Arsenite methyltransferase - Mus musculus (Mouse)

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Q91WU5 (AS3MT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Arsenite methyltransferase
EC=2.1.1.137

Alternative name(s):
Methylarsonite methyltransferase
S-adenosyl-L-methionine:arsenic(III) methyltransferase

Gene names

Name:	As3mt
Synonyms:	Cyt19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO₃H₂, which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me₂As(O)-OH By similarity.
Catalytic activity	S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arsonoacetate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB response to arsenic-containing substance Inferred from sequence alignment PubMed 15276411. Source: MGI toxin metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI
Molecular_function	arsenite methyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB methylarsonite methyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 376

376

Arsenite methyltransferase

PRO_0000204448

Experimental info

Sequence conflict

106

E → K in AAI45664. Ref.3

Sequence conflict

151

D → G in AAF00618. Ref.1

Sequence conflict

335 – 346

Missing in AAF00618. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q91WU5 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 9421A663FCC825E5
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FASTA

376

41,794

        10         20         30         40         50         60 
MAASRDADEI HKDVQNYYGN VLKTSADLQT NACVTRAKPV PSYIRESLQN VHEDVSSRYY 

        70         80         90        100        110        120 
GCGLTVPERL ENCRILDLGS GSGRDCYVLS QLVGEKGHVT GIDMTEVQVE VAKTYLEHHM 

       130        140        150        160        170        180 
EKFGFQAPNV TFLHGRIEKL AEAGIQSESY DIVISNCVIN LVPDKQQVLQ EVYRVLKHGG 

       190        200        210        220        230        240 
ELYFSDVYAS LEVPEDIKSH KVLWGECLGG ALYWKDLAII AQKIGFCPPR LVTADIITVE 

       250        260        270        280        290        300 
NKELEGVLGD CRFVSATFRL FKLPKTEPAE RCRVVYNGGI KGHEKELIFD ANFTFKEGEA 

       310        320        330        340        350        360 
VAVDEETAAV LKNSRFAPDF LFTPVDASLP APQGRSELET KVLIRDPFKL AEDSDKMKPR 

       370 
HAPEGTGGCC GKRKNC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel hematopoietic stem cell regulatory genes." Phillips R.L., Ernst R.E., Dosil M., Wesley C.K., Moore K.A., Kingsley P.D., Sykes S., Palis J., Lemischka I.R. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Liver.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Brain and Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF166383 mRNA. Translation: AAF00618.1. AC161865 Genomic DNA. No translation available. BC145663 mRNA. Translation: AAI45664.1. BC013468 mRNA. No translation available.
IPI	IPI00515140.
PIR	T44795.
RefSeq	NP_065602.2. NM_020577.2.
UniGene	Mm.28566.
3D structure databases
ProteinModelPortal	Q91WU5.
SMR	Q91WU5. Positions 40-316.
ModBase	Search...
PTM databases
PhosphoSite	Q91WU5.
Proteomic databases
PaxDb	Q91WU5.
PRIDE	Q91WU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003655; ENSMUSP00000003655; ENSMUSG00000003559.
GeneID	57344.
KEGG	mmu:57344.
UCSC	uc008huc.1. mouse.
Organism-specific databases
CTD	57412.
MGI	MGI:1929882. As3mt.
Phylogenomic databases
eggNOG	NOG257055.
GeneTree	ENSGT00390000001742.
HOGENOM	HOG000229966.
HOVERGEN	HBG050585.
InParanoid	A6H5W4.
KO	K07755.
OMA	ARYYGCG.
OrthoDB	EOG415GDK.
Gene expression databases
Bgee	Q91WU5.
CleanEx	MM_AS3MT.
Genevestigator	Q91WU5.
GermOnline	ENSMUSG00000003559. Mus musculus.
Family and domain databases
InterPro	IPR026669. Arsenite_MeTrfase. IPR025714. Methyltranfer_dom. [Graphical view]
PANTHER	PTHR10108:SF11. PTHR10108:SF11. 1 hit.
Pfam	PF13847. Methyltransf_31. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	313710.
SOURCE	Search...

Entry information

Entry name

AS3MT_MOUSE

Accession

Primary (citable) accession number: Q91WU5
Secondary accession number(s): A6H5W4, E9QLU6, Q9QZT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents