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Q91WW2 (MRGA4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mas-related G-protein coupled receptor member A4
Alternative name(s):
RF-amide G-protein coupled receptor
Gene names
Name:Mrgpra4
Synonyms:Mrga4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Expressed in a subset of sensory neurons that includes nociceptors. Expressed in the subclass of non-peptidergic sensory neurons that are IB4+ and VR1-. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Mas-related G-protein coupled receptor member A4
PRO_0000069750

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9318Extracellular Potential
Transmembrane94 – 11421Helical; Name=3; Potential
Topological domain115 – 13723Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 18224Extracellular Potential
Transmembrane183 – 20321Helical; Name=5; Potential
Topological domain204 – 21916Cytoplasmic Potential
Transmembrane220 – 24021Helical; Name=6; Potential
Topological domain241 – 25515Extracellular Potential
Transmembrane256 – 27621Helical; Name=7; Potential
Topological domain277 – 31337Cytoplasmic Potential

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation761N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2041A → G in AAK91790. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91WW2 [UniParc].

Last modified October 16, 2013. Version 2.
Checksum: A428C370BBD0F202

FASTA31335,682
        10         20         30         40         50         60 
MAPTTTNPMN ETIPGSIDIE TLIPNLMIII FGLVGLTGNV ILFWLLGFHL HRNAFLVYIL 

        70         80         90        100        110        120 
NLALADFLFL LCHIINSTML LLKVHLPNNI LNHCFDIIMT VLYITGLSML SAISTERCLS 

       130        140        150        160        170        180 
VLCPIWYRCR RPEHTSTVLC AVIWFLPLLI CILNGYFCHF FGPKYVIDSV CLATNFFIRT 

       190        200        210        220        230        240 
YPMFLFIVLC LSTLALLARL FCGAGKTKFT RLFVTIMLTV LVFLLCGLPL GFFWFLVPWI 

       250        260        270        280        290        300 
NRDFSVLDYI LFQTSLVLTS VNSCANPIIY FFVGSFRHRL KHKTLKMVLQ SALQDTPETP 

       310 
ENMVEMSRSK AEP 

« Hide

References

« Hide 'large scale' references
[1]"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."
Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J.
Cell 106:619-632(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Spinal ganglion.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY042194 mRNA. Translation: AAK91790.1.
AC144923 Genomic DNA. No translation available.
CH466603 Genomic DNA. Translation: EDL22963.1.
BC115741 mRNA. Translation: AAI15742.1.
RefSeqNP_705744.2. NM_153524.2.
UniGeneMm.207065.
Mm.297430.

3D structure databases

ProteinModelPortalQ91WW2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000084327.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbQ91WW2.
PRIDEQ91WW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087092; ENSMUSP00000084327; ENSMUSG00000067173.
GeneID235854.
KEGGmmu:235854.
UCSCuc009hak.1. mouse.

Organism-specific databases

CTD235854.
MGIMGI:3033100. Mrgpra4.

Phylogenomic databases

eggNOGeuNOG03703.
GeneTreeENSGT00550000074531.
HOGENOMHOG000015412.
HOVERGENHBG003592.
InParanoidQ91WW2.
OrthoDBEOG73Z2V2.
TreeFamTF336336.

Gene expression databases

CleanExMM_MRGPRA4.
GenevestigatorQ91WW2.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026233. MRGPCRA.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF9. PTHR11334:SF9. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR02109. MRGPCRA.
PR02108. MRGPCRFAMILY.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio382858.
PROQ91WW2.
SOURCESearch...

Entry information

Entry nameMRGA4_MOUSE
AccessionPrimary (citable) accession number: Q91WW2
Secondary accession number(s): Q1RLL1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 16, 2013
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries