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Protein

DnaJ homolog subfamily C member 17

Gene

Dnajc17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May negatively affect PAX8-induced thyroglobulin/TG transcription.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • toxin transport Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 17
Gene namesi
Name:Dnajc17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916658. Dnajc17.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly nuclear.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal after the morula stage.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303DnaJ homolog subfamily C member 17PRO_0000247119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91WT4.
MaxQBiQ91WT4.
PaxDbiQ91WT4.
PeptideAtlasiQ91WT4.
PRIDEiQ91WT4.

PTM databases

iPTMnetiQ91WT4.
PhosphoSiteiQ91WT4.

Expressioni

Tissue specificityi

Expressed in the thyroid gland.1 Publication

Gene expression databases

CleanExiMM_DNAJC17.
GenevisibleiQ91WT4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041841.

Structurei

3D structure databases

ProteinModelPortaliQ91WT4.
SMRiQ91WT4. Positions 13-74, 170-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 7666JPROSITE-ProRule annotationAdd
BLAST
Domaini178 – 24972RRMAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi113 – 1175Poly-Glu

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0691. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00550000074688.
HOGENOMiHOG000239711.
HOVERGENiHBG062744.
InParanoidiQ91WT4.
KOiK09537.
OMAiDSAQHRI.
OrthoDBiEOG7RRF89.
TreeFamiTF321770.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA
60 70 80 90 100
ELFHQLSQAL EVLTDAAARA AYDKVRKAKK QAAERTQRLD ENRKKVKLDL
110 120 130 140 150
EARERQAQAH GSEEEEESRS ATTLEQEIAR LREEGSRQLE EQQRLIQEQI
160 170 180 190 200
RQDREQRLRG RTENTEGKGT PKLKLKWKCK KEDESQGGYS RDVLLRLLQK
210 220 230 240 250
YGEVLNLVLS RKKAGNAIVE FATVRAAELA VRNEVGLADN PLKVSWLEGQ
260 270 280 290 300
PQSTVDPGPP GLSKGSVLSE RDFESLVMMR MRQAAERQQL IAQMQQEDEG

RPT
Length:303
Mass (Da):34,465
Last modified:October 3, 2012 - v2
Checksum:iBA9DBFAB149888B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521Q → R in AAH13487 (PubMed:15489334).Curated
Sequence conflicti161 – 1611R → E in AAH13487 (PubMed:15489334).Curated
Sequence conflicti184 – 1841E → D in AAH13487 (PubMed:15489334).Curated
Sequence conflicti258 – 2581G → S in AAH13487 (PubMed:15489334).Curated
Sequence conflicti273 – 2731F → Y in AAH13487 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772264 Genomic DNA. Translation: CAM45942.1.
BC013487 mRNA. Translation: AAH13487.1.
AK077385 mRNA. Translation: BAC36778.1.
CCDSiCCDS16593.1.
RefSeqiNP_631878.2. NM_139139.2.
UniGeneiMm.222241.

Genome annotation databases

EnsembliENSMUST00000038439; ENSMUSP00000041841; ENSMUSG00000034278.
GeneIDi69408.
KEGGimmu:69408.
UCSCiuc008ltg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772264 Genomic DNA. Translation: CAM45942.1.
BC013487 mRNA. Translation: AAH13487.1.
AK077385 mRNA. Translation: BAC36778.1.
CCDSiCCDS16593.1.
RefSeqiNP_631878.2. NM_139139.2.
UniGeneiMm.222241.

3D structure databases

ProteinModelPortaliQ91WT4.
SMRiQ91WT4. Positions 13-74, 170-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041841.

PTM databases

iPTMnetiQ91WT4.
PhosphoSiteiQ91WT4.

Proteomic databases

EPDiQ91WT4.
MaxQBiQ91WT4.
PaxDbiQ91WT4.
PeptideAtlasiQ91WT4.
PRIDEiQ91WT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038439; ENSMUSP00000041841; ENSMUSG00000034278.
GeneIDi69408.
KEGGimmu:69408.
UCSCiuc008ltg.2. mouse.

Organism-specific databases

CTDi55192.
MGIiMGI:1916658. Dnajc17.

Phylogenomic databases

eggNOGiKOG0691. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00550000074688.
HOGENOMiHOG000239711.
HOVERGENiHBG062744.
InParanoidiQ91WT4.
KOiK09537.
OMAiDSAQHRI.
OrthoDBiEOG7RRF89.
TreeFamiTF321770.

Miscellaneous databases

PROiQ91WT4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DNAJC17.
GenevisibleiQ91WT4. MM.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-303.
    Strain: C57BL/6J.
    Tissue: Head.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.
  5. "A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid."
    Amendola E., Sanges R., Galvan A., Dathan N., Manenti G., Ferrandino G., Alvino F.M., Di Palma T., Scarfo M., Zannini M., Dragani T.A., De Felice M., Di Lauro R.
    Endocrinology 151:1948-1958(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiDJC17_MOUSE
AccessioniPrimary (citable) accession number: Q91WT4
Secondary accession number(s): A3KGH2, Q8C5R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 3, 2012
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.