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Protein

Podocin

Gene

Nphs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-373753. Nephrin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Podocin
Gene namesi
Name:Nphs2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2157018. Nphs2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 104104CytoplasmicSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Topological domaini126 – 385260ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385PodocinPRO_0000094036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi103 – 1031S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ91X05.
PRIDEiQ91X05.

PTM databases

iPTMnetiQ91X05.
PhosphoSiteiQ91X05.

Expressioni

Gene expression databases

BgeeiQ91X05.
CleanExiMM_NPHS2.
ExpressionAtlasiQ91X05. baseline and differential.
GenevisibleiQ91X05. MM.

Interactioni

Subunit structurei

Interacts with nephrin/NPHS1, KIRRL1 and CD2AP. Interacts with DDN.2 Publications

Protein-protein interaction databases

BioGridi228352. 3 interactions.
DIPiDIP-61266N.
STRINGi10090.ENSMUSP00000027896.

Structurei

3D structure databases

ProteinModelPortaliQ91X05.
SMRiQ91X05. Positions 166-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOVERGENiHBG004815.
InParanoidiQ91X05.
KOiK18268.
OMAiWFCIKVV.
OrthoDBiEOG78D7KJ.
PhylomeDBiQ91X05.
TreeFamiTF105750.

Family and domain databases

InterProiIPR001107. Band_7.
IPR028509. Podocin.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF23. PTHR10264:SF23. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91X05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRARSSSR EAHGRSSRSS SRDDKKAKAG RGSRGRARPD AGAERQSTGR
60 70 80 90 100
TATRGEPRAP AATATVVDVD EVRGPGEEGT EVVALLESER PEEGIKPSGL
110 120 130 140 150
GACEWLLVLA SLIFIIMTFP FSIWFCIKVV QEYERVIIFR LGHLLPGRAK
160 170 180 190 200
GPGLFFFLPC LDTYHKVDLR LQTLEIPFHE VVTKDMFIME IDAVCYYRME
210 220 230 240 250
NASLLLSSLA HVSKAIQFLV QTTMKRLLAH RSLTEILLER KSIAQDVKVA
260 270 280 290 300
LDAVTCIWGI KVERTEIKDV RLPAGLQHSL AVEAEAQRQA KVRVIAAEGE
310 320 330 340 350
KAASESLRMA AEILSGTPAA VQLRYLHTLQ SLSTEKPATV VLPLPFDMLS
360 370 380
LLSSPGNRAQ GSINYPSSSK PVEPLNPKKK DSPML
Length:385
Mass (Da):42,337
Last modified:April 23, 2003 - v2
Checksum:i02B07F21FB98A0BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 42SR → FF in CAC44636 (PubMed:11733557).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302048 mRNA. Translation: CAC44636.1.
AY050309 mRNA. Translation: AAL06146.1.
BC067401 mRNA. Translation: AAH67401.1.
AK052746 mRNA. Translation: BAC35128.1.
CCDSiCCDS15391.1.
RefSeqiNP_569723.1. NM_130456.4.
UniGeneiMm.289099.

Genome annotation databases

EnsembliENSMUST00000027896; ENSMUSP00000027896; ENSMUSG00000026602.
GeneIDi170484.
KEGGimmu:170484.
UCSCiuc007dch.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302048 mRNA. Translation: CAC44636.1.
AY050309 mRNA. Translation: AAL06146.1.
BC067401 mRNA. Translation: AAH67401.1.
AK052746 mRNA. Translation: BAC35128.1.
CCDSiCCDS15391.1.
RefSeqiNP_569723.1. NM_130456.4.
UniGeneiMm.289099.

3D structure databases

ProteinModelPortaliQ91X05.
SMRiQ91X05. Positions 166-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228352. 3 interactions.
DIPiDIP-61266N.
STRINGi10090.ENSMUSP00000027896.

PTM databases

iPTMnetiQ91X05.
PhosphoSiteiQ91X05.

Proteomic databases

PaxDbiQ91X05.
PRIDEiQ91X05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027896; ENSMUSP00000027896; ENSMUSG00000026602.
GeneIDi170484.
KEGGimmu:170484.
UCSCiuc007dch.1. mouse.

Organism-specific databases

CTDi7827.
MGIiMGI:2157018. Nphs2.

Phylogenomic databases

eggNOGiKOG2621. Eukaryota.
COG0330. LUCA.
GeneTreeiENSGT00550000074454.
HOVERGENiHBG004815.
InParanoidiQ91X05.
KOiK18268.
OMAiWFCIKVV.
OrthoDBiEOG78D7KJ.
PhylomeDBiQ91X05.
TreeFamiTF105750.

Enzyme and pathway databases

ReactomeiR-MMU-373753. Nephrin interactions.

Miscellaneous databases

NextBioi370115.
PROiQ91X05.
SOURCEiSearch...

Gene expression databases

BgeeiQ91X05.
CleanExiMM_NPHS2.
ExpressionAtlasiQ91X05. baseline and differential.
GenevisibleiQ91X05. MM.

Family and domain databases

InterProiIPR001107. Band_7.
IPR028509. Podocin.
IPR001972. Stomatin_fam.
[Graphical view]
PANTHERiPTHR10264. PTHR10264. 1 hit.
PTHR10264:SF23. PTHR10264:SF23. 1 hit.
PfamiPF01145. Band_7. 1 hit.
[Graphical view]
PRINTSiPR00721. STOMATIN.
SMARTiSM00244. PHB. 1 hit.
[Graphical view]
SUPFAMiSSF117892. SSF117892. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin."
    Schwarz K., Simons M., Reiser J., Saleem M.A., Faul C., Kriz W., Shaw A.S., Holzman L.B., Mundel P.
    J. Clin. Invest. 108:1621-1629(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "Interaction with podocin facilitates nephrin signaling."
    Huber T.B., Kottgen M., Schilling B., Walz G., Benzing T.
    J. Biol. Chem. 276:41543-41546(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-377.
    Strain: C57BL/6J.
    Tissue: Kidney.
  5. "NEPH1 defines a novel family of podocin interacting proteins."
    Sellin L., Huber T.B., Gerke P., Quack I., Pavenstaedt H., Walz G.
    FASEB J. 17:115-117(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIRRL1.
    Strain: Swiss Webster.
    Tissue: Brain.
  6. "Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes."
    Asanuma K., Campbell K.N., Kim K., Faul C., Mundel P.
    Proc. Natl. Acad. Sci. U.S.A. 104:10134-10139(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDN.

Entry informationi

Entry nameiPODO_MOUSE
AccessioniPrimary (citable) accession number: Q91X05
Secondary accession number(s): Q8BWE6, Q91Z95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: March 16, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.