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Protein

Transmembrane and coiled-coil domain-containing protein 4

Gene

Tmco4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 4
Gene namesi
Name:Tmco4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924306. Tmco4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 631631Transmembrane and coiled-coil domain-containing protein 4PRO_0000305150Add
BLAST

Proteomic databases

PRIDEiQ91WU4.

PTM databases

PhosphoSiteiQ91WU4.

Expressioni

Gene expression databases

BgeeiQ91WU4.
CleanExiMM_TMCO4.
ExpressionAtlasiQ91WU4. baseline and differential.
GenevestigatoriQ91WU4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059320.

Structurei

3D structure databases

ProteinModelPortaliQ91WU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili156 – 18328Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TMCO4 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280803.
GeneTreeiENSGT00390000001400.
HOGENOMiHOG000019995.
HOVERGENiHBG096742.
InParanoidiQ91WU4.
OMAiNPWSVCL.
OrthoDBiEOG779NZJ.
PhylomeDBiQ91WU4.
TreeFamiTF312951.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view]
PANTHERiPTHR17920. PTHR17920. 1 hit.
PfamiPF05277. DUF726. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91WU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATWNRPHPR QPVAPEPAAE DDSQQPLGRE LSEANRFAYA ALCGFSLSQL
60 70 80 90 100
FPEPEQSSFC TEFVTGLVKW LHLSESVLPT IMAFASGLGG EGADIFAQTL
110 120 130 140 150
LQDPILRDNP SAVSQDLLSF SLKNGHYDAR ARVLVCHVTS LLQVPMEELD
160 170 180 190 200
ILEEVFLESL KDAKEEESET AEASRKRKEK RRKWKRYLLI GLATVGGGTV
210 220 230 240 250
IGVTGGLAAP LVAAGAATII GSAGAAALGS VAGIAVMTSL FGAAGAGLTG
260 270 280 290 300
YKMKKRVGAI EEFMFLPLTE GRQLHITIAI TGWLGSGRYR TFNAPWMALA
310 320 330 340 350
RSQEQYCLAW EAKYLMELGN ALETILSGLA NMVAQEALKY TVLSGIVAAL
360 370 380 390 400
TWPASLLSVA NVIDNPWGVC LHRSAEVGKH LAHILLSRQQ GRRPVTLIGF
410 420 430 440 450
SLGARVIYFC LQEMAQEQDC QGIIEDVVLL GAPVEGDPKH WEPFRNVVSG
460 470 480 490 500
RIINGYCRGD WLLSFVYRTS SVQLRVAGLQ PVLLQDRRME NVDLTSVVNG
510 520 530 540 550
HLDYAKQMDA ILKVVGIRTK PGWREKGLPL APGSLPQEEP LQTAIVSTDE
560 570 580 590 600
IILQDGQSQG PASEDSLKTT IPSSASQAQM PAGLNQSTED SLSTAAAPAE
610 620 630
GHLICSHGVG PNPLGCPDCT HGTQESCTEL D
Length:631
Mass (Da):67,945
Last modified:October 1, 2007 - v2
Checksum:iF00E35C1CB7EDE27
GO
Isoform 2 (identifier: Q91WU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-246: Missing.
     419-421: DCQ → VSG
     422-631: Missing.

Note: No experimental confirmation available.

Show »
Length:365
Mass (Da):40,722
Checksum:iE3AD5847A2A22AF0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811I → M in AAH13471 (PubMed:15489334).Curated
Sequence conflicti163 – 1631A → T in AAH13471 (PubMed:15489334).Curated
Sequence conflicti524 – 5241R → G in AAH13471 (PubMed:15489334).Curated
Sequence conflicti551 – 5511I → T in AAH13471 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei191 – 24656Missing in isoform 2. 1 PublicationVSP_028243Add
BLAST
Alternative sequencei419 – 4213DCQ → VSG in isoform 2. 1 PublicationVSP_028244
Alternative sequencei422 – 631210Missing in isoform 2. 1 PublicationVSP_028245Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014571 mRNA. Translation: BAB29436.1.
AK029092 mRNA. Translation: BAC26291.1.
AK054337 mRNA. Translation: BAC35737.1.
AK170619 mRNA. Translation: BAE41914.1.
AK171189 mRNA. Translation: BAE42299.1.
AL805923 Genomic DNA. Translation: CAM26544.1.
BC013471 mRNA. Translation: AAH13471.1.
CCDSiCCDS18837.1. [Q91WU4-1]
RefSeqiNP_084133.1. NM_029857.3. [Q91WU4-1]
XP_006539343.1. XM_006539280.2. [Q91WU4-1]
UniGeneiMm.122336.
Mm.478749.

Genome annotation databases

EnsembliENSMUST00000043042; ENSMUSP00000041388; ENSMUSG00000041143. [Q91WU4-1]
ENSMUST00000050949; ENSMUSP00000059320; ENSMUSG00000041143. [Q91WU4-1]
GeneIDi77056.
KEGGimmu:77056.
UCSCiuc008vlp.2. mouse. [Q91WU4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014571 mRNA. Translation: BAB29436.1.
AK029092 mRNA. Translation: BAC26291.1.
AK054337 mRNA. Translation: BAC35737.1.
AK170619 mRNA. Translation: BAE41914.1.
AK171189 mRNA. Translation: BAE42299.1.
AL805923 Genomic DNA. Translation: CAM26544.1.
BC013471 mRNA. Translation: AAH13471.1.
CCDSiCCDS18837.1. [Q91WU4-1]
RefSeqiNP_084133.1. NM_029857.3. [Q91WU4-1]
XP_006539343.1. XM_006539280.2. [Q91WU4-1]
UniGeneiMm.122336.
Mm.478749.

3D structure databases

ProteinModelPortaliQ91WU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059320.

PTM databases

PhosphoSiteiQ91WU4.

Proteomic databases

PRIDEiQ91WU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043042; ENSMUSP00000041388; ENSMUSG00000041143. [Q91WU4-1]
ENSMUST00000050949; ENSMUSP00000059320; ENSMUSG00000041143. [Q91WU4-1]
GeneIDi77056.
KEGGimmu:77056.
UCSCiuc008vlp.2. mouse. [Q91WU4-1]

Organism-specific databases

CTDi255104.
MGIiMGI:1924306. Tmco4.

Phylogenomic databases

eggNOGiNOG280803.
GeneTreeiENSGT00390000001400.
HOGENOMiHOG000019995.
HOVERGENiHBG096742.
InParanoidiQ91WU4.
OMAiNPWSVCL.
OrthoDBiEOG779NZJ.
PhylomeDBiQ91WU4.
TreeFamiTF312951.

Miscellaneous databases

NextBioi346396.
PROiQ91WU4.
SOURCEiSearch...

Gene expression databases

BgeeiQ91WU4.
CleanExiMM_TMCO4.
ExpressionAtlasiQ91WU4. baseline and differential.
GenevestigatoriQ91WU4.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view]
PANTHERiPTHR17920. PTHR17920. 1 hit.
PfamiPF05277. DUF726. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Skin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiTMCO4_MOUSE
AccessioniPrimary (citable) accession number: Q91WU4
Secondary accession number(s): Q8BIX8, Q9D675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 2007
Last sequence update: October 1, 2007
Last modified: March 31, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.