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Q91X43

- SH319_MOUSE

UniProt

Q91X43 - SH319_MOUSE

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Protein
SH3 domain-containing protein 19
Gene
Sh3d19
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  3. regulation of cell morphogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing protein 19
Alternative name(s):
Kryn
Gene namesi
Name:Sh3d19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1350923. Sh3d19.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. nucleus Source: Ensembl
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 789789SH3 domain-containing protein 19
PRO_0000318198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X43.
PRIDEiQ91X43.

PTM databases

PhosphoSiteiQ91X43.

Expressioni

Tissue specificityi

Expressed in hair follicles.1 Publication

Gene expression databases

BgeeiQ91X43.
CleanExiMM_SH3D19.
GenevestigatoriQ91X43.

Interactioni

Subunit structurei

Interacts with ADAM12. Isoform 2 (but not isoform 1) interacts with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2 By similarity. Interacts with SH3YL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sh3yl1O086413EBI-2024543,EBI-2024519

Protein-protein interaction databases

IntActiQ91X43. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91X43.
SMRiQ91X43. Positions 420-472, 501-786.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini417 – 47256SH3 1
Add
BLAST
Domaini494 – 55360SH3 2
Add
BLAST
Domaini570 – 62960SH3 3
Add
BLAST
Domaini660 – 71960SH3 4
Add
BLAST
Domaini729 – 78860SH3 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 352324Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 5 SH3 domains.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG296456.
GeneTreeiENSGT00690000101886.
HOGENOMiHOG000082398.
HOVERGENiHBG108486.
InParanoidiQ91X43.
OMAiVLDPFQL.
OrthoDBiEOG761BW2.
PhylomeDBiQ91X43.
TreeFamiTF330850.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028505. SH3D19.
[Graphical view]
PANTHERiPTHR10661:SF127. PTHR10661:SF127. 1 hit.
PfamiPF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 5 hits.
PROSITEiPS50002. SH3. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91X43-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNIMNTEQSQ NTIVSRIKAF EGQTNTEIPG LPKKPEIIPR TIPPKPAVSS    50
GKPLVAPKPA ANRASGEWDT WAENRLKVTS REGLTPYSSP QEAGITPVTK 100
PELPKKPTPG LTRSVNHETS GGRPMAESPD TGKKIPTPAP RPLLPKKSAS 150
TDAPPYPSIP PKLVSAPPRL SVASQAKAFR SLGEGLPSNP PVPAPQSKAL 200
GDIDLISFDD DVLPTSGSPA EEPTGSETVL DPFQLPTKTE ATKERAVQPA 250
PTRKPTVIRI PAKPGKCLHE EPQSPPPLPA EKPVGNTHSA VSGRPSHSDR 300
TRNPELEQAS ESGGLVQGPP RLPPRPVHGK VIPVWRPPPK GAPERPPPPK 350
LPASKSSNKN LPFNRSSSDM DLQKKQSHFV SGLSKAKSQI FKNQDPVLPP 400
RPKPGHPLYR KYMLSVPHGI ANEDIVSRNP TELSCKRGDV LVILKQAENN 450
YLECQRGEGT GRVHPSQMKI VTPLDERPRG RPNDSGHSQK PVDSGAPHAV 500
ALHDFPAEQA DDLSLTSGEI VYLLEKIDAE WYRGKCRNQT GVFPANYVKV 550
IVDIPEGRSG KRESFSSHCA KGPRCVARFE YIGDQKDELS FSEGEVIILT 600
EYVNEEWGRG EIRDRSGIFP LNFVELVGDH PTSGANILST KVPPKTKNED 650
PGSNSQDSSP PGEWCKALHS FTAETSEDLP FKRGDRILIL ERLDSDWYRG 700
RLHDREGIFP AVFVQPCPAE AKGVASAIPK GRKVKALYDF LGENEDELSF 750
KAGDVITELE PIDDAWMRGE LMGRAGMFPK NYVQFLQVS 789
Length:789
Mass (Da):86,077
Last modified:February 5, 2008 - v2
Checksum:iD3F866FB1A5BEB81
GO
Isoform 2 (identifier: Q91X43-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-369: Missing.

Show »
Length:420
Mass (Da):46,899
Checksum:i8B5D6F87EE5BA5A8
GO

Sequence cautioni

The sequence AAB82091.1 differs from that shown. Reason: Sequence contamination. Potenial vector sequence.
The sequence AAH12633.1 differs from that shown. Reason: Sequence contamination. Potential vector sequence.
The sequence AAH31117.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 369369Missing in isoform 2.
VSP_031185Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti559 – 5591S → G in BAC34114. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89677 mRNA. Translation: BAA19686.2.
AC133508 Genomic DNA. No translation available.
BC012633 mRNA. Translation: AAH12633.1. Sequence problems.
BC031117 mRNA. Translation: AAH31117.1. Different initiation.
AF003234 mRNA. Translation: AAB82091.1. Sequence problems.
AK050185 mRNA. Translation: BAC34114.1.
CCDSiCCDS38469.2. [Q91X43-1]
RefSeqiNP_001075883.2. NM_001082414.2. [Q91X43-1]
XP_006501613.1. XM_006501550.1.
UniGeneiMm.2454.

Genome annotation databases

EnsembliENSMUST00000107664; ENSMUSP00000103291; ENSMUSG00000028082. [Q91X43-1]
ENSMUST00000182666; ENSMUSP00000138320; ENSMUSG00000028082. [Q91X43-1]
GeneIDi27059.
KEGGimmu:27059.
UCSCiuc008pra.2. mouse. [Q91X43-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89677 mRNA. Translation: BAA19686.2 .
AC133508 Genomic DNA. No translation available.
BC012633 mRNA. Translation: AAH12633.1 . Sequence problems.
BC031117 mRNA. Translation: AAH31117.1 . Different initiation.
AF003234 mRNA. Translation: AAB82091.1 . Sequence problems.
AK050185 mRNA. Translation: BAC34114.1 .
CCDSi CCDS38469.2. [Q91X43-1 ]
RefSeqi NP_001075883.2. NM_001082414.2. [Q91X43-1 ]
XP_006501613.1. XM_006501550.1.
UniGenei Mm.2454.

3D structure databases

ProteinModelPortali Q91X43.
SMRi Q91X43. Positions 420-472, 501-786.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91X43. 1 interaction.

PTM databases

PhosphoSitei Q91X43.

Proteomic databases

MaxQBi Q91X43.
PRIDEi Q91X43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107664 ; ENSMUSP00000103291 ; ENSMUSG00000028082 . [Q91X43-1 ]
ENSMUST00000182666 ; ENSMUSP00000138320 ; ENSMUSG00000028082 . [Q91X43-1 ]
GeneIDi 27059.
KEGGi mmu:27059.
UCSCi uc008pra.2. mouse. [Q91X43-1 ]

Organism-specific databases

CTDi 152503.
MGIi MGI:1350923. Sh3d19.

Phylogenomic databases

eggNOGi NOG296456.
GeneTreei ENSGT00690000101886.
HOGENOMi HOG000082398.
HOVERGENi HBG108486.
InParanoidi Q91X43.
OMAi VLDPFQL.
OrthoDBi EOG761BW2.
PhylomeDBi Q91X43.
TreeFami TF330850.

Miscellaneous databases

ChiTaRSi SH3D19. mouse.
NextBioi 305017.
PROi Q91X43.
SOURCEi Search...

Gene expression databases

Bgeei Q91X43.
CleanExi MM_SH3D19.
Genevestigatori Q91X43.

Family and domain databases

InterProi IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028505. SH3D19.
[Graphical view ]
PANTHERi PTHR10661:SF127. PTHR10661:SF127. 1 hit.
Pfami PF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 5 hits.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 5 hits.
PROSITEi PS50002. SH3. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles."
    Shimomura Y., Aoki N., Ito K., Ito M.
    J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SH3YL1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-789 (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon and Kidney.
  4. Sekely S.A., Kay B.K.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 465-789.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 505-789.
    Strain: C57BL/6J.
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSH319_MOUSE
AccessioniPrimary (citable) accession number: Q91X43
Secondary accession number(s): O08635, O35146, Q8C7I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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