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Q91WU4 (TMCO4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane and coiled-coil domain-containing protein 4
Gene names
Name:Tmco4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length631 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMCO4 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91WU4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91WU4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     191-246: Missing.
     419-421: DCQ → VSG
     422-631: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 631631Transmembrane and coiled-coil domain-containing protein 4
PRO_0000305150

Regions

Transmembrane200 – 22021Helical; Potential
Transmembrane228 – 24821Helical; Potential
Transmembrane343 – 36321Helical; Potential
Coiled coil156 – 18328 Potential

Natural variations

Alternative sequence191 – 24656Missing in isoform 2.
VSP_028243
Alternative sequence419 – 4213DCQ → VSG in isoform 2.
VSP_028244
Alternative sequence422 – 631210Missing in isoform 2.
VSP_028245

Experimental info

Sequence conflict811I → M in AAH13471. Ref.3
Sequence conflict1631A → T in AAH13471. Ref.3
Sequence conflict5241R → G in AAH13471. Ref.3
Sequence conflict5511I → T in AAH13471. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: F00E35C1CB7EDE27

FASTA63167,945
        10         20         30         40         50         60 
MATWNRPHPR QPVAPEPAAE DDSQQPLGRE LSEANRFAYA ALCGFSLSQL FPEPEQSSFC 

        70         80         90        100        110        120 
TEFVTGLVKW LHLSESVLPT IMAFASGLGG EGADIFAQTL LQDPILRDNP SAVSQDLLSF 

       130        140        150        160        170        180 
SLKNGHYDAR ARVLVCHVTS LLQVPMEELD ILEEVFLESL KDAKEEESET AEASRKRKEK 

       190        200        210        220        230        240 
RRKWKRYLLI GLATVGGGTV IGVTGGLAAP LVAAGAATII GSAGAAALGS VAGIAVMTSL 

       250        260        270        280        290        300 
FGAAGAGLTG YKMKKRVGAI EEFMFLPLTE GRQLHITIAI TGWLGSGRYR TFNAPWMALA 

       310        320        330        340        350        360 
RSQEQYCLAW EAKYLMELGN ALETILSGLA NMVAQEALKY TVLSGIVAAL TWPASLLSVA 

       370        380        390        400        410        420 
NVIDNPWGVC LHRSAEVGKH LAHILLSRQQ GRRPVTLIGF SLGARVIYFC LQEMAQEQDC 

       430        440        450        460        470        480 
QGIIEDVVLL GAPVEGDPKH WEPFRNVVSG RIINGYCRGD WLLSFVYRTS SVQLRVAGLQ 

       490        500        510        520        530        540 
PVLLQDRRME NVDLTSVVNG HLDYAKQMDA ILKVVGIRTK PGWREKGLPL APGSLPQEEP 

       550        560        570        580        590        600 
LQTAIVSTDE IILQDGQSQG PASEDSLKTT IPSSASQAQM PAGLNQSTED SLSTAAAPAE 

       610        620        630 
GHLICSHGVG PNPLGCPDCT HGTQESCTEL D 

« Hide

Isoform 2 [UniParc].

Checksum: E3AD5847A2A22AF0
Show »

FASTA36540,722

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Skin.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK014571 mRNA. Translation: BAB29436.1.
AK029092 mRNA. Translation: BAC26291.1.
AK054337 mRNA. Translation: BAC35737.1.
AK170619 mRNA. Translation: BAE41914.1.
AK171189 mRNA. Translation: BAE42299.1.
AL805923 Genomic DNA. Translation: CAM26544.1.
BC013471 mRNA. Translation: AAH13471.1.
CCDSCCDS18837.1. [Q91WU4-1]
RefSeqNP_084133.1. NM_029857.3. [Q91WU4-1]
XP_006539343.1. XM_006539280.1. [Q91WU4-1]
XP_006539344.1. XM_006539281.1. [Q91WU4-1]
UniGeneMm.122336.
Mm.478749.

3D structure databases

ProteinModelPortalQ91WU4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000059320.

PTM databases

PhosphoSiteQ91WU4.

Proteomic databases

PRIDEQ91WU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043042; ENSMUSP00000041388; ENSMUSG00000041143. [Q91WU4-1]
ENSMUST00000050949; ENSMUSP00000059320; ENSMUSG00000041143. [Q91WU4-1]
GeneID77056.
KEGGmmu:77056.
UCSCuc008vlp.2. mouse. [Q91WU4-1]

Organism-specific databases

CTD255104.
MGIMGI:1924306. Tmco4.

Phylogenomic databases

eggNOGNOG280803.
GeneTreeENSGT00390000001400.
HOGENOMHOG000019995.
HOVERGENHBG096742.
InParanoidQ91WU4.
OMAPEQSSFC.
OrthoDBEOG779NZJ.
PhylomeDBQ91WU4.
TreeFamTF312951.

Gene expression databases

ArrayExpressQ91WU4.
BgeeQ91WU4.
CleanExMM_TMCO4.
GenevestigatorQ91WU4.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR007941. DUF726.
[Graphical view]
PANTHERPTHR17920. PTHR17920. 1 hit.
PfamPF05277. DUF726. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

NextBio346396.
PROQ91WU4.
SOURCESearch...

Entry information

Entry nameTMCO4_MOUSE
AccessionPrimary (citable) accession number: Q91WU4
Secondary accession number(s): Q8BIX8, Q9D675
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot