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Q91WY5

- Q91WY5_RAT

UniProt

Q91WY5 - Q91WY5_RAT

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Protein
Submitted name:

Zinc finger transcription factor GLI3

Gene

Gli3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. anterior semicircular canal development Source: Ensembl
  3. artery development Source: Ensembl
  4. axon guidance Source: Ensembl
  5. branching involved in ureteric bud morphogenesis Source: Ensembl
  6. camera-type eye morphogenesis Source: Ensembl
  7. cell differentiation involved in kidney development Source: Ensembl
  8. cerebral cortex radial glia guided migration Source: Ensembl
  9. developmental growth Source: Ensembl
  10. embryonic digestive tract morphogenesis Source: Ensembl
  11. embryonic digit morphogenesis Source: Ensembl
  12. embryonic skeletal system morphogenesis Source: Ensembl
  13. forebrain dorsal/ventral pattern formation Source: Ensembl
  14. forebrain radial glial cell differentiation Source: Ensembl
  15. frontal suture morphogenesis Source: Ensembl
  16. heart development Source: Ensembl
  17. hindgut morphogenesis Source: Ensembl
  18. hippocampus development Source: Ensembl
  19. in utero embryonic development Source: Ensembl
  20. lambdoid suture morphogenesis Source: Ensembl
  21. lateral ganglionic eminence cell proliferation Source: Ensembl
  22. lateral semicircular canal development Source: Ensembl
  23. lung development Source: Ensembl
  24. mammary gland specification Source: Ensembl
  25. melanocyte differentiation Source: Ensembl
  26. metanephros development Source: Ensembl
  27. multicellular organismal development Source: RGD
  28. negative regulation of alpha-beta T cell differentiation Source: Ensembl
  29. negative regulation of apoptotic process Source: Ensembl
  30. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  31. negative regulation of cell proliferation Source: Ensembl
  32. negative regulation of neuron differentiation Source: Ensembl
  33. negative regulation of smoothened signaling pathway Source: Ensembl
  34. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  35. negative thymic T cell selection Source: Ensembl
  36. odontogenesis of dentin-containing tooth Source: Ensembl
  37. oligodendrocyte differentiation Source: Ensembl
  38. optic nerve morphogenesis Source: Ensembl
  39. palate development Source: Ensembl
  40. positive regulation of alpha-beta T cell differentiation Source: Ensembl
  41. positive regulation of chondrocyte differentiation Source: Ensembl
  42. positive regulation of neuroblast proliferation Source: Ensembl
  43. positive regulation of osteoblast differentiation Source: Ensembl
  44. positive regulation of protein import into nucleus Source: Ensembl
  45. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  46. protein processing Source: Ensembl
  47. proximal/distal pattern formation Source: Ensembl
  48. response to estrogen Source: RGD
  49. sagittal suture morphogenesis Source: Ensembl
  50. smoothened signaling pathway Source: RGD
  51. smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: Ensembl
  52. smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: Ensembl
  53. smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: Ensembl
  54. thymocyte apoptotic process Source: Ensembl
  55. tongue development Source: Ensembl
  56. wound healing Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_269621. Hedgehog 'off' state.
REACT_269753. GLI3 is processed to GLI3R by the proteasome.

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger transcription factor GLI3Imported
Gene namesi
Name:Gli3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620272. Gli3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mediator complex Source: Ensembl
  3. nuclear speck Source: Ensembl
  4. primary cilium Source: Ensembl
  5. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ91WY5. baseline.
GenevestigatoriQ91WY5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019396.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG5048.

Sequencei

Sequence statusi: Fragment.

Q91WY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AESSIAKCPT RTDVSEKAVA SSTTSNEDES AGQIYHRERR NAITMQPQSV
60 70 80 90 100
QGLSKISEEP STSSDERASL IKKEIHGSLP HLAEPSLPYR GTVFAMDPRN

GYMEPHYHP
Length:109
Mass (Da):12,011
Last modified:December 1, 2001 - v1
Checksum:i6841EDC151A7F353
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei109 – 1091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073718 mRNA. Translation: BAB71724.1.
UniGeneiRn.199034.

Genome annotation databases

UCSCiRGD:620272. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB073718 mRNA. Translation: BAB71724.1 .
UniGenei Rn.199034.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000019396.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620272. rat.

Organism-specific databases

RGDi 620272. Gli3.

Phylogenomic databases

eggNOGi COG5048.

Enzyme and pathway databases

Reactomei REACT_269621. Hedgehog 'off' state.
REACT_269753. GLI3 is processed to GLI3R by the proteasome.

Gene expression databases

ExpressionAtlasi Q91WY5. baseline.
Genevestigatori Q91WY5.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Partial cDNA sequence amplified by RT-PCR."
    Kataoka H., Enomoto K.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: E18 whole embryoImported.

Entry informationi

Entry nameiQ91WY5_RAT
AccessioniPrimary (citable) accession number: Q91WY5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)