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Q91WU2

- S22A7_MOUSE

UniProt

Q91WU2 - S22A7_MOUSE

Protein

Solute carrier family 22 member 7

Gene

Slc22a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Mediates sodium-independent multispecific organic anion transport. High affinity transport of glutarate and prostaglandin E2 in a sodium-independent manner. Mediates also the uptake of alpha-ketoglutarate, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, allopurinol and bumetanide.1 Publication

    Kineticsi

    1. KM=15.8 µM for glutarate2 Publications
    2. KM=5.2 nM for prostaglandin E22 Publications
    3. KM=9.12 µM for bumetanide2 Publications

    GO - Molecular functioni

    1. organic anion transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. organic anion transport Source: MGI
    2. response to stilbenoid Source: UniProtKB

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198604. Organic anion transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 7
    Alternative name(s):
    Organic anion transporter 2
    Short name:
    mOAT2
    Gene namesi
    Name:Slc22a7
    Synonyms:Oat2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1859559. Slc22a7.

    Subcellular locationi

    Basolateral cell membrane; Multi-pass membrane protein
    Note: Apical side of the renal tubule.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Solute carrier family 22 member 7PRO_0000317482Add
    BLAST

    Proteomic databases

    PaxDbiQ91WU2.
    PRIDEiQ91WU2.

    PTM databases

    PhosphoSiteiQ91WU2.

    Expressioni

    Tissue specificityi

    Abundant expression in male and female kidney and also in female liver.1 Publication

    Gene expression databases

    BgeeiQ91WU2.
    GenevestigatoriQ91WU2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91WU2.
    SMRiQ91WU2. Positions 144-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei344 – 36421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei462 – 48423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei488 – 51023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00750000117345.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ91WU2.
    KOiK08204.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ91WU2.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91WU2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFEELLHKV GGFGPFQLRN LVLLALPRFL LPMHFLLPIF MAAVPAHHCA    50
    LPDAPANLSH QDLWLKTHLP RETDGSFSSC LRFAYPQALP NVTLGTEVYN 100
    SGEPEGEPLT VPCSQGWEYD RSEFSSTIAT EWDLVCEQRG LNKVTSTCFF 150
    IGVLLGAVVY GYLSDRFGRR RLLLVAYVST LALGLMSAAS VNYIMFVTTR 200
    MLTGSALAGF TIIVLPLELE WLDVEHRTVA GVISTTFWTG GVLLLTLVGY 250
    LIRSWRWLLL AATLPCVPGI ISIWWVPESA RWLLTQGRVE EAKKYLSICA 300
    KLNGRPISED SLSQEALNKV ITMERVSQRP SYLDLFRTSQ LRHVSLCCMM 350
    MWFGVNFSYY GLTLDASGLG LTVYQTQLLF GAVEVPSKIT VFFLVRLVGR 400
    RLTEAGMLLA TALTFGISLL VSSDTKSWIT ALVVIGKAFS EAAFTTAYLF 450
    TSELYPTVLR QTGMGFTALI GRLGASLAPL VVLLDGVWLL LPKLAYGGIS 500
    FLAACTVLLL PETKKAQLPE TIQDVERKGR KIDRSGTELA 540
    Length:540
    Mass (Da):59,614
    Last modified:December 1, 2001 - v1
    Checksum:i2A5AA5A5E0F30BAE
    GO
    Isoform 2 (identifier: Q91WU2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-124: Missing.
         125-131: SSTIATE → MGESSET

    Show »
    Length:416
    Mass (Da):45,803
    Checksum:i2A6DDB3800FC3136
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461A → T in BAC02736. (PubMed:12065749)Curated
    Sequence conflicti82 – 821R → H in BAC02736. (PubMed:12065749)Curated
    Sequence conflicti85 – 851Y → C in BAC38659. (PubMed:16141072)Curated
    Sequence conflicti137 – 1371E → Q in BAC38659. (PubMed:16141072)Curated
    Sequence conflicti137 – 1371E → Q in BAE25625. (PubMed:16141072)Curated
    Sequence conflicti193 – 1931Y → N in BAC38659. (PubMed:16141072)Curated
    Sequence conflicti255 – 2551W → S in AAH26598. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 124124Missing in isoform 2. 2 PublicationsVSP_030995Add
    BLAST
    Alternative sequencei125 – 1317SSTIATE → MGESSET in isoform 2. 2 PublicationsVSP_030996

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB069965 mRNA. Translation: BAC02736.1.
    AK082865 mRNA. Translation: BAC38659.1.
    AK143949 mRNA. Translation: BAE25625.1.
    BC013474 mRNA. Translation: AAH13474.1.
    BC024119 mRNA. Translation: AAH24119.1.
    BC025813 mRNA. Translation: AAH25813.1.
    BC026598 mRNA. Translation: AAH26598.1.
    BC026597 mRNA. Translation: AAH26597.1.
    CCDSiCCDS28829.1. [Q91WU2-1]
    RefSeqiNP_659105.2. NM_144856.2.
    UniGeneiMm.387538.

    Genome annotation databases

    EnsembliENSMUST00000087012; ENSMUSP00000084234; ENSMUSG00000067144.
    GeneIDi108114.
    KEGGimmu:108114.
    UCSCiuc008csw.2. mouse. [Q91WU2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB069965 mRNA. Translation: BAC02736.1 .
    AK082865 mRNA. Translation: BAC38659.1 .
    AK143949 mRNA. Translation: BAE25625.1 .
    BC013474 mRNA. Translation: AAH13474.1 .
    BC024119 mRNA. Translation: AAH24119.1 .
    BC025813 mRNA. Translation: AAH25813.1 .
    BC026598 mRNA. Translation: AAH26598.1 .
    BC026597 mRNA. Translation: AAH26597.1 .
    CCDSi CCDS28829.1. [Q91WU2-1 ]
    RefSeqi NP_659105.2. NM_144856.2.
    UniGenei Mm.387538.

    3D structure databases

    ProteinModelPortali Q91WU2.
    SMRi Q91WU2. Positions 144-514.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2073716.

    PTM databases

    PhosphoSitei Q91WU2.

    Proteomic databases

    PaxDbi Q91WU2.
    PRIDEi Q91WU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087012 ; ENSMUSP00000084234 ; ENSMUSG00000067144 .
    GeneIDi 108114.
    KEGGi mmu:108114.
    UCSCi uc008csw.2. mouse. [Q91WU2-1 ]

    Organism-specific databases

    CTDi 10864.
    MGIi MGI:1859559. Slc22a7.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00750000117345.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    InParanoidi Q91WU2.
    KOi K08204.
    OrthoDBi EOG7C8GH9.
    PhylomeDBi Q91WU2.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_198604. Organic anion transport.

    Miscellaneous databases

    NextBioi 360092.
    PROi Q91WU2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91WU2.
    Genevestigatori Q91WU2.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    IPR005828. Sub_transporter.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00898. 2A0119. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice."
      Kobayashi Y., Ohshiro N., Shibusawa A., Sasaki T., Tokuyama S., Sekine T., Endou H., Yamamoto T.
      Mol. Pharmacol. 62:7-14(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: FVB/N.
      Tissue: Kidney and Liver.
    4. "Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide."
      Kobayashi Y., Ohbayashi M., Kohyama N., Yamamoto T.
      Eur. J. Pharmacol. 524:44-48(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.

    Entry informationi

    Entry nameiS22A7_MOUSE
    AccessioniPrimary (citable) accession number: Q91WU2
    Secondary accession number(s): Q3UNX2
    , Q8BUQ9, Q8K4S9, Q8R0M7, Q8R125
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3