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Protein

DnaJ homolog subfamily C member 17

Gene

Dnajc17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May negatively affect PAX8-induced thyroglobulin/TG transcription.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • toxin transport Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChaperone, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 17
Gene namesi
Name:Dnajc17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916658. Dnajc17.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly nuclear.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal after the morula stage.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471191 – 303DnaJ homolog subfamily C member 17Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineBy similarity1
Modified residuei264N6-methyllysineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ91WT4.
MaxQBiQ91WT4.
PaxDbiQ91WT4.
PeptideAtlasiQ91WT4.
PRIDEiQ91WT4.

PTM databases

iPTMnetiQ91WT4.
PhosphoSitePlusiQ91WT4.

Expressioni

Tissue specificityi

Expressed in the thyroid gland.1 Publication

Gene expression databases

BgeeiENSMUSG00000034278.
CleanExiMM_DNAJC17.
GenevisibleiQ91WT4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041841.

Structurei

3D structure databases

ProteinModelPortaliQ91WT4.
SMRiQ91WT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 76JPROSITE-ProRule annotationAdd BLAST66
Domaini178 – 249RRMAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 117Poly-Glu5

Phylogenomic databases

eggNOGiKOG0691. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00550000074688.
HOGENOMiHOG000239711.
HOVERGENiHBG062744.
InParanoidiQ91WT4.
KOiK09537.
OMAiDSAQHRI.
OrthoDBiEOG091G0L2J.
TreeFamiTF321770.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
cd12429. RRM_DNAJC17. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR034254. DNAJC17_RRM.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
PF00076. RRM_1. 1 hit.
PRINTSiPR00625. JDOMAIN.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91WT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA
60 70 80 90 100
ELFHQLSQAL EVLTDAAARA AYDKVRKAKK QAAERTQRLD ENRKKVKLDL
110 120 130 140 150
EARERQAQAH GSEEEEESRS ATTLEQEIAR LREEGSRQLE EQQRLIQEQI
160 170 180 190 200
RQDREQRLRG RTENTEGKGT PKLKLKWKCK KEDESQGGYS RDVLLRLLQK
210 220 230 240 250
YGEVLNLVLS RKKAGNAIVE FATVRAAELA VRNEVGLADN PLKVSWLEGQ
260 270 280 290 300
PQSTVDPGPP GLSKGSVLSE RDFESLVMMR MRQAAERQQL IAQMQQEDEG

RPT
Length:303
Mass (Da):34,465
Last modified:October 3, 2012 - v2
Checksum:iBA9DBFAB149888B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152Q → R in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti161R → E in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti184E → D in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti258G → S in AAH13487 (PubMed:15489334).Curated1
Sequence conflicti273F → Y in AAH13487 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772264 Genomic DNA. Translation: CAM45942.1.
BC013487 mRNA. Translation: AAH13487.1.
AK077385 mRNA. Translation: BAC36778.1.
CCDSiCCDS16593.1.
RefSeqiNP_631878.2. NM_139139.2.
UniGeneiMm.222241.

Genome annotation databases

EnsembliENSMUST00000038439; ENSMUSP00000041841; ENSMUSG00000034278.
GeneIDi69408.
KEGGimmu:69408.
UCSCiuc008ltg.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDJC17_MOUSE
AccessioniPrimary (citable) accession number: Q91WT4
Secondary accession number(s): A3KGH2, Q8C5R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 3, 2012
Last modified: June 7, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot