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Q91WU4

- TMCO4_MOUSE

UniProt

Q91WU4 - TMCO4_MOUSE

Protein

Transmembrane and coiled-coil domain-containing protein 4

Gene

Tmco4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane and coiled-coil domain-containing protein 4
    Gene namesi
    Name:Tmco4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1924306. Tmco4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 631631Transmembrane and coiled-coil domain-containing protein 4PRO_0000305150Add
    BLAST

    Proteomic databases

    PRIDEiQ91WU4.

    PTM databases

    PhosphoSiteiQ91WU4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91WU4.
    BgeeiQ91WU4.
    CleanExiMM_TMCO4.
    GenevestigatoriQ91WU4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000059320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili156 – 18328Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TMCO4 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280803.
    GeneTreeiENSGT00390000001400.
    HOGENOMiHOG000019995.
    HOVERGENiHBG096742.
    InParanoidiQ91WU4.
    OMAiPEQSSFC.
    OrthoDBiEOG779NZJ.
    PhylomeDBiQ91WU4.
    TreeFamiTF312951.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR007941. DUF726.
    [Graphical view]
    PANTHERiPTHR17920. PTHR17920. 1 hit.
    PfamiPF05277. DUF726. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91WU4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATWNRPHPR QPVAPEPAAE DDSQQPLGRE LSEANRFAYA ALCGFSLSQL    50
    FPEPEQSSFC TEFVTGLVKW LHLSESVLPT IMAFASGLGG EGADIFAQTL 100
    LQDPILRDNP SAVSQDLLSF SLKNGHYDAR ARVLVCHVTS LLQVPMEELD 150
    ILEEVFLESL KDAKEEESET AEASRKRKEK RRKWKRYLLI GLATVGGGTV 200
    IGVTGGLAAP LVAAGAATII GSAGAAALGS VAGIAVMTSL FGAAGAGLTG 250
    YKMKKRVGAI EEFMFLPLTE GRQLHITIAI TGWLGSGRYR TFNAPWMALA 300
    RSQEQYCLAW EAKYLMELGN ALETILSGLA NMVAQEALKY TVLSGIVAAL 350
    TWPASLLSVA NVIDNPWGVC LHRSAEVGKH LAHILLSRQQ GRRPVTLIGF 400
    SLGARVIYFC LQEMAQEQDC QGIIEDVVLL GAPVEGDPKH WEPFRNVVSG 450
    RIINGYCRGD WLLSFVYRTS SVQLRVAGLQ PVLLQDRRME NVDLTSVVNG 500
    HLDYAKQMDA ILKVVGIRTK PGWREKGLPL APGSLPQEEP LQTAIVSTDE 550
    IILQDGQSQG PASEDSLKTT IPSSASQAQM PAGLNQSTED SLSTAAAPAE 600
    GHLICSHGVG PNPLGCPDCT HGTQESCTEL D 631
    Length:631
    Mass (Da):67,945
    Last modified:October 2, 2007 - v2
    Checksum:iF00E35C1CB7EDE27
    GO
    Isoform 2 (identifier: Q91WU4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         191-246: Missing.
         419-421: DCQ → VSG
         422-631: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:365
    Mass (Da):40,722
    Checksum:iE3AD5847A2A22AF0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811I → M in AAH13471. (PubMed:15489334)Curated
    Sequence conflicti163 – 1631A → T in AAH13471. (PubMed:15489334)Curated
    Sequence conflicti524 – 5241R → G in AAH13471. (PubMed:15489334)Curated
    Sequence conflicti551 – 5511I → T in AAH13471. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei191 – 24656Missing in isoform 2. 1 PublicationVSP_028243Add
    BLAST
    Alternative sequencei419 – 4213DCQ → VSG in isoform 2. 1 PublicationVSP_028244
    Alternative sequencei422 – 631210Missing in isoform 2. 1 PublicationVSP_028245Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014571 mRNA. Translation: BAB29436.1.
    AK029092 mRNA. Translation: BAC26291.1.
    AK054337 mRNA. Translation: BAC35737.1.
    AK170619 mRNA. Translation: BAE41914.1.
    AK171189 mRNA. Translation: BAE42299.1.
    AL805923 Genomic DNA. Translation: CAM26544.1.
    BC013471 mRNA. Translation: AAH13471.1.
    CCDSiCCDS18837.1. [Q91WU4-1]
    RefSeqiNP_084133.1. NM_029857.3. [Q91WU4-1]
    XP_006539343.1. XM_006539280.1. [Q91WU4-1]
    XP_006539344.1. XM_006539281.1. [Q91WU4-1]
    UniGeneiMm.122336.
    Mm.478749.

    Genome annotation databases

    EnsembliENSMUST00000043042; ENSMUSP00000041388; ENSMUSG00000041143. [Q91WU4-1]
    ENSMUST00000050949; ENSMUSP00000059320; ENSMUSG00000041143. [Q91WU4-1]
    GeneIDi77056.
    KEGGimmu:77056.
    UCSCiuc008vlp.2. mouse. [Q91WU4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014571 mRNA. Translation: BAB29436.1 .
    AK029092 mRNA. Translation: BAC26291.1 .
    AK054337 mRNA. Translation: BAC35737.1 .
    AK170619 mRNA. Translation: BAE41914.1 .
    AK171189 mRNA. Translation: BAE42299.1 .
    AL805923 Genomic DNA. Translation: CAM26544.1 .
    BC013471 mRNA. Translation: AAH13471.1 .
    CCDSi CCDS18837.1. [Q91WU4-1 ]
    RefSeqi NP_084133.1. NM_029857.3. [Q91WU4-1 ]
    XP_006539343.1. XM_006539280.1. [Q91WU4-1 ]
    XP_006539344.1. XM_006539281.1. [Q91WU4-1 ]
    UniGenei Mm.122336.
    Mm.478749.

    3D structure databases

    ProteinModelPortali Q91WU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000059320.

    PTM databases

    PhosphoSitei Q91WU4.

    Proteomic databases

    PRIDEi Q91WU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043042 ; ENSMUSP00000041388 ; ENSMUSG00000041143 . [Q91WU4-1 ]
    ENSMUST00000050949 ; ENSMUSP00000059320 ; ENSMUSG00000041143 . [Q91WU4-1 ]
    GeneIDi 77056.
    KEGGi mmu:77056.
    UCSCi uc008vlp.2. mouse. [Q91WU4-1 ]

    Organism-specific databases

    CTDi 255104.
    MGIi MGI:1924306. Tmco4.

    Phylogenomic databases

    eggNOGi NOG280803.
    GeneTreei ENSGT00390000001400.
    HOGENOMi HOG000019995.
    HOVERGENi HBG096742.
    InParanoidi Q91WU4.
    OMAi PEQSSFC.
    OrthoDBi EOG779NZJ.
    PhylomeDBi Q91WU4.
    TreeFami TF312951.

    Miscellaneous databases

    NextBioi 346396.
    PROi Q91WU4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91WU4.
    Bgeei Q91WU4.
    CleanExi MM_TMCO4.
    Genevestigatori Q91WU4.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR007941. DUF726.
    [Graphical view ]
    PANTHERi PTHR17920. PTHR17920. 1 hit.
    Pfami PF05277. DUF726. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Skin.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiTMCO4_MOUSE
    AccessioniPrimary (citable) accession number: Q91WU4
    Secondary accession number(s): Q8BIX8, Q9D675
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3