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Protein

Urocortin-2

Gene

Ucn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • receptor binding Source: UniProtKB

GO - Biological processi

  • cAMP biosynthetic process Source: UniProtKB
  • cell proliferation Source: RGD
  • cellular response to glucocorticoid stimulus Source: RGD
  • cellular response to hypoxia Source: RGD
  • digestion Source: InterPro
  • negative regulation of follicle-stimulating hormone secretion Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of luteinizing hormone secretion Source: RGD
  • response to immobilization stress Source: RGD
  • tissue regeneration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-2
Alternative name(s):
Urocortin II
Short name:
Ucn II
Gene namesi
Name:Ucn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620765. Ucn2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 6745By similarityPRO_0000006243Add
BLAST
Chaini69 – 10638Urocortin-2PRO_0000006244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei106 – 1061Valine amide; partialBy similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Amidation, Glycoprotein

Proteomic databases

PaxDbiQ91WW1.
PRIDEiQ91WW1.

Expressioni

Gene expression databases

GenevisibleiQ91WW1. RN.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028031.

Structurei

3D structure databases

ProteinModelPortaliQ91WW1.
SMRiQ91WW1. Positions 69-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5CP. Eukaryota.
ENOG4111C21. LUCA.
HOVERGENiHBG036242.
InParanoidiQ91WW1.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
TreeFamiTF330723.

Family and domain databases

InterProiIPR000187. CRF.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91WW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRWALVVFM VLMLDRVPGT PIPTFQLLPQ NYPETTPSSV SSESPSDTTT
60 70 80 90 100
GPSASWSNSK ASPYLDTRVI LSLDVPIGLL RILLEQARNK AARNQAATNA

QILARVGRR
Length:109
Mass (Da):11,922
Last modified:December 1, 2001 - v1
Checksum:iAA2B46D8903ED83E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044835 mRNA. Translation: AAK98780.1.
RefSeqiNP_596876.2. NM_133385.2.
UniGeneiRn.153037.

Genome annotation databases

GeneIDi170896.
KEGGirno:170896.
UCSCiRGD:620765. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044835 mRNA. Translation: AAK98780.1.
RefSeqiNP_596876.2. NM_133385.2.
UniGeneiRn.153037.

3D structure databases

ProteinModelPortaliQ91WW1.
SMRiQ91WW1. Positions 69-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028031.

Proteomic databases

PaxDbiQ91WW1.
PRIDEiQ91WW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170896.
KEGGirno:170896.
UCSCiRGD:620765. rat.

Organism-specific databases

CTDi90226.
RGDi620765. Ucn2.

Phylogenomic databases

eggNOGiENOG410J5CP. Eukaryota.
ENOG4111C21. LUCA.
HOVERGENiHBG036242.
InParanoidiQ91WW1.
KOiK05257.
OMAiQNSPQTT.
OrthoDBiEOG73BVGS.
TreeFamiTF330723.

Miscellaneous databases

PROiQ91WW1.

Gene expression databases

GenevisibleiQ91WW1. RN.

Family and domain databases

InterProiIPR000187. CRF.
IPR024273. Urocortin_II.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PTHR17575:SF0. PTHR17575:SF0. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
ProDomiPD455741. PD455741. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and analysis of tissue-specific mRNA expression of rat urocortin II."
    Park J.H., Ju S.K., Lee M.K.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Midbrain.

Entry informationi

Entry nameiUCN2_RAT
AccessioniPrimary (citable) accession number: Q91WW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.