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Protein

Podocin

Gene

Nphs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-373753 Nephrin family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Podocin
Gene namesi
Name:Nphs2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2157018 Nphs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 104CytoplasmicSequence analysisAdd BLAST104
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 385ExtracellularSequence analysisAdd BLAST260

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940361 – 385PodocinAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi103S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ91X05
PRIDEiQ91X05

PTM databases

iPTMnetiQ91X05
PhosphoSitePlusiQ91X05

Expressioni

Gene expression databases

BgeeiENSMUSG00000026602
CleanExiMM_NPHS2
ExpressionAtlasiQ91X05 baseline and differential
GenevisibleiQ91X05 MM

Interactioni

Subunit structurei

Interacts with nephrin/NPHS1, KIRRL1 and CD2AP. Interacts with DDN.2 Publications

Protein-protein interaction databases

BioGridi228352, 64 interactors
DIPiDIP-61266N
IntActiQ91X05, 7 interactors
STRINGi10090.ENSMUSP00000027896

Structurei

3D structure databases

ProteinModelPortaliQ91X05
SMRiQ91X05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2621 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074454
HOVERGENiHBG004815
InParanoidiQ91X05
KOiK18268
OMAiKKDSPML
OrthoDBiEOG091G0G9K
PhylomeDBiQ91X05
TreeFamiTF105750

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR028509 Podocin
IPR001972 Stomatin_fam
PANTHERiPTHR10264:SF23 PTHR10264:SF23, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequencei

Sequence statusi: Complete.

Q91X05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRARSSSR EAHGRSSRSS SRDDKKAKAG RGSRGRARPD AGAERQSTGR
60 70 80 90 100
TATRGEPRAP AATATVVDVD EVRGPGEEGT EVVALLESER PEEGIKPSGL
110 120 130 140 150
GACEWLLVLA SLIFIIMTFP FSIWFCIKVV QEYERVIIFR LGHLLPGRAK
160 170 180 190 200
GPGLFFFLPC LDTYHKVDLR LQTLEIPFHE VVTKDMFIME IDAVCYYRME
210 220 230 240 250
NASLLLSSLA HVSKAIQFLV QTTMKRLLAH RSLTEILLER KSIAQDVKVA
260 270 280 290 300
LDAVTCIWGI KVERTEIKDV RLPAGLQHSL AVEAEAQRQA KVRVIAAEGE
310 320 330 340 350
KAASESLRMA AEILSGTPAA VQLRYLHTLQ SLSTEKPATV VLPLPFDMLS
360 370 380
LLSSPGNRAQ GSINYPSSSK PVEPLNPKKK DSPML
Length:385
Mass (Da):42,337
Last modified:April 23, 2003 - v2
Checksum:i02B07F21FB98A0BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4SR → FF in CAC44636 (PubMed:11733557).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302048 mRNA Translation: CAC44636.1
AY050309 mRNA Translation: AAL06146.1
BC067401 mRNA Translation: AAH67401.1
AK052746 mRNA Translation: BAC35128.1
CCDSiCCDS15391.1
RefSeqiNP_569723.1, NM_130456.4
UniGeneiMm.289099

Genome annotation databases

EnsembliENSMUST00000027896; ENSMUSP00000027896; ENSMUSG00000026602
GeneIDi170484
KEGGimmu:170484
UCSCiuc007dch.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPODO_MOUSE
AccessioniPrimary (citable) accession number: Q91X05
Secondary accession number(s): Q8BWE6, Q91Z95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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