Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neutral and basic amino acid transport protein rBAT

Gene

Slc3a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the high-affinity sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney proximal tubule.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral and basic amino acid transport protein rBAT
Alternative name(s):
Solute carrier family 3 member 1
b(0,+)-type amino acid transport protein
Short name:
NBAT
Gene namesi
Name:Slc3a1
Synonyms:Nbat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1195264. Slc3a1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 88CytoplasmicSequence analysisAdd BLAST88
Transmembranei89 – 109Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini110 – 685ExtracellularSequence analysisAdd BLAST576

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004257411 – 685Neutral and basic amino acid transport protein rBATAdd BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei385PhosphoserineBy similarity1
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ91WV7.
PaxDbiQ91WV7.
PeptideAtlasiQ91WV7.
PRIDEiQ91WV7.

PTM databases

iPTMnetiQ91WV7.
PhosphoSitePlusiQ91WV7.

Expressioni

Tissue specificityi

Expressed in the brush border membrane in the kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000024131.
GenevisibleiQ91WV7. MM.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transporter SLC7A9.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203311. 1 interactor.
IntActiQ91WV7. 2 interactors.
MINTiMINT-4121539.
STRINGi10090.ENSMUSP00000024944.

Structurei

3D structure databases

ProteinModelPortaliQ91WV7.
SMRiQ91WV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0471. Eukaryota.
COG0366. LUCA.
GeneTreeiENSGT00890000139476.
HOVERGENiHBG053002.
InParanoidiQ91WV7.
KOiK14210.
OMAiVDVQKTQ.
OrthoDBiEOG091G03FE.
PhylomeDBiQ91WV7.
TreeFamiTF314498.

Family and domain databases

InterProiView protein in InterPro
IPR006047. Glyco_hydro_13_cat_dom.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDKGKRDP IQMSLKGCRT NNGFVQNEDI PEQDPDPGSR DTPQPNAVSI
60 70 80 90 100
PAPEEPHLKA VRPYAGMPKE VLFQFSGQAR YRVPREILFW LTVVSVFLLI
110 120 130 140 150
GATIAIIVIS PKCLDWWQAG PIYQIYPRSF KDSDKDGNGD LKGIQEKLDY
160 170 180 190 200
ITALNIKTLW ITSFYKSSLK DFRYAVEDFK EIDPIFGTMK DFENLVAAIH
210 220 230 240 250
DKGLKLIIDF IPNHTSDKHP WFQSSRTRSG KYTDYYIWHN CTHVNGVTTP
260 270 280 290 300
PNNWLSVYGN SSWHFDEVRK QCYFHQFLKE QPDLNFRNPA VQEEIKEIIT
310 320 330 340 350
FWLSKGVDGF SFDAVKFLLE AKDLRNEIQV NTSQIPDTVT HYSELYHDFT
360 370 380 390 400
TTQVGMHDIV RDFRQTMNQY SREPGRYRFM GAEASAESIE RTMMYYGLPF
410 420 430 440 450
IQEADFPFNK YFTTIGTLSG HTVYEVITSW MENMPEGKWP NWMTGGPETP
460 470 480 490 500
RLTSRVGSEY VNAMHMLLFT LPGTPITYYG EEIGMGDISV TNFNESYDST
510 520 530 540 550
TLVSKSPMQW DNSSNAGFTE ANHTWLPTNS DYHTVNVDVQ KTQPSSALRL
560 570 580 590 600
YQDLSLLHAT ELVLSRGWFC LLRDDSHSVV YTRELDGIDN VFLVVLNFGE
610 620 630 640 650
SSTVLNLQGI ISDLPPELRI RLSTNSASKG SAVDTRAISL EKGEGLVLEH
660 670 680
STKAPLHQQA AFRDRCFVSS RACYSSALDI LYSSC
Length:685
Mass (Da):78,118
Last modified:December 1, 2001 - v1
Checksum:i3316EBB9858AF9AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052623 mRNA. Translation: BAC35066.1.
AK132275 mRNA. Translation: BAE21075.1.
AC113476 Genomic DNA. No translation available.
CH466537 Genomic DNA. Translation: EDL38594.1.
BC013441 mRNA. Translation: AAH13441.1.
CCDSiCCDS37711.1.
RefSeqiNP_033231.2. NM_009205.2.
UniGeneiMm.227176.
Mm.461481.

Genome annotation databases

EnsembliENSMUST00000024944; ENSMUSP00000024944; ENSMUSG00000024131.
GeneIDi20532.
KEGGimmu:20532.
UCSCiuc008dtl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSLC31_MOUSE
AccessioniPrimary (citable) accession number: Q91WV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot