryota.
ENOG4111FBV. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ91X56.
KOiK04295.
OMAiYMANILM.
OrthoDBiEOG708W0B.
PhylomeDBiQ91X56.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

NextBioi352227.
PROiQ91X56.
SOURCEiSearch...

Gene expression databases

BgeeiQ91X56.
GenevisibleiQ91X56. MM.

Family and domain databases

InterProiIPR005386. EDG8_S1P_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01561. EDG8RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  2. "Molecular cloning of the mouse sphingosine-1-phosphate receptor gene, Lpb4."
    Yang A.H., Zhang G., Chun J.J.M.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-400.
    Strain: Swiss Webster / NIH.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-400.
  4. "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors."
    Im D.-S., Clemens J., Macdonald T.L., Lynch K.R.
    Biochemistry 40:14053-14060(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival."
    Jaillard C., Harrison S., Stankoff B., Aigrot M.S., Calver A.R., Duddy G., Walsh F.S., Pangalos M.N., Arimura N., Kaibuchi K., Zalc B., Lubetzki C.
    J. Neurosci. 25:1459-1469(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiS1PR5_MOUSE
AccessioniPrimary (citable) accession number: Q91X56
Secondary accession number(s): Q99MN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.