Q91X43 (SH319_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3 domain-containing protein 19

Alternative name(s):
Kryn

Gene names

Name:

Sh3d19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	789 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization By similarity.
Subunit structure	Interacts with ADAM12. Isoform 2 (but not isoform 1) interacts with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2 By similarity. Interacts with SH3YL1. Ref.1
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Expressed in hair follicles. Ref.1
Sequence similarities	Contains 5 SH3 domains.
Caution	It is uncertain whether Met-1 or Met-4 is the initiator.
Sequence caution	The sequence AAB82091.1 differs from that shown. Reason: Sequence contamination. Potenial vector sequence. The sequence AAH12633.1 differs from that shown. Reason: Sequence contamination. Potential vector sequence. The sequence AAH31117.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of membrane protein ectodomain proteolysis Inferred from electronic annotation. Source: Compara regulation of cell morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Sh3yl1	O08641	3	EBI-2024543,EBI-2024519

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91X43-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91X43-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-369: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 789	789	SH3 domain-containing protein 19		PRO_0000318198
Regions
	Domain	417 – 472	56	SH3 1
	Domain	494 – 553	60	SH3 2
	Domain	570 – 629	60	SH3 3
	Domain	660 – 719	60	SH3 4
	Domain	729 – 788	60	SH3 5
	Compositional bias	29 – 352	324	Pro-rich
Amino acid modifications
	Modified residue	676	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 369	369	Missing in isoform 2.		VSP_031185
Experimental info
	Sequence conflict	559	1	S → G in BAC34114. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: D3F866FB1A5BEB81	FASTA	789	86,077
	10 20 30 40 50 60 MNIMNTEQSQ NTIVSRIKAF EGQTNTEIPG LPKKPEIIPR TIPPKPAVSS GKPLVAPKPA 70 80 90 100 110 120 ANRASGEWDT WAENRLKVTS REGLTPYSSP QEAGITPVTK PELPKKPTPG LTRSVNHETS 130 140 150 160 170 180 GGRPMAESPD TGKKIPTPAP RPLLPKKSAS TDAPPYPSIP PKLVSAPPRL SVASQAKAFR 190 200 210 220 230 240 SLGEGLPSNP PVPAPQSKAL GDIDLISFDD DVLPTSGSPA EEPTGSETVL DPFQLPTKTE 250 260 270 280 290 300 ATKERAVQPA PTRKPTVIRI PAKPGKCLHE EPQSPPPLPA EKPVGNTHSA VSGRPSHSDR 310 320 330 340 350 360 TRNPELEQAS ESGGLVQGPP RLPPRPVHGK VIPVWRPPPK GAPERPPPPK LPASKSSNKN 370 380 390 400 410 420 LPFNRSSSDM DLQKKQSHFV SGLSKAKSQI FKNQDPVLPP RPKPGHPLYR KYMLSVPHGI 430 440 450 460 470 480 ANEDIVSRNP TELSCKRGDV LVILKQAENN YLECQRGEGT GRVHPSQMKI VTPLDERPRG 490 500 510 520 530 540 RPNDSGHSQK PVDSGAPHAV ALHDFPAEQA DDLSLTSGEI VYLLEKIDAE WYRGKCRNQT 550 560 570 580 590 600 GVFPANYVKV IVDIPEGRSG KRESFSSHCA KGPRCVARFE YIGDQKDELS FSEGEVIILT 610 620 630 640 650 660 EYVNEEWGRG EIRDRSGIFP LNFVELVGDH PTSGANILST KVPPKTKNED PGSNSQDSSP 670 680 690 700 710 720 PGEWCKALHS FTAETSEDLP FKRGDRILIL ERLDSDWYRG RLHDREGIFP AVFVQPCPAE 730 740 750 760 770 780 AKGVASAIPK GRKVKALYDF LGENEDELSF KAGDVITELE PIDDAWMRGE LMGRAGMFPK NYVQFLQVS
	Isoform 2 [UniParc]. Checksum: 8B5D6F87EE5BA5A8	FASTA	420	46,899
	10 20 30 40 50 60 MDLQKKQSHF VSGLSKAKSQ IFKNQDPVLP PRPKPGHPLY RKYMLSVPHG IANEDIVSRN 70 80 90 100 110 120 PTELSCKRGD VLVILKQAEN NYLECQRGEG TGRVHPSQMK IVTPLDERPR GRPNDSGHSQ 130 140 150 160 170 180 KPVDSGAPHA VALHDFPAEQ ADDLSLTSGE IVYLLEKIDA EWYRGKCRNQ TGVFPANYVK 190 200 210 220 230 240 VIVDIPEGRS GKRESFSSHC AKGPRCVARF EYIGDQKDEL SFSEGEVIIL TEYVNEEWGR 250 260 270 280 290 300 GEIRDRSGIF PLNFVELVGD HPTSGANILS TKVPPKTKNE DPGSNSQDSS PPGEWCKALH 310 320 330 340 350 360 SFTAETSEDL PFKRGDRILI LERLDSDWYR GRLHDREGIF PAVFVQPCPA EAKGVASAIP 370 380 390 400 410 420 KGRKVKALYD FLGENEDELS FKAGDVITEL EPIDDAWMRG ELMGRAGMFP KNYVQFLQVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles." Shimomura Y., Aoki N., Ito K., Ito M. J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SH3YL1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-789 (ISOFORM 1). Strain: FVB/N. Tissue: Colon and Kidney.
[4]	Sekely S.A., Kay B.K. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 465-789.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 505-789. Strain: C57BL/6J. Tissue: Liver.
[6]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-676, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89677 mRNA. Translation: BAA19686.2. AC133508 Genomic DNA. No translation available. BC012633 mRNA. Translation: AAH12633.1. Sequence problems. BC031117 mRNA. Translation: AAH31117.1. Different initiation. AF003234 mRNA. Translation: AAB82091.1. Sequence problems. AK050185 mRNA. Translation: BAC34114.1.
IPI	IPI00830768. IPI00886292.
RefSeq	NP_001075883.2. NM_001082414.2.
UniGene	Mm.2454.
3D structure databases
ProteinModelPortal	Q91X43.
SMR	Q91X43. Positions 418-471, 501-786.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q91X43. 1 interaction.
PTM databases
PhosphoSite	Q91X43.
Proteomic databases
PRIDE	Q91X43.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000107664; ENSMUSP00000103291; ENSMUSG00000028082.
GeneID	27059.
KEGG	mmu:27059.
UCSC	uc008pra.2. mouse.
Organism-specific databases
CTD	152503.
MGI	MGI:1350923. Sh3d19.
Phylogenomic databases
eggNOG	NOG296456.
GeneTree	ENSGT00690000101886.
HOGENOM	HOG000082398.
HOVERGEN	HBG108486.
InParanoid	Q91X43.
OMA	MNIMNTE.
OrthoDB	EOG4GB75H.
Gene expression databases
Bgee	Q91X43.
CleanEx	MM_SH3D19.
Genevestigator	Q91X43.
Family and domain databases
InterPro	IPR000108. p67phox. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00018. SH3_1. 4 hits. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 5 hits. [Graphical view]
SUPFAM	SSF50044. SH3. 5 hits.
PROSITE	PS50002. SH3. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SH3D19. mouse.
NextBio	305017.
SOURCE	Search...

Entry information

Entry name

SH319_MOUSE

Accession

Primary (citable) accession number: Q91X43
Secondary accession number(s): O08635, O35146, Q8C7I2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program