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Q91X43 (SH319_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH3 domain-containing protein 19
Alternative name(s):
Kryn
Gene names
Name:Sh3d19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length789 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization By similarity.

Subunit structure

Interacts with ADAM12. Isoform 2 (but not isoform 1)interacts with ADAM9, ADAM10, ADAM15 and ADAM17. Interacts with SH3GL1 SH3 domain. Interacts via SH3 3 and SH3 4 or SH3 4 and SH3 5 domains with SOS2. Probably forms a trimeric complex with SH3GL1 and SOS2 By similarity. Interacts with SH3YL1. Ref.1

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in hair follicles. Ref.1

Sequence similarities

Contains 5 SH3 domains.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.

Sequence caution

The sequence AAB82091.1 differs from that shown. Reason: Sequence contamination. Potenial vector sequence.

The sequence AAH12633.1 differs from that shown. Reason: Sequence contamination. Potential vector sequence.

The sequence AAH31117.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sh3yl1O086413EBI-2024543,EBI-2024519

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91X43-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91X43-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-369: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 789789SH3 domain-containing protein 19
PRO_0000318198

Regions

Domain417 – 47256SH3 1
Domain494 – 55360SH3 2
Domain570 – 62960SH3 3
Domain660 – 71960SH3 4
Domain729 – 78860SH3 5
Compositional bias29 – 352324Pro-rich

Amino acid modifications

Modified residue651Phosphoserine Ref.6

Natural variations

Alternative sequence1 – 369369Missing in isoform 2.
VSP_031185

Experimental info

Sequence conflict5591S → G in BAC34114. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: D3F866FB1A5BEB81

FASTA78986,077
        10         20         30         40         50         60 
MNIMNTEQSQ NTIVSRIKAF EGQTNTEIPG LPKKPEIIPR TIPPKPAVSS GKPLVAPKPA 

        70         80         90        100        110        120 
ANRASGEWDT WAENRLKVTS REGLTPYSSP QEAGITPVTK PELPKKPTPG LTRSVNHETS 

       130        140        150        160        170        180 
GGRPMAESPD TGKKIPTPAP RPLLPKKSAS TDAPPYPSIP PKLVSAPPRL SVASQAKAFR 

       190        200        210        220        230        240 
SLGEGLPSNP PVPAPQSKAL GDIDLISFDD DVLPTSGSPA EEPTGSETVL DPFQLPTKTE 

       250        260        270        280        290        300 
ATKERAVQPA PTRKPTVIRI PAKPGKCLHE EPQSPPPLPA EKPVGNTHSA VSGRPSHSDR 

       310        320        330        340        350        360 
TRNPELEQAS ESGGLVQGPP RLPPRPVHGK VIPVWRPPPK GAPERPPPPK LPASKSSNKN 

       370        380        390        400        410        420 
LPFNRSSSDM DLQKKQSHFV SGLSKAKSQI FKNQDPVLPP RPKPGHPLYR KYMLSVPHGI 

       430        440        450        460        470        480 
ANEDIVSRNP TELSCKRGDV LVILKQAENN YLECQRGEGT GRVHPSQMKI VTPLDERPRG 

       490        500        510        520        530        540 
RPNDSGHSQK PVDSGAPHAV ALHDFPAEQA DDLSLTSGEI VYLLEKIDAE WYRGKCRNQT 

       550        560        570        580        590        600 
GVFPANYVKV IVDIPEGRSG KRESFSSHCA KGPRCVARFE YIGDQKDELS FSEGEVIILT 

       610        620        630        640        650        660 
EYVNEEWGRG EIRDRSGIFP LNFVELVGDH PTSGANILST KVPPKTKNED PGSNSQDSSP 

       670        680        690        700        710        720 
PGEWCKALHS FTAETSEDLP FKRGDRILIL ERLDSDWYRG RLHDREGIFP AVFVQPCPAE 

       730        740        750        760        770        780 
AKGVASAIPK GRKVKALYDF LGENEDELSF KAGDVITELE PIDDAWMRGE LMGRAGMFPK 


NYVQFLQVS 

« Hide

Isoform 2 [UniParc].

Checksum: 8B5D6F87EE5BA5A8
Show »

FASTA42046,899

References

« Hide 'large scale' references
[1]"Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles."
Shimomura Y., Aoki N., Ito K., Ito M.
J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SH3YL1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-789 (ISOFORM 1).
Strain: FVB/N.
Tissue: Colon and Kidney.
[4]Sekely S.A., Kay B.K.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 465-789.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 505-789.
Strain: C57BL/6J.
Tissue: Liver.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89677 mRNA. Translation: BAA19686.2.
AC133508 Genomic DNA. No translation available.
BC012633 mRNA. Translation: AAH12633.1. Sequence problems.
BC031117 mRNA. Translation: AAH31117.1. Different initiation.
AF003234 mRNA. Translation: AAB82091.1. Sequence problems.
AK050185 mRNA. Translation: BAC34114.1.
CCDSCCDS38469.2. [Q91X43-1]
RefSeqNP_001075883.2. NM_001082414.2. [Q91X43-1]
XP_006501613.1. XM_006501550.1.
UniGeneMm.2454.

3D structure databases

ProteinModelPortalQ91X43.
SMRQ91X43. Positions 420-472, 501-786.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91X43. 1 interaction.

PTM databases

PhosphoSiteQ91X43.

Proteomic databases

MaxQBQ91X43.
PRIDEQ91X43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107664; ENSMUSP00000103291; ENSMUSG00000028082. [Q91X43-1]
ENSMUST00000182666; ENSMUSP00000138320; ENSMUSG00000028082. [Q91X43-1]
GeneID27059.
KEGGmmu:27059.
UCSCuc008pra.2. mouse. [Q91X43-1]

Organism-specific databases

CTD152503.
MGIMGI:1350923. Sh3d19.

Phylogenomic databases

eggNOGNOG296456.
GeneTreeENSGT00690000101886.
HOGENOMHOG000082398.
HOVERGENHBG108486.
InParanoidQ91X43.
OMAVLDPFQL.
OrthoDBEOG761BW2.
PhylomeDBQ91X43.
TreeFamTF330850.

Gene expression databases

BgeeQ91X43.
CleanExMM_SH3D19.
GenevestigatorQ91X43.

Family and domain databases

InterProIPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028505. SH3D19.
[Graphical view]
PANTHERPTHR10661:SF127. PTHR10661:SF127. 1 hit.
PfamPF00018. SH3_1. 2 hits.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 5 hits.
[Graphical view]
SUPFAMSSF50044. SSF50044. 5 hits.
PROSITEPS50002. SH3. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSH3D19. mouse.
NextBio305017.
PROQ91X43.
SOURCESearch...

Entry information

Entry nameSH319_MOUSE
AccessionPrimary (citable) accession number: Q91X43
Secondary accession number(s): O08635, O35146, Q8C7I2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot