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Protein

Transmembrane and coiled-coil domain-containing protein 4

Gene

Tmco4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein family/group databases

ESTHERimouse-tmco4 Duf_726

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 4
Gene namesi
Name:Tmco4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1924306 Tmco4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051501 – 631Transmembrane and coiled-coil domain-containing protein 4Add BLAST631

Proteomic databases

PaxDbiQ91WU4
PRIDEiQ91WU4

PTM databases

iPTMnetiQ91WU4
PhosphoSitePlusiQ91WU4

Expressioni

Gene expression databases

BgeeiENSMUSG00000041143
CleanExiMM_TMCO4
ExpressionAtlasiQ91WU4 baseline and differential
GenevisibleiQ91WU4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041388

Structurei

3D structure databases

ProteinModelPortaliQ91WU4
SMRiQ91WU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili156 – 183Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the TMCO4 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2385 Eukaryota
ENOG410YB1Z LUCA
GeneTreeiENSGT00390000001400
HOGENOMiHOG000019995
HOVERGENiHBG096742
InParanoidiQ91WU4
OMAiSFCTEFM
OrthoDBiEOG091G0F0H
PhylomeDBiQ91WU4
TreeFamiTF312951

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR007941 DUF726
PANTHERiPTHR17920 PTHR17920, 1 hit
PfamiView protein in Pfam
PF05277 DUF726, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91WU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATWNRPHPR QPVAPEPAAE DDSQQPLGRE LSEANRFAYA ALCGFSLSQL
60 70 80 90 100
FPEPEQSSFC TEFVTGLVKW LHLSESVLPT IMAFASGLGG EGADIFAQTL
110 120 130 140 150
LQDPILRDNP SAVSQDLLSF SLKNGHYDAR ARVLVCHVTS LLQVPMEELD
160 170 180 190 200
ILEEVFLESL KDAKEEESET AEASRKRKEK RRKWKRYLLI GLATVGGGTV
210 220 230 240 250
IGVTGGLAAP LVAAGAATII GSAGAAALGS VAGIAVMTSL FGAAGAGLTG
260 270 280 290 300
YKMKKRVGAI EEFMFLPLTE GRQLHITIAI TGWLGSGRYR TFNAPWMALA
310 320 330 340 350
RSQEQYCLAW EAKYLMELGN ALETILSGLA NMVAQEALKY TVLSGIVAAL
360 370 380 390 400
TWPASLLSVA NVIDNPWGVC LHRSAEVGKH LAHILLSRQQ GRRPVTLIGF
410 420 430 440 450
SLGARVIYFC LQEMAQEQDC QGIIEDVVLL GAPVEGDPKH WEPFRNVVSG
460 470 480 490 500
RIINGYCRGD WLLSFVYRTS SVQLRVAGLQ PVLLQDRRME NVDLTSVVNG
510 520 530 540 550
HLDYAKQMDA ILKVVGIRTK PGWREKGLPL APGSLPQEEP LQTAIVSTDE
560 570 580 590 600
IILQDGQSQG PASEDSLKTT IPSSASQAQM PAGLNQSTED SLSTAAAPAE
610 620 630
GHLICSHGVG PNPLGCPDCT HGTQESCTEL D
Length:631
Mass (Da):67,945
Last modified:October 2, 2007 - v2
Checksum:iF00E35C1CB7EDE27
GO
Isoform 2 (identifier: Q91WU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-246: Missing.
     419-421: DCQ → VSG
     422-631: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):40,722
Checksum:iE3AD5847A2A22AF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81I → M in AAH13471 (PubMed:15489334).Curated1
Sequence conflicti163A → T in AAH13471 (PubMed:15489334).Curated1
Sequence conflicti524R → G in AAH13471 (PubMed:15489334).Curated1
Sequence conflicti551I → T in AAH13471 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028243191 – 246Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_028244419 – 421DCQ → VSG in isoform 2. 1 Publication3
Alternative sequenceiVSP_028245422 – 631Missing in isoform 2. 1 PublicationAdd BLAST210

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014571 mRNA Translation: BAB29436.1
AK029092 mRNA Translation: BAC26291.1
AK054337 mRNA Translation: BAC35737.1
AK170619 mRNA Translation: BAE41914.1
AK171189 mRNA Translation: BAE42299.1
AL805923 Genomic DNA Translation: CAM26544.1
BC013471 mRNA Translation: AAH13471.1
CCDSiCCDS18837.1 [Q91WU4-1]
RefSeqiNP_001292352.1, NM_001305423.1 [Q91WU4-1]
NP_084133.1, NM_029857.3 [Q91WU4-1]
XP_006539343.1, XM_006539280.3 [Q91WU4-1]
UniGeneiMm.122336
Mm.478749

Genome annotation databases

EnsembliENSMUST00000043042; ENSMUSP00000041388; ENSMUSG00000041143 [Q91WU4-1]
ENSMUST00000050949; ENSMUSP00000059320; ENSMUSG00000041143 [Q91WU4-1]
GeneIDi77056
KEGGimmu:77056
UCSCiuc008vlp.2 mouse [Q91WU4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMCO4_MOUSE
AccessioniPrimary (citable) accession number: Q91WU4
Secondary accession number(s): Q8BIX8, Q9D675
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health