Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-xylulose reductase

Gene

Dcxr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

Catalytic activityi

Xylitol + NADP+ = L-xylulose + NADPH.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361SubstrateBy similarity
Active sitei149 – 1491Proton acceptorPROSITE-ProRule annotation
Active sitei153 – 1531By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 3929NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • D-xylose metabolic process Source: UniProtKB-KW
  • glucose metabolic process Source: UniProtKB
  • NADP metabolic process Source: MGI
  • oxidation-reduction process Source: MGI
  • protein homotetramerization Source: UniProtKB
  • xylulose metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism, Xylose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.10. 3474.
ReactomeiR-MMU-5661270. Catabolism of glucuronate to xylulose-5-phosphate.
SABIO-RKQ91X52.

Names & Taxonomyi

Protein namesi
Recommended name:
L-xylulose reductase (EC:1.1.1.10)
Short name:
XR
Alternative name(s):
Dicarbonyl/L-xylulose reductase
Gene namesi
Name:Dcxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915130. Dcxr.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB-SubCell
  • brush border Source: MGI
  • cytoplasmic microtubule Source: UniProtKB
  • extracellular exosome Source: MGI
  • microvillus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244L-xylulose reductasePRO_0000054556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91X52.
MaxQBiQ91X52.
PaxDbiQ91X52.
PeptideAtlasiQ91X52.
PRIDEiQ91X52.

2D gel databases

REPRODUCTION-2DPAGEQ91X52.

PTM databases

iPTMnetiQ91X52.
PhosphoSiteiQ91X52.
SwissPalmiQ91X52.

Expressioni

Tissue specificityi

Highly expressed in kidney, liver and epididymis. Expressed at intermediate level in lung. Weakly or not expressed in brain, heart, spleen and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000039450.
CleanExiMM_DCXR.
ExpressionAtlasiQ91X52. baseline and differential.
GenevisibleiQ91X52. MM.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

IntActiQ91X52. 2 interactions.
MINTiMINT-1869627.
STRINGi10090.ENSMUSP00000026144.

Structurei

3D structure databases

ProteinModelPortaliQ91X52.
SMRiQ91X52. Positions 1-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1207. Eukaryota.
ENOG410XQCY. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105069.
InParanoidiQ91X52.
KOiK03331.
OMAiWSDPCKA.
OrthoDBiEOG091G0GV2.
PhylomeDBiQ91X52.
TreeFamiTF313841.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91X52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGLAGRRA LVTGAGKGIG RSTVLALKAA GAQVVAVSRT REDLDDLVRE
60 70 80 90 100
CPGVEPVCVD LADWEATEQA LSNVGPVDLL VNNAAVALLQ PFLEVTKEAC
110 120 130 140 150
DTSFNVNLRA VIQVSQIVAK GMIARGVPGA IVNVSSQASQ RALTNHTVYC
160 170 180 190 200
STKGALDMLT KMMALELGPH KIRVNAVNPT VVMTPMGRTN WSDPHKAKAM
210 220 230 240
LDRIPLGKFA EVENVVDTIL FLLSNRSGMT TGSTLPVDGG FLAT
Length:244
Mass (Da):25,746
Last modified:July 19, 2004 - v2
Checksum:i9701111544053820
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271V → N in AAH12247 (PubMed:15489334).Curated
Sequence conflicti133 – 1353NVS → KKY in AAH12247 (PubMed:15489334).Curated
Sequence conflicti157 – 1582DM → FL in AAH12247 (PubMed:15489334).Curated
Sequence conflicti162 – 1621M → R in AAH12247 (PubMed:15489334).Curated
Sequence conflicti172 – 1721I → S in AAH12247 (PubMed:15489334).Curated
Sequence conflicti184 – 1841T → R in AAH12247 (PubMed:15489334).Curated
Sequence conflicti202 – 2032DR → ES in AAH12247 (PubMed:15489334).Curated
Sequence conflicti224 – 2241S → G in BAB23131 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89656 mRNA. Translation: BAB88678.1.
AK004023 mRNA. Translation: BAB23131.1.
AK007627 mRNA. Translation: BAB25146.1.
AK153521 mRNA. Translation: BAE32063.1.
BC012247 mRNA. Translation: AAH12247.1.
CCDSiCCDS25755.1.
RefSeqiNP_080704.2. NM_026428.2.
UniGeneiMm.231091.

Genome annotation databases

EnsembliENSMUST00000026144; ENSMUSP00000026144; ENSMUSG00000039450.
GeneIDi67880.
KEGGimmu:67880.
UCSCiuc007muh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89656 mRNA. Translation: BAB88678.1.
AK004023 mRNA. Translation: BAB23131.1.
AK007627 mRNA. Translation: BAB25146.1.
AK153521 mRNA. Translation: BAE32063.1.
BC012247 mRNA. Translation: AAH12247.1.
CCDSiCCDS25755.1.
RefSeqiNP_080704.2. NM_026428.2.
UniGeneiMm.231091.

3D structure databases

ProteinModelPortaliQ91X52.
SMRiQ91X52. Positions 1-243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91X52. 2 interactions.
MINTiMINT-1869627.
STRINGi10090.ENSMUSP00000026144.

PTM databases

iPTMnetiQ91X52.
PhosphoSiteiQ91X52.
SwissPalmiQ91X52.

2D gel databases

REPRODUCTION-2DPAGEQ91X52.

Proteomic databases

EPDiQ91X52.
MaxQBiQ91X52.
PaxDbiQ91X52.
PeptideAtlasiQ91X52.
PRIDEiQ91X52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026144; ENSMUSP00000026144; ENSMUSG00000039450.
GeneIDi67880.
KEGGimmu:67880.
UCSCiuc007muh.1. mouse.

Organism-specific databases

CTDi51181.
MGIiMGI:1915130. Dcxr.

Phylogenomic databases

eggNOGiKOG1207. Eukaryota.
ENOG410XQCY. LUCA.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105069.
InParanoidiQ91X52.
KOiK03331.
OMAiWSDPCKA.
OrthoDBiEOG091G0GV2.
PhylomeDBiQ91X52.
TreeFamiTF313841.

Enzyme and pathway databases

BRENDAi1.1.1.10. 3474.
ReactomeiR-MMU-5661270. Catabolism of glucuronate to xylulose-5-phosphate.
SABIO-RKQ91X52.

Miscellaneous databases

PROiQ91X52.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039450.
CleanExiMM_DCXR.
ExpressionAtlasiQ91X52. baseline and differential.
GenevisibleiQ91X52. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCXR_MOUSE
AccessioniPrimary (citable) accession number: Q91X52
Secondary accession number(s): Q3U5L5, Q9D129, Q9D8W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.