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Protein

S-methylmethionine--homocysteine S-methyltransferase BHMT2

Gene

Bhmt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.1 Publication

Catalytic activityi

S-methyl-L-methionine + L-homocysteine = 2 L-methionine.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route).
Proteins known to be involved in this subpathway in this organism are:
  1. Betaine--homocysteine S-methyltransferase 1 (Bhmt), S-methylmethionine--homocysteine S-methyltransferase BHMT2 (Bhmt2)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (BhmT route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi208ZincPROSITE-ProRule annotation1
Metal bindingi290ZincPROSITE-ProRule annotation1
Metal bindingi291ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1614635 Sulfur amino acid metabolism
UniPathwayiUPA00051; UER00083

Names & Taxonomyi

Protein namesi
Recommended name:
S-methylmethionine--homocysteine S-methyltransferase BHMT2 (EC:2.1.1.10)
Short name:
SMM-hcy methyltransferase
Alternative name(s):
Betaine--homocysteine S-methyltransferase 2
Gene namesi
Name:Bhmt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1891379 Bhmt2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002732251 – 363S-methylmethionine--homocysteine S-methyltransferase BHMT2Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91WS4
PaxDbiQ91WS4
PeptideAtlasiQ91WS4
PRIDEiQ91WS4

PTM databases

iPTMnetiQ91WS4
PhosphoSitePlusiQ91WS4
SwissPalmiQ91WS4

Expressioni

Tissue specificityi

Expressed in fetal heart, lung, liver, kidney and eye.1 Publication

Gene expression databases

BgeeiENSMUSG00000042118
CleanExiMM_BHMT2
GenevisibleiQ91WS4 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015941

Structurei

3D structure databases

ProteinModelPortaliQ91WS4
SMRiQ91WS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 305Hcy-bindingPROSITE-ProRule annotationAdd BLAST295

Phylogenomic databases

eggNOGiKOG1579 Eukaryota
COG0646 LUCA
GeneTreeiENSGT00390000003122
HOGENOMiHOG000231636
HOVERGENiHBG080367
InParanoidiQ91WS4
KOiK00547
OMAiFARKNVD
OrthoDBiEOG091G09QD
PhylomeDBiQ91WS4
TreeFamiTF329202

Family and domain databases

Gene3Di3.20.20.330, 1 hit
InterProiView protein in InterPro
IPR017226 Betaine-hCys_S-MeTrfase_BHMT
IPR003726 HCY_dom
IPR036589 HCY_dom_sf
PfamiView protein in Pfam
PF02574 S-methyl_trans, 1 hit
PIRSFiPIRSF037505 Betaine_HMT, 1 hit
SUPFAMiSSF82282 SSF82282, 1 hit
PROSITEiView protein in PROSITE
PS50970 HCY, 1 hit

Sequencei

Sequence statusi: Complete.

Q91WS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAGSTRAK KGILERLDSG EVVVGDSGFL FTLEKRGFVK AGLWTPEAVV
60 70 80 90 100
EHPSAVRQLH TEFLRAGADV LQTFTFSATE DNMASKWEAV NAAACDLAQE
110 120 130 140 150
VAGGGGALVA GGICQTSLYK YHKDETRIKN IFRLQLEVFA RKNVDFLIAE
160 170 180 190 200
YFEHVEEAVW AVEVLREVGA PVAVTMCIGP EGDMHDVTPG ECAVKLARAG
210 220 230 240 250
ADIIGVNCRF GPWTSLQTMK LMKEGLRDAS LQAHLMVQCL GFHTPDCGKG
260 270 280 290 300
GFVDLPEYPF GLEPRVATRW DIQKYAREAY NLGIRYIGGC CGFEPYHIRA
310 320 330 340 350
IAEELAPERG FLPPASEKHG SWGSGLNMHT KPWIRARARR EYWENLLPAS
360
GRPFCPSLSK PDA
Length:363
Mass (Da):39,872
Last modified:January 23, 2007 - v2
Checksum:iC7367F1B10B07EEF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13I → V in AAG41357 (PubMed:11087663).Curated1
Sequence conflicti27S → G in AAH13515 (PubMed:15489334).Curated1
Sequence conflicti36R → G in AAG41357 (PubMed:11087663).Curated1
Sequence conflicti327N → S in AAG41357 (PubMed:11087663).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257474 mRNA Translation: AAG41357.1
AK090308 mRNA Translation: BAC41163.1
AK145901 mRNA Translation: BAE26737.1
CT030023, AC158524 Genomic DNA Translation: CAO77969.1
BC013515 mRNA Translation: AAH13515.1
CCDSiCCDS26689.1
RefSeqiNP_075022.2, NM_022884.2
UniGeneiMm.29981

Genome annotation databases

EnsembliENSMUST00000015941; ENSMUSP00000015941; ENSMUSG00000042118
GeneIDi64918
KEGGimmu:64918
UCSCiuc007rlk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBHMT2_MOUSE
AccessioniPrimary (citable) accession number: Q91WS4
Secondary accession number(s): B1B1C9, Q8C1U2, Q9EQE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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