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Protein

SH3 domain-containing protein 19

Gene

Sh3d19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_342454. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing protein 19
Alternative name(s):
Kryn
Gene namesi
Name:Sh3d19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1350923. Sh3d19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 789789SH3 domain-containing protein 19PRO_0000318198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91X43.
PRIDEiQ91X43.

PTM databases

PhosphoSiteiQ91X43.

Expressioni

Tissue specificityi

Expressed in hair follicles.1 Publication

Gene expression databases

BgeeiQ91X43.
CleanExiMM_SH3D19.
GenevisibleiQ91X43. MM.

Interactioni

Subunit structurei

Interacts with ADAM12. Isoform 2 (but not isoform 1) interacts with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2 (By similarity). Interacts with SH3YL1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sh3yl1O086413EBI-2024543,EBI-2024519

Protein-protein interaction databases

IntActiQ91X43. 1 interaction.
STRINGi10090.ENSMUSP00000103291.

Structurei

3D structure databases

ProteinModelPortaliQ91X43.
SMRiQ91X43. Positions 420-455, 499-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini417 – 47256SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 55360SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 62960SH3 3PROSITE-ProRule annotationAdd
BLAST
Domaini660 – 71960SH3 4PROSITE-ProRule annotationAdd
BLAST
Domaini729 – 78860SH3 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 352324Pro-richAdd
BLAST

Sequence similaritiesi

Contains 5 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG296456.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000082398.
HOVERGENiHBG108486.
InParanoidiQ91X43.
OMAiSLSGEWC.
OrthoDBiEOG761BW2.
PhylomeDBiQ91X43.
TreeFamiTF330850.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028505. SH3D19.
[Graphical view]
PANTHERiPTHR10661:SF127. PTHR10661:SF127. 1 hit.
PfamiPF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 5 hits.
PROSITEiPS50002. SH3. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91X43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIMNTEQSQ NTIVSRIKAF EGQTNTEIPG LPKKPEIIPR TIPPKPAVSS
60 70 80 90 100
GKPLVAPKPA ANRASGEWDT WAENRLKVTS REGLTPYSSP QEAGITPVTK
110 120 130 140 150
PELPKKPTPG LTRSVNHETS GGRPMAESPD TGKKIPTPAP RPLLPKKSAS
160 170 180 190 200
TDAPPYPSIP PKLVSAPPRL SVASQAKAFR SLGEGLPSNP PVPAPQSKAL
210 220 230 240 250
GDIDLISFDD DVLPTSGSPA EEPTGSETVL DPFQLPTKTE ATKERAVQPA
260 270 280 290 300
PTRKPTVIRI PAKPGKCLHE EPQSPPPLPA EKPVGNTHSA VSGRPSHSDR
310 320 330 340 350
TRNPELEQAS ESGGLVQGPP RLPPRPVHGK VIPVWRPPPK GAPERPPPPK
360 370 380 390 400
LPASKSSNKN LPFNRSSSDM DLQKKQSHFV SGLSKAKSQI FKNQDPVLPP
410 420 430 440 450
RPKPGHPLYR KYMLSVPHGI ANEDIVSRNP TELSCKRGDV LVILKQAENN
460 470 480 490 500
YLECQRGEGT GRVHPSQMKI VTPLDERPRG RPNDSGHSQK PVDSGAPHAV
510 520 530 540 550
ALHDFPAEQA DDLSLTSGEI VYLLEKIDAE WYRGKCRNQT GVFPANYVKV
560 570 580 590 600
IVDIPEGRSG KRESFSSHCA KGPRCVARFE YIGDQKDELS FSEGEVIILT
610 620 630 640 650
EYVNEEWGRG EIRDRSGIFP LNFVELVGDH PTSGANILST KVPPKTKNED
660 670 680 690 700
PGSNSQDSSP PGEWCKALHS FTAETSEDLP FKRGDRILIL ERLDSDWYRG
710 720 730 740 750
RLHDREGIFP AVFVQPCPAE AKGVASAIPK GRKVKALYDF LGENEDELSF
760 770 780
KAGDVITELE PIDDAWMRGE LMGRAGMFPK NYVQFLQVS
Length:789
Mass (Da):86,077
Last modified:February 5, 2008 - v2
Checksum:iD3F866FB1A5BEB81
GO
Isoform 2 (identifier: Q91X43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-369: Missing.

Show »
Length:420
Mass (Da):46,899
Checksum:i8B5D6F87EE5BA5A8
GO

Sequence cautioni

The sequence AAB82091.1 differs from that shown.Sequence contamination. Potenial vector sequence.Curated
The sequence AAH12633.1 differs from that shown.Sequence contamination. Potential vector sequence.Curated
The sequence AAH31117.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti559 – 5591S → G in BAC34114 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 369369Missing in isoform 2. 1 PublicationVSP_031185Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89677 mRNA. Translation: BAA19686.2.
AC133508 Genomic DNA. No translation available.
BC012633 mRNA. Translation: AAH12633.1. Sequence problems.
BC031117 mRNA. Translation: AAH31117.1. Different initiation.
AF003234 mRNA. Translation: AAB82091.1. Sequence problems.
AK050185 mRNA. Translation: BAC34114.1.
CCDSiCCDS38469.2. [Q91X43-1]
RefSeqiNP_001075883.2. NM_001082414.2. [Q91X43-1]
XP_006501613.1. XM_006501550.2.
XP_011238438.1. XM_011240136.1.
UniGeneiMm.2454.

Genome annotation databases

EnsembliENSMUST00000107664; ENSMUSP00000103291; ENSMUSG00000028082. [Q91X43-1]
ENSMUST00000182666; ENSMUSP00000138320; ENSMUSG00000028082. [Q91X43-1]
GeneIDi27059.
KEGGimmu:27059.
UCSCiuc008pra.2. mouse. [Q91X43-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89677 mRNA. Translation: BAA19686.2.
AC133508 Genomic DNA. No translation available.
BC012633 mRNA. Translation: AAH12633.1. Sequence problems.
BC031117 mRNA. Translation: AAH31117.1. Different initiation.
AF003234 mRNA. Translation: AAB82091.1. Sequence problems.
AK050185 mRNA. Translation: BAC34114.1.
CCDSiCCDS38469.2. [Q91X43-1]
RefSeqiNP_001075883.2. NM_001082414.2. [Q91X43-1]
XP_006501613.1. XM_006501550.2.
XP_011238438.1. XM_011240136.1.
UniGeneiMm.2454.

3D structure databases

ProteinModelPortaliQ91X43.
SMRiQ91X43. Positions 420-455, 499-787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91X43. 1 interaction.
STRINGi10090.ENSMUSP00000103291.

PTM databases

PhosphoSiteiQ91X43.

Proteomic databases

MaxQBiQ91X43.
PRIDEiQ91X43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107664; ENSMUSP00000103291; ENSMUSG00000028082. [Q91X43-1]
ENSMUST00000182666; ENSMUSP00000138320; ENSMUSG00000028082. [Q91X43-1]
GeneIDi27059.
KEGGimmu:27059.
UCSCiuc008pra.2. mouse. [Q91X43-1]

Organism-specific databases

CTDi152503.
MGIiMGI:1350923. Sh3d19.

Phylogenomic databases

eggNOGiNOG296456.
GeneTreeiENSGT00760000119190.
HOGENOMiHOG000082398.
HOVERGENiHBG108486.
InParanoidiQ91X43.
OMAiSLSGEWC.
OrthoDBiEOG761BW2.
PhylomeDBiQ91X43.
TreeFamiTF330850.

Enzyme and pathway databases

ReactomeiREACT_342454. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSiSh3d19. mouse.
NextBioi305017.
PROiQ91X43.
SOURCEiSearch...

Gene expression databases

BgeeiQ91X43.
CleanExiMM_SH3D19.
GenevisibleiQ91X43. MM.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028505. SH3D19.
[Graphical view]
PANTHERiPTHR10661:SF127. PTHR10661:SF127. 1 hit.
PfamiPF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 5 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 5 hits.
PROSITEiPS50002. SH3. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles."
    Shimomura Y., Aoki N., Ito K., Ito M.
    J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SH3YL1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-789 (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Colon and Kidney.
  4. Sekely S.A., Kay B.K.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 465-789.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 505-789.
    Strain: C57BL/6J.
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSH319_MOUSE
AccessioniPrimary (citable) accession number: Q91X43
Secondary accession number(s): O08635, O35146, Q8C7I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 22, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.