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Q91WS4

- BHMT2_MOUSE

UniProt

Q91WS4 - BHMT2_MOUSE

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Protein
S-methylmethionine--homocysteine S-methyltransferase BHMT2
Gene
Bhmt2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.1 Publication

Catalytic activityi

S-methyl-L-methionine + L-homocysteine = 2 L-methionine.1 Publication

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi208 – 2081Zinc By similarity
Metal bindingi290 – 2901Zinc By similarity
Metal bindingi291 – 2911Zinc By similarity

GO - Molecular functioni

  1. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: MGI
  2. betaine-homocysteine S-methyltransferase activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. methionine biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00051; UER00083.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methylmethionine--homocysteine S-methyltransferase BHMT2 (EC:2.1.1.10)
Short name:
SMM-hcy methyltransferase
Alternative name(s):
Betaine--homocysteine S-methyltransferase 2
Gene namesi
Name:Bhmt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1891379. Bhmt2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363S-methylmethionine--homocysteine S-methyltransferase BHMT2
PRO_0000273225Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei321 – 3211Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91WS4.
PRIDEiQ91WS4.

PTM databases

PhosphoSiteiQ91WS4.

Expressioni

Tissue specificityi

Expressed in fetal heart, lung, liver, kidney and eye.1 Publication

Gene expression databases

BgeeiQ91WS4.
CleanExiMM_BHMT2.
GenevestigatoriQ91WS4.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ91WS4.
SMRiQ91WS4. Positions 10-363.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 305295Hcy-binding
Add
BLAST

Sequence similaritiesi

Contains 1 Hcy-binding domain.

Phylogenomic databases

eggNOGiCOG0646.
GeneTreeiENSGT00390000003122.
HOGENOMiHOG000231636.
HOVERGENiHBG080367.
InParanoidiB1B1C9.
OMAiPEGDMHD.
OrthoDBiEOG79GT7C.
PhylomeDBiQ91WS4.
TreeFamiTF329202.

Family and domain databases

Gene3Di3.20.20.330. 1 hit.
InterProiIPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. S_MeTrfase.
[Graphical view]
PfamiPF02574. S-methyl_trans. 1 hit.
[Graphical view]
PIRSFiPIRSF037505. Betaine_HMT. 1 hit.
SUPFAMiSSF82282. SSF82282. 1 hit.
PROSITEiPS50970. HCY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91WS4-1 [UniParc]FASTAAdd to Basket

« Hide

MAPAGSTRAK KGILERLDSG EVVVGDSGFL FTLEKRGFVK AGLWTPEAVV    50
EHPSAVRQLH TEFLRAGADV LQTFTFSATE DNMASKWEAV NAAACDLAQE 100
VAGGGGALVA GGICQTSLYK YHKDETRIKN IFRLQLEVFA RKNVDFLIAE 150
YFEHVEEAVW AVEVLREVGA PVAVTMCIGP EGDMHDVTPG ECAVKLARAG 200
ADIIGVNCRF GPWTSLQTMK LMKEGLRDAS LQAHLMVQCL GFHTPDCGKG 250
GFVDLPEYPF GLEPRVATRW DIQKYAREAY NLGIRYIGGC CGFEPYHIRA 300
IAEELAPERG FLPPASEKHG SWGSGLNMHT KPWIRARARR EYWENLLPAS 350
GRPFCPSLSK PDA 363
Length:363
Mass (Da):39,872
Last modified:January 23, 2007 - v2
Checksum:iC7367F1B10B07EEF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131I → V in AAG41357. 1 Publication
Sequence conflicti27 – 271S → G in AAH13515. 1 Publication
Sequence conflicti36 – 361R → G in AAG41357. 1 Publication
Sequence conflicti327 – 3271N → S in AAG41357. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF257474 mRNA. Translation: AAG41357.1.
AK090308 mRNA. Translation: BAC41163.1.
AK145901 mRNA. Translation: BAE26737.1.
CT030023, AC158524 Genomic DNA. Translation: CAO77969.1.
BC013515 mRNA. Translation: AAH13515.1.
CCDSiCCDS26689.1.
RefSeqiNP_075022.2. NM_022884.2.
UniGeneiMm.29981.

Genome annotation databases

EnsembliENSMUST00000015941; ENSMUSP00000015941; ENSMUSG00000042118.
GeneIDi64918.
KEGGimmu:64918.
UCSCiuc007rlk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF257474 mRNA. Translation: AAG41357.1 .
AK090308 mRNA. Translation: BAC41163.1 .
AK145901 mRNA. Translation: BAE26737.1 .
CT030023 , AC158524 Genomic DNA. Translation: CAO77969.1 .
BC013515 mRNA. Translation: AAH13515.1 .
CCDSi CCDS26689.1.
RefSeqi NP_075022.2. NM_022884.2.
UniGenei Mm.29981.

3D structure databases

ProteinModelPortali Q91WS4.
SMRi Q91WS4. Positions 10-363.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q91WS4.

Proteomic databases

PaxDbi Q91WS4.
PRIDEi Q91WS4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015941 ; ENSMUSP00000015941 ; ENSMUSG00000042118 .
GeneIDi 64918.
KEGGi mmu:64918.
UCSCi uc007rlk.1. mouse.

Organism-specific databases

CTDi 23743.
MGIi MGI:1891379. Bhmt2.

Phylogenomic databases

eggNOGi COG0646.
GeneTreei ENSGT00390000003122.
HOGENOMi HOG000231636.
HOVERGENi HBG080367.
InParanoidi B1B1C9.
OMAi PEGDMHD.
OrthoDBi EOG79GT7C.
PhylomeDBi Q91WS4.
TreeFami TF329202.

Enzyme and pathway databases

UniPathwayi UPA00051 ; UER00083 .

Miscellaneous databases

NextBioi 320219.
PROi Q91WS4.
SOURCEi Search...

Gene expression databases

Bgeei Q91WS4.
CleanExi MM_BHMT2.
Genevestigatori Q91WS4.

Family and domain databases

Gene3Di 3.20.20.330. 1 hit.
InterProi IPR017226. Betaine-hCys_S-MeTrfase_BHMT.
IPR003726. S_MeTrfase.
[Graphical view ]
Pfami PF02574. S-methyl_trans. 1 hit.
[Graphical view ]
PIRSFi PIRSF037505. Betaine_HMT. 1 hit.
SUPFAMi SSF82282. SSF82282. 1 hit.
PROSITEi PS50970. HCY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes."
    Chadwick L.H., McCandless S.E., Silverman G.L., Schwartz S., Westaway D., Nadeau J.H.
    Genomics 70:66-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Gall bladder and Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase."
    Szegedi S.S., Castro C.C., Koutmos M., Garrow T.A.
    J. Biol. Chem. 283:8939-8945(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiBHMT2_MOUSE
AccessioniPrimary (citable) accession number: Q91WS4
Secondary accession number(s): B1B1C9, Q8C1U2, Q9EQE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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