SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91WU2

- S22A7_MOUSE

UniProt

Q91WU2 - S22A7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Solute carrier family 22 member 7
Gene
Slc22a7, Oat2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates sodium-independent multispecific organic anion transport. High affinity transport of glutarate and prostaglandin E2 in a sodium-independent manner. Mediates also the uptake of alpha-ketoglutarate, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, allopurinol and bumetanide.1 Publication

Kineticsi

  1. KM=15.8 µM for glutarate2 Publications
  2. KM=5.2 nM for prostaglandin E2
  3. KM=9.12 µM for bumetanide

GO - Molecular functioni

  1. organic anion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. organic anion transport Source: MGI
  2. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198604. Organic anion transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 7
Alternative name(s):
Organic anion transporter 2
Short name:
mOAT2
Gene namesi
Name:Slc22a7
Synonyms:Oat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1859559. Slc22a7.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein
Note: Apical side of the renal tubule By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Transmembranei202 – 22221Helical; Reviewed prediction
Add
BLAST
Transmembranei232 – 25221Helical; Reviewed prediction
Add
BLAST
Transmembranei257 – 27721Helical; Reviewed prediction
Add
BLAST
Transmembranei344 – 36421Helical; Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Transmembranei402 – 42221Helical; Reviewed prediction
Add
BLAST
Transmembranei429 – 44921Helical; Reviewed prediction
Add
BLAST
Transmembranei462 – 48423Helical; Reviewed prediction
Add
BLAST
Transmembranei488 – 51023Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Solute carrier family 22 member 7
PRO_0000317482Add
BLAST

Proteomic databases

PaxDbiQ91WU2.
PRIDEiQ91WU2.

PTM databases

PhosphoSiteiQ91WU2.

Expressioni

Tissue specificityi

Abundant expression in male and female kidney and also in female liver.1 Publication

Gene expression databases

BgeeiQ91WU2.
GenevestigatoriQ91WU2.

Structurei

3D structure databases

ProteinModelPortaliQ91WU2.
SMRiQ91WU2. Positions 144-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00750000117345.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ91WU2.
KOiK08204.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ91WU2.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91WU2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGFEELLHKV GGFGPFQLRN LVLLALPRFL LPMHFLLPIF MAAVPAHHCA    50
LPDAPANLSH QDLWLKTHLP RETDGSFSSC LRFAYPQALP NVTLGTEVYN 100
SGEPEGEPLT VPCSQGWEYD RSEFSSTIAT EWDLVCEQRG LNKVTSTCFF 150
IGVLLGAVVY GYLSDRFGRR RLLLVAYVST LALGLMSAAS VNYIMFVTTR 200
MLTGSALAGF TIIVLPLELE WLDVEHRTVA GVISTTFWTG GVLLLTLVGY 250
LIRSWRWLLL AATLPCVPGI ISIWWVPESA RWLLTQGRVE EAKKYLSICA 300
KLNGRPISED SLSQEALNKV ITMERVSQRP SYLDLFRTSQ LRHVSLCCMM 350
MWFGVNFSYY GLTLDASGLG LTVYQTQLLF GAVEVPSKIT VFFLVRLVGR 400
RLTEAGMLLA TALTFGISLL VSSDTKSWIT ALVVIGKAFS EAAFTTAYLF 450
TSELYPTVLR QTGMGFTALI GRLGASLAPL VVLLDGVWLL LPKLAYGGIS 500
FLAACTVLLL PETKKAQLPE TIQDVERKGR KIDRSGTELA 540
Length:540
Mass (Da):59,614
Last modified:December 1, 2001 - v1
Checksum:i2A5AA5A5E0F30BAE
GO
Isoform 2 (identifier: Q91WU2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-124: Missing.
     125-131: SSTIATE → MGESSET

Show »
Length:416
Mass (Da):45,803
Checksum:i2A6DDB3800FC3136
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 124124Missing in isoform 2.
VSP_030995Add
BLAST
Alternative sequencei125 – 1317SSTIATE → MGESSET in isoform 2.
VSP_030996

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461A → T in BAC02736. 1 Publication
Sequence conflicti82 – 821R → H in BAC02736. 1 Publication
Sequence conflicti85 – 851Y → C in BAC38659. 1 Publication
Sequence conflicti137 – 1371E → Q in BAC38659. 1 Publication
Sequence conflicti137 – 1371E → Q in BAE25625. 1 Publication
Sequence conflicti193 – 1931Y → N in BAC38659. 1 Publication
Sequence conflicti255 – 2551W → S in AAH26598. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB069965 mRNA. Translation: BAC02736.1.
AK082865 mRNA. Translation: BAC38659.1.
AK143949 mRNA. Translation: BAE25625.1.
BC013474 mRNA. Translation: AAH13474.1.
BC024119 mRNA. Translation: AAH24119.1.
BC025813 mRNA. Translation: AAH25813.1.
BC026598 mRNA. Translation: AAH26598.1.
BC026597 mRNA. Translation: AAH26597.1.
CCDSiCCDS28829.1. [Q91WU2-1]
RefSeqiNP_659105.2. NM_144856.2.
UniGeneiMm.387538.

Genome annotation databases

EnsembliENSMUST00000087012; ENSMUSP00000084234; ENSMUSG00000067144.
GeneIDi108114.
KEGGimmu:108114.
UCSCiuc008csw.2. mouse. [Q91WU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB069965 mRNA. Translation: BAC02736.1 .
AK082865 mRNA. Translation: BAC38659.1 .
AK143949 mRNA. Translation: BAE25625.1 .
BC013474 mRNA. Translation: AAH13474.1 .
BC024119 mRNA. Translation: AAH24119.1 .
BC025813 mRNA. Translation: AAH25813.1 .
BC026598 mRNA. Translation: AAH26598.1 .
BC026597 mRNA. Translation: AAH26597.1 .
CCDSi CCDS28829.1. [Q91WU2-1 ]
RefSeqi NP_659105.2. NM_144856.2.
UniGenei Mm.387538.

3D structure databases

ProteinModelPortali Q91WU2.
SMRi Q91WU2. Positions 144-514.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073716.

PTM databases

PhosphoSitei Q91WU2.

Proteomic databases

PaxDbi Q91WU2.
PRIDEi Q91WU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087012 ; ENSMUSP00000084234 ; ENSMUSG00000067144 .
GeneIDi 108114.
KEGGi mmu:108114.
UCSCi uc008csw.2. mouse. [Q91WU2-1 ]

Organism-specific databases

CTDi 10864.
MGIi MGI:1859559. Slc22a7.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00750000117345.
HOGENOMi HOG000234569.
HOVERGENi HBG108433.
InParanoidi Q91WU2.
KOi K08204.
OrthoDBi EOG7C8GH9.
PhylomeDBi Q91WU2.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_198604. Organic anion transport.

Miscellaneous databases

NextBioi 360092.
PROi Q91WU2.
SOURCEi Search...

Gene expression databases

Bgeei Q91WU2.
Genevestigatori Q91WU2.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice."
    Kobayashi Y., Ohshiro N., Shibusawa A., Sasaki T., Tokuyama S., Sekine T., Endou H., Yamamoto T.
    Mol. Pharmacol. 62:7-14(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Kidney and Liver.
  4. "Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide."
    Kobayashi Y., Ohbayashi M., Kohyama N., Yamamoto T.
    Eur. J. Pharmacol. 524:44-48(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

Entry informationi

Entry nameiS22A7_MOUSE
AccessioniPrimary (citable) accession number: Q91WU2
Secondary accession number(s): Q3UNX2
, Q8BUQ9, Q8K4S9, Q8R0M7, Q8R125
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi