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Q91X43

- SH319_MOUSE

UniProt

Q91X43 - SH319_MOUSE

Protein

SH3 domain-containing protein 19

Gene

Sh3d19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cytoskeleton organization Source: UniProtKB
    2. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    3. regulation of cell morphogenesis Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 domain-containing protein 19
    Alternative name(s):
    Kryn
    Gene namesi
    Name:Sh3d19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1350923. Sh3d19.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. nucleus Source: Ensembl
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 789789SH3 domain-containing protein 19PRO_0000318198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei65 – 651Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ91X43.
    PRIDEiQ91X43.

    PTM databases

    PhosphoSiteiQ91X43.

    Expressioni

    Tissue specificityi

    Expressed in hair follicles.1 Publication

    Gene expression databases

    BgeeiQ91X43.
    CleanExiMM_SH3D19.
    GenevestigatoriQ91X43.

    Interactioni

    Subunit structurei

    Interacts with ADAM12. Isoform 2 (but not isoform 1) interacts with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2 By similarity. Interacts with SH3YL1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Sh3yl1O086413EBI-2024543,EBI-2024519

    Protein-protein interaction databases

    IntActiQ91X43. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91X43.
    SMRiQ91X43. Positions 420-472, 501-786.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini417 – 47256SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini494 – 55360SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini570 – 62960SH3 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini660 – 71960SH3 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini729 – 78860SH3 5PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi29 – 352324Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 5 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG296456.
    GeneTreeiENSGT00690000101886.
    HOGENOMiHOG000082398.
    HOVERGENiHBG108486.
    InParanoidiQ91X43.
    OMAiVLDPFQL.
    OrthoDBiEOG761BW2.
    PhylomeDBiQ91X43.
    TreeFamiTF330850.

    Family and domain databases

    InterProiIPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR028505. SH3D19.
    [Graphical view]
    PANTHERiPTHR10661:SF127. PTHR10661:SF127. 1 hit.
    PfamiPF00018. SH3_1. 2 hits.
    PF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 2 hits.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 5 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 5 hits.
    PROSITEiPS50002. SH3. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91X43-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNIMNTEQSQ NTIVSRIKAF EGQTNTEIPG LPKKPEIIPR TIPPKPAVSS    50
    GKPLVAPKPA ANRASGEWDT WAENRLKVTS REGLTPYSSP QEAGITPVTK 100
    PELPKKPTPG LTRSVNHETS GGRPMAESPD TGKKIPTPAP RPLLPKKSAS 150
    TDAPPYPSIP PKLVSAPPRL SVASQAKAFR SLGEGLPSNP PVPAPQSKAL 200
    GDIDLISFDD DVLPTSGSPA EEPTGSETVL DPFQLPTKTE ATKERAVQPA 250
    PTRKPTVIRI PAKPGKCLHE EPQSPPPLPA EKPVGNTHSA VSGRPSHSDR 300
    TRNPELEQAS ESGGLVQGPP RLPPRPVHGK VIPVWRPPPK GAPERPPPPK 350
    LPASKSSNKN LPFNRSSSDM DLQKKQSHFV SGLSKAKSQI FKNQDPVLPP 400
    RPKPGHPLYR KYMLSVPHGI ANEDIVSRNP TELSCKRGDV LVILKQAENN 450
    YLECQRGEGT GRVHPSQMKI VTPLDERPRG RPNDSGHSQK PVDSGAPHAV 500
    ALHDFPAEQA DDLSLTSGEI VYLLEKIDAE WYRGKCRNQT GVFPANYVKV 550
    IVDIPEGRSG KRESFSSHCA KGPRCVARFE YIGDQKDELS FSEGEVIILT 600
    EYVNEEWGRG EIRDRSGIFP LNFVELVGDH PTSGANILST KVPPKTKNED 650
    PGSNSQDSSP PGEWCKALHS FTAETSEDLP FKRGDRILIL ERLDSDWYRG 700
    RLHDREGIFP AVFVQPCPAE AKGVASAIPK GRKVKALYDF LGENEDELSF 750
    KAGDVITELE PIDDAWMRGE LMGRAGMFPK NYVQFLQVS 789
    Length:789
    Mass (Da):86,077
    Last modified:February 5, 2008 - v2
    Checksum:iD3F866FB1A5BEB81
    GO
    Isoform 2 (identifier: Q91X43-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-369: Missing.

    Show »
    Length:420
    Mass (Da):46,899
    Checksum:i8B5D6F87EE5BA5A8
    GO

    Sequence cautioni

    The sequence AAB82091.1 differs from that shown. Reason: Sequence contamination. Potenial vector sequence.
    The sequence AAH12633.1 differs from that shown. Reason: Sequence contamination. Potential vector sequence.
    The sequence AAH31117.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti559 – 5591S → G in BAC34114. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 369369Missing in isoform 2. 1 PublicationVSP_031185Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89677 mRNA. Translation: BAA19686.2.
    AC133508 Genomic DNA. No translation available.
    BC012633 mRNA. Translation: AAH12633.1. Sequence problems.
    BC031117 mRNA. Translation: AAH31117.1. Different initiation.
    AF003234 mRNA. Translation: AAB82091.1. Sequence problems.
    AK050185 mRNA. Translation: BAC34114.1.
    CCDSiCCDS38469.2. [Q91X43-1]
    RefSeqiNP_001075883.2. NM_001082414.2. [Q91X43-1]
    XP_006501613.1. XM_006501550.1.
    UniGeneiMm.2454.

    Genome annotation databases

    EnsembliENSMUST00000107664; ENSMUSP00000103291; ENSMUSG00000028082. [Q91X43-1]
    ENSMUST00000182666; ENSMUSP00000138320; ENSMUSG00000028082. [Q91X43-1]
    GeneIDi27059.
    KEGGimmu:27059.
    UCSCiuc008pra.2. mouse. [Q91X43-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89677 mRNA. Translation: BAA19686.2 .
    AC133508 Genomic DNA. No translation available.
    BC012633 mRNA. Translation: AAH12633.1 . Sequence problems.
    BC031117 mRNA. Translation: AAH31117.1 . Different initiation.
    AF003234 mRNA. Translation: AAB82091.1 . Sequence problems.
    AK050185 mRNA. Translation: BAC34114.1 .
    CCDSi CCDS38469.2. [Q91X43-1 ]
    RefSeqi NP_001075883.2. NM_001082414.2. [Q91X43-1 ]
    XP_006501613.1. XM_006501550.1.
    UniGenei Mm.2454.

    3D structure databases

    ProteinModelPortali Q91X43.
    SMRi Q91X43. Positions 420-472, 501-786.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91X43. 1 interaction.

    PTM databases

    PhosphoSitei Q91X43.

    Proteomic databases

    MaxQBi Q91X43.
    PRIDEi Q91X43.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107664 ; ENSMUSP00000103291 ; ENSMUSG00000028082 . [Q91X43-1 ]
    ENSMUST00000182666 ; ENSMUSP00000138320 ; ENSMUSG00000028082 . [Q91X43-1 ]
    GeneIDi 27059.
    KEGGi mmu:27059.
    UCSCi uc008pra.2. mouse. [Q91X43-1 ]

    Organism-specific databases

    CTDi 152503.
    MGIi MGI:1350923. Sh3d19.

    Phylogenomic databases

    eggNOGi NOG296456.
    GeneTreei ENSGT00690000101886.
    HOGENOMi HOG000082398.
    HOVERGENi HBG108486.
    InParanoidi Q91X43.
    OMAi VLDPFQL.
    OrthoDBi EOG761BW2.
    PhylomeDBi Q91X43.
    TreeFami TF330850.

    Miscellaneous databases

    ChiTaRSi SH3D19. mouse.
    NextBioi 305017.
    PROi Q91X43.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91X43.
    CleanExi MM_SH3D19.
    Genevestigatori Q91X43.

    Family and domain databases

    InterProi IPR011511. SH3_2.
    IPR001452. SH3_domain.
    IPR028505. SH3D19.
    [Graphical view ]
    PANTHERi PTHR10661:SF127. PTHR10661:SF127. 1 hit.
    Pfami PF00018. SH3_1. 2 hits.
    PF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 2 hits.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 5 hits.
    PROSITEi PS50002. SH3. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles."
      Shimomura Y., Aoki N., Ito K., Ito M.
      J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SH3YL1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-789 (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Colon and Kidney.
    4. Sekely S.A., Kay B.K.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 465-789.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 505-789.
      Strain: C57BL/6J.
      Tissue: Liver.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSH319_MOUSE
    AccessioniPrimary (citable) accession number: Q91X43
    Secondary accession number(s): O08635, O35146, Q8C7I2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-4 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3