Unreviewed, UniProtKB/TrEMBL Q91WX9 (Q91WX9_RAT)

Names and origin

Protein names

Submitted name:
    Voltage-gated calcium channel pore forming subunit CaV1.3alpha1 EMBL AAK72959.1

Gene names

Name:

Cacna1d RGD 70973

Organism

Rattus norvegicus (Rat) EMBL AAK72959.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1643 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW calcium-mediated signaling Inferred from direct assay. Source: RGD memory Inferred from expression pattern. Source: RGD transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	apical plasma membrane Inferred from direct assay. Source: RGD voltage-gated calcium channel complex Ref.1 Traceable author statement. Source: RGD
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Ref.1 Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q91WX9-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 97AAA34B073EA520	FASTA	1,643	186,829
	10 20 30 40 50 60 MQHQRQQQED HANEANYARG TRLPISGEGP TSQPNSSKQT VLSWQAAIDA ARQAKAAQTM 70 80 90 100 110 120 STSAPPPVGS LSQRKRQQYA KSKKQGNSSN SRPARALFCL SLNNPIRRAC ISIVDWKPFD 130 140 150 160 170 180 IFILLAIFAN CVALAIYIPF PEDDSNSTNH NLEKVEYAFL IIFTVETFLK IIAYGLLLHP 190 200 210 220 230 240 NAYVRNGWNL LDFVIVIVGL FSVILEQLTK ETEGGNHSSG KSGGFDVKAL RAFRVLRPLR 250 260 270 280 290 300 LVSSVPSLQV VLNSIIKAMV PLLHIALLVL FVIIIYAIIG LELFIGKMHK TCFFADSDIV 310 320 330 340 350 360 AEEDPAPCAF SGNGRQCAAN GTECRSGWVG PNGGITNFDN FAFAMLTVFQ CITMEGWTDV 370 380 390 400 410 420 LYWVNDAIGW EWPWVYFVSL IILGSFFVLN LVLGVLSGEF SKEREKAKAR GDFQKLREKQ 430 440 450 460 470 480 QLEEDLKGYL DWITQAEDID PENEEEGGEE GKRNTSMPTS ETESVNTENV SGEGETQGCC 490 500 510 520 530 540 GSLWCWWKRR GAAKTGPSGC RRWGQAISKS KLSRRWRRWN RFNRRRCRAA VKSVTFYWLV 550 560 570 580 590 600 IVLVFLNTLT ISSEHYNQPD WLTQIQDIAN KVLLALFTCE MLVKMYSLGL QAYFVSLFNR 610 620 630 640 650 660 FDCFVVCGGI TETILVELEL MSPLGVSVFR CVRLLRIFKV TRHWTSLSNL VASLLNSMKS 670 680 690 700 710 720 IASLLLLLFL FIIIFSLLGM QLFGGKFNFD ETQTKRSTFD NFPQALLTVF QILTGEDWNA 730 740 750 760 770 780 VMYDGIMAYG GPSSSGMIVC IYFIILFICG NYILLNVFLA IAVDNLADAE SLNTAQKEEA 790 800 810 820 830 840 EEKERKKIAR KESLENKKNN KPEVNQIANS DNKVTIDDYQ EEAEDKDPYP PCDVPVGEEE 850 860 870 880 890 900 EEEEEDEPEV PAGPRPRRIS ELNMKEKIAP IPEGSAFFIL SKTNPIRVGC HKLINHHIFT 910 920 930 940 950 960 NLILVFIMLS SAALAAEDPI RSHSFRNTIL GYFDYAFTAI FTVEILLKMT TFGAFLHKGA 970 980 990 1000 1010 1020 FCRNYFNLLD MLVVGVSLVS FGIQSSAISV VKILRVLRVL RPLRAINRAK GLKHVVQCVF 1030 1040 1050 1060 1070 1080 VAIRTIGNIM IVTTLLQFMF ACIGVQLFKG KFYRCTDEAK SNPEECRGLF ILYKDGDVDS 1090 1100 1110 1120 1130 1140 PVVRERIWQN SDFNFDNVLS AMMVLFTVST FEGWPALLYK AIDSNGENVG PVYNYRVEIS 1150 1160 1170 1180 1190 1200 IFFIIYIIIV AFFMMNIFVG FVIVTFQEQG EKEYKNCELD KNQRQCVEYA LKARPLRRYI 1210 1220 1230 1240 1250 1260 PKNPYQYKFW YVVNSSPFEY MMFVLIMLNT LCLAMQHYEQ SKMFNDAMDI LNMVFTGVFT 1270 1280 1290 1300 1310 1320 VEMVLKVIAF KPKHYFTDAW NTFDALIVVG SVVDIAITEV NNSEESNRIS ITFFRLFRVM 1330 1340 1350 1360 1370 1380 RLVKLLSRGE GIRTLLWTFI KSFQALPYVA LLIAMLFFIY AVIGMQMFGK VAMRDNNQIN 1390 1400 1410 1420 1430 1440 RNNNFQTFPQ AVLLLFRCAT GEAWQEIMLA CLPGKLCDPD SDYNPGEEYT CGSNFAIVYF 1450 1460 1470 1480 1490 1500 ISFYMLCAFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE FKRIWSEYDP EAKGRIKHLD 1510 1520 1530 1540 1550 1560 VVTLLRRIQP PLGFGKLCPH RVACKRLVAM NMPLNSDGTV MFNATLFALV RTALKIKTEG 1570 1580 1590 1600 1610 1620 NLEQANEELR AVIKKIWKKT SMKLLDQVVP PAGDDEVTVG KFYATFLIQD YFRKFKKRKE 1630 1640 QGLVGKYPAK NTTIALQMLE RML

References

[1]

"Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines." Xu W., Lipscombe D. J. Neurosci. 21:5944-5951(2001) [PubMed: 11487617] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAK72959.1. Tissue: Superior cervical ganglia EMBL AAK72959.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF370009 mRNA. Translation: AAK72959.1.
IPI	IPI00231113.
UniGene	Rn.89671
3D structure databases
HSSP	HSSP built from PDB template 1T0J based on UniProtKB Q13933.
SMR	Q91WX9. Positions 118-193, 1210-1464, 1596-1624.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91WX9.
Genome annotation databases
Ensembl	ENSRNOT00000019520; ENSRNOP00000019520; ENSRNOG00000013147; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	Q91WX9.
Gene expression databases
ArrayExpress	Q91WX9.
Genevestigator	Q91WX9.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR005452. LVDCC_a1dsu. IPR014873. VDCC_a1su_IQ. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF48. LVDCCAlpha1D. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01636. LVDCCALPHA1D.
ProtoNet	Search...

Entry information

Entry name

Q91WX9_RAT

Accession

Primary (citable) accession number: Q91WX9

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)