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Protein

Patatin-like phospholipase domain-containing protein 3

Gene

Pnpla3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Pathwayi: triacylglycerol degradation

This protein is involved in the pathway triacylglycerol degradation, which is part of Glycerolipid metabolism.
View all proteins of this organism that are known to be involved in the pathway triacylglycerol degradation and in Glycerolipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Hydrolase, Transferase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00256.

Chemistry

SwissLipidsiSLP:000000281.

Names & Taxonomyi

Protein namesi
Recommended name:
Patatin-like phospholipase domain-containing protein 3 (EC:3.1.1.3)
Alternative name(s):
Acylglycerol O-acyltransferase (EC:2.3.1.-)
Adiponutrin
Calcium-independent phospholipase A2-epsilon
Short name:
iPLA2-epsilon
Gene namesi
Name:Pnpla3
Synonyms:Adpn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2151796. Pnpla3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242CytoplasmicSequence analysisAdd
BLAST
Transmembranei43 – 6321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini64 – 413350LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Patatin-like phospholipase domain-containing protein 3PRO_0000064459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ91WW7.
PRIDEiQ91WW7.

PTM databases

PhosphoSiteiQ91WW7.

Expressioni

Tissue specificityi

Restricted to adipose tissue. Expressed in inguinal and epididymal white adipose tissues and in interscapular brown adipose tissue.1 Publication

Inductioni

Down-regulated after starvation and up-regulated after refeeding.

Gene expression databases

BgeeiQ91WW7.
CleanExiMM_PNPLA3.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997871.
STRINGi10090.ENSMUSP00000043826.

Structurei

3D structure databases

ProteinModelPortaliQ91WW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 179170PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 495GXSXG

Sequence similaritiesi

Contains 1 patatin domain.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3773. Eukaryota.
ENOG410XSQS. LUCA.
HOGENOMiHOG000007467.
HOVERGENiHBG007046.
InParanoidiQ91WW7.
KOiK13534.
PhylomeDBiQ91WW7.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002641. Patatin/PLipase_A2-rel.
[Graphical view]
PfamiPF01734. Patatin. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDPERRWSL SFAGCGFLGF YHVGATLCLS ERAPHLLRDA RTFFGCSAGA
60 70 80 90 100
LHAVTFVCSL PLGRIMEILM DLVRKARSRN IGTLHPFFNI NKCIRDGLQE
110 120 130 140 150
SLPDNVHQVI SGKVHISLTR VSDGENVLVS EFHSKDEVVD ALVCSCFIPL
160 170 180 190 200
FSGLIPPSFR GERYVDGGVS DNVPVLDAKT TITVSPFYGE HDICPKVKST
210 220 230 240 250
NFFHVNITNL SLRLCTGNLQ LLTRALFPSD VKVMGELCYQ GYLDAFRFLE
260 270 280 290 300
ENGICNGPQR SLSLSLVAPE ACLENGKLVG DKVPVSLCFT DENIWETLSP
310 320 330 340 350
ELSTALSEAI KDREGYLSKV CNLLPVRILS YIMLPCSLPV ESAIAAVHRL
360 370 380 390 400
VTWLPDIQDD IQWLQWATSQ VCARMTMCLL PSTRSRASKD DHRMLKHGHH
410
PSPHKPQGNS AGL
Length:413
Mass (Da):45,772
Last modified:December 1, 2001 - v1
Checksum:i7D697E81F66A83C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037763 mRNA. Translation: AAK68636.1.
BC028792 mRNA. Translation: AAH28792.1.
RefSeqiNP_473429.2. NM_054088.3.
UniGeneiMm.390817.

Genome annotation databases

GeneIDi116939.
KEGGimmu:116939.
UCSCiuc007xbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037763 mRNA. Translation: AAK68636.1.
BC028792 mRNA. Translation: AAH28792.1.
RefSeqiNP_473429.2. NM_054088.3.
UniGeneiMm.390817.

3D structure databases

ProteinModelPortaliQ91WW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997871.
STRINGi10090.ENSMUSP00000043826.

Chemistry

SwissLipidsiSLP:000000281.

PTM databases

PhosphoSiteiQ91WW7.

Proteomic databases

PaxDbiQ91WW7.
PRIDEiQ91WW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116939.
KEGGimmu:116939.
UCSCiuc007xbw.1. mouse.

Organism-specific databases

CTDi80339.
MGIiMGI:2151796. Pnpla3.

Phylogenomic databases

eggNOGiKOG3773. Eukaryota.
ENOG410XSQS. LUCA.
HOGENOMiHOG000007467.
HOVERGENiHBG007046.
InParanoidiQ91WW7.
KOiK13534.
PhylomeDBiQ91WW7.

Enzyme and pathway databases

UniPathwayiUPA00256.

Miscellaneous databases

PROiQ91WW7.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WW7.
CleanExiMM_PNPLA3.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002641. Patatin/PLipase_A2-rel.
[Graphical view]
PfamiPF01734. Patatin. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage."
    Baulande S., Lasnier F., Lucas M., Pairault J.
    J. Biol. Chem. 276:33336-33344(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: SWR/J.
    Tissue: Adipose tissue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue.

Entry informationi

Entry nameiPLPL3_MOUSE
AccessioniPrimary (citable) accession number: Q91WW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.