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Protein

Palmitoyltransferase ZDHHC7

Gene

Zdhhc7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (PubMed:15603741, PubMed:25253725). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).By similarity2 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18051DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • peptidyl-L-cysteine S-palmitoylation Source: UniProtKB
  • protein palmitoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC7Curated (EC:2.3.1.2252 Publications)
Alternative name(s):
GABA-A receptor-associated membrane protein 2Imported
Zinc finger DHHC domain-containing protein 7Imported
Short name:
DHHC-71 Publication
Gene namesi
Name:Zdhhc7Imported
Synonyms:Gramp2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142662. Zdhhc7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi157 – 1582DH → AA: Fails to enhance DLG4 palmitoylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Palmitoyltransferase ZDHHC7PRO_0000212875Add
BLAST

Post-translational modificationi

Autopalmitoylated.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ91WU6.
PaxDbiQ91WU6.
PRIDEiQ91WU6.

PTM databases

PhosphoSiteiQ91WU6.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in liver, kidney and brain. Expressed in all brain regions.1 Publication

Gene expression databases

BgeeiQ91WU6.
CleanExiMM_ZDHHC7.
GenevisibleiQ91WU6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034280.

Structurei

3D structure databases

ProteinModelPortaliQ91WU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 18051DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ91WU6.
KOiK18932.
OMAiNGVLFNC.
OrthoDBiEOG7QK0CG.
PhylomeDBiQ91WU6.
TreeFamiTF319798.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSGHRLRD IEHHPLLTDN DNYDSASSSS SETDMADRVW FIRDGCGMVC
60 70 80 90 100
AVMTWLLVVY ADFVVTFVML LPSKDFWYSV VNGVLFNCLA VLALSSHLRT
110 120 130 140 150
MLTDPGAVPK GNATKEYMES LQLKPGEVIY KCPKCCCIKP ERAHHCSICK
160 170 180 190 200
RCIRKMDHHC PWVNNCVGEK NQRFFVLFTM YIALSSVHAL ILCGLQFISC
210 220 230 240 250
VRGQWTECSD FSPPITVILL VFLCLEGLLF FTFTAVMFGT QIHSICNDET
260 270 280 290 300
EIERLKSEKP TWERRLRWEG MKSVFGGPPS LLWMNPFVGF RLRRLQMRTR

KGGPEFSV
Length:308
Mass (Da):35,213
Last modified:December 1, 2001 - v1
Checksum:i03BD4CB85245DF28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561L → F in BAE42116 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY166673 mRNA. Translation: AAO27360.1.
AK041905 mRNA. Translation: BAC31093.1.
AK157968 mRNA. Translation: BAE34289.1.
AK170639 mRNA. Translation: BAE41929.1.
AK170923 mRNA. Translation: BAE42116.1.
AK172462 mRNA. Translation: BAE43018.1.
BC013467 mRNA. Translation: AAH13467.1.
BC029666 mRNA. Translation: AAH29666.1.
BC075666 mRNA. Translation: AAH75666.1.
CCDSiCCDS22715.1.
RefSeqiNP_598728.1. NM_133967.3.
XP_011246559.1. XM_011248257.1.
UniGeneiMm.240076.

Genome annotation databases

EnsembliENSMUST00000034280; ENSMUSP00000034280; ENSMUSG00000031823.
GeneIDi102193.
KEGGimmu:102193.
UCSCiuc009nqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY166673 mRNA. Translation: AAO27360.1.
AK041905 mRNA. Translation: BAC31093.1.
AK157968 mRNA. Translation: BAE34289.1.
AK170639 mRNA. Translation: BAE41929.1.
AK170923 mRNA. Translation: BAE42116.1.
AK172462 mRNA. Translation: BAE43018.1.
BC013467 mRNA. Translation: AAH13467.1.
BC029666 mRNA. Translation: AAH29666.1.
BC075666 mRNA. Translation: AAH75666.1.
CCDSiCCDS22715.1.
RefSeqiNP_598728.1. NM_133967.3.
XP_011246559.1. XM_011248257.1.
UniGeneiMm.240076.

3D structure databases

ProteinModelPortaliQ91WU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034280.

PTM databases

PhosphoSiteiQ91WU6.

Proteomic databases

MaxQBiQ91WU6.
PaxDbiQ91WU6.
PRIDEiQ91WU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034280; ENSMUSP00000034280; ENSMUSG00000031823.
GeneIDi102193.
KEGGimmu:102193.
UCSCiuc009nqr.1. mouse.

Organism-specific databases

CTDi55625.
MGIiMGI:2142662. Zdhhc7.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234755.
HOVERGENiHBG056583.
InParanoidiQ91WU6.
KOiK18932.
OMAiNGVLFNC.
OrthoDBiEOG7QK0CG.
PhylomeDBiQ91WU6.
TreeFamiTF319798.

Miscellaneous databases

NextBioi355334.
PROiQ91WU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WU6.
CleanExiMM_ZDHHC7.
GenevisibleiQ91WU6. MM.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ."
    Keller C.A., Yuan X., Panzanelli P., Martin M.L., Alldred M., Sassoe-Pognetto M., Luescher B.
    J. Neurosci. 24:5881-5891(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Colon, Inner ear, Spleen and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon, Eye and Retina.
  4. "Identification of PSD-95 palmitoylating enzymes."
    Fukata M., Fukata Y., Adesnik H., Nicoll R.A., Bredt D.S.
    Neuron 44:987-996(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY, MUTAGENESIS OF 157-ASP-HIS-158.
  5. "The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity."
    Lemonidis K., Gorleku O.A., Sanchez-Perez M.C., Grefen C., Chamberlain L.H.
    Mol. Biol. Cell 25:3870-3883(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, AUTOPALMITOYLATION.

Entry informationi

Entry nameiZDHC7_MOUSE
AccessioniPrimary (citable) accession number: Q91WU6
Secondary accession number(s): Q3TC41, Q6EMK2, Q8K1H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.