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Protein

Glucokinase regulatory protein

Gene

Gckr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei153Fructose 1-phosphateBy similarity1
Binding sitei348Fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate derivative metabolic process Source: InterPro
  • carbohydrate metabolic process Source: UniProtKB-KW
  • cellular glucose homeostasis Source: MGI
  • negative regulation of glucokinase activity Source: MGI
  • positive regulation of glucokinase activity Source: BHF-UCL
  • protein import into nucleus, translocation Source: MGI
  • protein localization to nucleus Source: MGI
  • response to fructose Source: MGI
  • triglyceride homeostasis Source: MGI
  • urate metabolic process Source: MGI

Keywordsi

Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-MMU-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase regulatory protein
Short name:
Glucokinase regulator
Gene namesi
Name:Gckr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1096345 Gckr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3232700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002488321 – 587Glucokinase regulatory proteinAdd BLAST587

Proteomic databases

MaxQBiQ91X44
PaxDbiQ91X44
PeptideAtlasiQ91X44
PRIDEiQ91X44

PTM databases

iPTMnetiQ91X44
PhosphoSitePlusiQ91X44
SwissPalmiQ91X44

Expressioni

Gene expression databases

BgeeiENSMUSG00000059434
CleanExiMM_GCKR
ExpressionAtlasiQ91X44 baseline and differential
GenevisibleiQ91X44 MM

Interactioni

Subunit structurei

Interacts (fructose 6-phosphate bound form) with GCK.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231083, 1 interactor
IntActiQ91X44, 1 interactor
MINTiQ91X44
STRINGi10090.ENSMUSP00000072084

Chemistry databases

BindingDBiQ91X44

Structurei

3D structure databases

ProteinModelPortaliQ91X44
SMRiQ91X44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 286SIS 1PROSITE-ProRule annotationAdd BLAST197
Domaini320 – 476SIS 2PROSITE-ProRule annotationAdd BLAST157

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 110Fructose 1-phosphate/Fructose 6-phosphate bindingBy similarity2
Regioni179 – 181Fructose 1-phosphate/Fructose 6-phosphate bindingBy similarity3
Regioni199 – 200Important for interaction with GCKBy similarity2
Regioni463 – 465Essential for interaction with GCKBy similarity3

Domaini

Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site.By similarity

Sequence similaritiesi

Belongs to the GCKR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHMK Eukaryota
ENOG4111GRB LUCA
GeneTreeiENSGT00390000005345
HOGENOMiHOG000031501
HOVERGENiHBG005818
InParanoidiQ91X44
OrthoDBiEOG091G03ET
PhylomeDBiQ91X44
TreeFamiTF329177

Family and domain databases

InterProiView protein in InterPro
IPR005486 Glucokinase_regulatory_CS
IPR001347 SIS
PROSITEiView protein in PROSITE
PS01272 GCKR, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Q91X44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSTKRYQHV IETPEPGEWE LSGYEAAVPI TEKSNPLTRN LDKADAEKIV
60 70 80 90 100
QLLGQCDAEI FQEEGQIMPT YQRLYSESVL TTMLQVAGKV QEVLKEPDGG
110 120 130 140 150
LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE
160 170 180 190 200
RTEDSALHGI EELKKVAAGK KRVVVIGISV GLSAPFVAGQ MDYCMDNTAV
210 220 230 240 250
FLPVLVGFNP VSMARNDPIE DWRSTFRQVA ERMQKMQEKQ EAFVLNPAIG
260 270 280 290 300
PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGVVSSQR CLLEILRTFE
310 320 330 340 350
RAHQVTYSQS SKIATLTKQV GISLEKKGHV HLVGWQTLGI IAIMDGVECI
360 370 380 390 400
HTFGADFRDI RGFLIGDHND MFNQKDELSN QGPQFTFSQD DFLTSVLPSL
410 420 430 440 450
TEIDTVVFIF TLDDNLAEVQ ALAERVREKS WNIQALVHST VGQSLPAPLK
460 470 480 490 500
KLFPSLISIT WPLLFFDYEG SYVQKFQREL STKWVLNTRF SGQSKARCIE
510 520 530 540 550
SLLQVIHFPQ PLSNDVRAAP ISCHVQVAHE KEKVIPTALL SLLLRCSITE
560 570 580
AKERLAAASS VCEVVRSALS GPGQKRSIQA FGDPVVP
Length:587
Mass (Da):64,679
Last modified:January 23, 2007 - v3
Checksum:i54319C68A136952A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012412 mRNA Translation: AAH12412.1
CCDSiCCDS19182.1
RefSeqiNP_659158.1, NM_144909.1
UniGeneiMm.100043

Genome annotation databases

EnsembliENSMUST00000072228; ENSMUSP00000072084; ENSMUSG00000059434
GeneIDi231103
KEGGimmu:231103
UCSCiuc008wyf.1 mouse

Entry informationi

Entry nameiGCKR_MOUSE
AccessioniPrimary (citable) accession number: Q91X44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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