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Protein

L-xylulose reductase

Gene

Dcxr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.

Catalytic activityi

Xylitol + NADP+ = L-xylulose + NADPH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136SubstrateBy similarity1
Active sitei149Proton acceptorPROSITE-ProRule annotation1
Active sitei153By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 39NADPBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • D-xylose metabolic process Source: UniProtKB-KW
  • glucose metabolic process Source: UniProtKB
  • NADP metabolic process Source: MGI
  • oxidation-reduction process Source: MGI
  • protein homotetramerization Source: UniProtKB
  • xylulose metabolic process Source: MGI

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism, Xylose metabolism
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.10 3474
ReactomeiR-MMU-5661270 Catabolism of glucuronate to xylulose-5-phosphate
SABIO-RKiQ91X52

Names & Taxonomyi

Protein namesi
Recommended name:
L-xylulose reductase (EC:1.1.1.10)
Short name:
XR
Alternative name(s):
Dicarbonyl/L-xylulose reductase
Gene namesi
Name:Dcxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915130 Dcxr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545561 – 244L-xylulose reductaseAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei21Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiQ91X52
MaxQBiQ91X52
PaxDbiQ91X52
PeptideAtlasiQ91X52
PRIDEiQ91X52

2D gel databases

REPRODUCTION-2DPAGEiQ91X52

PTM databases

iPTMnetiQ91X52
PhosphoSitePlusiQ91X52
SwissPalmiQ91X52

Expressioni

Tissue specificityi

Highly expressed in kidney, liver and epididymis. Expressed at intermediate level in lung. Weakly or not expressed in brain, heart, spleen and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000039450
CleanExiMM_DCXR
ExpressionAtlasiQ91X52 baseline and differential
GenevisibleiQ91X52 MM

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91X52, 2 interactors
MINTiQ91X52
STRINGi10090.ENSMUSP00000026144

Structurei

3D structure databases

ProteinModelPortaliQ91X52
SMRiQ91X52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1207 Eukaryota
ENOG410XQCY LUCA
GeneTreeiENSGT00910000144022
HOVERGENiHBG105069
InParanoidiQ91X52
KOiK03331
OMAiRECPGIE
OrthoDBiEOG091G0GV2
PhylomeDBiQ91X52
TreeFamiTF313841

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q91X52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGLAGRRA LVTGAGKGIG RSTVLALKAA GAQVVAVSRT REDLDDLVRE
60 70 80 90 100
CPGVEPVCVD LADWEATEQA LSNVGPVDLL VNNAAVALLQ PFLEVTKEAC
110 120 130 140 150
DTSFNVNLRA VIQVSQIVAK GMIARGVPGA IVNVSSQASQ RALTNHTVYC
160 170 180 190 200
STKGALDMLT KMMALELGPH KIRVNAVNPT VVMTPMGRTN WSDPHKAKAM
210 220 230 240
LDRIPLGKFA EVENVVDTIL FLLSNRSGMT TGSTLPVDGG FLAT
Length:244
Mass (Da):25,746
Last modified:July 19, 2004 - v2
Checksum:i9701111544053820
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127V → N in AAH12247 (PubMed:15489334).Curated1
Sequence conflicti133 – 135NVS → KKY in AAH12247 (PubMed:15489334).Curated3
Sequence conflicti157 – 158DM → FL in AAH12247 (PubMed:15489334).Curated2
Sequence conflicti162M → R in AAH12247 (PubMed:15489334).Curated1
Sequence conflicti172I → S in AAH12247 (PubMed:15489334).Curated1
Sequence conflicti184T → R in AAH12247 (PubMed:15489334).Curated1
Sequence conflicti202 – 203DR → ES in AAH12247 (PubMed:15489334).Curated2
Sequence conflicti224S → G in BAB23131 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89656 mRNA Translation: BAB88678.1
AK004023 mRNA Translation: BAB23131.1
AK007627 mRNA Translation: BAB25146.1
AK153521 mRNA Translation: BAE32063.1
BC012247 mRNA Translation: AAH12247.1
CCDSiCCDS25755.1
RefSeqiNP_080704.2, NM_026428.2
UniGeneiMm.231091

Genome annotation databases

EnsembliENSMUST00000026144; ENSMUSP00000026144; ENSMUSG00000039450
GeneIDi67880
KEGGimmu:67880
UCSCiuc007muh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDCXR_MOUSE
AccessioniPrimary (citable) accession number: Q91X52
Secondary accession number(s): Q3U5L5, Q9D129, Q9D8W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health