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Protein

DnaJ homolog subfamily C member 17

Gene

Dnajc17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May negatively affect PAX8-induced thyroglobulin/TG transcription.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • toxin transport Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChaperone, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 17
Gene namesi
Name:Dnajc17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916658 Dnajc17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal after the morula stage.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471191 – 303DnaJ homolog subfamily C member 17Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineBy similarity1
Modified residuei264N6-methyllysineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ91WT4
MaxQBiQ91WT4
PaxDbiQ91WT4
PeptideAtlasiQ91WT4
PRIDEiQ91WT4

PTM databases

iPTMnetiQ91WT4
PhosphoSitePlusiQ91WT4

Expressioni

Tissue specificityi

Expressed in the thyroid gland.1 Publication

Gene expression databases

BgeeiENSMUSG00000034278
CleanExiMM_DNAJC17
GenevisibleiQ91WT4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041841

Structurei

3D structure databases

ProteinModelPortaliQ91WT4
SMRiQ91WT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 76JPROSITE-ProRule annotationAdd BLAST66
Domaini178 – 249RRMAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 117Poly-Glu5

Phylogenomic databases

eggNOGiKOG0691 Eukaryota
COG2214 LUCA
GeneTreeiENSGT00550000074688
HOGENOMiHOG000239711
HOVERGENiHBG062744
InParanoidiQ91WT4
KOiK09537
OMAiDSAQHRI
OrthoDBiEOG091G0L2J
TreeFamiTF321770

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd12429 RRM_DNAJC17, 1 hit
Gene3Di1.10.287.110, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR034254 DNAJC17_RRM
IPR036869 J_dom_sf
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA
60 70 80 90 100
ELFHQLSQAL EVLTDAAARA AYDKVRKAKK QAAERTQRLD ENRKKVKLDL
110 120 130 140 150
EARERQAQAH GSEEEEESRS ATTLEQEIAR LREEGSRQLE EQQRLIQEQI
160 170 180 190 200
RQDREQRLRG RTENTEGKGT PKLKLKWKCK KEDESQGGYS RDVLLRLLQK
210 220 230 240 250
YGEVLNLVLS RKKAGNAIVE FATVRAAELA VRNEVGLADN PLKVSWLEGQ
260 270 280 290 300
PQSTVDPGPP GLSKGSVLSE RDFESLVMMR MRQAAERQQL IAQMQQEDEG

RPT
Length:303
Mass (Da):34,465
Last modified:October 3, 2012 - v2
Checksum:iBA9DBFAB149888B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152Q → R in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti161R → E in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti184E → D in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti258G → S in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti273F → Y in AAH13487 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772264 Genomic DNA No translation available.
BC013487 mRNA Translation: AAH13487.1
AK077385 mRNA Translation: BAC36778.1
CCDSiCCDS16593.1
RefSeqiNP_631878.2, NM_139139.2
UniGeneiMm.222241

Genome annotation databases

EnsembliENSMUST00000038439; ENSMUSP00000041841; ENSMUSG00000034278
GeneIDi69408
KEGGimmu:69408
UCSCiuc008ltg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDJC17_MOUSE
AccessioniPrimary (citable) accession number: Q91WT4
Secondary accession number(s): A3KGH2, Q8C5R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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