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Q91WU2

- S22A7_MOUSE

UniProt

Q91WU2 - S22A7_MOUSE

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Protein

Solute carrier family 22 member 7

Gene

Slc22a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Mediates sodium-independent multispecific organic anion transport. High affinity transport of glutarate and prostaglandin E2 in a sodium-independent manner. Mediates also the uptake of alpha-ketoglutarate, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, allopurinol and bumetanide.1 Publication

Kineticsi

  1. KM=15.8 µM for glutarate2 Publications
  2. KM=5.2 nM for prostaglandin E22 Publications
  3. KM=9.12 µM for bumetanide2 Publications

GO - Molecular functioni

  1. organic anion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. organic anion transport Source: MGI
  2. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198604. Organic anion transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 7
Alternative name(s):
Organic anion transporter 2
Short name:
mOAT2
Gene namesi
Name:Slc22a7
Synonyms:Oat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1859559. Slc22a7.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein
Note: Apical side of the renal tubule.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Transmembranei402 – 42221HelicalSequence AnalysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST
Transmembranei462 – 48423HelicalSequence AnalysisAdd
BLAST
Transmembranei488 – 51023HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Solute carrier family 22 member 7PRO_0000317482Add
BLAST

Proteomic databases

PaxDbiQ91WU2.
PRIDEiQ91WU2.

PTM databases

PhosphoSiteiQ91WU2.

Expressioni

Tissue specificityi

Abundant expression in male and female kidney and also in female liver.1 Publication

Gene expression databases

BgeeiQ91WU2.
GenevestigatoriQ91WU2.

Structurei

3D structure databases

ProteinModelPortaliQ91WU2.
SMRiQ91WU2. Positions 144-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ91WU2.
KOiK08204.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ91WU2.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91WU2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFEELLHKV GGFGPFQLRN LVLLALPRFL LPMHFLLPIF MAAVPAHHCA
60 70 80 90 100
LPDAPANLSH QDLWLKTHLP RETDGSFSSC LRFAYPQALP NVTLGTEVYN
110 120 130 140 150
SGEPEGEPLT VPCSQGWEYD RSEFSSTIAT EWDLVCEQRG LNKVTSTCFF
160 170 180 190 200
IGVLLGAVVY GYLSDRFGRR RLLLVAYVST LALGLMSAAS VNYIMFVTTR
210 220 230 240 250
MLTGSALAGF TIIVLPLELE WLDVEHRTVA GVISTTFWTG GVLLLTLVGY
260 270 280 290 300
LIRSWRWLLL AATLPCVPGI ISIWWVPESA RWLLTQGRVE EAKKYLSICA
310 320 330 340 350
KLNGRPISED SLSQEALNKV ITMERVSQRP SYLDLFRTSQ LRHVSLCCMM
360 370 380 390 400
MWFGVNFSYY GLTLDASGLG LTVYQTQLLF GAVEVPSKIT VFFLVRLVGR
410 420 430 440 450
RLTEAGMLLA TALTFGISLL VSSDTKSWIT ALVVIGKAFS EAAFTTAYLF
460 470 480 490 500
TSELYPTVLR QTGMGFTALI GRLGASLAPL VVLLDGVWLL LPKLAYGGIS
510 520 530 540
FLAACTVLLL PETKKAQLPE TIQDVERKGR KIDRSGTELA
Length:540
Mass (Da):59,614
Last modified:December 1, 2001 - v1
Checksum:i2A5AA5A5E0F30BAE
GO
Isoform 2 (identifier: Q91WU2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.
     125-131: SSTIATE → MGESSET

Show »
Length:416
Mass (Da):45,803
Checksum:i2A6DDB3800FC3136
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461A → T in BAC02736. (PubMed:12065749)Curated
Sequence conflicti82 – 821R → H in BAC02736. (PubMed:12065749)Curated
Sequence conflicti85 – 851Y → C in BAC38659. (PubMed:16141072)Curated
Sequence conflicti137 – 1371E → Q in BAC38659. (PubMed:16141072)Curated
Sequence conflicti137 – 1371E → Q in BAE25625. (PubMed:16141072)Curated
Sequence conflicti193 – 1931Y → N in BAC38659. (PubMed:16141072)Curated
Sequence conflicti255 – 2551W → S in AAH26598. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 124124Missing in isoform 2. 2 PublicationsVSP_030995Add
BLAST
Alternative sequencei125 – 1317SSTIATE → MGESSET in isoform 2. 2 PublicationsVSP_030996

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB069965 mRNA. Translation: BAC02736.1.
AK082865 mRNA. Translation: BAC38659.1.
AK143949 mRNA. Translation: BAE25625.1.
BC013474 mRNA. Translation: AAH13474.1.
BC024119 mRNA. Translation: AAH24119.1.
BC025813 mRNA. Translation: AAH25813.1.
BC026598 mRNA. Translation: AAH26598.1.
BC026597 mRNA. Translation: AAH26597.1.
CCDSiCCDS28829.1. [Q91WU2-1]
RefSeqiNP_659105.2. NM_144856.2.
UniGeneiMm.387538.

Genome annotation databases

EnsembliENSMUST00000087012; ENSMUSP00000084234; ENSMUSG00000067144.
GeneIDi108114.
KEGGimmu:108114.
UCSCiuc008csw.2. mouse. [Q91WU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB069965 mRNA. Translation: BAC02736.1 .
AK082865 mRNA. Translation: BAC38659.1 .
AK143949 mRNA. Translation: BAE25625.1 .
BC013474 mRNA. Translation: AAH13474.1 .
BC024119 mRNA. Translation: AAH24119.1 .
BC025813 mRNA. Translation: AAH25813.1 .
BC026598 mRNA. Translation: AAH26598.1 .
BC026597 mRNA. Translation: AAH26597.1 .
CCDSi CCDS28829.1. [Q91WU2-1 ]
RefSeqi NP_659105.2. NM_144856.2.
UniGenei Mm.387538.

3D structure databases

ProteinModelPortali Q91WU2.
SMRi Q91WU2. Positions 144-514.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073716.

PTM databases

PhosphoSitei Q91WU2.

Proteomic databases

PaxDbi Q91WU2.
PRIDEi Q91WU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087012 ; ENSMUSP00000084234 ; ENSMUSG00000067144 .
GeneIDi 108114.
KEGGi mmu:108114.
UCSCi uc008csw.2. mouse. [Q91WU2-1 ]

Organism-specific databases

CTDi 10864.
MGIi MGI:1859559. Slc22a7.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00760000118852.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q91WU2.
KOi K08204.
OrthoDBi EOG7C8GH9.
PhylomeDBi Q91WU2.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_198604. Organic anion transport.

Miscellaneous databases

NextBioi 360092.
PROi Q91WU2.
SOURCEi Search...

Gene expression databases

Bgeei Q91WU2.
Genevestigatori Q91WU2.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice."
    Kobayashi Y., Ohshiro N., Shibusawa A., Sasaki T., Tokuyama S., Sekine T., Endou H., Yamamoto T.
    Mol. Pharmacol. 62:7-14(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Kidney and Liver.
  4. "Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide."
    Kobayashi Y., Ohbayashi M., Kohyama N., Yamamoto T.
    Eur. J. Pharmacol. 524:44-48(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiS22A7_MOUSE
AccessioniPrimary (citable) accession number: Q91WU2
Secondary accession number(s): Q3UNX2
, Q8BUQ9, Q8K4S9, Q8R0M7, Q8R125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3