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Protein

Urocortin-2

Gene

Ucn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • hormone activity Source: UniProtKB-KW
  • receptor binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • cAMP biosynthetic process Source: UniProtKB
  • cell proliferation Source: RGD
  • cellular response to glucocorticoid stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • cellular response to nutrient levels Source: GO_Central
  • digestion Source: InterPro
  • negative regulation of follicle-stimulating hormone secretion Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of luteinizing hormone secretion Source: RGD
  • response to immobilization stress Source: RGD
  • tissue regeneration Source: RGD

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Urocortin II
Short name:
Ucn II
Gene namesi
Name:Ucn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620765. Ucn2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000624323 – 67By similarityAdd BLAST45
ChainiPRO_000000624469 – 106Urocortin-2Add BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106Valine amide; partialBy similarity1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Amidation, Glycoprotein

Proteomic databases

PaxDbiQ91WW1.
PRIDEiQ91WW1.

Expressioni

Gene expression databases

GenevisibleiQ91WW1. RN.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • hormone activity Source: UniProtKB-KW
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028031.

Structurei

3D structure databases

ProteinModelPortaliQ91WW1.
SMRiQ91WW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5CP. Eukaryota.
ENOG4111C21. LUCA.
HOVERGENiHBG036242.
InParanoidiQ91WW1.
OMAiQNSPQTT.
OrthoDBiEOG091G171N.
TreeFamiTF330723.

Family and domain databases

InterProiView protein in InterPro
IPR000187. CRF.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF3. PTHR17575:SF3. 1 hit.
PfamiView protein in Pfam
PF00473. CRF. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD455741. PD455741. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRWALVVFM VLMLDRVPGT PIPTFQLLPQ NYPETTPSSV SSESPSDTTT
60 70 80 90 100
GPSASWSNSK ASPYLDTRVI LSLDVPIGLL RILLEQARNK AARNQAATNA

QILARVGRR
Length:109
Mass (Da):11,922
Last modified:December 1, 2001 - v1
Checksum:iAA2B46D8903ED83E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044835 mRNA. Translation: AAK98780.1.
UniGeneiRn.153037.

Genome annotation databases

UCSCiRGD:620765. rat.

Similar proteinsi

Entry informationi

Entry nameiUCN2_RAT
AccessioniPrimary (citable) accession number: Q91WW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families